SREBP

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SREBP Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S8284 Fatostatin (125B11) HBr Fatostatin HBr (Fatostatin A, 125B11) is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
EMBO Rep, 2021, e52537
Nat Metab, 2021, 10.1038/s42255-021-00479-4
Cell, 2020, S0092-8674(20)31626-3
S9067 Pseudoprotodioscin Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
S9785 Fatostatin

Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin suppresses growth and enhances apoptosis in cancer cells.

EMBO Rep, 2021, e52537
Reproduction, 2021, 162(6):397-410
S8284 Fatostatin (125B11) HBr Fatostatin HBr (Fatostatin A, 125B11) is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
EMBO Rep, 2021, e52537
Nat Metab, 2021, 10.1038/s42255-021-00479-4
Cell, 2020, S0092-8674(20)31626-3
S9067 Pseudoprotodioscin Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. Pseudoprotodioscin inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.
S9785 Fatostatin

Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin suppresses growth and enhances apoptosis in cancer cells.

EMBO Rep, 2021, e52537
Reproduction, 2021, 162(6):397-410