Lansoprazole

Catalog No.S1354 Synonyms: A-65006, AG-1749

Lansoprazole Chemical Structure

Molecular Weight(MW): 369.36

Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.

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Biological Activity

Description Lansoprazole is a proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid.
Targets
Proton pump [1]
In vitro

Lansoprazole inhibits gastric acid secretion via inhibition of gastric hydrogen/potassium adenosine triphosphatase (H+,K(+)-ATPase), an enzyme of the gastric parietal cell membrane that forms part of the proton pump that performs the final step in the acid secretory process. Lansoprazole binds covalently to parietal cell H+,K(+)-ATPase, rendering it nonfunctional and inhibiting the secretion of gastric acid. [1] Lansoprazole is a strong anti-secretory agent that acts on gastric H+/K+-adenosine triphosphatase (H+/K+ ATPase) of parietal cells. Lansoprazole inhibits the increased expression of vascular adhesion molecules, the activation of neutrophils, and the production of pro-inflammatory cytokines from activated endothelial cells. Lansoprazole induces several genes, including phase II detoxifying enzyme (NADPH-ubiquinone oxidoreductase, glutathione S-transferase) and antioxidant stress proteins (HO-1, thioredoxin reductase, and superoxide dismutase) in gastric epithelial cells. Lansoprazole significantly inhibits the production of CINC-1 from stimulated RGM-1 cells with IL-1β. Lansoprazole up-regulates HO-1 expression throughout Nrf2 in rat gastric epithelial cells, and the up-regulated HO-1 has anti-inflammatory effects. [2]

In vivo Lansoprazole inhibits acute inflammatory reactions as well as intestinal mucosal injuries induced by ischemia-reperfusion or indomethacin administration in rats. Lansoprazole significantly inhibits intestinal injuries induced by ischemia-reperfusion or indomethacin. lansoprazole administered exogenously prevents the small intestine against ischemia-reperfusion or indomethacin-induced damage, the action being dependent on its anti-inflammatory and anti-oxidative responses. [2]

Protocol

Solubility (25°C)

In vitro DMSO 74 mg/mL (200.34 mM)
Ethanol 14 mg/mL (37.9 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 369.36
Formula

C16H14F3N3O2S

CAS No. 103577-45-3
Storage powder
Synonyms A-65006, AG-1749

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03050307 Not yet recruiting Gastric Ulcer|Peptic Ulcer|Gastrointestinal Diseases|Digestive System Diseases|Lansoprazole|Anti-Ulcer Agents|Gastrointestinal Agents|Proton Pump Inhibitors|Enzyme Inhibitors|Molecular Mechanisms of Pharmacological Action Takeda April 2017 Phase 3
NCT03050359 Not yet recruiting Duodenal Ulcer Takeda April 2017 Phase 3
NCT03015610 Not yet recruiting Asthma|Gastroesophageal Reflux Jason Lang, M.D., M.P.H.|Thrasher Research Fund|Nemours Childrens Clinic|Duke University January 2017 Phase 3
NCT03011125 Not yet recruiting Safety Issues First Affiliated Hospital of Zhejiang University|Jiangsu Aosaikang Oharmaceutical Co. Ltd January 2017 Phase 1
NCT02873689 Recruiting Heartburn|Gastroesophageal Reflux Disease Takeda December 2016 Phase 3
NCT02873702 Recruiting Erosive Esophagitis Takeda December 2016 Phase 3

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Proton Pump Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID