Home Protein Tyrosine Kinase CSF-1R inhibitor Adrixetinib TFA

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Adrixetinib TFA CSF-1R inhibitor

Cat.No.E6733

Adrixetinib TFA(Q702 TFA) is an orally active, selective triple kinase inhibitor of CSF1R, Mer, and Axl receptors within the TAM (Tyro3/Axl/Mer), exhibiting Kd of 8.7 nM (CSF1R), 0.8 nM (Mer), and 0.3 nM (Axl). It also binds the ATP-binding pockets of these RTKs to block ligand-induced autophosphorylation, disrupting downstream PI3K/Akt and Gas6-mediated survival signaling while repolarizing tumor-associated macrophages from pro-tumorigenic M2 to anti-tumor M1 phenotypes.

Chemical Structure

Molecular Weight: 645.51

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Molecular Weight 645.51 Formula Storage (From the date of receipt)
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