E1 Activating

Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S7129 PYR-41 <1 mg/mL 74 mg/mL <1 mg/mL
S7109 Pevonedistat (MLN4924) <1 mg/mL 88 mg/mL 88 mg/mL
Catalog No. Information Product Use Citations Product Validations


PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.


Pevonedistat (MLN4924)

MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM.