SREBP

Inhibitory Selectivity

SREBP Products

All (3) SREBP Inhibitors (3)

Catalog No.	Information	Product Use Citations
S8284	Fatostatin (125B11) HBr Fatostatin HBr (Fatostatin A, 125B11) is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.	Cell, 2020, S0092-8674(20)31626-3 J Immunol, 2020, 205(8):2066-2076 Drug Des Devel Ther, 2020, 14:3535-3545
S9067	Pseudoprotodioscin Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
S9785^New	Fatostatin Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin suppresses growth and enhances apoptosis in cancer cells.

Catalog No.

Information

Product Use Citations

Product Validations

S8284

Fatostatin (125B11) HBr

Fatostatin HBr (Fatostatin A, 125B11) is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.

Cell, 2020, S0092-8674(20)31626-3

J Immunol, 2020, 205(8):2066-2076

Drug Des Devel Ther, 2020, 14:3535-3545

S9067

Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.

S9785^New

Fatostatin

Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin suppresses growth and enhances apoptosis in cancer cells.

Catalog No.	Information	Product Use Citations
S8284	Fatostatin (125B11) HBr Fatostatin HBr (Fatostatin A, 125B11) is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.	Cell, 2020, S0092-8674(20)31626-3 J Immunol, 2020, 205(8):2066-2076 Drug Des Devel Ther, 2020, 14:3535-3545
S9067	Pseudoprotodioscin Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
S9785^New	Fatostatin Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin suppresses growth and enhances apoptosis in cancer cells.