Palbociclib (PD-0332991) HCl

For research use only.

Licensed by Pfizer Catalog No.S1116

193 publications

Palbociclib (PD-0332991) HCl Chemical Structure

Molecular Weight(MW): 483.99

Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.

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Selleck's Palbociclib (PD-0332991) HCl has been cited by 193 publications

Purity & Quality Control

Choose Selective CDK Inhibitors

Biological Activity

Description Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.
Features Non-cytotoxic, and halts cancer cell growth & could be used in glioblastoma that has relapsed after temozolomide treatment (a chemotherapeutic used to treat many cancers).
Targets
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
In vitro

PD 0332991 has little effect on other protein kinases including EGFR, FGFR, PGFR, IR. PD 0332991 is a non-ATP competitive inhibitor of Cdk4. PD 0332991 inhibits MDA-MB-435 breast carcinoma cells with IC50 of 66 nM, which is due to reduced Rb phosphorylation at Ser780. PD 0332991 inhibits thymidine incorporation into the DNA of Rb-positive human breast, colon, and lung carcinomas as well as human leukemias, with IC50 values ranging from 0.04-0.17 μM. PD 0332991 shows no activity in Rb-negative cells. PD 0332991 causes an accumulation of cells in G1 in MDA-MB-453 breast and Colo-205 carcinoma cells. [1] PD 0332991 also shows activity in 5T33MM myeloma cells (immunocompetent model) and sensitizes the cells to killing by bortezomib. [2] PD 0332991 inhibits luminal ER-positive as well as HER2-amplified breast cancer cell lines including MDA-MB-175, ZR-75-30, CAMA-1, MDA-MB-134, HCC-202 and UACC-893. PD 0332991 enhances the activity of tamoxifen and trastuzumab in these cell lines. PD 0332991 enhances the sensitivity of tamoxifen in the MCF7 tamoxifen-resistant cells. [3] A recent study shows that PD 0332991 could suppress malignant rhabdoid tumor (MRT) cell lines including MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS and the sensitivity of the MRT cell lines to PD 0332991 is inversely correlated with expression of p16. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 MWPLbY5ie2ViQYPzZZk> NVry[IdTOjRiaB?= M36zVmlvcGmkaYTpc44hd2ZiQ1TLOEBie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJHJjKHCqb4PwbI9zgWyjdHnvckB4cXSqIFnDOVAhd2ZiMD6wNFIh|ryP NVPlR|VkOjR4NEGxNFM>
COLO205 NX:4VolzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3TXblczKGh? NGL1UXdCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMEO2JO69VQ>? M{\XWlI1PjRzMUCz
U937 MlLCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVS3NkBp NUTFTWFHSW62aYDyc4xq\mW{YYTpeoUh[WO2aY\peJkh[XO|ZYPz[YQh[XNiaX7jc5Jxd3KjdHnvckBw\iCdM1jdeIh6dWmmaX7lJIlvfG9iRF7BJJdqfGhiSVO1NEBw\iByLkG0JO69VQ>? MYGyOFY1OTFyMx?=
MOLM13 M1XR[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVr2[lRFPzJiaB?= M2fkNGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTV;MUVE{KGOnbHzzJIhiemKxcnnu[{BHVFR|IFnUSEBufXSjboSgZZN{\XO|ZXSgZZMhcW6lb4Lwc5JifGmxbjDv[kBcO0ifdHj5cYllcW6nIHnueI8hTE6DIIfpeIghUUN3MDDv[kAxNjB7NjFOwG0> NXfkcpBFOjR4NEGxNFM>
MOLM13 M1rLPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXq3NkBp NEjYc5VCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JJNwemGoZX7pZk1z\XOrc4ThcpQhcHWvYX6gUW9NVTF|IHPlcIx{KGG|c3Xzd4VlKGG|IHnuZ49zeG:{YYTpc44hd2ZiW{PIYZRpgW2rZHnu[UBqdnSxIFTORUB4cXSqIFnDOVAhd2ZiMD6wPVYh|ryP NX2xPW1nOjR4NEGxNFM>
MDA-MB-435 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWKyOEBp M2LncGlEPTB;MD6xOkDPxE1? MWSxOVgxOTh|MR?=
K562 NEH6OWFEgXSxdH;4bYMhSXO|YYm= MVi5OkBp M2\rZmROW09? NHm3V3BKSzVyPUKg{txO NF3MSHQzPDRzN{W2Oi=>
DU145 MlHUR5l1d3SxeHnjJGF{e2G7 MXe5OkBp NIrh[49FVVOR MlXLTWM2OD15LkWg{txO MlfFNlQ1OTd3Nk[=
MDA-MB-231 NUDVSmRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPTWWoyKM7:TR?= MoXNNlQhcA>? M{jVcGROW09? NFvEOI5E\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzFicHjhd4U> NWPOdog4OjR2MUe1OlY>
MCF7 NUjPTpRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvSbmoyKM7:TR?= Mn\ONlQhcA>? NXLlS5FiTE2VTx?= NGTCPG9E\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzFicHjhd4U> M{DBXlI1PDF5NU[2
MCF7 NVn5RVlHU2mwYYPlJGF{e2G7 MkW3OUDPxE1? MYWyOEBp NIXBTolFVVOR M2nXZWlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgR2RMPC:leXPsbY5FOSCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHKndHnuc4Jt[XO2b33hJJBpd3OyaH;yfYxifGmxbjDheEBU\XJ5OEC= MoT0NlQ1OTd3Nk[=
MDA-MB-231 M{LzfWtqdmG|ZTDBd5NigQ>? MVi1JO69VQ>? M2rSUFI1KGh? MnvISG1UVw>? MnvuTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDDSGs1N2O7Y3zpcmQyKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhemW2aX7vZoxie3SxbXGgdIhwe3Cqb4L5cIF1cW:wIHH0JHNmejd6MB?= MVSyOFQyPzV4Nh?=
MDA-MB-231 MkD6SpVv[3Srb36gRZN{[Xl? M2n5WVEuOTBizszN M4XkXFI1KGh? Ml\6SG1UVw>? M1j6c4Rw\XNibn;0JIlv\HWlZTDhdI9xfG:|aYOgZZN{\XO|ZXSgZZMhWEGUUDDjcIVifmGpZR?= NWnyUJV3OjR2MUe1OlY>
MCF7 NGrKUpNHfW6ldHnvckBCe3OjeR?= NXHTRpZNOS1zMDFOwG0> MUeyOEBp NVLGeJJOTE2VTx?= MnnF[I9meyCwb4SgbY5lfWOnIHHwc5B1d3OrczDhd5Nme3OnZDDhd{BRSVKSIHPs[YF3[Wen MWSyOFQyPzV4Nh?=
MDA-MB-231 MmPXSpVv[3Srb36gRZN{[Xl? MUSwMlUuOSEQvF2= MUO0PEBp MW\EUXNQ NILG[Y9p[XNibn:gR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JJN2[i2JMTDwbIF{\Q>? NWHHOXY5OjR2MUe1OlY>
MCF7 NYTE[WhJTnWwY4Tpc44hSXO|YYm= NH;KOIYxNjVvMTFOwG0> MXu0PEBp NXvVW45YTE2VTx?= MVHoZZMhdm9iQ3XscEBkgWOuZTDhdpJme3RiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IIP1Zk1IOSCyaHHz[S=> NWDGfYRiOjR2MUe1OlY>
697 NEnWcodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLsUYVmUUN3ME2xOFgvOzhibl2= MUXTRW5ITVJ?
P12-ICHIKAWA M{nmSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGL6e2lKSzVyPUm2MlA1KG6P NWHrcoZJW0GQR1XS
NB69 NXHJVJlNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTF4MT64JI5O Ml[zV2FPT0WU
EoL-1 NELYbFdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTF6Nz6yOkBvVQ>? MmLLV2FPT0WU
BHT-101 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDMTWM2OD1zOUiuNlUhdk1? NXPSS|lRW0GQR1XS
SK-NEP-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3KXWRKSzVyPUKyNE4xOiCwTR?= NG[xUWJUSU6JRWK=
MHH-NB-11 NWG2dIljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkDaTWM2OD1{MkCuNVkhdk1? NVH6[3NmW0GQR1XS
AsPC-1 NWTkcoxGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLUTWM2OD1{NUKuOVMhdk1? M1mzfHNCVkeHUh?=
ES1 MkjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlH3TWM2OD1{NU[uNlUhdk1? NFKwXZVUSU6JRWK=
LAMA-84 M3zITGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2fOUWlEPTB;MkW4MlE6KG6P M2iwNHNCVkeHUh?=
MOLT-16 MoHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEf1bodKSzVyPUK1PE41QSCwTR?= NFLOcXFUSU6JRWK=
ES7 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHpcGkyUUN3ME2yO|MvODlibl2= NIHHR3FUSU6JRWK=
KY821 NEW4SlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUTHTnZ4UUN3ME2zNVQvOSCwTR?= NYjwcVA3W0GQR1XS
RT-112 MofGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXrmZYM2UUN3ME2zNlEvODVibl2= NXHQUFJmW0GQR1XS
HL-60 NHHPeotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWLaUFYzUUN3ME2zOFAvPjZibl2= M2\aNXNCVkeHUh?=
MOLT-4 M4XLZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPqcGNKSzVyPUO0OU4yOyCwTR?= M3vzW3NCVkeHUh?=
KARPAS-45 NEPyWpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPoTWM2OD1|N{[uNVYhdk1? MYTTRW5ITVJ?
SK-N-AS NUOyUZhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mln3TWM2OD1|OEeuPFMhdk1? NHS1eFFUSU6JRWK=
CTB-1 MnzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTRyNT6wNkBvVQ>? M4XheXNCVkeHUh?=
NKM-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmHwTWM2OD12MUGuPFkhdk1? NIjhSGdUSU6JRWK=
HTC-C3 M1ewVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnWR2xKSzVyPUSzNk46PSCwTR?= NF\DbXpUSU6JRWK=
BE-13 NYX1bnJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zIXmlEPTB;NES0MlI4KG6P MkK3V2FPT0WU
KOSC-2 Mn3nS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LKfWlEPTB;NE[2Mlkhdk1? MWLTRW5ITVJ?
NB14 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTR6Mz61PEBvVQ>? NIn6b4pUSU6JRWK=
CAL-27 M1vqd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S0PWlEPTB;NEm0MlU6KG6P Mn\qV2FPT0WU
H9 MlnMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVXoemV6UUN3ME20PVUvPDNibl2= MUDTRW5ITVJ?
RS4-11 M4rlPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTVyND63N{BvVQ>? MWnTRW5ITVJ?
PA-1 NXzBToJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DIS2lEPTB;NUC5Mlg3KG6P MVzTRW5ITVJ?
MV-4-11 M122d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHiTWM2OD13MUOuPFUhdk1? NVLwbGc1W0GQR1XS
OS-RC-2 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTVTWM2OD13MkGuOlIhdk1? M1TrTHNCVkeHUh?=
RPMI-8226 NHP3fVFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37F[mlEPTB;NUK2Mlg3KG6P Mlf6V2FPT0WU
HGC-27 NIXwTINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PIemlEPTB;NU[0Mlk6KG6P NWDOWmZ5W0GQR1XS
CHP-212 MmD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn7oTWM2OD13OUOuOVkhdk1? MUDTRW5ITVJ?
NB10 NUfkd25NT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEGyRY1KSzVyPUW5PU4yQCCwTR?= NYSxZmVMW0GQR1XS
HH M4naemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fpOWlEPTB;NUm5MlQ{KG6P MXrTRW5ITVJ?
EW-16 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIGyTWZKSzVyPU[wN{42OiCwTR?= MWfTRW5ITVJ?
ES8 NEPJWoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTZyNT6yNUBvVQ>? NF;GenFUSU6JRWK=
HAL-01 M33lbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFnDXFNKSzVyPU[wOU43PyCwTR?= MVXTRW5ITVJ?
A204 M{[xSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjDcIJKSzVyPU[zN{46OSCwTR?= NWn5Tm5[W0GQR1XS
MHH-PREB-1 M3iwWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\JV2JPUUN3ME22N|YvQTlibl2= Mn\xV2FPT0WU
EM-2 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPMTWM2OD14NUCuOlQhdk1? NI\scFFUSU6JRWK=
BV-173 M13sNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXe2fIVRUUN3ME22OVIvPDhibl2= MVzTRW5ITVJ?
ONS-76 M{njOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7mOIVlUUN3ME22O|cvQDJibl2= MmrnV2FPT0WU
KM-H2 NVflNGI2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXXTWM2OD14OUWuOVQhdk1? MW\TRW5ITVJ?
D-263MG M1PkRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUO1WmdOUUN3ME23NVcvOTJibl2= MkH6V2FPT0WU
ES3 MoXkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXfwTHpyUUN3ME23NlgvQTNibl2= NUWxO4xPW0GQR1XS
VA-ES-BJ NIW2XIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfpTWM2OD15M{KuNlchdk1? M1[wd3NCVkeHUh?=
NBsusSR MnzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPPTWM2OD15NEKuPVkhdk1? MWrTRW5ITVJ?
NCI-H520 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7GTWM2OD15NE[uOVIhdk1? NEe4WXJUSU6JRWK=
ES5 NEXMW4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlTaTWM2OD15NUKuPEBvVQ>? MVXTRW5ITVJ?
T-24 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX7JR|UxRTd5OD63NUBvVQ>? NXPoPZJlW0GQR1XS
SW962 NEi5T4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoL6TWM2OD16MEiuOlMhdk1? M361NHNCVkeHUh?=
EW-3 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRThyOD63OkBvVQ>? MXrTRW5ITVJ?
RXF393 NVjZUWxoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoO3TWM2OD16MUKuO|khdk1? M1\mbXNCVkeHUh?=
U251 NWTCe3dNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYTJR|UxRThzMz64PEBvVQ>? NF64OXhUSU6JRWK=
CAMA-1 M2SxeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTkTWM2OD16M{OuPVQhdk1? MWHTRW5ITVJ?
JVM-3 NETlUHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTh3MT63PEBvVQ>? NIHGSG5USU6JRWK=
COLO-800 M3S4W2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M16wWWlEPTB;OEm3Mlc5KG6P MX7TRW5ITVJ?
OVCAR-5 NF75WXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXy[m5KSzVyPUmwNE4yKG6P NXjlbpFOW0GQR1XS
LB1047-RCC MlPDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jVcGlEPTB;OUK3MlU3KG6P MV7TRW5ITVJ?
SW954 NEeyOJJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{i0V2lEPTB;OUK5MlQyKG6P NW\zOYpIW0GQR1XS
J-RT3-T3-5 M3vQT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGLBdm9KSzVyPUmzOk4xPiCwTR?= MX;TRW5ITVJ?
Mewo MkPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTl|Nj62JI5O NYewXYY5W0GQR1XS
NCI-H1770 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rE[mlEPTB;OUSwMlU2KG6P MkC2V2FPT0WU
HO-1-N-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTl4Mj64NUBvVQ>? MmSyV2FPT0WU
HSC-3 Mlv0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHCd3NiUUN3ME25OlYvPDhibl2= MmmzV2FPT0WU
TYK-nu NH\RWXFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIT3W4FKSzVyPUm5PE4zPSCwTR?= M4r6e3NCVkeHUh?=
KYSE-150 NInG[GZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4njdGlEPTB;MT6wNFA4PiEQvF2= M{SzUXNCVkeHUh?=
SN12C NHX1O25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\iVnhKSzVyPUGuNFA5PzVizszN MoSwV2FPT0WU
MOLT-13 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33WTmlEPTB;MT6wNVQzOSEQvF2= NGSydZhUSU6JRWK=
TE-11 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MorhTWM2OD1zLkC0PFEzKM7:TR?= NF7zR4VUSU6JRWK=
DB MojaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXtW|V6UUN3ME2xMlA4Ojd|IN88US=> NG[2TIlUSU6JRWK=
CAL-39 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlezTWM2OD1zLkC3OVIzKM7:TR?= MXzTRW5ITVJ?
A3-KAW NYX6[4RZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTFwMEi0NFgh|ryP NY\RfppIW0GQR1XS
CHP-134 NVzKOo5yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHCOVVKSzVyPUGuNVE5ODdizszN NVrnToxTW0GQR1XS
TGW NH\ufnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HmdGlEPTB;MT6xNlM6PSEQvF2= M1XXOXNCVkeHUh?=
QIMR-WIL M2DmNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEXKc25KSzVyPUGuNVMyOzRizszN Mmj2V2FPT0WU
NCI-SNU-1 NFnFPZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHObI1KSzVyPUGuNVY{PTRizszN M1TifHNCVkeHUh?=
CGTH-W-1 M1zjbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH;Wc5ZKSzVyPUGuNVcyQDZizszN NVjjdmwyW0GQR1XS
MHH-ES-1 MnKxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTFwMUe5PFYh|ryP NF35[4hUSU6JRWK=
LB2241-RCC M2HVR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTFwMUi2NkDPxE1? NHv3O5JUSU6JRWK=
ML-2 NHXCPWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG\qR49KSzVyPUGuNlA4OzRizszN MVvTRW5ITVJ?
COR-L23 M{OyPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTFwMkK5N|Mh|ryP MUDTRW5ITVJ?
BFTC-905 MnTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4TUTGlEPTB;MT6yOFI3PyEQvF2= NX;5c3Q3W0GQR1XS
Hs-578-T MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTFwMkW4NVch|ryP M4PKXXNCVkeHUh?=
KG-1 Mn\sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIe4NmpKSzVyPUGuNlY3QDZizszN NVLTd4pTW0GQR1XS
HEL NYS3eXc5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\SWG5KSzVyPUGuNlk{OzhizszN NGfjdI5USU6JRWK=
A549 M{T1[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEH1WIJKSzVyPUGuNlk{QTlizszN M4jUNHNCVkeHUh?=
COLO-741 NIK5ZpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTFwM{KwPFkh|ryP M2jiRXNCVkeHUh?=
