CAS No. 254740-64-2

Batch: Purity:99.71
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Sparsentan (PS-433540, RE-021) Chemical Structure
Chemical Structure
Check the Sparsentan (PS-433540, RE-021) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide
CAS Number 254740-64-2
Molecular Formula

C32H40N4O5S
Molecular Weight (MW) 592.75
SMILES CCCCC1=NC2(CCCC2)C(=O)N1CC3=CC(=C(C=C3)C4=CC=CC=C4S(=O)(=O)NC5=NOC(=C5C)C)COCC
InChIKey WRFHGDPIDHPWIQ-UHFFFAOYSA-N

Ordering Information

Biological Activity

Sparsentan (PS-433540) is a dual endothelin type A (ETA) and angiotensin II type 1 (AT1) receptor antagonist. By concurrently blocking ETA and AT1 receptors, sparsentan inhibits downstream endothelin-1 and angiotensin II signaling pathways. This dual blockade reduces vascular resistance, suppresses cellular proliferation, attenuates proteinuria, and protects against renal inflammation and tissue fibrosis in preclinical models of kidney disease. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (168.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 40 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.