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GPCR19

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Cat.No. Product Name Information Product Use Citations Product Validations
S6806 SBI-115 SBI-115 is a novel TGR5 (GPCR19) antagonist. This compound decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.
J Cachexia Sarcopenia Muscle, 2025, 16(3):e13853
J Cachexia Sarcopenia Muscle, 2025, 16(3):e13853
Cells, 2023, 12(4)526
S4689 Deoxycholic acid Deoxycholic acid (Deoxycholate, Desoxycholic acid, Cholerebic, Cholorebic) is a cytolytic agent. The physiologic effect of this compound is by means of decreased cell membrane integrity. It is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
Pharmaceuticals (Basel), 2025, 18(5)763
Phytomedicine, 2024, 135:156251
Bio Protoc, 2022, 12(20)e4533
S0193 TGR5 Receptor Agonist TGR5 Receptor Agonist (TGR5, CCDC, MDK00245, compd 6) is a potent agonist of TGR5(GPCR19, GPBAR1, M-BAR). This compound shows improved potency with pEC50 of 6.8 and 7.5 in the U2-OS cell assay and in melanophore cells, respectively.
Research Square, 2021, 10.21203/rs.3.rs-274411/v1
S0034 BAR501 BAR501 is a potent and selective G protein-coupled bile acid receptor 1 (GPBAR1, GPCR19, TGR5) agonist that effectively transactivates GPBAR1 in HEK293 cells overexpressing a CRE along with GPBAR1 with EC50 of 1 μM.
S2311 Hyodeoxycholic acid (HDCA) Hyodeoxycholic (HDCA, NSC 60672) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.
S3069 Deoxycholic acid sodium salt

Deoxycholic acid sodium salt (Sodium Deoxycholate, Sodium Desoxycholate, Cholanoic Acid, ATX-101, Kythera, Belkyra, DCA) is specifically responsible for activating the TGR5 receptor (GPCR19) that stimulates brown adipose tissue (BAT) thermogenic activity.
S8223New INT-777 INT-777 (S-EMCA) is a potent and selective agonist of TGR5(GPCR19) with EC50 of 0.18 μM, 3.9 μM and 1.45 μM for TGR5, TGR5(N76A) and TGR5(Y89F) respectively.
S6741 SB-756050 SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).