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SREBP

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR
Cat.No. Product Name Information Product Use Citations Product Validations
S8284 Fatostatin HBr Fatostatin HBr is an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
Cancer Commun (Lond), 2025, 10.1002/cac2.70038
Cell Commun Signal, 2025, 23(1):438
ACS Omega, 2024, 9(47):47042-47051
E0209 Cinobufotalin

Cinobufotalin, extracted from the skin secretion of the giant toad, is a novel SREBP1 inhibitor that suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
S9785 Fatostatin

Fatostatin (125B11), a diarylthiazole derivative, is a specific inhibitor of Sterol regulatory element binding proteins (SREBPs) activation. This compound binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. It suppresses growth and enhances apoptosis in cancer cells.
J Transl Med, 2025, 23(1):1055
iScience, 2025, 28(8):113097
Oncol Lett, 2025, 29(4):175
E7041 Desmosterol Desmosterol is the immediate unsaturated precursor of cholesterol and the final biosynthetic intermediate in the Bloch pathway and a key activator of liver X receptors(LXR) while inhibiting SREBP to regulate lipid homeostasis. Its reduction promotes mitochondrial ROS production in macrophages and activates the NLRP3 inflammasome exhibiting potential for research in inflammation, metabolism, and cardiovascular diseases.
S9067 Pseudoprotodioscin Pseudoprotodioscin is a steroidal saponin from plants and exhibits anti-inflammatory and anticancer activities. This compound inhibits SREBP1/2 and microRNA 33a/b levels and reduces the gene expression regarding the synthesis of cholesterol and triglycerides.