GPCR19

Inhibitory Selectivity

GPCR19 Products

Catalog No. Information Product Use Citations Product Validations
S4689

Deoxycholic acid

Deoxycholic acid is a cytolytic agent. The physiologic effect of deoxycholic acid is by means of decreased cell membrane integrity. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

S6806New

SBI-115

SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.

S2311

Hyodeoxycholic acid (HDCA)

Hyodeoxycholic (HDCA, NSC 60672) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.

S6741New

SB-756050

SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).

Catalog No. Information Product Use Citations Product Validations
S4689

Deoxycholic acid

Deoxycholic acid is a cytolytic agent. The physiologic effect of deoxycholic acid is by means of decreased cell membrane integrity. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

Catalog No. Information Product Use Citations Product Validations
S6806New

SBI-115

SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.

Catalog No. Information Product Use Citations Product Validations
S2311

Hyodeoxycholic acid (HDCA)

Hyodeoxycholic (HDCA, NSC 60672) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.

S6741New

SB-756050

SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).