Omeprazole (Prilosec)

Related Proton Pump Inhibitors

• ABT-737

  ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively.

• PI-103

  PI-103 is a potent, ATP-competitive PI3K inhibitor of DNA-PK, p110α, mTORC1, PI3KC2β, p110δ, mTORC2, p110β, and p110γ with IC50 of 2 nM, 8 nM, 20 nM, 26 nM, 48 nM, 83 nM, 88 nM and 150 nM, respectively.

• Y-27632 2HCl

  Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with K_i of 140 nM.

• Obatoclax mesylate (GX15-070)

  Obatoclax (GX15-070) is an inhibitor of Bcl-2 with K_i of 0.22 μM.

• LY294002

  LY294002 is a PI3K inhibitor for p110α, p110δ and p110β with IC50 of 0.5 μM, 0.57 μM and 0.97 μM, and also blocks autophagosome formation.

• PP242

  PP242 is a selective mTOR inhibitor with IC50 of 8 nM.

• PF 3716556

  PF 3716556 is a potent, and selective acid pump antagonist with pIC50 of 6.026, 6.038 and 6.009 at pH 6.4 for the inhibition of H+/K+-ATPase activity of porcine, canine and human ion-leaky membrane vesicles, respectively.

• Geldanamycin

  Geldanamycin is a natural existing HSP90 inhibitor with K_d of 1.2 μM.

• Wortmannin

  Wortmannin is a multi-target inhibitor of MLCK and PI3K with IC50 of 170 nM and 3 nM, also blocks autophagosome formation and potently inhibits DNA-PK/ATM with IC50 of 16 nM and 150 nM

• 3-Methyladenine

  3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM and also blocks autophagosome formation.