Reserpine

Catalog No.S1601

Reserpine Chemical Structure

Molecular Weight(MW): 608.68

Reserpine is an inhibitor of multidrug efflux pumps, used as an antipsychotic and antihypertensive drug.

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In DMSO USD 130 In stock
USD 97 In stock
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1 Customer Review

  • (A) Changes of cAMP levels measured by the cAMP-Glo assay (Promega). Gpr52 siRNAs were tranfected for 3 days, whereas the compound treatment (forskolin: 1 μM; reserpine: 10 μM) lasts for 24 hr; statistical analyses performed by the twotailed Mann-Whitney U test. (B) Htt level measured by the 2B7/2166 HTRF upon treatment of different doses of the Gpr52 agonist reserpine for 48 hr, with transfection of Gpr52 siRNA (Gpr52_si1) vs the non-targeting control (Neg_si), n = 4.

    Elife, 2015, 4:e05449.. Reserpine purchased from Selleck.

Purity & Quality Control

Biological Activity

Description Reserpine is an inhibitor of multidrug efflux pumps, used as an antipsychotic and antihypertensive drug.
In vitro

Reserpine inhibits efflux pumps and reduces sparfloxacin, moxifloxacin and ciprofloxacin IC50s and MICs by up to four-fold in 11, 21 and 48 of the 102 unrelated clinical isolates tested. [1]

In vivo Reserpine (5 mg/kg s.c.) reduces extracellular DA levels to 4% of basal values in intact rats. Reserpine (5 mg/kg s.c.) diminishes L-DOPA (50 mg/kg i.p.)-induced increases in extracellular dopamine levels to 16% of those obtained in denervated animals not pretreated with reserpine in 6-hydroxydopamine-lesioned rats. [2] Reserpine causes a marked depletion of vasopressin/oxytocin-neu-rophysin-like immunoreactivity (LI) and CRH-L1 in the median eminence of the rat. [3] Reserpine significantly restores performance on the delayed response task in monkeys. Reserpine has little effect on performance of a visual discrimination task, a reference memory task which does not depend on the prefrontal cortex. [4] Reserpine injection (one dose of 1 mg/kg s.c.) every other day for 3 days causes a significant increase in vacuous chewing, tongue protrusion and duration of facial twitching in rats, compared to the control. Reserpine results in a decreased glutamate uptake in the subcortical parts of rats. [5] Reserpine (5 mg/kg) significantly increases vacuous jaw movements, and also reduces rearing behavior in all age groups of rats. [6]

Protocol

Solubility (25°C)

In vitro DMSO 13 mg/mL (21.35 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 608.68
Formula

C33H40N2O9

CAS No. 50-55-5
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02684786 Not yet recruiting Pulmonary Artery Hypertension Mayo Clinic March 2016 Phase 1
NCT00267657 Unknown status Amphetamine-Related Disorders National Institute on Drug Abuse (NIDA) January 2004 Phase 1
NCT00033033 Completed Cocaine-Related Disorders|Substance-Related Disorders National Institute on Drug Abuse (NIDA)|Cincinnati VA Medical Center July 2001 Phase 2
NCT00000514 Completed Cardiovascular Diseases|Cerebrovascular Disorders|Heart Diseases|Hypertension National Heart, Lung, and Blood Institute (NHLBI)|National Institute on Aging (NIA) June 1984 Phase 3
NCT00000499 Completed Cardiovascular Diseases|Heart Diseases|Hypertension|Vascular Diseases National Heart, Lung, and Blood Institute (NHLBI)|National Institute on Aging (NIA) September 1980 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID