Integrase

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Integrase Inhibitors (5)

water-soluble

Cat.No. Product Name Information Product Citations Customer Reviews
S2005 Raltegravir (MK-0518) Raltegravir (MK-0518) is a potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM, respectively.
  • J Virol, 2012, 86(17):9337-50
  • PLoS One, 2013, 8(11):e81489
  • Vet Microbiol, 2011, 152(1-2):165-8
S2001 Elvitegravir (GS-9137, JTK-303) Elvitegravir (EVG, JTK-303/GS-9137) is an HIV integrase inhibitor for HIV-1 IIIB, HIV-2 EHO and HIV-2 ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.
  • Cancer Res, 2012, 72(23):6200-8
  • Retrovirology, 2010, 7:70
  • J Antimicrob Chemother, 2011, 66(4):802-12
S2667 Dolutegravir (GSK1349572) S/GSK1349572 (GSK1349572) is a two-metal-binding HIV integrase inhibitor with IC50 of 2.7 nM, modest activity against raltegravir-resistant signature mutants Y143R, Q148K, N155H, and G140S/Q148H. Phase 3.
S1366 BMS-707035 BMS-707035 is a specific HIV-I integrase (IN) inhibitor with IC50 of 15 nM. Phase 2.
S2765 MK-2048 MK-2048 is a potent inhibitor of integrase (IN) and INR263K with IC50 of 2.6 nM and 1.5 nM, respectively.