Name: Pamoic acid disodium
Brand: Selleck Chemicals
SKU: E2660
Rating: 5 (1 reviews)

Pamoic acid disodium, a potent GPR35 agonist with an EC50 value of 79 nM, induces GPR35a internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively, also potently recruits β-arrestin2 to GPR35 showing an antinociceptive effect.

Pamoic acid disodium Chemical Structure

CAS: 6640-22-8

Purity & Quality Control

Batch: Purity: 99.59%

99.59

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Biological Activity

Description

Pamoic acid disodium, a potent GPR35 agonist with an EC50 value of 79 nM, induces GPR35a internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively, also potently recruits β-arrestin2 to GPR35 showing an antinociceptive effect.

Targets

GPR35a ^[1] (in internalization assay)	ERK1/2 ^[1] (in western blot analysis for determination of ERK activity)	GPR35 ^[1] (in β-arrestin assay)
22 nM(EC50)	65 nM(EC50)	79 nM(EC50)

References

[1] Zhao P, et al. Mol Pharmacol. 2010 Oct;78(4):560-8.

Chemical Information & Solubility

Molecular Weight	432.33	Formula	C₂₃H₁₆O₆.2Na
CAS No.	6640-22-8	SDF	--
Smiles	[Na+].[Na+].OC1=C(C=C2C=CC=CC2=C1CC3=C4C=CC=CC4=CC(=C3O)C([O-])=O)C([O-])=O
Storage (From the date of receipt)	3 years -20°C powder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years -20°C powder		1 month-20°Cin solvent

In vitro
Batch:

Water : 86 mg/mL

DMSO : 29 mg/mL ( (67.07 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble

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In vivo
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