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GDC-4198 CDK inhibitor

Name: GDC-4198
Brand: Selleck Chemicals
SKU: E6727
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E6727

GDC-4198 (Vustanaciclib, RGT-419B, RG6794) is an orally bioavailable, next-generation inhibitor of CDK4/2, which exhibits a therapeutic approach for treating estrogen receptor-positive (ER+/HR+), HER2-negative advanced breast cancers that have progressed on first-line CDK4/6 inhibitor regimens.

Chemical Structure

Molecular Weight: 470.57

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Cited in Nature Medicine for its top-tier quality
SDS
Datasheet

Related Targets	HSP PD-1/PD-L1 ROCK Wee1 DNA/RNA Synthesis Microtubule Associated Ras KRas Aurora Kinase Casein Kinase
Other CDK Inhibitors	AS2863619 Ro-3306 SEL120 (SEL120-34A) hydrochloride INX-315 Tagtociclib (PF-07104091) PF-07220060 (CDK4/6-IN-6) AZD4573 ON123300 Enitociclib (BAY 1251152) Samuraciclib (ICEC0942) hydrochloride

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Mass	Concentration	Volume	Molecular Weight
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Chemical Information, Storage & Stability

Molecular Weight	470.57	Formula	C₂₆H₃₀N₈O	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	2531743-46-9	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Mechanism of Action

References	[1] https://aacrjournals.org/cancerres/article/81/4_Supplement/PS16-22/648420/Abstract-PS16-22-Targeting-resistance-to-current

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