Home GPCR & G Protein KRas inhibitor Salvianolic acid F

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Salvianolic acid F KRas inhibitor

Cat.No.E2540

Salvianolic acid F acts as a KRAS inhibitor, with activity against KRAS G12D. It suppresses NF-kB, MMP-9, and NO production. In vitro studies show it reduces cancer cell proliferation, invasion, and migration while promoting apoptosis through the EP300/PI3K/AKT pathway. In vivo experiments demonstrate its inhibition of KRAS-dependent lung cancer cell growth via PI3K/AKT signaling. This compound has potential applications in studying multiple cancer types, particularly KRAS G12D-associated NSCLC and ovarian cancer.
Salvianolic acid F KRas inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 314.29

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Chemical Information, Storage & Stability

Molecular Weight 314.29 Formula

C17H14O6

 Storage (From the date of receipt)
CAS No. 158732-59-3 Download SDF Storage of Stock Solutions

Mechanism of Action

In vivo
Salvianolic acid F (10-20 mg/kg, i.p., each day for 15 days) is effective in inhibiting KRAS-driven lung tumor growth by influencing the downstream PI3K/AKT pathway in A549 xenografts nude mice model. Salvianolic acid F (10-20 mg/kg, i.p., every 2 days for 40 days) inhibits lung tumor growth by influencing the downstream PI3K/AKT pathway in KrasG12D mice model.
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