PC-3 MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoXJTWM2OD1zLkO1NlIyKM7:TR?= NITYdWFUSU6JRWK=
HOS NXnxcZNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELjd3pKSzVyPUGuN|UzQTZizszN NYjScHR1W0GQR1XS
HT-1080 NF7DRWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7TTWM2OD1zLkO3OVE6KM7:TR?= NUfhcFJIW0GQR1XS
TE-8 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHhTWM2OD1zLkSxO|c1KM7:TR?= NUXsVY5FW0GQR1XS
BHY M2D5[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvKTWM2OD1zLkS2PVI{KM7:TR?= NWf5eGx[W0GQR1XS
BB65-RCC MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT3TWM2OD1zLkWwOVI5KM7:TR?= NVzFcpZiW0GQR1XS
HN MmrJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzFNGtKSzVyPUGuOVQxPzFizszN MmmzV2FPT0WU
NCI-H441 NF\iW2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nZV2lEPTB;MT61OFkxPyEQvF2= MlG2V2FPT0WU
RPMI-8866 MnriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrJTWM2OD1zLkW4OVA4KM7:TR?= M4\od3NCVkeHUh?=
CAL-62 MmTzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jBXWlEPTB;MT62NFg3OiEQvF2= MWrTRW5ITVJ?
MG-63 M3KzNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETkUnhKSzVyPUGuOlE5OTNizszN M{HzdnNCVkeHUh?=
SK-LU-1 NEDOOmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHq0b5RKSzVyPUGuOlIyPTJizszN MljBV2FPT0WU
BCPAP MlfTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlu3TWM2OD1zLk[2OFU4KM7:TR?= NXfOdY1sW0GQR1XS
22RV1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvpOJlKSzVyPUGuOlc5PDNizszN MWfTRW5ITVJ?
T47D NETtfJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHmy[WlKSzVyPUGuOlgxPjFizszN NH;OfIlUSU6JRWK=
MSTO-211H NHPRXVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTFwNkm2NFMh|ryP M1qzR3NCVkeHUh?=
DEL NVrZe|MyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\YfpZ5UUN3ME2xMlcxOjd|IN88US=> MkX1V2FPT0WU
H4 MlvUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvjTWM2OD1zLkezNlEzKM7:TR?= MV7TRW5ITVJ?
CAL-51 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XzWGlEPTB;MT63OFg2PSEQvF2= M4LzVnNCVkeHUh?=
ABC-1 M{Hxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Pl[WlEPTB;MT63PFU5OiEQvF2= NFXwOYdUSU6JRWK=
MZ2-MEL NULjdYxpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfYUo5uUUN3ME2xMlc6PTR{IN88US=> M4XOUnNCVkeHUh?=
YKG-1 NFLhWXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTFwOEGwOlEh|ryP NH3PUVhUSU6JRWK=
KM12 M3PwSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1i1TWlEPTB;MT64NVYxOiEQvF2= MmftV2FPT0WU
L-363 M1LYW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfvTWM2OD1zLki3OFEzKM7:TR?= NIH6S4pUSU6JRWK=
KU812 M{jYdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEX2[oVKSzVyPUGuPFkzQDJizszN M2jLS3NCVkeHUh?=
LOXIMVI M3vuWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\zZ|RpUUN3ME2xMlkyOjJ6IN88US=> MmTWV2FPT0WU
G-401 MlS4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTFwOUK0Nlgh|ryP MlLhV2FPT0WU
SW780 NHrufoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmK4TWM2OD1zLkm2NlQ3KM7:TR?= NHjScWpUSU6JRWK=
SW872 Mk\MS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\LclRyUUN3ME2xMlk5OzNizszN MYPTRW5ITVJ?
NB7 NV\xZoV2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7JXlY6UUN3ME2xMlk6OzJ|IN88US=> NFrxZoxUSU6JRWK=
T98G NXf6PXR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJwMEC2OlYh|ryP NEjIeFFUSU6JRWK=
SW1710 NWe5UII4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTJwME[5OFUh|ryP NIXzZWhUSU6JRWK=
NCI-H1573 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHjTWM2OD1{LkC3Nlk5KM7:TR?= NGWyNJhUSU6JRWK=
KE-37 NFv3[YVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVHKbGZjUUN3ME2yMlA5QTVzIN88US=> M3;LW3NCVkeHUh?=
786-0 MkW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3y0dWlEPTB;Mj6xOVQ{QSEQvF2= NH;GSGdUSU6JRWK=
SAS MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILWVIJKSzVyPUKuNlA{PzRizszN NYXudWtXW0GQR1XS
CAL-54 M2PWfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moe4TWM2OD1{LkKwOFE{KM7:TR?= MVXTRW5ITVJ?
SF268 NY\aS4VMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\2OVBKSzVyPUKuNlMyOjJizszN MnryV2FPT0WU
SW620 NV:yeIpNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTJwMk[xOlkh|ryP M3e0RnNCVkeHUh?=
MN-60 M1TlN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTJwM{GwOkDPxE1? NYnwbmlXW0GQR1XS
EFO-27 NIXscoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTJwM{KwOVgh|ryP MlnIV2FPT0WU
NCI-H747 M1Xo[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDHS29FUUN3ME2yMlMzOTl7IN88US=> NEf6[YNUSU6JRWK=
HCC2218 MknES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XTNmlEPTB;Mj6zOVM4PCEQvF2= M2myS3NCVkeHUh?=
MIA-PaCa-2 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTMXmRKSzVyPUKuN|Y1OzdizszN NIHJSXRUSU6JRWK=
SJSA-1 NH3tS4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjQ[HcxUUN3ME2yMlM4Pzl4IN88US=> MWnTRW5ITVJ?
RKO NWXRVmtXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYi1[5gxUUN3ME2yMlM5PDl4IN88US=> M16wN3NCVkeHUh?=
NB6 M2nXVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTJwNECzO|Qh|ryP NIrmN49USU6JRWK=
