Home Others Others Pimonidazole

research use only

Pimonidazole

Cat.No.S9919

Pimonidazole (Ro 03-8799) is a novel hypoxia marker used for complementary study of tumor hypoxia and cell proliferation in cervical carcinoma.
Pimonidazole Chemical Structure

Chemical Structure

Molecular Weight: 254.29

Jump to

Quality Control

Batch: S991901 DMSO]51 mg/mL]false]Ethanol]51 mg/mL]false]Water]Insoluble]false Purity: 99.52%
  • Cited in Nature Medicine for its top-tier quality
  • COA
  • NMR
  • HPLC
  • SDS
  • Datasheet
99.52

Solubility

In vitro
Batch:

DMSO : 51 mg/mL (200.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 51 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 254.29 Formula

C11H18N4O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 70132-50-2 -- Storage of Stock Solutions

Synonyms Ro 03-8799 Smiles OC(CN1CCCCC1)C[N]2C=CN=C2[N+]([O-])=O

Mechanism of Action

In vitro

Pimonidazole has radio-sensitivity and recovery capacity from radiation-induced damage depend on p53 status of the tumor cell.<sup><a class="sref" href="#s_ref">[3]</a></sup>
In vivo

Pimonidazole can overcome radiation resistance in hypoxiaby melanoma cells, which is enhanced by liposome modification.<sup><a class="sref" href="#s_ref">[2]</a></sup>
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03718650 Withdrawn
Pancreatic Cancer|Resectable Pancreatic Cancer
H. Lee Moffitt Cancer Center and Research Institute|Varian Medical Systems
 April 1 2021 Early Phase 1
NCT03410420 Suspended
Aortic Aneurysm Thoracic
University of Maryland Baltimore
 October 1 2018 Phase 1
NCT03262311 Completed
Cancer
Institute of Cancer Research United Kingdom
 November 10 2017 Not Applicable
NCT02624115 Completed
Colon Rectal Cancer Adenocarcinoma
University Health Network Toronto
 May 1 2016 --
NCT02095249 Active not recruiting
Prostate Cancer
University Health Network Toronto
 September 2014 Not Applicable
NCT00374517 Withdrawn
Refractory Pulmonary Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)|International Tuberculosis Research Center|National Institutes of Health Clinical Center (CC)
 September 5 2006 Phase 2

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.