CAS No. 212631-79-3
Batch:
Purity:99.96
Chemical Structure
Check the
CI-1040 (PD184352)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide | |
|---|---|---|
| CAS Number | 212631-79-3 | |
| Molecular Formula |
C17H14ClF2IN2O2 |
|
| Molecular Weight (MW) | 478.67 | |
| SMILES | C1CC1CONC(=O)C2=C(C(=C(C=C2)F)F)NC3=C(C=C(C=C3)I)Cl | |
| InChIKey | GFMMXOIFOQCCGU-UHFFFAOYSA-N |
CI-1040 (PD184352) is an ATP non-competitive MEK inhibitor that directly targets MEK1 with an IC50 of. By blocking MEK activity within the MAPK/ERK signaling cascade, CI-1040 prevents the downstream phosphorylation of ERK1/2. This targeted inhibition effectively disrupts MAPK pathway signal transduction, resulting in suppressed cell proliferation and the induction of apoptosis in cancer cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
96 mg/mL
(200.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
| DMSO |
96 mg/mL
(200.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
| DMSO |
96 mg/mL
(200.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
| DMSO |
96 mg/mL
(200.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
| DMSO |
96 mg/mL
(200.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 14 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- CI-1040 (PD184352) Clinical Trials
- CI-1040 (PD184352) Solubility in DMSO
- CI-1040 (PD184352) Stock Solution
- CI-1040 (PD184352) Storage
- CI-1040 (PD184352) Stability
- CI-1040 (PD184352) Molecular Weight
- CI-1040 (PD184352) SMILES
- CI-1040 (PD184352) Chemical Structure (2D and 3D)
- CI-1040 (PD184352) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.