ES4 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEj1fXBKSzVyPUKuOFU1OjJizszN NWDNfnl4W0GQR1XS
EGI-1 NVPkOZZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXFcXN3UUN3ME2yMlQ3QDh|IN88US=> NGToWXFUSU6JRWK=
CTV-1 NEXYdGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TwUmlEPTB;Mj61Nlc4OyEQvF2= NELBRWNUSU6JRWK=
NCI-H1355 NH3MRplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NELBfpBKSzVyPUKuOVU6PTFizszN MWPTRW5ITVJ?
GT3TKB NYr6NolPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkCxTWM2OD1{LkW5NVk6KM7:TR?= NVfuO49RW0GQR1XS
SK-HEP-1 M1fPUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXkTWM2OD1{LkW5NlY3KM7:TR?= MWjTRW5ITVJ?
GAMG MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF6xSGJKSzVyPUKuOVk{QTRizszN MlG4V2FPT0WU
SK-MES-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjrN3hKSzVyPUKuOlE5ODNizszN M1HsWnNCVkeHUh?=
RO82-W-1 M4K1[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm\rTWM2OD1{Lk[yNFU4KM7:TR?= NVnaeoZqW0GQR1XS
ECC10 MkPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLnU4lGUUN3ME2yMlcxOjB4IN88US=> MV7TRW5ITVJ?
MCF7 NEXiTIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLWSYMzUUN3ME2yMlcyPDZ2IN88US=> NUTMOlBCW0GQR1XS
D-283MED M{H4[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\I[GlvUUN3ME2yMlczPDNizszN NFHmOIxUSU6JRWK=
RPMI-7951 NUDEN4hjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGX6NlhKSzVyPUKuO|U3QTRizszN NGTYZ4RUSU6JRWK=
Ramos-2G6-4C10 M3XXTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTJwN{ewPVkh|ryP NIDNbpNUSU6JRWK=
KGN M1K0cGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTJwOEG4PFQh|ryP NVrISJFkW0GQR1XS
NUGC-3 NV6zVmNZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HiTGlEPTB;Mj64NlUxPSEQvF2= M{e0VXNCVkeHUh?=
NCI-H292 M2Xlbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\YPGlEPTB;Mj64OVA2OyEQvF2= NWnyWopWW0GQR1XS
Becker MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HIUWlEPTB;Mj65OVg{OiEQvF2= MYfTRW5ITVJ?
NCI-H1299 NIS5bmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTNwMEWyOlMh|ryP MXnTRW5ITVJ?
ETK-1 NGC1cJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTNwMEW0N{DPxE1? MWnTRW5ITVJ?
TK10 NHzwNFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvhTZZPUUN3ME2zMlIxOTZ3IN88US=> M1\yNHNCVkeHUh?=
VMRC-RCZ Mne5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;sTWM2OD1|LkO2OFg5KM7:TR?= MULTRW5ITVJ?
YH-13 NY[0dnM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1Pmd2lEPTB;Mz60OFA4QSEQvF2= NVLkU3B3W0GQR1XS
DU-145 NHn0boNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVu3NGljUUN3ME2zMlQ3OjZ7IN88US=> NHfxc41USU6JRWK=
SW1088 MoTNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XVOmlEPTB;Mz60O|Q4KM7:TR?= MXHTRW5ITVJ?
HOP-92 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWnwU3NUUUN3ME2zMlUxOzR{IN88US=> NFLmUWpUSU6JRWK=
KP-N-YS M1vodGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrYUplKSzVyPUOuOlIyOzlizszN NHfBV4RUSU6JRWK=
NCI-H460 NH2xT3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWLJR|UxRTNwNk[3N{DPxE1? M1:4S3NCVkeHUh?=
U-2-OS NY\k[2tnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vCXGlEPTB;Mz63NlU{PSEQvF2= NFfIUnlUSU6JRWK=
A101D NVfBVHVLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3UTWM2OD1|Lke2PVM3KM7:TR?= M4fu[nNCVkeHUh?=
MDA-MB-231 M33NSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTNwOEG5OVEh|ryP MV7TRW5ITVJ?
IST-MES1 Mo\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnOfYx1UUN3ME2zMlg{OiEQvF2= NYfTcWhMW0GQR1XS
COR-L105 MlKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfHTWM2OD12LkCxPEDPxE1? NFTGPXFUSU6JRWK=
NCI-H1437 NGfUVpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW1TWM2OD12LkCyN|AzKM7:TR?= NWPSTo5XW0GQR1XS
CAL-85-1 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYC4ZmM1UUN3ME20MlAzPDZzIN88US=> NELxZZNUSU6JRWK=
MZ1-PC MknCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTRwMUi1OVYh|ryP M4XjWHNCVkeHUh?=
VM-CUB-1 NXvYWZh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHh[ppKSzVyPUSuN|EzQDRizszN NV7sNYhiW0GQR1XS
CHL-1 MkLHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2TTc2lEPTB;ND6zNlE3QSEQvF2= M1XiN3NCVkeHUh?=
MDA-MB-361 M{LDZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIq2clFKSzVyPUSuN|MyPTNizszN M3\IbnNCVkeHUh?=
NCI-H661 NHixPGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjaV4NCUUN3ME20MlUxODl{IN88US=> M1PDdHNCVkeHUh?=
EW-11 MnnES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnmTWM2OD12LkWyNlMyKM7:TR?= M3n6SXNCVkeHUh?=
BEN NFXIfIxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonsTWM2OD12LkWyPFE2KM7:TR?= NGDkeZRUSU6JRWK=
BFTC-909 M2e1WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe1R2p7UUN3ME20MlU3Ojd3IN88US=> NFjlWpVUSU6JRWK=
NCI-H2087 M{TON2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkKzTWM2OD12LkW4NVY1KM7:TR?= MWfTRW5ITVJ?
RVH-421 M3zr[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjrUnRKSzVyPUSuOlY3QSEQvF2= M3X4TnNCVkeHUh?=
