Palbociclib (PD-0332991) HCl

Licensed by Pfizer Catalog No.S1116

Palbociclib (PD-0332991) HCl Chemical Structure

Molecular Weight(MW): 483.99

Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.

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Cited by 155 Publications

Purity & Quality Control

Choose Selective CDK Inhibitors

Biological Activity

Description Palbociclib (PD-0332991) HCl is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM in cell-free assays, respectively. It shows no activity against CDK1/2/5, EGFR, FGFR, PDGFR, InsR, etc. Phase 3.
Features Non-cytotoxic, and halts cancer cell growth & could be used in glioblastoma that has relapsed after temozolomide treatment (a chemotherapeutic used to treat many cancers).
Targets
CDK4/CyclinD3 [1]
(Cell-free assay)
CDK4/CyclinD1 [1]
(Cell-free assay)
CDK6/CyclinD2 [1]
(Cell-free assay)
9 nM 11 nM 15 nM
In vitro

PD 0332991 has little effect on other protein kinases including EGFR, FGFR, PGFR, IR. PD 0332991 is a non-ATP competitive inhibitor of Cdk4. PD 0332991 inhibits MDA-MB-435 breast carcinoma cells with IC50 of 66 nM, which is due to reduced Rb phosphorylation at Ser780. PD 0332991 inhibits thymidine incorporation into the DNA of Rb-positive human breast, colon, and lung carcinomas as well as human leukemias, with IC50 values ranging from 0.04-0.17 μM. PD 0332991 shows no activity in Rb-negative cells. PD 0332991 causes an accumulation of cells in G1 in MDA-MB-453 breast and Colo-205 carcinoma cells. [1] PD 0332991 also shows activity in 5T33MM myeloma cells (immunocompetent model) and sensitizes the cells to killing by bortezomib. [2] PD 0332991 inhibits luminal ER-positive as well as HER2-amplified breast cancer cell lines including MDA-MB-175, ZR-75-30, CAMA-1, MDA-MB-134, HCC-202 and UACC-893. PD 0332991 enhances the activity of tamoxifen and trastuzumab in these cell lines. PD 0332991 enhances the sensitivity of tamoxifen in the MCF7 tamoxifen-resistant cells. [3] A recent study shows that PD 0332991 could suppress malignant rhabdoid tumor (MRT) cell lines including MP-MRT-AN, KP-MRT-RY, G401, KP-MRT-NS and the sensitivity of the MRT cell lines to PD 0332991 is inversely correlated with expression of p16. [4]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MOLM13 MV\LbY5ie2ViQYPzZZk> NHSxcm0zPCCq MnfyTY5pcWKrdHnvckBw\iCFRFu0JIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[gVoIheGixc4Doc5J6dGG2aX;uJJdqfGhiSVO1NEBw\iByLkCwNkDPxE1? M2GzfVI1PjRzMUCz
COLO205 Mn73S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPqU|k4PzJiaB?= Mn[1RY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{\XO|ZXSgZZMhcW6lb4Lwc5JifGmxbjDv[kBcO0ifdHj5cYllcW6nIHnueI8hTE6DIIfpeIghUUN3MDDv[kAxNjB|NjFOwG0> M2\hOVI1PjRzMUCz
U937 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzo[FA4OiCq MoHJRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZZN{\XO|ZXSgZZMhcW6lb4Lwc5JifGmxbjDv[kBcO0ifdHj5cYllcW6nIHnueI8hTE6DIIfpeIghUUN3MDDv[kAxNjF2IN88US=> MWOyOFY1OTFyMx?=
MOLM13 NULZS|c4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVm3NkBp MkLoRY51cXC{b3zp[oVz[XSrdnWgZYN1cX[rdImgZYdicW6|dDDoeY1idiCPT1zNNVMh[2WubIOgbIFz[m:{aX7nJGZNXDNiSWTEJI12fGGwdDDhd5Nme3OnZDDhd{BqdmOxcoDvdoF1cW:wIH;mJHs{UF22aIntbYRqdmViaX70c{BFVkFid3n0bEBKSzVyIH;mJFAvODl4IN88US=> M1nCRVI1PjRzMUCz
MOLM13 MkfGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXqyV2ZuPzJiaB?= MWDBcpRqeHKxbHnm[ZJifGm4ZTDhZ5Rqfmm2eTDh[4FqdnO2IIPvdoFn\W6rYj3y[ZNqe3SjboSgbJVu[W5iTV;MUVE{KGOnbHzzJIF{e2W|c3XkJIF{KGmwY3;ydI9z[XSrb36gc4YhYzOKXYTofY1q\GmwZTDpcpRwKESQQTD3bZRpKEmFNUCgc4YhOC5yOU[g{txO M4D0[FI1PjRzMUCz
MDA-MB-435 MlPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPiUXNFOjRiaB?= M3PiXWlEPTB;MD6xOkDPxE1? MVWxOVgxOTh|MR?=
K562 MVrDfZRwfG:6aXOgRZN{[Xl? NIfn[Ic6PiCq NUHpSGhGTE2VTx?= MX3JR|UxRTJizszN M1OzSFI1PDF5NU[2
DU145 NFHQUJlEgXSxdH;4bYMhSXO|YYm= NV;ac|VvQTZiaB?= M1XMR2ROW09? NV7zc49DUUN3ME23MlUh|ryP NHzWfYEzPDRzN{W2Oi=>
MDA-MB-231 M17xVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXKyWXljOSEQvF2= NYXL[mFPOjRiaB?= M3\nOWROW09? MkiwR4VtdCCleXPs[UBienKnc4SgZZN{\XO|ZXSgZZMh[WOldX31cIF1cW:wIHH0JGcyKHCqYYPl MX2yOFQyPzV4Nh?=
MCF7 NYrsdWdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnLKNUDPxE1? NY\nZYpVOjRiaB?= NIH5V21FVVOR NYjxWJdMS2WubDDjfYNt\SCjcoLld5Qh[XO|ZYPz[YQh[XNiYXPjeY12dGG2aX;uJIF1KEdzIIDoZZNm NUXJW5ZJOjR2MUe1OlY>
MCF7 NYTPXpY2U2mwYYPlJGF{e2G7 NHv3OFc2KM7:TR?= M{j5OFI1KGh? MVjEUXNQ MoDRTY5pcWKrdHnvckBw\iC{ZXPvcYJqdmGwdDDDSGs1N2O7Y3zpcmQyKGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhemW2aX7vZoxie3SxbXGgdIhwe3Cqb4L5cIF1cW:wIHH0JHNmejd6MB?= MmXXNlQ1OTd3Nk[=
MDA-MB-231 MWfLbY5ie2ViQYPzZZk> MXu1JO69VQ>? NGTKPZIzPCCq NEW5TnRFVVOR NX6zO4pkUW6qaXLpeIlwdiCxZjDy[YNwdWKrbnHueEBETEt2L3P5Z4xqdkRzIHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZicnX0bY5w[myjc4TvcYEheGixc4Doc5J6dGG2aX;uJIF1KFOncke4NC=> NFLXVIszPDRzN{W2Oi=>
MDA-MB-231 NGTlb3BHfW6ldHnvckBCe3OjeR?= NWP5NllOOS1zMDFOwG0> MnLXNlQhcA>? M{jO[WROW09? NIHxZVJld2W|IH7veEBqdmS3Y3WgZZBweHSxc3nzJIF{e2W|c3XkJIF{KFCDUmCgZ4xm[X[jZ3W= NH\UcoMzPDRzN{W2Oi=>
MCF7 Mk\KSpVv[3Srb36gRZN{[Xl? M3fyNlEuOTBizszN M2j2PFI1KGh? MWrEUXNQ NXvVVHhV\G:nczDuc5QhcW6mdXPlJIFxd3C2b4Ppd{Bie3Onc4Pl[EBieyCSQWLQJINt\WG4YXfl MXSyOFQyPzV4Nh?=
MDA-MB-231 M4O3cGZ2dmO2aX;uJGF{e2G7 MWewMlUuOSEQvF2= MlK4OFghcA>? NGHWbpdFVVOR MnLQbIF{KG6xIFPlcIwh[3mlbHWgZZJz\XO2IHHzd4V{e2WmIHHzJIFk[3WvdXzheIlwdiCjdDDzeYIuTzFicHjhd4U> NIniXHAzPDRzN{W2Oi=>
MCF7 MYTGeY5kfGmxbjDBd5NigQ>? MXWwMlUuOSEQvF2= NIPDUI81QCCq NI[wXHFFVVOR M1LLNYhieyCwbzDD[YxtKGO7Y3zlJIFzemW|dDDhd5Nme3OnZDDhd{Bi[2O3bYXsZZRqd25iYYSgd5VjNUdzIIDoZZNm MXqyOFQyPzV4Nh?=
697 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrJXVRJUUN3ME2xOFgvOzhibl2= M3j0T3NCVkeHUh?=
P12-ICHIKAWA MmW2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTl4LkC0JI5O MUPTRW5ITVJ?
NB69 M4nX[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnxfHFKSzVyPUG2NU45KG6P MVzTRW5ITVJ?
EoL-1 NHWxSJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTF6Nz6yOkBvVQ>? MmDCV2FPT0WU
BHT-101 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\peXNKSzVyPUG5PE4zPSCwTR?= M1TieHNCVkeHUh?=
SK-NEP-1 MkHsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fSV2lEPTB;MkKwMlAzKG6P M1K5NXNCVkeHUh?=
MHH-NB-11 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTJ{MD6xPUBvVQ>? NIjOZlJUSU6JRWK=
AsPC-1 NX3EfYhvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTJ3Mj61N{BvVQ>? MorqV2FPT0WU
ES1 NUHMSGRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlP3TWM2OD1{NU[uNlUhdk1? NFfZU2lUSU6JRWK=
LAMA-84 NGjielNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnKXmM1UUN3ME2yOVgvOTlibl2= MnLmV2FPT0WU
MOLT-16 M2LJO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEL3Vo9KSzVyPUK1PE41QSCwTR?= MU\TRW5ITVJ?
ES7 M4HKVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIqyWmFKSzVyPUK3N{4xQSCwTR?= NXvmPHhIW0GQR1XS
KY821 NWTjUFJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTNzND6xJI5O MUXTRW5ITVJ?
RT-112 NEG0OlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTN{MT6wOUBvVQ>? MkHFV2FPT0WU
HL-60 NVXGWG1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\2dVJKSzVyPUO0NE43PiCwTR?= MWnTRW5ITVJ?
MOLT-4 M17FUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTN2NT6xN{BvVQ>? NHTucY5USU6JRWK=
KARPAS-45 M1nTWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLsTWM2OD1|N{[uNVYhdk1? MoOyV2FPT0WU
SK-N-AS NXLHbFB7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3KyTmlEPTB;M{i3Mlg{KG6P NFO2SWRUSU6JRWK=
CTB-1 MlK4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXWTWM2OD12MEWuNFIhdk1? M2myWXNCVkeHUh?=
NKM-1 Mm\TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTRzMT64PUBvVQ>? NF\hZo5USU6JRWK=
HTC-C3 NGD3b2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTR|Mj65OUBvVQ>? MW\TRW5ITVJ?
BE-13 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrVTWM2OD12NESuNlchdk1? Mn;NV2FPT0WU
KOSC-2 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTR4Nj65JI5O MV;TRW5ITVJ?
NB14 NELVclRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\zTWM2OD12OEOuOVghdk1? NWXLe3NKW0GQR1XS
CAL-27 M{S5V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTR7ND61PUBvVQ>? MXPTRW5ITVJ?
H9 NYfrOIc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M33nd2lEPTB;NEm1MlQ{KG6P Mm\YV2FPT0WU
RS4-11 NEfqcmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vlN2lEPTB;NUC0Mlc{KG6P NWPTPWE2W0GQR1XS
PA-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX4TndKSzVyPUWwPU45PiCwTR?= MYLTRW5ITVJ?
MV-4-11 NV:1R2hCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTVzMz64OUBvVQ>? MXPTRW5ITVJ?
OS-RC-2 Mnq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHycGtKSzVyPUWyNU43OiCwTR?= NGnxcW1USU6JRWK=
RPMI-8226 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILqWGRKSzVyPUWyOk45PiCwTR?= M1;JT3NCVkeHUh?=
HGC-27 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nOdmlEPTB;NU[0Mlk6KG6P MojoV2FPT0WU
CHP-212 NF;iVG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTV7Mz61PUBvVQ>? NWfL[o5IW0GQR1XS
NB10 NHrIUZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnH3TWM2OD13OUmuNVghdk1? NVjwWJJUW0GQR1XS
HH MonrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXL3W3g6UUN3ME21PVkvPDNibl2= NGTWZZBUSU6JRWK=
EW-16 NWqxdmg3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoX3TWM2OD14MEOuOVIhdk1? MX7TRW5ITVJ?
ES8 NVHn[FVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUn1R2F5UUN3ME22NFUvOjFibl2= MXTTRW5ITVJ?
HAL-01 NV;jUGVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjDXoJKSzVyPU[wOU43PyCwTR?= NXr4PHh4W0GQR1XS
A204 NXPZUnl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXDflVJUUN3ME22N|MvQTFibl2= MVXTRW5ITVJ?
MHH-PREB-1 M{O5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIPTeI9KSzVyPU[zOk46QSCwTR?= NInzeoJUSU6JRWK=
