CAS No. 923288-90-8
Batch:
Purity:99.98
Chemical Structure
Check the
Nilotinib hydrochloride monohydrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide;hydrate;hydrochloride | |
|---|---|---|
| CAS Number | 923288-90-8 | |
| Molecular Formula |
C28H25ClF3N7O2 |
|
| Molecular Weight (MW) | 583.99 | |
| SMILES | O.Cl.CC1=C[N](C=N1)C2=CC(=CC(=C2)NC(=O)C3=CC(=C(C)C=C3)NC4=NC=CC(=N4)C5=CN=CC=C5)C(F)(F)F | |
| InChIKey | YCBPQSYLYYBPDW-UHFFFAOYSA-N |
Nilotinib hydrochloride monohydrate is a selective, orally bioavailable tyrosine kinase inhibitor that targets Bcr-Abl with an IC50 of less than 30 nM. By inhibiting Bcr-Abl autophosphorylation and downstream signaling pathways including STAT5 and AKT, it effectively suppresses cellular proliferation and induces apoptosis in chronic myeloid leukemia models expressing wild-type and mutant Bcr-Abl. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(171.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Nilotinib hydrochloride monohydrate Clinical Trials
- Nilotinib hydrochloride monohydrate Solubility in DMSO
- Nilotinib hydrochloride monohydrate Stock Solution
- Nilotinib hydrochloride monohydrate Storage
- Nilotinib hydrochloride monohydrate Stability
- Nilotinib hydrochloride monohydrate Molecular Weight
- Nilotinib hydrochloride monohydrate SMILES
- Nilotinib hydrochloride monohydrate Chemical Structure (2D and 3D)
- Nilotinib hydrochloride monohydrate SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.