P30-OHK MlfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2DCU2lEPTB;ND62PFAxQCEQvF2= MkPMV2FPT0WU
NCI-H28 M1i1Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\vO2RKSzVyPUSuPFE3PjFizszN MlLwV2FPT0WU
ES6 NYm0TmdTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIr3Sm5KSzVyPUSuPFMxOTZizszN Ml\kV2FPT0WU
769-P NXzscHU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33ZemlEPTB;ND64OVkzPiEQvF2= NVXpXGxWW0GQR1XS
OE33 NIrSXGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGS2Z2pKSzVyPUSuPFgyPjFizszN M4\KNXNCVkeHUh?=
SW982 NEj2dnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn7rTWM2OD12Lkm1NFYyKM7:TR?= M3;Wc3NCVkeHUh?=
A388 M{jyUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;1TWM2OD13LkCyPVg{KM7:TR?= M4TCe3NCVkeHUh?=
TI-73 NGTCW4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFzQ[nVKSzVyPUWuNFYyQTRizszN NHLhN|VUSU6JRWK=
HCT-116 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTkNVlHUUN3ME21MlA6QDh7IN88US=> NX\zWWJEW0GQR1XS
HuP-T3 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2rIemlEPTB;NT6xPFcxQSEQvF2= MWLTRW5ITVJ?
G-402 MmKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\zTYRlUUN3ME21MlE6PDF4IN88US=> M3;ZRXNCVkeHUh?=
NCI-H1792 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7tTWM2OD13LkK0OlIzKM7:TR?= NID1ZXZUSU6JRWK=
NCI-H209 MlriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXiwW4g6UUN3ME21MlI2QTR{IN88US=> NXXiSlhFW0GQR1XS
NCI-H1650 M1fDO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXq1RWtvUUN3ME21MlMxPjN2IN88US=> NYTYbYdVW0GQR1XS
LCLC-97TM1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTiOmdTUUN3ME21MlMyQDB6IN88US=> MULTRW5ITVJ?
S-117 NFnmNmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4GycWlEPTB;NT6zOlk4PiEQvF2= NE\Nd49USU6JRWK=
GI-ME-N MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTVwM{m2PFEh|ryP NF;qVJNUSU6JRWK=
NCI-H2122 M2nzS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NET3UI5KSzVyPUWuOFk{QTdizszN M2P5O3NCVkeHUh?=
NCI-H1793 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17RTGlEPTB;NT62O|U6OyEQvF2= NIj3TopUSU6JRWK=
C2BBe1 M2X0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTVwN{CwPFgh|ryP M1XEOXNCVkeHUh?=
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CaR-1 M3TkSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoP1TWM2OD1zOT62PFA1KM7:TR?= NVzn[GNTW0GQR1XS
KYSE-410 M4rjbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPpNmVKSzVyPUG5MlkyOzlizszN MXLTRW5ITVJ?
HuCCT1 Mmq4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTJyLk[yPVQh|ryP MX3TRW5ITVJ?
LB996-RCC M3fnfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTJyLkexOlgh|ryP Mor6V2FPT0WU
KYSE-70 M4H5UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWj0dW9WUUN3ME2yNE45ODV7IN88US=> M4f6OHNCVkeHUh?=
CAL-72 NXTMbGM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTJyLkmxOUDPxE1? NGGxZ4hUSU6JRWK=
Capan-2 Mlr0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7ROYV[UUN3ME2yNU4xPDF|IN88US=> M1LiWHNCVkeHUh?=
PANC-08-13 NWW3NZpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTJzLkK1NVUh|ryP MXPTRW5ITVJ?
SBC-1 NF63TW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmC4TWM2OD1{MT6zNFgyKM7:TR?= MofnV2FPT0WU
MFM-223 M{X1PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml;mTWM2OD1{MT6zN|QzKM7:TR?= NVH0XGJKW0GQR1XS
BB49-HNC NVf1eFNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXjkXlNRUUN3ME2yNU42PzF4IN88US=> M{ThPXNCVkeHUh?=
SH-4 M3q3N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NECxOG5KSzVyPUKxMlY3OThizszN MkG5V2FPT0WU
HuO9 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnwNHc6UUN3ME2yNU46QDJ3IN88US=> MlLLV2FPT0WU
AM-38 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXOcGFKSzVyPUKyMlA1QDVizszN M2LWdXNCVkeHUh?=
A431 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTJ|LkKxNVkh|ryP M{Di[XNCVkeHUh?=
YAPC NWHv[VZwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7DTWM2OD1{Mz6yOlUyKM7:TR?= NEj5W|lUSU6JRWK=
LU-139 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7VTWM2OD1{Mz60PFA6KM7:TR?= MoWyV2FPT0WU
HEC-1 NHf4[IRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHyTWM2OD1{Mz60PVM4KM7:TR?= NIrHdGhUSU6JRWK=
SCC-25 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTJ2LkOwNFYh|ryP NV\DZZlDW0GQR1XS
HT-29 NUiyV5lxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknKTWM2OD1{ND6zPFI{KM7:TR?= NEDDRVFUSU6JRWK=
PC-14 NXG3dW1zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLCTWM2OD1{ND62OVcyKM7:TR?= MVfTRW5ITVJ?
Calu-6 MmrTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIX2cGNKSzVyPUK1MlUxPzFizszN NGDQdWRUSU6JRWK=
SJRH30 M17zVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LRV2lEPTB;MkWuOlQ6PiEQvF2= MVzTRW5ITVJ?
ChaGo-K-1 M2\XPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoC2TWM2OD1{Nj6xOlI6KM7:TR?= MljRV2FPT0WU
IA-LM M{XtTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXaOW0xUUN3ME2yOk4{PjR3IN88US=> MonPV2FPT0WU
