- Inhibitory Selectivity
|Catalog No.||Product Name||Solubility(25°C)|
|S8696||2-D08||<1 mg/mL||54 mg/mL||<1 mg/mL|
- SUMO Inhibitors (2)
- New SUMO Products
|Catalog No.||Information||Product Use Citations||Product Validations|
2-D08 is a cell permeable, mechanistically unique inhibitor of protein sumoylation. It is also inhibits Axl, IRAK4, ROS1, MLK4, GSK3β, RET, KDR and PI3Kα with IC50 values of 0.49, 3.9, 5.3, 9.8, 11, 11, 17 and 35 nM respectively in biochemical assays.
Ginkgolic acid, toxic phenolic compounds present in the fruits and leaves of Ginkgo biloba L., is a potent sumoylation inhibitor also reported to inhibit histone acetylation transferase (HAT).