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SUMO

Other Ubiquitin Related Inhibitors

E1 Activating DUB E2 conjugating E3 Ligase p97 TRAF

Isoform-selective Products

SENP SENP2

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S8829	Subasumstat (TAK-981)	Subasumstat (TAK-981) is a novel, selective inhibitor of the SUMOylation enzymatic cascade with potential immune-activating and antineoplastic activities.	Journal of Nanobiotechnology, June 18, 2024, 338 Nature Structural & Molecular Biology, July 20, 2023, 1303-1313 Frontiers in Cell and Developmental Biology, December 17, 2021, 741736
S8696	2-D08	2-D08 (2',3',4'-trihydroxy flavone) is a cell permeable, mechanistically unique inhibitor of protein sumoylation. This compound is a cell permeable, mechanistically unique inhibitor of protein sumoylation.	Commun Biol, 2025, 8(1):1118 Int Immunopharmacol, 2025, 149:114187 Journal of General Physiology, 2025, e202513837
S9432	Ginkgolic Acid	Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).	Microbiologyopen, 2025, 14(4):e70038 Pharmaceutics, 2024, 16(5)638 CNS Neurosci Ther, 2022, 10.1111/cns.13871
S9159	momordin-Ic	Momordin Ic, a natural triterpenoid saponin, is a novel SENP1 (SUMO-specific protease 1) inhibitor that inhibited proliferation of prostate cancer cells in vitro and in vivo.	Scientific Reports, 2025, 39054 International Journal of Molecular Sciences, 2022, 8282 Int J Mol Sci, 2022, 23(15)8282
S9445	Ginkgolic Acid (C13:0)	Ginkgolic Acid (C13:0), a natural anticariogenic agent in Ginkgo biloba L., exhibits antimicrobial activity against S. mutans and suppresses the specific virulence factors associated with its cariogenicity. This compound is a potent sumoylation inhibitor and reported to inhibit histone acetylation transferase (HAT).
S4922	NSC 632839	NSC 632839 is not only a DUB inhibitor, but also a deSUMOylase inhibitor, it inhibits USP2, USP7, and SENP2 with EC50 of 45 μM, 37 μM, and 9.8 μM, respectively.