Product Categories

Hedgehog Inhibitors & Chemicals

Cat.No.	Product Name	Information	Product Citations
S1082	Vismodegib (GDC-0449)	GDC-0449 (Vismodegib, HhAntag691) is a potent, novel and specific hedgehog inhibitor with IC50 of 3 nM and also inhibits P-gp with IC50 of 3.0 μM.	Gastroenterology, 2012, 143(5):1319-29.e1-11 Hepatology, 2011, 54(5):1580-90 Gut, 2012, 61(9):1323-9
S1146	Cyclopamine	Cyclopamine is a specific Hedgehog (Hh) signaling pathway antagonist of Smoothened (Smo) with IC50 of 46 nM.	Cancer Res, 2012, 72(9), 2262-2274 Neuro Oncol, 2012, 14(12):1441-51 Cancer Lett, 2012, 322(2), 169-176
S2157	LY2940680	LY2940680 binds to the Smo receptor and potently inhibits Hh signaling.