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UNC8153 NSD chemical

Name: UNC8153
Brand: Selleck Chemicals
SKU: E1613
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E1613

UNC8153 is a selective degrader of nuclear receptor-binding SET domain-containing 2 (NSD2) with a binding Kd of 24 nM, effectively reducing NSD2 protein levels and the dimethylate lysine 36 of histone 3 (H3K36me2) chromatin mark. Its simple warhead promotes proteasome-dependent degradation of NSD2 via a novel mechanism.

Chemical Structure

Molecular Weight: 583.68

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Quality Control

Batch: E161301 DMSO]100 mg/mL]false]Ethanol]50 mg/mL]false]Water]25 mg/mL]false Purity: 99.01%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS
Datasheet

99.01

Related Targets	PRMT EZH2 MAT2A DNA Methyltransferase LSD1 JMJD G9a/GLP MLL FTO SETD
Other NSD Inhibitors	LLC0424 UNC6934

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (171.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 50 mg/mL

Water : 25 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	583.68	Formula	C₃₃H₃₇N₅O₅	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	2929304-60-7	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

Targets/IC₅₀/Ki	NSD2 24 nM(Kd)
References	[1] https://pubmed.ncbi.nlm.nih.gov/36976643/

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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