GP5d NEjLOlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV7leIxxUUN3ME2yOk41PDlzIN88US=> MonUV2FPT0WU
NCI-H2291 MkHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLZPVN6UUN3ME2yOk43PTRzIN88US=> Moj1V2FPT0WU
BALL-1 NGL2OIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoW1TWM2OD1{Nj65N|k4KM7:TR?= MVTTRW5ITVJ?
HCC1954 M3P6Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTJ4Lkm4NFgh|ryP MVTTRW5ITVJ?
NCI-H2452 NFnTO4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof0TWM2OD1{Nz60NVY{KM7:TR?= MlzCV2FPT0WU
LU-99A MmLoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjCbllKSzVyPUK3MlU2QDJizszN NUPme2trW0GQR1XS
NTERA-S-cl-D1 MojoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHySItKSzVyPUK3MlczQTlizszN NIfuNYNUSU6JRWK=
PANC-10-05 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHXTWM2OD1{Nz63O|c2KM7:TR?= MWTTRW5ITVJ?
NCI-H2405 M2\ZOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3:wW2lEPTB;MkeuPVM5PyEQvF2= MWnTRW5ITVJ?
MDA-MB-415 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHFTWM2OD1{OD60NVM4KM7:TR?= NYXHVmJlW0GQR1XS
NCI-H2342 M4DOeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fBW2lEPTB;MkiuOVI5OSEQvF2= NGfW[pBUSU6JRWK=
TGBC24TKB M{T2NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoW4TWM2OD1{OD63NVE4KM7:TR?= MXfTRW5ITVJ?
LU-134-A MmDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrwTWM2OD1{OD65NlYyKM7:TR?= Mn7tV2FPT0WU
SCC-4 MmTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P2ZWlEPTB;M{GuNFQ6PCEQvF2= MVPTRW5ITVJ?
Saos-2 NWn3bZhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYK3WIlFUUN3ME2zNU46OzB4IN88US=> M{XoWnNCVkeHUh?=
RERF-LC-MS NX;CO2tKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTRcnlyUUN3ME2zNk45OjNzIN88US=> M2TiPXNCVkeHUh?=
M14 MlL3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zLO2lEPTB;M{KuPVc3PCEQvF2= NHf0[5pUSU6JRWK=
HPAF-II NIrjWXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjvN|BTUUN3ME2zN{42ODFzIN88US=> MXnTRW5ITVJ?
NCI-H1755 Ml3PS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLrTWM2OD1|ND6zN|A2KM7:TR?= MVzTRW5ITVJ?
D-392MG MoXZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHW0VYtKSzVyPUO1Mlg3PzRizszN MV;TRW5ITVJ?
A704 M3X4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\3bnR[UUN3ME2zOk4xPDJ5IN88US=> MkGyV2FPT0WU
CP50-MEL-B MnXPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTN4LkG5NVEh|ryP MlvSV2FPT0WU
EW-18 NYHHbmY{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTN4LkS1NkDPxE1? NWfHWGdlW0GQR1XS
WM-115 NXrGOmJ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PETWlEPTB;M{[uPFA6QSEQvF2= NUHHOFRKW0GQR1XS
LU-65 M2rOOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rWcGlEPTB;M{euNVQyPyEQvF2= MkjMV2FPT0WU
NCI-H1563 MnzWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLG[oRKSzVyPUO3MlI1QDRizszN NYnocVNvW0GQR1XS
DBTRG-05MG MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPWeItKSzVyPUO4MlA3QTFizszN NUHUOJllW0GQR1XS
NCI-H630 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfGRnVWUUN3ME2zPE41PzF2IN88US=> NFXyWGRUSU6JRWK=
NCI-H1155 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPZTWM2OD1|OT6yOFIh|ryP NYTsPFNDW0GQR1XS
OVACR-3 NYSxTWNoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPmXmpKSzVyPUO5MlkyQTVizszN NYfJNGs2W0GQR1XS
OAW-42 NFXXcXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2P3cWlEPTB;NECuOFI2QCEQvF2= NUjSW294W0GQR1XS
JVM-2 Mny3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrpZWVKSzVyPUSxMlI1OTVizszN NIjTTJJUSU6JRWK=
C3A MojuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTRzLkO0OFch|ryP M3jRN3NCVkeHUh?=
HT55 M2rH[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHPOHh4UUN3ME20Nk4zQDRzIN88US=> MWHTRW5ITVJ?
OVCAR-4 NYjEVoR{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLvW3dYUUN3ME20Nk4zQTd2IN88US=> NH;l[lVUSU6JRWK=
MEG-01 M4DDPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3NTWM2OD12Mj60OlE3KM7:TR?= M2HsTXNCVkeHUh?=
NCI-H82 MljUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInPNoNKSzVyPUSzMlk5QTJizszN MX7TRW5ITVJ?
JEG-3 NHvuOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjqcVdKSzVyPUS0Mlk1PyEQvF2= MXHTRW5ITVJ?
BPH-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIfyRYpKSzVyPUS2MlM6QThizszN NEjnPVlUSU6JRWK=
MPP-89 NXvFe4FCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjxeGxjUUN3ME20O{4zQDl6IN88US=> M{jp[nNCVkeHUh?=
ALL-PO M3f1TGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTITWM2OD12Nz60NVg5KM7:TR?= Ml\wV2FPT0WU
HT MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTR5LkS5NkDPxE1? MkPrV2FPT0WU
NCI-H2347 NYPXfZVqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe4TWM2OD12OD6wO|E2KM7:TR?= NU\NWo55W0GQR1XS
A2780 NEnFdHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTR7LkSyNlgh|ryP MoXlV2FPT0WU
KARPAS-299 MlfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTR7LkWxNVkh|ryP MmrsV2FPT0WU
NCI-H1651 NYfoU4Q1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3\wWGlEPTB;NEmuPFgzOSEQvF2= Ml;FV2FPT0WU

