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SUMO

Other Ubiquitin Related Inhibitors

E1 Activating DUB E2 conjugating E3 Ligase p97

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S8829 Subasumstat (TAK-981) Subasumstat (TAK-981) is a novel, selective inhibitor of the SUMOylation enzymatic cascade with potential immune-activating and antineoplastic activities.
Oncogene, 2025, none
Commun Biol, 2025, 8(1):1005
Int Immunopharmacol, 2025, 149:114187
S8696 2-D08 2-D08 (2',3',4'-trihydroxy flavone) is a cell permeable, mechanistically unique inhibitor of protein sumoylation. This compound is a cell permeable, mechanistically unique inhibitor of protein sumoylation.
Commun Biol, 2025, 8(1):1118
Int Immunopharmacol, 2025, 149:114187
Nat Commun, 2024, 15(1):9195
S9432 Ginkgolic Acid Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).
Microbiologyopen, 2025, 14(4):e70038
Pharmaceutics, 2024, 16(5)638
CNS Neurosci Ther, 2022, 10.1111/cns.13871
S9159 momordin-Ic Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo.
Int J Mol Sci, 2022, 23(15)8282
S9445 Ginkgolic Acid (C13:0) Ginkgolic Acid (C13:0), a natural anticariogenic agent in Ginkgo biloba L., exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity. This compound is a potent sumoylation inhibitor and reported to inhibit histone acetylation transferase (HAT).
S4922 NSC 632839 NSC 632839 is not only a DUB inhibitor, but also a deSUMOylase inhibitor, it inhibits USP2, USP7, and SENP2 with EC50 of 45 μM, 37 μM, and 9.8 μM, respectively.