(R)-CR8 trihydrochloride

Catalog No.E0647

For research use only.

(R)-CR8 trihydrochloride, one of CR8 isomers, is a potent inhibitor CDK1/2/5/7/9 with antiproliferative effect and proapoptotic effect on CML cell lines.

(R)-CR8 trihydrochloride Chemical Structure

CAS No. 1786438-30-9

Purity & Quality Control

Choose Selective CDK Inhibitors

Other CDK Products

Biological Activity

Description (R)-CR8 trihydrochloride, one of CR8 isomers, is a potent inhibitor CDK1/2/5/7/9 with antiproliferative effect and proapoptotic effect on CML cell lines.

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(184.87 mM)
Water 100 mg/mL
(184.87 mM)
Ethanol 25 mg/mL
(46.21 mM)

Chemical Information

Molecular Weight 540.92
Formula

C24H29N7O.3ClH

CAS No. 1786438-30-9
Storage 3 years -20°C powder
2 years -80°C in solvent

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy (R)-CR8 trihydrochloride | (R)-CR8 trihydrochloride supplier | purchase (R)-CR8 trihydrochloride | (R)-CR8 trihydrochloride cost | (R)-CR8 trihydrochloride manufacturer | order (R)-CR8 trihydrochloride | (R)-CR8 trihydrochloride distributor