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
RB1 (pT821) / RB1 (pS780) / RB1 / CDK6 / CCND2 / RUNX1 / ETO; 

PubMed: 30300583     


Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells.

pRb(S807, 811) / CDK4 / CDK6 / PARP; 

PubMed: 28453226     


Effects of palbociclib on CDK4/6-Rb pathway. HCC cells were treated with different doses of palbociclib for 24 h, and then, the cells were subjected to western blot analysis. CF, cleaved fragment. 

LC3-I / LC3-II; 

PubMed: 28453226     


Palbociclib increases LC3-II amount in a dose-dependent manner in HCC cell lines. 

pAMPKα(T172) / pULK1(S317); 

PubMed: 28453226     


Dose-dependent response of palbociclib on AMPK-related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. 

SMAD2 (pS255); 

PubMed: 30343527     


T47D cells were treated with indicated concentrations of palbociclib for 24 h to evaluate substrate phosphorylation.

30300583 28453226 30343527
Growth inhibition assay
Cell viability; 

PubMed: 29670090     


Cell viability was determined by MTT assays after palbociclib exposure for 2, 4, and 6 days. The cell cycle of SYO-1 and Fuji cells was assessed after exposure to palbociclib (1 µM) for 24 h by flow cytometry analysis.

29670090
Immunofluorescence
SAHF/ATRX; 

PubMed: 26988987     


DAPI staining for senescence-associated heterochromatic foci (SAHF, left panel) and ATRX staining (right panel) in 1205Lu cells +/− palbociclib for 8 days. 

LC3B; 

PubMed: 28453226     


LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3-positive autophagosomes. Nuclei were counterstained with DAPI (blue).

26988987 28453226
ELISA
PGE2; 

PubMed: 26540629     


The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.

26540629
In vivo PD 0332991 indicates complete tumor stasis in a MDA-MB-435 xenograft at 150 mg/kg. PD 0332991 also shows broad-spectrum antitumor activity in multiple human tumor xenografts by eliminating phospho-Rb and the proliferative marker Ki-67 from tumor tissue and down-regulation of genes under the transcriptional control of E2F. [1]

Protocol

Kinase Assay:

[1]

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Cdk Assays:

A stock solution of PD0332991 is prepared in DMSO. CDK assays are performed in 96-well filter plates. All CDK-cyclin kinase complexes are expressed in insect cells through baculovirus infection and purified. The substrate for the assays is a fragment (amino acids 792–928) of pRb fused to GST (GST·RB-Cterm). The total volume in each well is 0.1 mL containing a final concentration of 20 mM Tris-HCl, pH 7.4, 50 mM NaCl, 1 mM dithiothreitol, 10 mM MgCl2, 25 μM ATP (for CDK4-cyclin D1, CDK6-cyclin D2, and CDK6-cyclin D3) or 12 μM ATP (for CDK2-cyclin E, CDK2-cyclin A, and CDC2-cyclin B) containing 0.25 μCi of [γ-32P]ATP, 20 ng of enzyme, 1 μg of GST·RB-Cterm, and PD 0332991 (0.001-0.1μM). All components except the [γ-32P]ATP are added to the wells, and the plate is placed on a plate mixer for 2 min. The reaction is started by adding the [γ-32P]ATP and the plate is incubated at 25 °C for 15 min. The reaction is terminated by addition of 0.1 mL of 20% trichloroacetic acid and the plate is kept at 4  °C for at least 1 hour to allow the substrate to precipitate. The wells are then washed 5 times with 0.2 mL of 10% trichloroacetic acid and radioactive incorporation is determined with a β plate counter.
Cell Research:

[1]

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  • Cell lines: Tumor cell lines including MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM and K562
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24 hours
  • Method:

    Cells are seeded at 2 × 104 per well in a 96-well plate and incubated overnight. PD 0332991 (0.01-1 μM) is added to the wells and incubated at 37 °C for another 24 hours. [14C]Thymidine (0.1 μCi) is added to each well and incorporation of the radiolabel is allowed to proceed for 72 hours. Incorporated radioactivity is determined with a β plate counter.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Advanced stage human tumor xenografts including Colo-205, MDA-MB-435 breast, SF-295 glioblastoma, ZR-75-1 breast, PC-3 prostate, H125 lung, SW-620 colon, H23 lung and MDA-MB-468 breast (Rb negative) are established in severe combined immunodeficient mice.
  • Dosages: 0-150 mg/kg
  • Administration: Given by gavage
    (Only for Reference)

Solubility (25°C)

In vitro Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
6 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 483.99
Formula

C24H29N7O2.HCl

CAS No. 827022-32-2
Storage powder
in solvent
Synonyms N/A
Smiles Cl.CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
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Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04360941 Not yet recruiting Drug: Palbociclib|Drug: Avelumab Triple Negative Breast Cancer|Locally Advanced Breast Cancer|Recurrent Breast Cancer|Metastatic Breast Cancer|ER+ Breast Cancer|HER2-positive Breast Cancer Royal Marsden NHS Foundation Trust|Pfizer|Breast Cancer Now July 1 2020 Phase 1
NCT03870919 Suspended Drug: Palbociclib|Other: locoregional treatment Breast Cancer Stage IV|Radiotherapy|Surgery UNICANCER|Pfizer October 23 2019 Not Applicable
NCT03900884 Not yet recruiting Drug: Venetoclax|Drug: Palbociclib|Drug: Letrozole Breast Neoplasm Female Peter MacCallum Cancer Centre Australia September 2019 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID