Home Cell Cycle Wee1 inhibitor Debio 0123 For research use only.

Debio 0123

Synonyms: WEE1-IN-5

WEE1-IN-5 (Debio 0123) is a potent Wee1 inhibitor that inhibits phospho-CDC2 and abrogates the G2 check point.

Debio 0123 Chemical Structure

Debio 0123 Chemical Structure

CAS: 2243882-74-6

Selleck's Debio 0123 has been cited by 1 publication

Purity & Quality Control

Batch: S977801 DMSO] 100 mg/mL] false] Ethanol] 5 mg/mL] false] Water] Insoluble] false Purity: 99.99%
99.99

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Signaling Pathway

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Biological Activity

Description WEE1-IN-5 (Debio 0123) is a potent Wee1 inhibitor that inhibits phospho-CDC2 and abrogates the G2 check point.
Targets
Wee1 [1]
0.8 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05815160 Recruiting
Small Cell Lung Cancer Recurrent
Debiopharm International SA
 May 2 2023 Phase 1
NCT05765812 Recruiting
Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype|Astrocytoma Grade III
Debiopharm International SA
 March 1 2023 Phase 1|Phase 2
NCT05109975 Recruiting
Advanced Solid Tumors
Debiopharm International SA
 November 5 2021 Phase 1
NCT03968653 Recruiting
Advanced Solid Tumors
Debiopharm International SA
 July 30 2019 Phase 1

Chemical Information & Solubility

Molecular Weight 511.45 Formula

C26H28CI2N6O
CAS No. 2243882-74-6 SDF --
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 100 mg/mL ( (195.52 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 5 mg/mL

Water : Insoluble


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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