EM-2 M{XybGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFK3NHdKSzVyPU[1NE43PCCwTR?= NXP3SYRUW0GQR1XS
BV-173 MnXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTZ3Mj60PEBvVQ>? NFXRfHhUSU6JRWK=
ONS-76 NHL6[lRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTZ5Nz64NkBvVQ>? MUnTRW5ITVJ?
KM-H2 MljuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PQS2lEPTB;Nkm1MlU1KG6P MoC4V2FPT0WU
D-263MG Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHf2V3lKSzVyPUexO{4yOiCwTR?= MX;TRW5ITVJ?
ES3 M3XNbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoHRTWM2OD15MkiuPVMhdk1? MnLiV2FPT0WU
VA-ES-BJ NIX5WG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2D2[mlEPTB;N{OyMlI4KG6P M4\3V3NCVkeHUh?=
NBsusSR NV3yclVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHz3[|hKSzVyPUe0Nk46QSCwTR?= NVfoO21lW0GQR1XS
NCI-H520 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33VeWlEPTB;N{S2MlUzKG6P Mn;ZV2FPT0WU
ES5 NHrIPFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLyTWM2OD15NUKuPEBvVQ>? MWjTRW5ITVJ?
T-24 M2\sRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHPqcllKSzVyPUe3PE44OSCwTR?= NXPnZpEzW0GQR1XS
SW962 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlrkTWM2OD16MEiuOlMhdk1? NFrOcmVUSU6JRWK=
EW-3 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XCOGlEPTB;OEC4Mlc3KG6P M3vXZXNCVkeHUh?=
RXF393 NFriTZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjLSJF{UUN3ME24NVIvPzlibl2= NX\ROXBnW0GQR1XS
U251 MlvXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRThzMz64PEBvVQ>? M{TmR3NCVkeHUh?=
CAMA-1 NYrZbmdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\MTWM2OD16M{OuPVQhdk1? MWDTRW5ITVJ?
JVM-3 NUTucGhRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3q4OWlEPTB;OEWxMlc5KG6P Mnf2V2FPT0WU
COLO-800 NE[2PWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDzTWM2OD16OUeuO|ghdk1? MlzwV2FPT0WU
OVCAR-5 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWT3W4htUUN3ME25NFAvOSCwTR?= M1PxXHNCVkeHUh?=
LB1047-RCC NHrBNZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTl{Nz61OkBvVQ>? NV\VT5Q3W0GQR1XS
SW954 Ml7ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVXJR|UxRTl{OT60NUBvVQ>? MXXTRW5ITVJ?
J-RT3-T3-5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTl|Nj6wOkBvVQ>? NX\jSFhsW0GQR1XS
Mewo MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XOfmlEPTB;OUO2MlYhdk1? NVzEcpRKW0GQR1XS
NCI-H1770 NH75b25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTl2MD61OUBvVQ>? NWe1bId6W0GQR1XS
HO-1-N-1 NIS5dJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MojITWM2OD17NkKuPFEhdk1? M3\RcnNCVkeHUh?=
HSC-3 NW\FfpVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTl4Nj60PEBvVQ>? MV\TRW5ITVJ?
TYK-nu M3m0dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnfZTWM2OD17OUiuNlUhdk1? NVHn[nNMW0GQR1XS
KYSE-150 NVXF[WRjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3f4S2lEPTB;MT6wNFA4PiEQvF2= NXHCXW5UW0GQR1XS
SN12C NF\n[ZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTlTWM2OD1zLkCwPFc2KM7:TR?= MVPTRW5ITVJ?
MOLT-13 NEjKS|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXqPWw6UUN3ME2xMlAyPDJzIN88US=> NHvkeVJUSU6JRWK=
TE-11 MlnHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHnuSXpKSzVyPUGuNFQ5OTJizszN NEXN[nBUSU6JRWK=
DB NHeyXoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGThWXZKSzVyPUGuNFczPzNizszN M4PEdXNCVkeHUh?=
CAL-39 NFrLV|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTFwMEe1NlIh|ryP M33pZXNCVkeHUh?=
A3-KAW NHn5[mJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPFS3VkUUN3ME2xMlA5PDB6IN88US=> MmDmV2FPT0WU
CHP-134 M4fU[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33JRWlEPTB;MT6xNVgxPyEQvF2= Mo\sV2FPT0WU
TGW MlHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIW1WnpKSzVyPUGuNVI{QTVizszN NFjKb4JUSU6JRWK=
QIMR-WIL M4HPWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPuTWM2OD1zLkGzNVM1KM7:TR?= MXLTRW5ITVJ?
NCI-SNU-1 M3\6XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LrdWlEPTB;MT6xOlM2PCEQvF2= NGPodHBUSU6JRWK=
CGTH-W-1 M{n4Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFeyNo9KSzVyPUGuNVcyQDZizszN NEf6XIpUSU6JRWK=
MHH-ES-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTGdodKSzVyPUGuNVc6QDZizszN Mn3uV2FPT0WU
LB2241-RCC NYXMT4FoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvIbYxKSzVyPUGuNVg3OiEQvF2= NUX6R41nW0GQR1XS
ML-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmXjTWM2OD1zLkKwO|M1KM7:TR?= MVzTRW5ITVJ?
COR-L23 MoT0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn1TWM2OD1zLkKyPVM{KM7:TR?= MnPHV2FPT0WU
BFTC-905 M1mwcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{P2V2lEPTB;MT6yOFI3PyEQvF2= NVfwVYNiW0GQR1XS
Hs-578-T Ml;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zwWmlEPTB;MT6yOVgyPyEQvF2= NFfIeJhUSU6JRWK=
KG-1 M2raV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTFwMk[2PFYh|ryP NE\jXVhUSU6JRWK=
HEL M{SyT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;MeJpbUUN3ME2xMlI6OzN6IN88US=> MVjTRW5ITVJ?
A549 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFO0fVFKSzVyPUGuNlk{QTlizszN NFnaTXJUSU6JRWK=
COLO-741 NF32eY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV7JR|UxRTFwM{KwPFkh|ryP MmrZV2FPT0WU
PC-3 M{m5fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmn3TWM2OD1zLkO1NlIyKM7:TR?= Ml30V2FPT0WU
HOS Mmn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojMTWM2OD1zLkO1Nlk3KM7:TR?= NITHUVJUSU6JRWK=
HT-1080 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTFwM{e1NVkh|ryP MYfTRW5ITVJ?
TE-8 M1u0VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nDSGlEPTB;MT60NVc4PCEQvF2= NH62eWZUSU6JRWK=
BHY M4rVRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTFwNE[5NlMh|ryP MVvTRW5ITVJ?
BB65-RCC MmD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PrVGlEPTB;MT61NFUzQCEQvF2= NHTTWGJUSU6JRWK=
HN M{n4TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfpPYFKSzVyPUGuOVQxPzFizszN NXHRT|ZlW0GQR1XS
NCI-H441 NFez[IFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWi5TJNnUUN3ME2xMlU1QTB5IN88US=> MmTJV2FPT0WU
RPMI-8866 M4nx[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTFwNUi1NFch|ryP Mo\iV2FPT0WU
CAL-62 MoTZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HpSWlEPTB;MT62NFg3OiEQvF2= NHTROmhUSU6JRWK=
MG-63 MlK3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlHaTWM2OD1zLk[xPFE{KM7:TR?= NInSVVlUSU6JRWK=
SK-LU-1 NYDYTI84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7NTWM2OD1zLk[yNVUzKM7:TR?= NVHNOGJLW0GQR1XS
BCPAP NHrIN5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLFTWM2OD1zLk[2OFU4KM7:TR?= MV;TRW5ITVJ?
22RV1 M3TPUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULLfoVCUUN3ME2xMlY4QDR|IN88US=> MW\TRW5ITVJ?
T47D MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnKxTWM2OD1zLk[4NFYyKM7:TR?= MoLpV2FPT0WU
MSTO-211H MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHXkZpNKSzVyPUGuOlk3ODNizszN M2LwdnNCVkeHUh?=
DEL MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVOwXIR4UUN3ME2xMlcxOjd|IN88US=> MXPTRW5ITVJ?
H4 NFLyO2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTFwN{OyNVIh|ryP Ml;yV2FPT0WU
CAL-51 MoizS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTFwN{S4OVUh|ryP NIDtcIVUSU6JRWK=
ABC-1 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4rxOWlEPTB;MT63PFU5OiEQvF2= NXv1Z3dpW0GQR1XS
MZ2-MEL NX\5bpVvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXvJR|UxRTFwN{m1OFIh|ryP NViyfJliW0GQR1XS
YKG-1 M1rtVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlThTWM2OD1zLkixNFYyKM7:TR?= Ml7xV2FPT0WU
KM12 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjPT4NpUUN3ME2xMlgyPjB{IN88US=> M3jsOXNCVkeHUh?=
L-363 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTFwOEe0NVIh|ryP M1\NNXNCVkeHUh?=
KU812 NUS3WIZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nTe2lEPTB;MT64PVI5OiEQvF2= NWrYXHh4W0GQR1XS
LOXIMVI NX\xXpVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1qz[mlEPTB;MT65NVIzQCEQvF2= NFnyTFJUSU6JRWK=
G-401 M3;Jfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjBTWM2OD1zLkmyOFI5KM7:TR?= MkXOV2FPT0WU
SW780 NUjRN2hRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTSTWM2OD1zLkm2NlQ3KM7:TR?= NUDQfFZ2W0GQR1XS
SW872 NYXDeppET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUW5Vpc5UUN3ME2xMlk5OzNizszN M1TZPHNCVkeHUh?=
NB7 NIDKT5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTFwOUmzNlMh|ryP NF\nXYJUSU6JRWK=
T98G MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;wWFZKSzVyPUKuNFA3PjZizszN MmW3V2FPT0WU
SW1710 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEju[pVKSzVyPUKuNFY6PDVizszN M4L3b3NCVkeHUh?=
NCI-H1573 NXj0c5B[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfFWnNKSzVyPUKuNFczQThizszN MWLTRW5ITVJ?
KE-37 NUH5S2NQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmGxTWM2OD1{LkC4PVUyKM7:TR?= MkjaV2FPT0WU
786-0 M3\XSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEi1dGdKSzVyPUKuNVU1OzlizszN NV7wZo9{W0GQR1XS
SAS M2LUUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFe0eW1KSzVyPUKuNlA{PzRizszN MWPTRW5ITVJ?
CAL-54 NHvVOHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4HXfmlEPTB;Mj6yNFQyOyEQvF2= M1nMb3NCVkeHUh?=
SF268 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvLcJlKSzVyPUKuNlMyOjJizszN NHraXJdUSU6JRWK=
SW620 Mn[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmPSTWM2OD1{LkK2NVY6KM7:TR?= NXnXRmVVW0GQR1XS
MN-60 NU\sNW9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LXOWlEPTB;Mj6zNVA3KM7:TR?= NF\MPJVUSU6JRWK=
EFO-27 M3XLcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFn1V|hKSzVyPUKuN|IxPThizszN MmHBV2FPT0WU
NCI-H747 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYexZlMyUUN3ME2yMlMzOTl7IN88US=> NF7hTFhUSU6JRWK=
HCC2218 NYXKOmE6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPNcIFuUUN3ME2yMlM2Ozd2IN88US=> MWHTRW5ITVJ?
MIA-PaCa-2 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDCNnZyUUN3ME2yMlM3PDN5IN88US=> MUXTRW5ITVJ?
SJSA-1 NUTFeGc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HrUGlEPTB;Mj6zO|c6PiEQvF2= M1faPXNCVkeHUh?=
RKO M4LJW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M334TWlEPTB;Mj6zPFQ6PiEQvF2= NYjnRpV3W0GQR1XS
NB6 M{TYcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFTJXZNKSzVyPUKuOFA{PzRizszN M4jEZnNCVkeHUh?=
ES4 NW[2eWVXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moe3TWM2OD1{LkS1OFIzKM7:TR?= MkTNV2FPT0WU
EGI-1 MlfzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkj1TWM2OD1{LkS2PFg{KM7:TR?= NYDTVIM6W0GQR1XS
CTV-1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYr3WWQzUUN3ME2yMlUzPzd|IN88US=> M3rJO3NCVkeHUh?=
NCI-H1355 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYruTIVJUUN3ME2yMlU2QTVzIN88US=> M{e4UHNCVkeHUh?=
GT3TKB NFvkRoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmHhTWM2OD1{LkW5NVk6KM7:TR?= M3XwWXNCVkeHUh?=
SK-HEP-1 MnL4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjhdXFKSzVyPUKuOVkzPjZizszN NGnad2NUSU6JRWK=
GAMG NXznSFFNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTJwNUmzPVQh|ryP MmLPV2FPT0WU
SK-MES-1 M13oRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTJwNkG4NFMh|ryP NHzsTZNUSU6JRWK=
RO82-W-1 M3LrRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTJwNkKwOVch|ryP NUL5fohYW0GQR1XS
ECC10 M1HLOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHzsSlRKSzVyPUKuO|AzODZizszN NIK5S25USU6JRWK=
MCF7 M3XnO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vheWlEPTB;Mj63NVQ3PCEQvF2= Mn\NV2FPT0WU
D-283MED NXLKT4NUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfPTWM2OD1{LkeyOFMh|ryP NHfMfJlUSU6JRWK=
RPMI-7951 MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TYcGlEPTB;Mj63OVY6PCEQvF2= MYDTRW5ITVJ?
Ramos-2G6-4C10 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLTTWM2OD1{Lke3NFk6KM7:TR?= NFLuU5BUSU6JRWK=
KGN Ml7mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfPcnNVUUN3ME2yMlgyQDh2IN88US=> NX;SeGtGW0GQR1XS
NUGC-3 M3X2[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nXZmlEPTB;Mj64NlUxPSEQvF2= MlmyV2FPT0WU
NCI-H292 NVLac3d7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojYTWM2OD1{Lki1NFU{KM7:TR?= MkDWV2FPT0WU
Becker MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTJwOUW4N|Ih|ryP MVrTRW5ITVJ?
NCI-H1299 M1jp[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3RTWM2OD1|LkC1NlY{KM7:TR?= MkLVV2FPT0WU
ETK-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFz1OWlKSzVyPUOuNFU1OyEQvF2= M2ntT3NCVkeHUh?=
TK10 Mn\IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fkbGlEPTB;Mz6yNFE3PSEQvF2= NUXzVIk1W0GQR1XS
VMRC-RCZ MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDzTWM2OD1|LkO2OFg5KM7:TR?= NHnGNGNUSU6JRWK=
YH-13 NWfuTHU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{ezdGlEPTB;Mz60OFA4QSEQvF2= NE\yUZlUSU6JRWK=
DU-145 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHCTnNKSzVyPUOuOFYzPjlizszN MnrWV2FPT0WU
SW1088 NF\rTGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmH6TWM2OD1|LkS3OFch|ryP NHy0fohUSU6JRWK=
HOP-92 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF:3PVZKSzVyPUOuOVA{PDJizszN MXLTRW5ITVJ?
KP-N-YS NYLiTYZIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;FVGlEPTB;Mz62NlE{QSEQvF2= MoLiV2FPT0WU
NCI-H460 NFrRZlNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTNwNk[3N{DPxE1? M{XRb3NCVkeHUh?=
U-2-OS NFr1bo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3q4SmlEPTB;Mz63NlU{PSEQvF2= NITuZYRUSU6JRWK=
A101D MofKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{nJXGlEPTB;Mz63Olk{PiEQvF2= MXfTRW5ITVJ?
MDA-MB-231 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[0TWM2OD1|LkixPVUyKM7:TR?= MknwV2FPT0WU
IST-MES1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPqTWM2OD1|LkizNkDPxE1? NFy5U29USU6JRWK=
COR-L105 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3PKXWlEPTB;ND6wNVgh|ryP NWrQR3pRW0GQR1XS
NCI-H1437 Moq2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTRwMEKzNFIh|ryP Mo\qV2FPT0WU
CAL-85-1 MnrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV;RWWZ3UUN3ME20MlAzPDZzIN88US=> M2rsNXNCVkeHUh?=
MZ1-PC NYH5W2tYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjIe4dKSzVyPUSuNVg2PTZizszN MVHTRW5ITVJ?
VM-CUB-1 NFjnWFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkfNTWM2OD12LkOxNlg1KM7:TR?= MYjTRW5ITVJ?
CHL-1 MnTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW2Xm5KSzVyPUSuN|IyPjlizszN NEi3S4xUSU6JRWK=
MDA-MB-361 M2LiS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTRwM{OxOVMh|ryP NVX3VWoyW0GQR1XS
NCI-H661 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjmZYN5UUN3ME20MlUxODl{IN88US=> MVjTRW5ITVJ?
EW-11 NF;oWIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTRwNUKyN|Eh|ryP MlLUV2FPT0WU
BEN MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnXGTWM2OD12LkWyPFE2KM7:TR?= NUjVT4ljW0GQR1XS
BFTC-909 MlvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XoNmlEPTB;ND61OlI4PSEQvF2= MmjuV2FPT0WU
NCI-H2087 M{nEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXThVlkzUUN3ME20MlU5OTZ2IN88US=> MWrTRW5ITVJ?
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P30-OHK MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTRwNkiwNFgh|ryP NYDRUJdkW0GQR1XS
NCI-H28 NEe2TWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTRwOEG2OlEh|ryP NXv1fYNIW0GQR1XS
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769-P MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTPTWM2OD12Lki1PVI3KM7:TR?= NGjDSXJUSU6JRWK=
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TI-73 MmftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUjY[4ZVUUN3ME21MlA3OTl2IN88US=> MoX5V2FPT0WU
HCT-116 NIXMelRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWDJR|UxRTVwMEm4PFkh|ryP M2KyfHNCVkeHUh?=
HuP-T3 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fON2lEPTB;NT6xPFcxQSEQvF2= NHH6XI5USU6JRWK=
G-402 NVLMZVRiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTVwMUm0NVYh|ryP MWPTRW5ITVJ?
NCI-H1792 M2fFVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jPeWlEPTB;NT6yOFYzOiEQvF2= MYTTRW5ITVJ?
NCI-H209 M3f4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTVwMkW5OFIh|ryP NEnHOGNUSU6JRWK=
NCI-H1650 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTVwM{C2N|Qh|ryP MmGzV2FPT0WU
LCLC-97TM1 NFG0bW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTVwM{G4NFgh|ryP NHPnN|hUSU6JRWK=
S-117 NVjhdJFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUDSO4x7UUN3ME21MlM3QTd4IN88US=> M2GxUHNCVkeHUh?=
GI-ME-N NHjRWZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17oUmlEPTB;NT6zPVY5OSEQvF2= NFLwclFUSU6JRWK=
NCI-H2122 M2LZdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTVwNEmzPVch|ryP M2rrVXNCVkeHUh?=
NCI-H1793 M{PNbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTVwNke1PVMh|ryP MWfTRW5ITVJ?
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KYSE-410 NYfnTXZ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmG1TWM2OD1zOT65NVM6KM7:TR?= MXHTRW5ITVJ?
HuCCT1 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDQT2V6UUN3ME2yNE43Ojl2IN88US=> NF7pVFJUSU6JRWK=
LB996-RCC MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3Xx[GlEPTB;MkCuO|E3QCEQvF2= MUHTRW5ITVJ?
KYSE-70 NYHKfmN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPBTWM2OD1{MD64NFU6KM7:TR?= NIrsZpFUSU6JRWK=
CAL-72 NYfte25LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nleGlEPTB;MkCuPVE2KM7:TR?= MXrTRW5ITVJ?
Capan-2 M{DJNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\LTWM2OD1{MT6wOFE{KM7:TR?= M1PyfXNCVkeHUh?=
PANC-08-13 NVL4Zo9UT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1izTGlEPTB;MkGuNlUyPSEQvF2= MX;TRW5ITVJ?
SBC-1 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjPWVlKSzVyPUKxMlMxQDFizszN M{O1VXNCVkeHUh?=
MFM-223 M2niO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzsTWM2OD1{MT6zN|QzKM7:TR?= MVfTRW5ITVJ?
BB49-HNC MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWL4dGZqUUN3ME2yNU42PzF4IN88US=> NUP6d3ZyW0GQR1XS
SH-4 M1nqT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWHJR|UxRTJzLk[2NVgh|ryP MW\TRW5ITVJ?
HuO9 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PncGlEPTB;MkGuPVgzPSEQvF2= M4DHZXNCVkeHUh?=
AM-38 NYjSdGJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTJ{LkC0PFUh|ryP NEXGNHJUSU6JRWK=
A431 M1XZZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7jTWM2OD1{Mz6yNVE6KM7:TR?= NILWcYVUSU6JRWK=
YAPC Mmr6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7Ue25KSzVyPUKzMlI3PTFizszN NYnEXJkxW0GQR1XS
LU-139 NHjkWItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHHMPGFKSzVyPUKzMlQ5ODlizszN NG\mSnpUSU6JRWK=
HEC-1 Mn76S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkP1TWM2OD1{Mz60PVM4KM7:TR?= NWDZO|ljW0GQR1XS
SCC-25 M3HPOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTJ2LkOwNFYh|ryP NX\3cZh4W0GQR1XS
HT-29 MkXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmLvTWM2OD1{ND6zPFI{KM7:TR?= M37MSnNCVkeHUh?=
PC-14 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF36bXNKSzVyPUK0MlY2PzFizszN M4nyR3NCVkeHUh?=
Calu-6 M4rVNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTJ3LkWwO|Eh|ryP NYLwXlV{W0GQR1XS
SJRH30 M37mW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTJ3Lk[0PVYh|ryP NHWyb|RUSU6JRWK=
ChaGo-K-1 M1S2R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LUbGlEPTB;Mk[uNVYzQSEQvF2= NIfNTW9USU6JRWK=
IA-LM MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTJ4LkO2OFUh|ryP MUXTRW5ITVJ?
GP5d NEO0XFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTJ4LkS0PVEh|ryP M{fYTXNCVkeHUh?=
NCI-H2291 M{nZN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYPJR|UxRTJ4Lk[1OFEh|ryP NFvleHJUSU6JRWK=
BALL-1 NIjGNI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3X2eWlEPTB;Mk[uPVM6PyEQvF2= MV\TRW5ITVJ?
HCC1954 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;zWGlTUUN3ME2yOk46QDB6IN88US=> M1OxeHNCVkeHUh?=
NCI-H2452 NFyxelFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTJ5LkSxOlMh|ryP NGTMS3hUSU6JRWK=
LU-99A MoLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoH6TWM2OD1{Nz61OVgzKM7:TR?= Ml;VV2FPT0WU
NTERA-S-cl-D1 M{e4UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTGOVh6UUN3ME2yO{44Ojl7IN88US=> Mli5V2FPT0WU
PANC-10-05 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLUfIJKSzVyPUK3Mlc4PzVizszN M4[xU3NCVkeHUh?=
NCI-H2405 NXqxeZF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX\DfVhpUUN3ME2yO{46Ozh5IN88US=> M2rwSnNCVkeHUh?=
MDA-MB-415 MmCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTJ6LkSxN|ch|ryP MWHTRW5ITVJ?
NCI-H2342 NXPmcWFMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nBUWlEPTB;MkiuOVI5OSEQvF2= MVzTRW5ITVJ?
TGBC24TKB NUfwc3FHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkGwTWM2OD1{OD63NVE4KM7:TR?= NUPUfWFqW0GQR1XS
LU-134-A M335fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zVUmlEPTB;MkiuPVI3OSEQvF2= NWPndZlnW0GQR1XS
SCC-4 Mn3tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnNNodjUUN3ME2zNU4xPDl2IN88US=> M3jZfXNCVkeHUh?=
Saos-2 NIDJc41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTNzLkmzNFYh|ryP NXP4T5ZKW0GQR1XS
RERF-LC-MS NHfSTIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1mweWlEPTB;M{KuPFI{OSEQvF2= MYDTRW5ITVJ?
M14 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkDFTWM2OD1|Mj65O|Y1KM7:TR?= MoK5V2FPT0WU
HPAF-II NVz4VJo6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3ZTWM2OD1|Mz61NFEyKM7:TR?= Mom3V2FPT0WU
NCI-H1755 M1yy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPwTWM2OD1|ND6zN|A2KM7:TR?= M4q2[HNCVkeHUh?=
D-392MG M2nkUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTN3Lki2O|Qh|ryP NVG3VlhSW0GQR1XS
A704 NH3rS|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTN4LkC0Nlch|ryP NGPqVYpUSU6JRWK=
CP50-MEL-B MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGry[G5KSzVyPUO2MlE6OTFizszN NEPqW5BUSU6JRWK=
EW-18 MmDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGrNe4pKSzVyPUO2MlQ2OiEQvF2= MnjHV2FPT0WU
WM-115 MoXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkewTWM2OD1|Nj64NFk6KM7:TR?= M1rKfXNCVkeHUh?=
LU-65 MoC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoKxTWM2OD1|Nz6xOFE4KM7:TR?= M2LkenNCVkeHUh?=
NCI-H1563 NH;6WGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF;ISYVKSzVyPUO3MlI1QDRizszN MVzTRW5ITVJ?
DBTRG-05MG M4XteGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV[1foR7UUN3ME2zPE4xPjlzIN88US=> Mnq0V2FPT0WU
NCI-H630 M3i0S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLSTWM2OD1|OD60O|E1KM7:TR?= MWLTRW5ITVJ?
NCI-H1155 NVPVVGg2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoPQTWM2OD1|OT6yOFIh|ryP MYHTRW5ITVJ?
OVACR-3 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NILaUlFKSzVyPUO5MlkyQTVizszN NXHNd|I4W0GQR1XS
OAW-42 MnzqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzvPWRKSzVyPUSwMlQzPThizszN M2O3TXNCVkeHUh?=
JVM-2 M4f5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDXTWM2OD12MT6yOFE2KM7:TR?= M2r5[XNCVkeHUh?=
C3A M17mfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{XmXmlEPTB;NEGuN|Q1PyEQvF2= NX7CXmZLW0GQR1XS
HT55 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2[5SmlEPTB;NEKuNlg1OSEQvF2= NG[5bllUSU6JRWK=
OVCAR-4 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jPdmlEPTB;NEKuNlk4PCEQvF2= MUDTRW5ITVJ?
MEG-01 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITOR4xKSzVyPUSyMlQ3OTZizszN NX3QNJJ3W0GQR1XS
NCI-H82 MorvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPzXYYzUUN3ME20N{46QDl{IN88US=> NH\ISWRUSU6JRWK=
JEG-3 MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoTHTWM2OD12ND65OFch|ryP NYnBR2JLW0GQR1XS
BPH-1 MnfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LYcmlEPTB;NE[uN|k6QCEQvF2= NH;JblRUSU6JRWK=
MPP-89 NYn1PWVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7FTWM2OD12Nz6yPFk5KM7:TR?= NEXZOZNUSU6JRWK=
ALL-PO MlfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnDTWM2OD12Nz60NVg5KM7:TR?= NFW3XoVUSU6JRWK=
HT M4mzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY[5XG1oUUN3ME20O{41QTJizszN NY\2[XJ1W0GQR1XS
NCI-H2347 NUDyNJVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rx[mlEPTB;NEiuNFcyPSEQvF2= NIroUnhUSU6JRWK=
A2780 MlHvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTR7LkSyNlgh|ryP NELRUVNUSU6JRWK=
KARPAS-299 NImxSY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPiWJp[UUN3ME20PU42OTF7IN88US=> MmrMV2FPT0WU
NCI-H1651 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWXtZnJoUUN3ME20PU45QDJzIN88US=> MYrTRW5ITVJ?

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
RB1 (pT821) / RB1 (pS780) / RB1 / CDK6 / CCND2 / RUNX1 / ETO; 

PubMed: 30300583     


Immunoblots showing dose-dependent impact of 72 hr palbociclib treatment on indicated protein levels in Kasumi-1 and SKNO-1 cells.

pRb(S807, 811) / CDK4 / CDK6 / PARP; 

PubMed: 28453226     


Effects of palbociclib on CDK4/6-Rb pathway. HCC cells were treated with different doses of palbociclib for 24 h, and then, the cells were subjected to western blot analysis. CF, cleaved fragment. 

LC3-I / LC3-II; 

PubMed: 28453226     


Palbociclib increases LC3-II amount in a dose-dependent manner in HCC cell lines. 

pAMPKα(T172) / pULK1(S317); 

PubMed: 28453226     


Dose-dependent response of palbociclib on AMPK-related molecules. HCC cells were treated with different concentrations of palbociclib for 24 h. The phosphorylation of the indicated proteins was determined by western blotting. 

SMAD2 (pS255); 

PubMed: 30343527     


T47D cells were treated with indicated concentrations of palbociclib for 24 h to evaluate substrate phosphorylation.

30300583 28453226 30343527
Growth inhibition assay
Cell viability; 

PubMed: 29670090     


Cell viability was determined by MTT assays after palbociclib exposure for 2, 4, and 6 days. The cell cycle of SYO-1 and Fuji cells was assessed after exposure to palbociclib (1 µM) for 24 h by flow cytometry analysis.

29670090
Immunofluorescence
SAHF/ATRX; 

PubMed: 26988987     


DAPI staining for senescence-associated heterochromatic foci (SAHF, left panel) and ATRX staining (right panel) in 1205Lu cells +/− palbociclib for 8 days. 

LC3B; 

PubMed: 28453226     


LC3B immunofluorescence in palbociclib‐treated Hep3B cells. Arrowheads indicate LC3-positive autophagosomes. Nuclei were counterstained with DAPI (blue).

26988987 28453226
ELISA
PGE2; 

PubMed: 26540629     


The supernatant of control and 7.5 μM palbociclib-treated cells was collected and stored at −80°C. PGE2 secretion was detected using ELISA.

26540629
In vivo PD 0332991 indicates complete tumor stasis in a MDA-MB-435 xenograft at 150 mg/kg. PD 0332991 also shows broad-spectrum antitumor activity in multiple human tumor xenografts by eliminating phospho-Rb and the proliferative marker Ki-67 from tumor tissue and down-regulation of genes under the transcriptional control of E2F. [1]

Protocol

Kinase Assay:

[1]

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Cdk Assays:

A stock solution of PD0332991 is prepared in DMSO. CDK assays are performed in 96-well filter plates. All CDK-cyclin kinase complexes are expressed in insect cells through baculovirus infection and purified. The substrate for the assays is a fragment (amino acids 792–928) of pRb fused to GST (GST·RB-Cterm). The total volume in each well is 0.1 mL containing a final concentration of 20 mM Tris-HCl, pH 7.4, 50 mM NaCl, 1 mM dithiothreitol, 10 mM MgCl2, 25 μM ATP (for CDK4-cyclin D1, CDK6-cyclin D2, and CDK6-cyclin D3) or 12 μM ATP (for CDK2-cyclin E, CDK2-cyclin A, and CDC2-cyclin B) containing 0.25 μCi of [γ-32P]ATP, 20 ng of enzyme, 1 μg of GST·RB-Cterm, and PD 0332991 (0.001-0.1μM). All components except the [γ-32P]ATP are added to the wells, and the plate is placed on a plate mixer for 2 min. The reaction is started by adding the [γ-32P]ATP and the plate is incubated at 25 °C for 15 min. The reaction is terminated by addition of 0.1 mL of 20% trichloroacetic acid and the plate is kept at 4  °C for at least 1 hour to allow the substrate to precipitate. The wells are then washed 5 times with 0.2 mL of 10% trichloroacetic acid and radioactive incorporation is determined with a β plate counter.
Cell Research:

[1]

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  • Cell lines: Tumor cell lines including MDA-MB-435, ZR-75-1, T-47D, MCF-7, H1299, Colo-205, MDA-MB-468, H2009, CRRF-CEM and K562
  • Concentrations: 0.01-1 μM
  • Incubation Time: 24 hours
  • Method:

    Cells are seeded at 2 × 104 per well in a 96-well plate and incubated overnight. PD 0332991 (0.01-1 μM) is added to the wells and incubated at 37 °C for another 24 hours. [14C]Thymidine (0.1 μCi) is added to each well and incorporation of the radiolabel is allowed to proceed for 72 hours. Incorporated radioactivity is determined with a β plate counter.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Advanced stage human tumor xenografts including Colo-205, MDA-MB-435 breast, SF-295 glioblastoma, ZR-75-1 breast, PC-3 prostate, H125 lung, SW-620 colon, H23 lung and MDA-MB-468 breast (Rb negative) are established in severe combined immunodeficient mice.
  • Formulation: Dissolved in sodium lactate buffer (50 mM, pH 4.0)
  • Dosages: 0-150 mg/kg
  • Administration: Given by gavage
    (Only for Reference)

Solubility (25°C)

In vitro Water 30 mg/mL (61.98 mM)
DMSO 3 mg/mL warmed (6.19 mM)
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.
6 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 483.99
Formula

C24H29N7O2.HCl

CAS No. 827022-32-2
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
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Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT03870919 Not yet recruiting Drug: Palbociclib|Other: locoregional treatment Breast Cancer Stage IV|Radiotherapy|Surgery UNICANCER|Pfizer October 15 2019 Not Applicable
NCT03900884 Not yet recruiting Drug: Venetoclax|Drug: Palbociclib|Drug: Letrozole Breast Neoplasm Female Peter MacCallum Cancer Centre Australia September 2019 Phase 1
NCT03844997 Recruiting Drug: Palcociclib|Drug: CPX-351 Acute Myeloid Leukemia|AML Aziz Nazha|Case Comprehensive Cancer Center May 31 2019 Phase 1|Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID