CAS No. 478188-26-0
Batch:
Purity:99.19
Chemical Structure
Check the
DX600
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 478188-26-0 | |
|---|---|---|
| Molecular Formula |
C141H185N35O40S2 |
|
| Molecular Weight (MW) | 3074.32 | |
| SMILES | CC(C)CC1NC(=O)C2CCCN2C(=O)C(CO)NC(=O)C(CSSCC(NC(=O)C(CCCCN)NC(=O)C(CC3=C[NH]C4=C3C=CC=C4)NC(=O)C(CC5=C[NH]C6=C5C=CC=C6)NC(=O)C7CCCN7C(=O)C(CC8=CC=C(O)C=C8)NC(=O)C(CC9=CC=C(O)C=C9)NC(=O)C(CCCNC(N)=N)NC1=O)C(=O)NC(C(C)O)C(=O)NC(CC%10=CC=C(O)C=C%10)C(=O)N%11CCCC%11C(=O)NC(CC(O)=O)C(=O)N%12CCCC%12C(=O)NC(CCC(O)=O)C(=O)NCC(=O)NCC(=O)NCC(N)=O)NC(=O)C(CC%13=CN=C[NH]%13)NC(=O)C(CO)NC(=O)C(CC%14=CC=C(O)C=C%14)NC(=O)C(CC(O)=O)NC(=O)CNC(C)=O |
DX600 is a peptide inhibitor of angiotensin-converting enzyme 2 (ACE2) that exhibits high specificity for ACE2 without cross-reacting with ACE. By competitively inhibiting ACE2 catalytic activity, DX600 blocks the enzymatic conversion of angiotensin II into angiotensin-(1-7), thereby modulating renin-angiotensin system signaling. In experimental models, ACE2 inhibition by DX600 suppresses downstream signaling phenotypes linked to peptide degradation while preserving ACE activity.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.