- Substance P Inhibitors (3)
- New Substance P Products
|Catalog No.||Information||Product Use Citations||Product Validations|
Aprepitant is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM.
HepT1, HepG2, and HuH6 cells were treated with increasing doses of aprepitant or SP [100 nM] and Western blot analysis was performed for the apoptotic markers PARP, Caspase-3, and BID.
Rolapitant is a selective and competitive antagonist of human substance P/NK1 receptors with antiemetic activity. It has a high affinity for the human NK1 receptor of 0.66 nM and high selectivity over the human NK2 and NK3 subtypes of >1000-fold, as well as preferential affinity for human, guinea pig, gerbil and monkey NK1 receptors over rat, mouse and rabbit.
Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity.