Home Metabolism SCD

SCD

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8076 PluriSIn #1 (NSC 14613) PluriSIn #1 (NSC 14613) is an inhibitor of the stearoyl-coA desaturase 1 (SCD1) and is able to selectively eliminate hPSCs.
Cell Rep Med, 2024, 5(9):101692
Cells, 2021, 10(1)E106
Biochem Biophys Res Commun, 2019, 519(1):100-105
S1158 MK-8245 MK-8245 is an liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Phase 2.
Dev Cell, 2022, S1534-5807(22)00070-3
Int J Mol Sci, 2020, 21(15):E5193
Genes Dev, 2013, 27(10):1115-31
S9607 A939572 A939572 is a potent and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 of <4 nM and 37 nM for mSCD1 and hSCD1, respectively.
Cell Rep Med, 2024, 5(9):101692
NAT CANCER, 2021, 2, 201–217
S6842 MF-438 MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with IC50 of 2.3 nM for rSCD1.
E1527 Aramchol Aramchol (C20-FABAC, Icomidocholic acid) is a fatty acid-bile acid conjugate that reduces liver fat content and is a inhibitor of stearoyl CoA desaturase 1 (SCD1) and a cholesterol solubilizer. It can be used in research on fatty liver disease, blocking fibrosis by targeting hepatic stellate cells in liver injury, non-alcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD).
E1227 CAY10566 CAY10566 is a potent, orally bioavailable and selective inhibitor of stearoyl-CoA desaturase1 (SCD1) with IC50 of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. It also demonstrates excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells.
S4470 CVT-11127 CVT-11127 (FMK13918) is an inhibitor of stearoylCoA desaturase-1 (SCD1). This compound reduces lipid synthesis and impaires proliferation by blocking the progression of cell cycle through the G(1)/S boundary and by triggering programmed cell death.
S5120 Elemicin Elemicin (3,4,5-trimethoxyallylbenzene) is a constituent of the oleoresin and the essential oil of Canarium luzonicum. This compound is a constituent of natural aromatic phenylpropanoids present in many herbs and spices. It inhibits Stearoyl-CoA Desaturase 1(SCD1) activity in the liver by metabolic activation.