Research Area
Product Type
United States ( Change Country )
Apixaban Chemical Structure
BMS-740808
BMS-740808 is a highly potent, selective, efficacious, and orally bioavailable blood coagulation factor Xa inhibitor with a Ki of 30 pM.
Rivaroxaban (Xarelto)
Rivaroxaban (Xarelto, BAY 59-7939) is an oral, direct inhibitor of Factor Xa with a Ki of 0.4 nM and an IC50 of 0.7 nM for purified human FXa.
LY315920(Varespladib)
LY315920(Varespladib) is a sPLA2 inhibitor (IC50 of 9.6 ±1 nM)
Abiraterone (CB-7598)
Abiraterone (CB-7598) is a potent steroidal cytochrome P450 17alpha-hydroxylase-17,20-lyase (CYP17) inhibitor with an IC50 at 4 nM.
TAK-700 (Orteronel)
Inhibitor of the 17,20 lyase.
Cilostazol
Cilostazol is a medication used in the alleviation of the symptom of intermittent claudication in individuals with peripheral vascular disease.
Isotretinoin
It was developed to be used as a chemotherapy medication for the treatment of brain cancer, pancreatic cancer and more.
Trilostane
Trilostane is an inhibitor of 3 β-hydroxysteroid dehydrogenase used in the treatment of Cushing’s syndrome.
Sildenafil citrate
Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH).
Voriconazole
Voriconazole (VFEND) is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections.
Biological Activity
Apixaban is a direct factor Xa inhibitor with an IC50 of 0.22±0.02 µM. It is a compound being investigated as an anticoagulant. Apixaban has similar affinity for human and rabbit factor Xa (FXa). Rabbits are commonly used in development of thrombosis disease models; however, unlike in other species, apixaban demonstrated poor oral bioavailability (F = 3%) and a high clearance rate in rabbits. Oxidative metabolism of [14C] apixaban by liver microsomes was approximately 20 times faster in rabbits than in rats or humans. [1][2]
References on Apixaban
- [1] http://en.wikipedia.org/wiki/Apixaban ;
- [2] J Thromb Thrombolysis. 2010 Jan;29(1):70-80.
Product Information
| Molecular Weight (WM): | 459.5 |
|---|---|
| Formula: | C25H25N5O4 |
| CAS No.: | 503612-47-3 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥18mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
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