GPCR19

Inhibitory Selectivity

GPCR19 Products

Catalog No. Information Product Use Citations Product Validations
S4689

Deoxycholic acid

Deoxycholic acid is a cytolytic agent. The physiologic effect of deoxycholic acid is by means of decreased cell membrane integrity. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

S6806New

SBI-115

SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.

S2311

Hyodeoxycholic acid (HDCA)

Hyodeoxycholic(HDCA) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.

S6741New

SB-756050

SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).

Catalog No. Information Product Use Citations Product Validations
S4689

Deoxycholic acid

Deoxycholic acid is a cytolytic agent. The physiologic effect of deoxycholic acid is by means of decreased cell membrane integrity. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.

Catalog No. Information Product Use Citations Product Validations
S6806New

SBI-115

SBI-115 is a novel TGR5 (GPCR19) antagonist. SBI-115 decreases cell proliferation, cholangiocyte spheroid growth and cAMP levels in cystic cholangiocytes.

Catalog No. Information Product Use Citations Product Validations
S2311

Hyodeoxycholic acid (HDCA)

Hyodeoxycholic(HDCA) acid is a secondary bile acid, one of the metabolic byproducts of intestinal bacteria.

S6741New

SB-756050

SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).