Pamoic acid disodium

Catalog No.E2660 Batch:E266002

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Technical Data

Formula

C23H16O6.2Na

Molecular Weight 432.33 CAS No. 6640-22-8
Solubility (25°C)* In vitro Water 86 mg/mL (198.92 mM)
DMSO 29 mg/mL (67.07 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Pamoic acid disodium, a potent GPR35 agonist with an EC50 value of 79 nM, induces GPR35a internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively, also potently recruits β-arrestin2 to GPR35 showing an antinociceptive effect.
Targets
GPR35a [1]
(in internalization assay)
ERK1/2 [1]
(in western blot analysis for determination of ERK activity)
GPR35 [1]
(in β-arrestin assay)
22 nM(EC50) 65 nM(EC50) 79 nM(EC50)

Protocol (from reference)

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.