Omeprazole

Catalog No.S1389

Omeprazole  Chemical Structure

Molecular Weight(MW): 345.42

Omeprazole is a proton pump inhibitor, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 60 In stock
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Biological Activity

Description Omeprazole is a proton pump inhibitor, used to treat dyspepsia, peptic ulcer disease, gastroesophageal reflux disease, laryngopharyngeal reflux, and Zollinger–Ellison syndrome.
Targets
Proton pump [1]
In vitro

Omeprazole potently induces cytochrome P4501A1 mRNA expression in primary human hepatocytes, whereas this effect is not detected in mouse primary hepatocytes. Omeprazole induces transcription of reporter genes via the xenobiotic response element that is recognized by the ligand-activated dioxin receptor in human hepatoma cells. [1] Omeprazole causes a strong inhibition of basal natural killer (NK) activity in spleen cells (SC) from untreated CD2F1 mice. Omeprazole causes a rapid, strong effect on various types of cytotoxic lymphocytes ranging from cytotoxicity inhibition to irreversible cell damage. Omeprazole induces a significant inhibition of cytotoxic activity of all types of effector cells after 30 min incubation. [2] Omeprazole decreases the activation ofosteoclasts but increases that of osteoblasts in vitro, in part causing an osteopetrosis-like effect. [3]

In vivo Omeprazole blocks H(+)-K(+)-ATPase, thus enhances degeneration and macrophage-mediated elimination of parietal cells and also causes an increase in preparietal cell production. Omeprazole temporarily changes the dynamic features of parietal cells in the rabbit to make them die early and grow fast. [4]

Protocol

Solubility (25°C)

In vitro DMSO 69 mg/mL (199.75 mM)
Ethanol 13 mg/mL (37.63 mM)
Water Insoluble
In vivo Add solvents individually and in order:
2% DMSO+30% PEG 300+ddH2O
5mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 345.42
Formula

C17H19N3O3S

CAS No. 73590-58-6
Storage powder
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00339768 Completed Precancerous Gastric Lesions National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) May 8, 1995 Phase 3
NCT00001191 Completed Gastrinoma|Zollinger Ellison Syndrome National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Institutes of Health Clinical Center (CC) February 3, 1983 Phase 2
NCT02724150 Not yet recruiting Gastroduodenal Ulcer|Marginal Ulcer|Peptic Ulcer Hemorrhage Damascus Hospital December 2020 Phase 4
NCT02892357 Not yet recruiting Non-erosive Reflux Disease Xiyuan Hospital of China Academy of Chinese Medical Sciences January 2017 Phase 2
NCT02760615 Not yet recruiting Colitis, Ulcerative|Crohn Disease Takeda January 2017 Phase 4
NCT03028103 Not yet recruiting Diffuse Large B Cell Lymphoma|Primary Mediastinal Lymphoma|Mantle Cell Lymphoma Epizyme, Inc. January 2017 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID