Palbociclib (PD-0332991) HCl

For research use only.

Licensed by Pfizer Catalog No.S1116

177 publications

Palbociclib (PD-0332991) HCl Chemical Structure

Molecular Weight(MW): 483.99

Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.

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Selleck's Palbociclib (PD-0332991) HCl has been cited by 177 publications

Purity & Quality Control

Choose Selective CDK Inhibitors

Biological Activity

Description Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.
Features Non-cytotoxic, and halts cancer cell growth & could be used in glioblastoma that has relapsed after temozolomide treatment (a chemotherapeutic used to treat many cancers).
Targets
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
In vitro

PD 0332991 has little effect on other protein kinases including EGFR, FGFR, PGFR, IR. PD 0332991 is a non-ATP competitive inhibitor of Cdk4. PD 0332991 inhibits MDA-MB-435 breast carcinoma cells with IC50 of 66 nM, which is due to reduced Rb phosphorylation at Ser780. PD 0332991 inhibits thymidine incorporation into the DNA of Rb-positive human breast, colon, and lung carcinomas as well as human leukemias, with IC50 values ranging from 0.04-0.17 μM. PD 0332991 shows no activity in Rb-negative cells. PD 0332991 causes an accumulation of cells in G1 in MDA-MB-453 breast and Colo-205 carcinoma cells. [1] PD 0332991 also shows activity in 5T33MM myeloma cells (immunocompetent model) and sensitizes the cells to killing by bortezomib. [2] PD 0332991 inhibits luminal ER-positive as well as HER2-amplified breast cancer cell lines including MDA-MB-175, ZR-75-30, CAMA-1, MDA-MB-134, HCC-202 and UACC-893. PD 0332991 enhances the activity of tamoxifen and trastuzumab in these cell lines. PD 0332991 enhances the sensitivity of tamoxifen in the MCF7 tamoxifen-resistant cells. [3] A recent study shows that PD 0332991 could suppress malignant rhabdoid tumor (MRT) cell lines including MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS and the sensitivity of the MRT cell lines to PD 0332991 is inversely correlated with expression of p16. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 MX3LbY5ie2ViQYPzZZk> MWWyOEBp NVe3PGJlUW6qaXLpeIlwdiCxZjDDSGs1KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhWmJicHjvd5Bpd3K7bHH0bY9vKHerdHigTWM2OCCxZjCwMlAxOiEQvF2= Mn3GNlQ3PDFzMEO=
COLO205 NEfaR4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjaXHQ4OiCq MoXCRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{\XO|ZXSgZZMhcW6lb4Lwc5JifGmxbjDv[kBcO0ifdHj5cYllcW6nIHnueI8hTE6DIIfpeIghUUN3MDDv[kAxNjB|NjFOwG0> MU[yOFY1OTFyMx?=
U937 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX[3NkBp NEfGXYNCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBie3Onc4Pl[EBieyCrbnPvdpBwemG2aX;uJI9nKFt|SG30bJlucWSrbnWgbY51dyCGTlGge4l1cCCLQ{WwJI9nKDBwMUSg{txO M4\lcVI1PjRzMUCz
MOLM13 NXTjb4ZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DXUVczKGh? M{OydGFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5iTV;MUVE{KGOnbHzzJIhiemKxcnnu[{BHVFR|IFnUSEBufXSjboSgZZN{\XO|ZXSgZZMhcW6lb4Lwc5JifGmxbjDv[kBcO0ifdHj5cYllcW6nIHnueI8hTE6DIIfpeIghUUN3MDDv[kAxNjB7NjFOwG0> M3LENFI1PjRzMUCz
MOLM13 M1;sVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4n1b|czKGh? MWXBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IIPvdoFn\W6rYj3y[ZNqe3SjboSgbJVu[W5iTV;MUVE{KGOnbHzzJIF{e2W|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5yOU[g{txO NYLWZppCOjR4NEGxNFM>
MDA-MB-435 Mm\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPT[YkzPCCq NX7lWlNsUUN3ME2wMlE3KM7:TR?= NX6zWZZSOTV6MEG4N|E>
K562 NIXBem9EgXSxdH;4bYMhSXO|YYm= MoHYPVYhcA>? NH:2enRFVVOR NWrEWVJDUUN3ME2yJO69VQ>? NX;kS5VMOjR2MUe1OlY>
DU145 MlPaR5l1d3SxeHnjJGF{e2G7 M{fGeVk3KGh? MU\EUXNQ MULJR|UxRTdwNTFOwG0> NWHyPJlyOjR2MUe1OlY>
MDA-MB-231 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWTXSmliOSEQvF2= MXWyOEBp MoKxSG1UVw>? NFq4TIZE\WyuIHP5Z4xmKGG{cnXzeEBie3Onc4Pl[EBieyCjY3P1cZVt[XSrb36gZZQhTzFicHjhd4U> NVnJbIpbOjR2MUe1OlY>
MCF7 NY\nU2oyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTBbnQyKM7:TR?= MXWyOEBp M3XQbGROW09? NWr3V5FQS2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdzIIDoZZNm M{HZblI1PDF5NU[2
MCF7 MWrLbY5ie2ViQYPzZZk> MVG1JO69VQ>? MknSNlQhcA>? MmXUSG1UVw>? Ml3DTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDDSGs1N2O7Y3zpcmQyKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhemW2aX7vZoxie3SxbXGgdIhwe3Cqb4L5cIF1cW:wIHH0JHNmejd6MB?= NGXUXZIzPDRzN{W2Oi=>
MDA-MB-231 MUHLbY5ie2ViQYPzZZk> NUC5NHhxPSEQvF2= NILjT5MzPCCq M3rQWGROW09? M13kOGlvcGmkaYTpc44hd2ZicnXjc41jcW6jboSgR2RMPC:leXPsbY5FOSCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKHKndHnuc4Jt[XO2b33hJJBpd3OyaH;yfYxifGmxbjDheEBU\XJ5OEC= M4\kTlI1PDF5NU[2
MDA-MB-231 MmDkSpVv[3Srb36gRZN{[Xl? NVXUPVllOS1zMDFOwG0> MojINlQhcA>? NWPBSpR1TE2VTx?= MYnkc4V{KG6xdDDpcoR2[2ViYYDvdJRwe2m|IHHzd4V{e2WmIHHzJHBCWlBiY3zlZZZi\2V? MX2yOFQyPzV4Nh?=
MCF7 M1TWTmZ2dmO2aX;uJGF{e2G7 NYPoU2R[OS1zMDFOwG0> MWqyOEBp NX3hcY0zTE2VTx?= NVvPXnVj\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppd{Bie3Onc4Pl[EBieyCSQWLQJINt\WG4YXfl Mkn5NlQ1OTd3Nk[=
MDA-MB-231 NFr5OFJHfW6ldHnvckBCe3OjeR?= NIrw[VkxNjVvMTFOwG0> NVGxN3pNPDhiaB?= M4TqTWROW09? NUi3NZczcGG|IH7vJGNmdGxiY4njcIUh[XK{ZYP0JIF{e2W|c3XkJIF{KGGlY4XteYxifGmxbjDheEB{fWJvR{GgdIhie2V? MXuyOFQyPzV4Nh?=
MCF7 NHXzNGJHfW6ldHnvckBCe3OjeR?= Ml7VNE42NTFizszN MkOwOFghcA>? Mkn1SG1UVw>? MWToZZMhdm9iQ3XscEBkgWOuZTDhdpJme3RiYYPz[ZN{\WRiYYOgZYNkfW23bHH0bY9vKGG2IIP1Zk1IOSCyaHHz[S=> M4H3blI1PDF5NU[2
697 NVHSb3k{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTF2OD6zPEBvVQ>? MoH1V2FPT0WU
P12-ICHIKAWA NEfh[odIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjoWVBLUUN3ME25Ok4xPCCwTR?= MmTLV2FPT0WU
NB69 NHLZTmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;oZ2hqUUN3ME2xOlEvQCCwTR?= M3faW3NCVkeHUh?=
EoL-1 NXj5eGlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnFTWM2OD1zOEeuNlYhdk1? M{fKW3NCVkeHUh?=
BHT-101 NWfIelRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTF7OD6yOUBvVQ>? M2D4cHNCVkeHUh?=
SK-NEP-1 MmjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1rHZWlEPTB;MkKwMlAzKG6P MYDTRW5ITVJ?
MHH-NB-11 Mof5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nyNGlEPTB;MkKwMlE6KG6P M2nPdnNCVkeHUh?=
AsPC-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1qwPGlEPTB;MkWyMlU{KG6P NYnSTGZCW0GQR1XS
ES1 NWDVZo9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXLJR|UxRTJ3Nj6yOUBvVQ>? NUPp[mNpW0GQR1XS
LAMA-84 M4\KbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTJ3OD6xPUBvVQ>? MYnTRW5ITVJ?
MOLT-16 NEKwXWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTJ3OD60PUBvVQ>? MofJV2FPT0WU
ES7 NFSydHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T5U2lEPTB;MkezMlA6KG6P NVfaUXprW0GQR1XS
KY821 M3LnR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPyd5hMUUN3ME2zNVQvOSCwTR?= MVzTRW5ITVJ?
RT-112 M2\SbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XZZ2lEPTB;M{KxMlA2KG6P NFTsWJVUSU6JRWK=
HL-60 MnjnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jWemlEPTB;M{SwMlY3KG6P MXjTRW5ITVJ?
MOLT-4 M3S4bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33CNmlEPTB;M{S1MlE{KG6P MmnkV2FPT0WU
KARPAS-45 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTN5Nj6xOkBvVQ>? MnXOV2FPT0WU
SK-N-AS M4rPTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTN6Nz64N{BvVQ>? NGO2T5BUSU6JRWK=
CTB-1 NX3jNZFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGq1NnBKSzVyPUSwOU4xOiCwTR?= MVnTRW5ITVJ?
NKM-1 NY\xd3NbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXJTVd6UUN3ME20NVEvQDlibl2= M3vFV3NCVkeHUh?=
HTC-C3 MofiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1\BemlEPTB;NEOyMlk2KG6P NU\DXlZzW0GQR1XS
BE-13 NVfpTYNDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTR2ND6yO{BvVQ>? Mn\UV2FPT0WU
KOSC-2 NG[4dGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfWZVFlUUN3ME20OlYvQSCwTR?= NF;kRpFUSU6JRWK=
NB14 NGexfVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzveVFMUUN3ME20PFMvPThibl2= MlnBV2FPT0WU
CAL-27 NFLrOoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGCwe5lKSzVyPUS5OE42QSCwTR?= NVHnVYsxW0GQR1XS
H9 M3v2VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\mdWlEPTB;NEm1MlQ{KG6P NE[5W5pUSU6JRWK=
RS4-11 NFW2XVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Tt[GlEPTB;NUC0Mlc{KG6P NFHDcWdUSU6JRWK=
PA-1 MoPkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLNTWM2OD13MEmuPFYhdk1? M3;0[3NCVkeHUh?=
MV-4-11 M2LGdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTVzMz64OUBvVQ>? MY\TRW5ITVJ?
OS-RC-2 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTV{MT62NkBvVQ>? NFPqNJNUSU6JRWK=
RPMI-8226 NEfBT4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TMNGlEPTB;NUK2Mlg3KG6P NEfMbZhUSU6JRWK=
HGC-27 MkPjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnWwTWM2OD13NkSuPVkhdk1? M1nR[nNCVkeHUh?=
CHP-212 M4DXPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknaTWM2OD13OUOuOVkhdk1? NW\0OVRVW0GQR1XS
NB10 NFTM[HdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3f3S2lEPTB;NUm5MlE5KG6P M3\DbnNCVkeHUh?=
HH Mm\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHGTWM2OD13OUmuOFMhdk1? MkP5V2FPT0WU
EW-16 NEDqcoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmrTTWM2OD14MEOuOVIhdk1? M4f0XHNCVkeHUh?=
ES8 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWjJR|UxRTZyNT6yNUBvVQ>? MmTrV2FPT0WU
HAL-01 MnvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DYWGlEPTB;NkC1MlY4KG6P M33vc3NCVkeHUh?=
A204 MnfIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zETmlEPTB;NkOzMlkyKG6P M3TCPXNCVkeHUh?=
MHH-PREB-1 NWjxNlRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4G4cGlEPTB;NkO2Mlk6KG6P NVXwNJR6W0GQR1XS
EM-2 NFvrUZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDXTWM2OD14NUCuOlQhdk1? MX;TRW5ITVJ?
BV-173 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M321O2lEPTB;NkWyMlQ5KG6P MWPTRW5ITVJ?
ONS-76 NHvGclFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjuTWM2OD14N{euPFIhdk1? MnfVV2FPT0WU
KM-H2 M{LTeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTZ7NT61OEBvVQ>? M{jqVnNCVkeHUh?=
D-263MG M3zicmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\C[WlEPTB;N{G3MlEzKG6P Ml7KV2FPT0WU
ES3 NX3Qc2Q1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\PfJZKSzVyPUeyPE46OyCwTR?= M1fnS3NCVkeHUh?=
VA-ES-BJ MlrwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXLcpFKSzVyPUezNk4zPyCwTR?= NFjJWXNUSU6JRWK=
NBsusSR MnXjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjrcGZYUUN3ME23OFIvQTlibl2= M4LBdnNCVkeHUh?=
NCI-H520 Ml\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHMTWM2OD15NE[uOVIhdk1? M4TRPXNCVkeHUh?=
ES5 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTd3Mj64JI5O Mn23V2FPT0WU
T-24 MkjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\iS4d4UUN3ME23O|gvPzFibl2= NVPIdYFyW0GQR1XS
SW962 NFnPfHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLDc5dFUUN3ME24NFgvPjNibl2= MkXoV2FPT0WU
EW-3 NHXXSWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmPPTWM2OD16MEiuO|Yhdk1? MnO4V2FPT0WU
RXF393 M{nHdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDQTWM2OD16MUKuO|khdk1? MlnjV2FPT0WU
U251 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRThzMz64PEBvVQ>? MoPPV2FPT0WU
CAMA-1 NYHFUFRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTh|Mz65OEBvVQ>? NGfaV2hUSU6JRWK=
JVM-3 NGDOdmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTh3MT63PEBvVQ>? NEDpVm5USU6JRWK=
COLO-800 M{DSSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFH6W2dKSzVyPUi5O{44QCCwTR?= NXL4Z2h3W0GQR1XS
OVCAR-5 NIfXSnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTlyMD6xJI5O MnHxV2FPT0WU
LB1047-RCC NX6wT3lHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfzdolXUUN3ME25NlcvPTZibl2= NGDvUIZUSU6JRWK=
SW954 NXm4dZRGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTl{OT60NUBvVQ>? MVXTRW5ITVJ?
J-RT3-T3-5 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HhdWlEPTB;OUO2MlA3KG6P M4r5b3NCVkeHUh?=
Mewo M3LxWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fReWlEPTB;OUO2MlYhdk1? M1jrVXNCVkeHUh?=
NCI-H1770 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDiZXJkUUN3ME25OFAvPTVibl2= MXHTRW5ITVJ?
HO-1-N-1 NH[2WXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzZTWM2OD17NkKuPFEhdk1? NVTXR21EW0GQR1XS
HSC-3 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTl4Nj60PEBvVQ>? MoLtV2FPT0WU
TYK-nu M1jMUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTl7OD6yOUBvVQ>? Mon3V2FPT0WU
KYSE-150 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrNOHZ5UUN3ME2xMlAxODd4IN88US=> M3;TV3NCVkeHUh?=
SN12C MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLNUZRJUUN3ME2xMlAxQDd3IN88US=> MnXBV2FPT0WU
MOLT-13 NHvoZYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfV[o9KSzVyPUGuNFE1OjFizszN M1rkOnNCVkeHUh?=
TE-11 MlfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTFwMES4NVIh|ryP MYPTRW5ITVJ?
DB NXv4cZg1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGGwcZpKSzVyPUGuNFczPzNizszN MoDvV2FPT0WU
CAL-39 NXvFVWNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLFdnFYUUN3ME2xMlA4PTJ{IN88US=> NYTaTnFwW0GQR1XS
A3-KAW NEPYfHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\KS2lEPTB;MT6wPFQxQCEQvF2= M4\rd3NCVkeHUh?=
CHP-134 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFi4UFVKSzVyPUGuNVE5ODdizszN MlLkV2FPT0WU
TGW NYq4[WM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXPemxKSzVyPUGuNVI{QTVizszN NEjFUW9USU6JRWK=
QIMR-WIL M{fyXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfyV2ZKSzVyPUGuNVMyOzRizszN MnrDV2FPT0WU
NCI-SNU-1 Mn34S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjHbHZKSzVyPUGuNVY{PTRizszN MYPTRW5ITVJ?
CGTH-W-1 NHfiZ4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWn6S49JUUN3ME2xMlE4OTh4IN88US=> MonIV2FPT0WU
MHH-ES-1 M2rtNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\YTWM2OD1zLkG3PVg3KM7:TR?= M1rLOXNCVkeHUh?=
LB2241-RCC MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHnDNI1KSzVyPUGuNVg3OiEQvF2= MmflV2FPT0WU
ML-2 MmnvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGn5fpNKSzVyPUGuNlA4OzRizszN MnXVV2FPT0WU
COR-L23 NGLReIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPEW5pKSzVyPUGuNlI6OzNizszN MX;TRW5ITVJ?
BFTC-905 NE\Z[mFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37GO2lEPTB;MT6yOFI3PyEQvF2= NUO4fZZIW0GQR1XS
Hs-578-T NHny[JFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTFwMkW4NVch|ryP MkXxV2FPT0WU
KG-1 M1LnV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFThcnFKSzVyPUGuNlY3QDZizszN M1vBS3NCVkeHUh?=
HEL MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1rOOGlEPTB;MT6yPVM{QCEQvF2= NXT0OXhHW0GQR1XS
A549 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTFwMkmzPVkh|ryP M4HjXXNCVkeHUh?=
COLO-741 M4fwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPDN2hKSzVyPUGuN|IxQDlizszN MYXTRW5ITVJ?
PC-3 NYC2ZVZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoK3TWM2OD1zLkO1NlIyKM7:TR?= MoDtV2FPT0WU
HOS NUTRUlh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnnlTWM2OD1zLkO1Nlk3KM7:TR?= NGTZS4dUSU6JRWK=
HT-1080 NXnX[YVKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjLTWM2OD1zLkO3OVE6KM7:TR?= MnPOV2FPT0WU
TE-8 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTFwNEG3O|Qh|ryP NYjxfZFbW0GQR1XS
BHY M3HKOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTFwNE[5NlMh|ryP NIfoSWhUSU6JRWK=
BB65-RCC NV:4d4RET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorCTWM2OD1zLkWwOVI5KM7:TR?= M{XxR3NCVkeHUh?=
HN NWrmNZFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTFwNUSwO|Eh|ryP MlfqV2FPT0WU
NCI-H441 NX3DRYdbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlToTWM2OD1zLkW0PVA4KM7:TR?= MlnWV2FPT0WU
RPMI-8866 Moe2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVf4XW1SUUN3ME2xMlU5PTB5IN88US=> MXTTRW5ITVJ?
CAL-62 MoHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mny0TWM2OD1zLk[wPFYzKM7:TR?= MnniV2FPT0WU
MG-63 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPZN2UzUUN3ME2xMlYyQDF|IN88US=> MojZV2FPT0WU
SK-LU-1 M4TINmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlqyTWM2OD1zLk[yNVUzKM7:TR?= MojEV2FPT0WU
BCPAP MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrYUIRxUUN3ME2xMlY3PDV5IN88US=> MlPuV2FPT0WU
22RV1 NGDtdotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzlTWM2OD1zLk[3PFQ{KM7:TR?= NIrPVotUSU6JRWK=
T47D Mn63S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\LV2lEPTB;MT62PFA3OSEQvF2= MXPTRW5ITVJ?
MSTO-211H MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3ToNWlEPTB;MT62PVYxOyEQvF2= MYfTRW5ITVJ?
DEL Mn7iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3WXIJKSzVyPUGuO|AzPzNizszN NHrNVmhUSU6JRWK=
H4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHpTWM2OD1zLkezNlEzKM7:TR?= MU\TRW5ITVJ?
CAL-51 MnnhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn60TWM2OD1zLke0PFU2KM7:TR?= NUPaN3BxW0GQR1XS
ABC-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\URW9TUUN3ME2xMlc5PTh{IN88US=> M{DVVHNCVkeHUh?=
MZ2-MEL NUfBWWprT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTFwN{m1OFIh|ryP MmPOV2FPT0WU
YKG-1 M3TCZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTFwOEGwOlEh|ryP MmLjV2FPT0WU
KM12 NIL3XpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXndXlFUUN3ME2xMlgyPjB{IN88US=> NWDaZlB[W0GQR1XS
L-363 NY\sPJpyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXOfYdCUUN3ME2xMlg4PDF{IN88US=> NGf4SoFUSU6JRWK=
KU812 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlf5TWM2OD1zLki5NlgzKM7:TR?= NWnvbYNIW0GQR1XS
LOXIMVI MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTFwOUGyNlgh|ryP MUfTRW5ITVJ?
G-401 NEfBWXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3YTWM2OD1zLkmyOFI5KM7:TR?= MlzEV2FPT0WU
SW780 M1G5XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnS2TWM2OD1zLkm2NlQ3KM7:TR?= NUDzWVlJW0GQR1XS
SW872 MoSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPCVpZoUUN3ME2xMlk5OzNizszN MVPTRW5ITVJ?
NB7 NIfuWVZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jPSGlEPTB;MT65PVMzOyEQvF2= MVTTRW5ITVJ?
T98G NFHCOGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{W4Z2lEPTB;Mj6wNFY3PiEQvF2= M2O2NXNCVkeHUh?=
SW1710 MnXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTJwME[5OFUh|ryP NEK5RXVUSU6JRWK=
NCI-H1573 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTDTWM2OD1{LkC3Nlk5KM7:TR?= NEDOb2tUSU6JRWK=
KE-37 NFvtZXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVKwNGt[UUN3ME2yMlA5QTVzIN88US=> M1HGd3NCVkeHUh?=
786-0 NF7MfYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTJwMUW0N|kh|ryP NFSxfXlUSU6JRWK=
SAS NV23Z4JNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTJwMkCzO|Qh|ryP NIS5PYZUSU6JRWK=
CAL-54 NFnuN3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILzW3hKSzVyPUKuNlA1OTNizszN NHrVZlhUSU6JRWK=
SF268 NFHnOIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfRTWM2OD1{LkKzNVIzKM7:TR?= MYfTRW5ITVJ?
SW620 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnyVYRKSzVyPUKuNlYyPjlizszN Ml\6V2FPT0WU
MN-60 NUjlRlZCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLsTWM2OD1{LkOxNFYh|ryP NFm1ZmFUSU6JRWK=
EFO-27 M2TZZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TIU2lEPTB;Mj6zNlA2QCEQvF2= MoPzV2FPT0WU
NCI-H747 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTJwM{KxPVkh|ryP NYjEPFFZW0GQR1XS
HCC2218 M3iyPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTJwM{WzO|Qh|ryP MVvTRW5ITVJ?
MIA-PaCa-2 MorGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DDO2lEPTB;Mj6zOlQ{PyEQvF2= MYrTRW5ITVJ?
SJSA-1 NInuWVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7HfXlKSzVyPUKuN|c4QTZizszN Mmr4V2FPT0WU
RKO NGr1S25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnUS3VMUUN3ME2yMlM5PDl4IN88US=> MX3TRW5ITVJ?
NB6 NVTJTXZYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjZUm9KSzVyPUKuOFA{PzRizszN MUHTRW5ITVJ?
ES4 MlHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTJwNEW0NlIh|ryP Mlj1V2FPT0WU
EGI-1 MmP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIf0[JNKSzVyPUKuOFY5QDNizszN MoH6V2FPT0WU
CTV-1 MnToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTJwNUK3O|Mh|ryP NH3VPWVUSU6JRWK=
NCI-H1355 MmTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTJwNUW5OVEh|ryP M2i0NHNCVkeHUh?=
GT3TKB MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\1eHZKSzVyPUKuOVkyQTlizszN MVzTRW5ITVJ?
SK-HEP-1 M3ruemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPtTWM2OD1{LkW5NlY3KM7:TR?= MkTwV2FPT0WU
GAMG NH\r[pZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfFd4I1UUN3ME2yMlU6Ozl2IN88US=> NWD2eYxQW0GQR1XS
SK-MES-1 NETSe3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTJwNkG4NFMh|ryP M2fZ[nNCVkeHUh?=
RO82-W-1 NWfyR2pOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTzTWM2OD1{Lk[yNFU4KM7:TR?= MUPTRW5ITVJ?
ECC10 M1m5PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[1d3FKSzVyPUKuO|AzODZizszN M1LwfHNCVkeHUh?=
MCF7 M2nINWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYW2U3lJUUN3ME2yMlcyPDZ2IN88US=> M{ezSXNCVkeHUh?=
D-283MED NIfFboZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjYSWpKSzVyPUKuO|I1OyEQvF2= MoH4V2FPT0WU
RPMI-7951 MlroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnW0TWM2OD1{Lke1Olk1KM7:TR?= M4Hhd3NCVkeHUh?=
Ramos-2G6-4C10 MonTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVK1XG15UUN3ME2yMlc4ODl7IN88US=> NELISWVUSU6JRWK=
KGN M1XZfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nGTWlEPTB;Mj64NVg5PCEQvF2= NX\vSXd{W0GQR1XS
NUGC-3 NEjKVphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYCzflJZUUN3ME2yMlgzPTB3IN88US=> NH2zd2NUSU6JRWK=
NCI-H292 NGHZdJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTJwOEWwOVMh|ryP NEnYOoRUSU6JRWK=
Becker M3;uW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHtSmNKSzVyPUKuPVU5OzJizszN NYDEeJFMW0GQR1XS
NCI-H1299 NIfYPZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfieXMzUUN3ME2zMlA2OjZ|IN88US=> MlHUV2FPT0WU
ETK-1 M4Ozcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTNwMEW0N{DPxE1? M2D0dnNCVkeHUh?=
TK10 NGfSR4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M36yV2lEPTB;Mz6yNFE3PSEQvF2= NUDIdo1qW0GQR1XS
VMRC-RCZ MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\OSVhHUUN3ME2zMlM3PDh6IN88US=> MlrIV2FPT0WU
YH-13 NHTpSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTNwNESwO|kh|ryP Mnv1V2FPT0WU
DU-145 NW\QSmpsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFva[4JKSzVyPUOuOFYzPjlizszN NHrDOZRUSU6JRWK=
SW1088 MoK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTZNWxTUUN3ME2zMlQ4PDdizszN MorJV2FPT0WU
HOP-92 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDMZXhtUUN3ME2zMlUxOzR{IN88US=> NWLROI5NW0GQR1XS
KP-N-YS NHHBVXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MW\JR|UxRTNwNkKxN|kh|ryP MYfTRW5ITVJ?
NCI-H460 MmO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTNwNk[3N{DPxE1? M{fldnNCVkeHUh?=
U-2-OS M1TvR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHLUSVNKSzVyPUOuO|I2OzVizszN NWjYcVJDW0GQR1XS
A101D MoXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1S2bWlEPTB;Mz63Olk{PiEQvF2= NVrmUmYzW0GQR1XS
MDA-MB-231 MnG5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P2R2lEPTB;Mz64NVk2OSEQvF2= NFj3NI9USU6JRWK=
IST-MES1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3HTWM2OD1|LkizNkDPxE1? NVLzdYg3W0GQR1XS
COR-L105 NHTmbWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTRwMEG4JO69VQ>? M2XK[nNCVkeHUh?=
NCI-H1437 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTLPJhKSzVyPUSuNFI{ODJizszN M4rTN3NCVkeHUh?=
CAL-85-1 M{PYfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7NVFdJUUN3ME20MlAzPDZzIN88US=> M3rXWXNCVkeHUh?=
MZ1-PC NVvLZo8xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzwOXhKSzVyPUSuNVg2PTZizszN MoXwV2FPT0WU
VM-CUB-1 NGfDNoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlL2TWM2OD12LkOxNlg1KM7:TR?= MnTOV2FPT0WU
CHL-1 NGnEb4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLuTWM2OD12LkOyNVY6KM7:TR?= NGf2NlhUSU6JRWK=
MDA-MB-361 M3HYS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33PTWlEPTB;ND6zN|E2OyEQvF2= MWPTRW5ITVJ?
NCI-H661 MorqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnrPTWM2OD12LkWwNFkzKM7:TR?= Ml7jV2FPT0WU
EW-11 NH\pc2hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr4doJKSzVyPUSuOVIzOzFizszN NYe4XWZJW0GQR1XS
BEN M3;2bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG[2[WRKSzVyPUSuOVI5OTVizszN MVTTRW5ITVJ?
BFTC-909 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDhUFlKSzVyPUSuOVYzPzVizszN MVTTRW5ITVJ?
NCI-H2087 Mnm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\WTWM2OD12LkW4NVY1KM7:TR?= MVzTRW5ITVJ?
RVH-421 M3P4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjlTWM2OD12Lk[2Olkh|ryP NFj5cHBUSU6JRWK=
P30-OHK M1Kyc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\JeWhKSzVyPUSuOlgxODhizszN MmjyV2FPT0WU
NCI-H28 NV6zNYd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfjTWM2OD12LkixOlYyKM7:TR?= MV;TRW5ITVJ?
ES6 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DO[GlEPTB;ND64N|AyPiEQvF2= MUDTRW5ITVJ?
769-P NFHyfFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfqUoZ6UUN3ME20Mlg2QTJ4IN88US=> M4O3SHNCVkeHUh?=
OE33 Mo[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LReWlEPTB;ND64PFE3OSEQvF2= NYWycWpHW0GQR1XS
SW982 MlvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFn3V45KSzVyPUSuPVUxPjFizszN MmjLV2FPT0WU
A388 Mke2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfHO4l6UUN3ME21MlAzQTh|IN88US=> M1y5OXNCVkeHUh?=
TI-73 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LBbGlEPTB;NT6wOlE6PCEQvF2= NHfYVYJUSU6JRWK=
HCT-116 NHvWVXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHwenA4UUN3ME21MlA6QDh7IN88US=> NEHXclJUSU6JRWK=
HuP-T3 MnrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTVwMUi3NFkh|ryP MorFV2FPT0WU
G-402 NH\pWGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrLWVI3UUN3ME21MlE6PDF4IN88US=> NHflc4lUSU6JRWK=
NCI-H1792 NULVb3JvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjsfJNKSzVyPUWuNlQ3OjJizszN NVvBS4J1W0GQR1XS
NCI-H209 MnHLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTVwMkW5OFIh|ryP MVvTRW5ITVJ?
NCI-H1650 M{PkN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{DmTWlEPTB;NT6zNFY{PCEQvF2= M1XPZnNCVkeHUh?=
LCLC-97TM1 MmfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTVwM{G4NFgh|ryP M2KydnNCVkeHUh?=
S-117 NED2R4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{Dxb2lEPTB;NT6zOlk4PiEQvF2= MkfDV2FPT0WU
GI-ME-N NV;0U4RbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGOzbm9KSzVyPUWuN|k3QDFizszN NX[4OIFQW0GQR1XS
NCI-H2122 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkL3TWM2OD13LkS5N|k4KM7:TR?= MkDkV2FPT0WU
NCI-H1793 M17JN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjCXnFKSzVyPUWuOlc2QTNizszN NVHuWnl7W0GQR1XS
C2BBe1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3TiZWlEPTB;NT63NFA5QCEQvF2= NUO2XZBpW0GQR1XS
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CaR-1 M4fDe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHNXWoxUUN3ME2xPU43QDB2IN88US=> Mk\2V2FPT0WU
KYSE-410 MoC4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnB[IVuUUN3ME2xPU46OTN7IN88US=> MojOV2FPT0WU
HuCCT1 NYjReWlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTJyLk[yPVQh|ryP MXHTRW5ITVJ?
LB996-RCC Mny0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDLTWM2OD1{MD63NVY5KM7:TR?= MXjTRW5ITVJ?
KYSE-70 M{jjVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVGydWhMUUN3ME2yNE45ODV7IN88US=> M163WHNCVkeHUh?=
CAL-72 M13VV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWSx[IJvUUN3ME2yNE46OTVizszN MkP1V2FPT0WU
Capan-2 MnnCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7FTWM2OD1{MT6wOFE{KM7:TR?= MYjTRW5ITVJ?
PANC-08-13 M1y5PWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGey[lBKSzVyPUKxMlI2OTVizszN NUDreVlpW0GQR1XS
SBC-1 NHH3Z4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XBU2lEPTB;MkGuN|A5OSEQvF2= M1HtXXNCVkeHUh?=
MFM-223 NUK1[YhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnmVnZSUUN3ME2yNU4{OzR{IN88US=> MnXwV2FPT0WU
BB49-HNC NFTsd2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUHJR|UxRTJzLkW3NVYh|ryP MmTTV2FPT0WU
SH-4 NXLNSGc1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTJzLk[2NVgh|ryP NHvaWGxUSU6JRWK=
HuO9 Moj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mof1TWM2OD1{MT65PFI2KM7:TR?= MV;TRW5ITVJ?
AM-38 MkT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXX0cnNrUUN3ME2yNk4xPDh3IN88US=> NIrWWFdUSU6JRWK=
A431 NFXRXoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfUV41rUUN3ME2yN{4zOTF7IN88US=> MX;TRW5ITVJ?
YAPC MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{nkZ2lEPTB;MkOuNlY2OSEQvF2= MWrTRW5ITVJ?
LU-139 NXPuSGR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{mwXWlEPTB;MkOuOFgxQSEQvF2= NFTxeJFUSU6JRWK=
HEC-1 M4S0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTJ|LkS5N|ch|ryP M3f4N3NCVkeHUh?=
SCC-25 MkmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfCNFJrUUN3ME2yOE4{ODB4IN88US=> MlHNV2FPT0WU
HT-29 NFHYcWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjwTWM2OD1{ND6zPFI{KM7:TR?= NIDsXIhUSU6JRWK=
PC-14 NV3vUVNXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWCxTINzUUN3ME2yOE43PTdzIN88US=> MlHjV2FPT0WU
Calu-6 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTDTWM2OD1{NT61NFcyKM7:TR?= NUTSRnFmW0GQR1XS
SJRH30 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGexS4pKSzVyPUK1MlY1QTZizszN MoexV2FPT0WU
ChaGo-K-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTiZoFSUUN3ME2yOk4yPjJ7IN88US=> NIrZSGZUSU6JRWK=
IA-LM MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF21bmtKSzVyPUK2MlM3PDVizszN MlXlV2FPT0WU
GP5d NGHjZ3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnjTZFUUUN3ME2yOk41PDlzIN88US=> NHnkV4NUSU6JRWK=
NCI-H2291 NIfSXGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTJ4Lk[1OFEh|ryP NXWyeGtWW0GQR1XS
BALL-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTsTWM2OD1{Nj65N|k4KM7:TR?= NFWxSZhUSU6JRWK=
HCC1954 M4f1ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnKTWM2OD1{Nj65PFA5KM7:TR?= MoPEV2FPT0WU
NCI-H2452 MkPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPCTWM2OD1{Nz60NVY{KM7:TR?= MoTTV2FPT0WU
LU-99A NIT0RpFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3f2emlEPTB;MkeuOVU5OiEQvF2= MWjTRW5ITVJ?
NTERA-S-cl-D1 MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;IT|JYUUN3ME2yO{44Ojl7IN88US=> M3[zOXNCVkeHUh?=
PANC-10-05 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYXHS4dZUUN3ME2yO{44Pzd3IN88US=> Mlz5V2FPT0WU
NCI-H2405 Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYfMVWpWUUN3ME2yO{46Ozh5IN88US=> M1viXXNCVkeHUh?=
MDA-MB-415 NYLucIFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;MNFFKSzVyPUK4MlQyOzdizszN NYSwO5pWW0GQR1XS
NCI-H2342 Mn3YS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3VTWM2OD1{OD61NlgyKM7:TR?= NVzONWlPW0GQR1XS
TGBC24TKB NFvSSZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnS5TWM2OD1{OD63NVE4KM7:TR?= MUXTRW5ITVJ?
LU-134-A Mn;TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PLZWlEPTB;MkiuPVI3OSEQvF2= NXXMOJJwW0GQR1XS
SCC-4 M4D4bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nCU2lEPTB;M{GuNFQ6PCEQvF2= Mlq1V2FPT0WU
Saos-2 M33XcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PRZWlEPTB;M{GuPVMxPiEQvF2= NHu3cIhUSU6JRWK=
RERF-LC-MS Mo\OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PPXmlEPTB;M{KuPFI{OSEQvF2= NHv0ZXlUSU6JRWK=
M14 Ml;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHyWVVKSzVyPUOyMlk4PjRizszN MWTTRW5ITVJ?
HPAF-II MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEnaeolKSzVyPUOzMlUxOTFizszN MVXTRW5ITVJ?
NCI-H1755 Mne2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITaSYZKSzVyPUO0MlM{ODVizszN M{fMUXNCVkeHUh?=
D-392MG MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTN3Lki2O|Qh|ryP MlPFV2FPT0WU
A704 NHnRO|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk\MTWM2OD1|Nj6wOFI4KM7:TR?= M37JSXNCVkeHUh?=
CP50-MEL-B NGTW[mZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTN4LkG5NVEh|ryP NHfXfJBUSU6JRWK=
EW-18 MonPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2r3c2lEPTB;M{[uOFUzKM7:TR?= Mli1V2FPT0WU
WM-115 M4rNT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDKTmpKSzVyPUO2MlgxQTlizszN MUHTRW5ITVJ?
LU-65 NXiycJlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2T2NWlEPTB;M{euNVQyPyEQvF2= MnXRV2FPT0WU
NCI-H1563 MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTN5LkK0PFQh|ryP MmDWV2FPT0WU
DBTRG-05MG MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTN6LkC2PVEh|ryP NGjBepFUSU6JRWK=
NCI-H630 NX;PN5pxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\rV2pKSzVyPUO4MlQ4OTRizszN NY\4eWNRW0GQR1XS
NCI-H1155 MnrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTocHNnUUN3ME2zPU4zPDJizszN NVWxeoZCW0GQR1XS
OVACR-3 MnTpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHJWVVKSzVyPUO5MlkyQTVizszN MnqyV2FPT0WU
OAW-42 MlraS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTRyLkSyOVgh|ryP NWniTFZ4W0GQR1XS
JVM-2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTRzLkK0NVUh|ryP MULTRW5ITVJ?
C3A MoLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\2TFFPUUN3ME20NU4{PDR5IN88US=> MYLTRW5ITVJ?
HT55 NYrlNWt7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zuSmlEPTB;NEKuNlg1OSEQvF2= M3HNNXNCVkeHUh?=
OVCAR-4 NHjTXnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTR{LkK5O|Qh|ryP MYLTRW5ITVJ?
MEG-01 NUWxSVhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jRe2lEPTB;NEKuOFYyPiEQvF2= M1HTSHNCVkeHUh?=
NCI-H82 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnqeppKSzVyPUSzMlk5QTJizszN MoXTV2FPT0WU
JEG-3 MmfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTR2Lkm0O{DPxE1? MYDTRW5ITVJ?
BPH-1 MnLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTNTWM2OD12Nj6zPVk5KM7:TR?= MmD5V2FPT0WU
MPP-89 M3XUPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjJTWM2OD12Nz6yPFk5KM7:TR?= NGrBWGdUSU6JRWK=
ALL-PO NXfvNWtET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\hTWM2OD12Nz60NVg5KM7:TR?= M3m0TXNCVkeHUh?=
HT Mk\hS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDrWGVKUUN3ME20O{41QTJizszN MkfHV2FPT0WU
NCI-H2347 M{X2T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnnXTWM2OD12OD6wO|E2KM7:TR?= NWrFO4k4W0GQR1XS
A2780 NV7GSZlvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;uOmtGUUN3ME20PU41OjJ6IN88US=> M1uyNHNCVkeHUh?=
KARPAS-299 NFPvNohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEf3NlBKSzVyPUS5MlUyOTlizszN NYHMVpAzW0GQR1XS
NCI-H1651 MkHOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHVTWM2OD12OT64PFIyKM7:TR?= M1zEO3NCVkeHUh?=

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
RB1 (pT821) / RB1 (pS780) / RB1 / CDK6 / CCND2 / RUNX1 / ETO; 

PubMed: 30300583     


Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells.

pRb(S807, 811) / CDK4 / CDK6 / PARP; 

PubMed: 28453226     


Effects of palbociclib on CDK4/6-Rb pathway. HCC cells were treated with different doses of palbociclib for 24 h, and then, the cells were subjected to western blot analysis. CF, cleaved fragment. 

LC3-I / LC3-II; 

PubMed: 28453226     


Palbociclib increases LC3-II amount in a dose-dependent manner in HCC cell lines. 

pAMPKα(T172) / pULK1(S317); 

PubMed: 28453226     


Dose-dependent response of palbociclib on AMPK-related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. 

SMAD2 (pS255); 

PubMed: 30343527     


T47D cells were treated with indicated concentrations of palbociclib for 24 h to evaluate substrate phosphorylation.

30300583 28453226 30343527
Growth inhibition assay
Cell viability; 

PubMed: 29670090     


Cell viability was determined by MTT assays after palbociclib exposure for 2, 4, and 6 days. The cell cycle of SYO-1 and Fuji cells was assessed after exposure to palbociclib (1 µM) for 24 h by flow cytometry analysis.

29670090
Immunofluorescence
SAHF/ATRX; 

PubMed: 26988987     


DAPI staining for senescence-associated heterochromatic foci (SAHF, left panel) and ATRX staining (right panel) in 1205Lu cells +/− palbociclib for 8 days. 

LC3B; 

PubMed: 28453226     


LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3-positive autophagosomes. Nuclei were counterstained with DAPI (blue).

26988987 28453226
ELISA
PGE2; 

PubMed: 26540629     


The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.

26540629
In vivo PD 0332991 indicates complete tumor stasis in a MDA-MB-435 xenograft at 150 mg/kg. PD 0332991 also shows broad-spectrum antitumor activity in multiple human tumor xenografts by eliminating phospho-Rb and the proliferative marker Ki-67 from tumor tissue and down-regulation of genes under the transcriptional control of E2F. [1]

Protocol

Kinase Assay:

[1]

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Cdk Assays:

A stock solution of PD0332991 is prepared in DMSO. CDK assays are performed in 96-well filter plates. All CDK-cyclin kinase complexes are expressed in insect cells through baculovirus infection and purified. The substrate for the assays is a fragment (amino acids 792–928) of pRb fused to GST (GST·RB-Cterm). The total volume in each well is 0.1 mL containing a final concentration of 20 mM Tris-HCl, pH 7.4, 50 mM NaCl, 1 mM dithiothreitol, 10 mM MgCl2, 25 μM ATP (for CDK4-cyclin D1, CDK6-cyclin D2, and CDK6-cyclin D3) or 12 μM ATP (for CDK2-cyclin E, CDK2-cyclin A, and CDC2-cyclin B) containing 0.25 μCi of [γ-32P]ATP, 20 ng of enzyme, 1 μg of GST·RB-Cterm, and PD 0332991 (0.001-0.1μM). All components except the [γ-32P]ATP are added to the wells, and the plate is placed on a plate mixer for 2 min. The reaction is started by adding the [γ-32P]ATP and the plate is incubated at 25 °C for 15 min. The reaction is terminated by addition of 0.1 mL of 20% trichloroacetic acid and the plate is kept at 4  °C for at least 1 hour to allow the substrate to precipitate. The wells are then washed 5 times with 0.2 mL of 10% trichloroacetic acid and radioactive incorporation is determined with a β plate counter.
Cell Research:

[1]

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  • Cell lines: Tumor cell lines including MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM and K562
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24 hours
  • Method:

    Cells are seeded at 2 × 104 per well in a 96-well plate and incubated overnight. PD 0332991 (0.01-1 μM) is added to the wells and incubated at 37 °C for another 24 hours. [14C]Thymidine (0.1 μCi) is added to each well and incorporation of the radiolabel is allowed to proceed for 72 hours. Incorporated radioactivity is determined with a β plate counter.


    (Only for Reference)
Animal Research:

[1]

- Collapse
  • Animal Models: Advanced stage human tumor xenografts including Colo-205, MDA-MB-435 breast, SF-295 glioblastoma, ZR-75-1 breast, PC-3 prostate, H125 lung, SW-620 colon, H23 lung and MDA-MB-468 breast (Rb negative) are established in severe combined immunodeficient mice.
  • Dosages: 0-150 mg/kg
  • Administration: Given by gavage
    (Only for Reference)

Solubility (25°C)

In vitro Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
6 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 483.99
Formula

C24H29N7O2.HCl

CAS No. 827022-32-2
Storage powder
in solvent
Synonyms N/A
Smiles Cl.CC(=O)C1=C(C)C2=CN=C(NC3=NC=C(C=C3)N4CCNCC4)N=C2N(C5CCCC5)C1=O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation (Different batches have different solubility ratios, please contact Selleck to provide you with the correct ratio)
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04360941 Not yet recruiting Drug: Palbociclib|Drug: Avelumab Triple Negative Breast Cancer|Locally Advanced Breast Cancer|Recurrent Breast Cancer|Metastatic Breast Cancer|ER+ Breast Cancer|HER2-positive Breast Cancer Royal Marsden NHS Foundation Trust|Pfizer|Breast Cancer Now July 1 2020 Phase 1
NCT03870919 Suspended Drug: Palbociclib|Other: locoregional treatment Breast Cancer Stage IV|Radiotherapy|Surgery UNICANCER|Pfizer October 23 2019 Not Applicable
NCT03900884 Not yet recruiting Drug: Venetoclax|Drug: Palbociclib|Drug: Letrozole Breast Neoplasm Female Peter MacCallum Cancer Centre Australia September 2019 Phase 1

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID