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Tat-beclin 1 Autophagy Inducer

Cat.No.S8595

Tat-beclin 1 (Tat-BECN1), a peptide known to stimulate autophagy through mobilization of endogenous Beclin 1, induces autophagy in vitro and in vivo and improves clinical outcomes.
Tat-beclin 1 Beclin activator Chemical Structure

Chemical Structure

Molecular Weight: 3741.1

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Quality Control

Batch: Purity: 99.89%
99.89

Solubility

In vitro
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Water : 100 mg/mL

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Chemical Information, Storage & Stability

Molecular Weight 3741.1 Formula

C164H251N57O45

 Storage (From the date of receipt)
CAS No. 1423821-88-8 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CCC(C)C(NNC(CC1=C[NH]C2=C1C=CC=C2)C(=O)NC(CC3=CN=C[NH]3)C(=O)NC(CC(O)=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CC4=CC=CC=C4)C(=O)NCC(=O)NC(C(C)O)C(O)=O)C(=O)NC(CCC(O)=O)C(=O)NC(CC5=CC=CC=C5)C(=O)C(=O)C(NC(=O

Mechanism of Action

Targets/IC50/Ki
Beclin 1
In vitro
Tat-beclin 1 (Tat-BECN1) is a cell-permeable peptide that induces autophagy. Treatment with this compound, but not Tat-scrambled, results in a dose-dependent decrease in amounts of p62, a selective autophagy substrate, and a dose-dependent conversion of the non-lipidated form of LC3, LC3-I, to the lipidated, autophagosome-associated form of LC3, LC3-II, in multiple cell lines and primary murine embryonic fibroblasts (MEFs). It markedly inhibits HIV-1 replication in primary human monocyte-derived macrophages.
In vivo
Tat-beclin 1 (Tat-BECN1) can induce autophagy in peripheral tissues in adult mice as well as in the central nervous system of neonatal mice. Daily treatment with this compound is well-tolerated in both neonatal and adult mice, and it improves the clinical outcome of mice with CNS WNV(West Nile virus) infection.
References

Applications

Methods Biomarkers Images PMID
Western blot LC3A-II / LC3B-II POU5F1 / NANOG / SOX2 TUBB3 / CSN2
S8595-WB1
27929731

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