TET

Other Epigenetics Related Inhibitors

Histone Methyltransferase BET DNA Methyltransferase p300/CBP Histone Demethylase Histone Acetyltransferase MicroRNA NSD EZH1 RNA Methyltransferase

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S6682	Bobcat339 Hydrochloride	Bobcat339 is a selective cytosine-based TET enzyme inhibitor with IC50 of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe.	EMBO Mol Med, 2025, 17(10):2809-2826 Nat Cell Biol, 2024, 10.1038/s41556-024-01475-y Cell Death Dis, 2024, 15(8):617

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S6682

Bobcat339 Hydrochloride

Bobcat339 is a selective cytosine-based TET enzyme inhibitor with IC50 of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe.

EMBO Mol Med, 2025, 17(10):2809-2826

Nat Cell Biol, 2024, 10.1038/s41556-024-01475-y

Cell Death Dis, 2024, 15(8):617