NEDD8

Other Apoptosis Related Inhibitors

Caspase Bcl-2 p53 Ferroptosis PD-1/PD-L1 Survivin TNF-alpha MDM2/MDMX KRas IAP

Cat.No.	Product Name	Information	Product Use Citations
S7109	MLN4924 (Pevonedistat)	MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM.	Nature, 2025, 642(8068):785-795 Nat Commun, 2025, 16(1):2526 Nat Commun, 2025, 16(1):3756
S0346	NAcM-OPT	NAcM-OPT is a specific, reversible and orally bioavailable inhibitor of cullin neddylation 1 (DCN1) that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.	Cell Death Dis, 2021, 12(9):836
E1953	Pevonedistat hydrochloride	Pevonedistat hydrochloride (MLN4924 hydrochloride) is a potent and selective inhibitor of NEDD8-activating enzyme (NAE) with an IC50 of 4.7 nM. It disrupts cullin-RING ligase-mediated protein degradation, leading to apoptotic cell death in human tumor cells through the deregulation of S-phase DNA synthesis.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S7109

MLN4924 (Pevonedistat)

MLN4924 is a small molecule inhibitor of Nedd8 activating enzyme (NAE) with IC50 of 4 nM.

Nature, 2025, 642(8068):785-795

Nat Commun, 2025, 16(1):2526

Nat Commun, 2025, 16(1):3756

Verified customer review of MLN4924 (Pevonedistat)

S0346

NAcM-OPT

NAcM-OPT is a specific, reversible and orally bioavailable inhibitor of cullin neddylation 1 (DCN1) that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.

Cell Death Dis, 2021, 12(9):836

E1953

Pevonedistat hydrochloride

Pevonedistat hydrochloride (MLN4924 hydrochloride) is a potent and selective inhibitor of NEDD8-activating enzyme (NAE) with an IC50 of 4.7 nM. It disrupts cullin-RING ligase-mediated protein degradation, leading to apoptotic cell death in human tumor cells through the deregulation of S-phase DNA synthesis.