CAS No. 2243882-74-6

Batch: Purity:99.99
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Zedoresertib (Debio-0123, WEE1-IN-5) Chemical Structure
Chemical Structure
Check the Zedoresertib (Debio-0123, WEE1-IN-5) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-(2,6-dichlorophenyl)-8-methyl-2-[3-methyl-4-(1-methylpiperidin-4-yl)anilino]-7H-pyrimido[4,5-d]pyrimidin-5-one
CAS Number 2243882-74-6
Molecular Formula

C26H28CI2N6O
Molecular Weight (MW) 511.45
InChIKey VWHNEYAANMETIA-UHFFFAOYSA-N

Ordering Information

Biological Activity

Zedoresertib (Debio-0123) is a potent small-molecule inhibitor targeting WEE1 kinase. By inhibiting WEE1 activity, it prevents the inhibitory phosphorylation of CDC2 (CDK1), thereby abrogating the G2 cell cycle checkpoint. This loss of checkpoint control forces cells with DNA damage to prematurely enter mitosis, leading to severe genomic instability, persistent double-strand DNA breaks, and cell death via apoptosis within cancer cells dependent on the DNA damage response pathway. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (195.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 5 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.