CAS No. 21018-84-8
Batch:
Purity:99.17
Chemical Structure
Check the
Amarogentin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 21018-84-8 | |
|---|---|---|
| Molecular Formula |
C29H30O13 |
|
| Molecular Weight (MW) | 586.54 | |
| SMILES | OCC1OC(OC2OC=C3C(CCOC3=O)C2C=C)C(OC(=O)C4=C(O)C=C(O)C=C4C5=CC=CC(=C5)O)C(O)C1O |
Amarogentin is a natural secoiridoid glycoside that acts as a potent agonist of human bitter taste receptors, including TAS2R1. Activation of TAS2R signaling pathways by amarogentin modulates intracellular signaling cascades, contributing to its reported anti-inflammatory and anti-proliferative cellular responses. Additionally, amarogentin suppresses cancer cell growth by regulating key pathways such as PI3K/Akt, resulting in G2/M cell cycle arrest and induction of apoptosis. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(170.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.