Home GPCR & G Protein Ras inhibitor Salvianolic acid F

research use only

Salvianolic acid F Ras inhibitor

Salvianolic acid F acts as a KRAS inhibitor, with activity against KRAS G12D. It suppresses NF-kB, MMP-9, and NO production. In vitro studies show it reduces cancer cell proliferation, invasion, and migration while promoting apoptosis through the EP300/PI3K/AKT pathway. In vivo experiments demonstrate its inhibition of KRAS-dependent lung cancer cell growth via PI3K/AKT signaling. This compound has potential applications in studying multiple cancer types, particularly KRAS G12D-associated NSCLC and ovarian cancer.

Salvianolic acid F Ras inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 314.29

Purity & Quality Control

Related Products

Signaling Pathway

Ras Signaling Pathways

Ras Signaling Pathway

Mechanism of Action

In Vivo
In vivo Salvianolic acid F (10-20 mg/kg, i.p., each day for 15 days) is effective in inhibiting KRAS-driven lung tumor growth by influencing the downstream PI3K/AKT pathway in A549 xenografts nude mice model. Salvianolic acid F (10-20 mg/kg, i.p., every 2 days for 40 days) inhibits lung tumor growth by influencing the downstream PI3K/AKT pathway in KrasG12D mice model.

References
  • https://pubmed.ncbi.nlm.nih.gov/37783131/
  • https://pubmed.ncbi.nlm.nih.gov/40237524/

Chemical Information

Molecular Weight 314.29 Formula

C17H14O6
CAS No. 158732-59-3 SDF Download SDF
Smiles O=C(O)/C=C/C1=CC=C(O)C(O)=C1/C=C/C2=CC=C(O)C(O)=C2

Storage and Stability

Storage (From the date of receipt)

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.