| S7273 |
SC75741
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SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. This compound efficiently blocks influenza virus propagation.
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Cell Mol Life Sci, 2025, 82(1):152
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Physiol Rep, 2025, 13(20):e70595
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J Transl Med, 2024, 22(1):672
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| S1848 |
Curcumin
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Curcumin (Diferuloylmethane, Natural Yellow 3, Turmeric yellow) is the principal curcuminoid of the popular Indian spice turmeric, which is a member of the ginger family (Zingiberaceae). It is an inhibitor of p300 histone acetylatransferase(IC50~25 μM)and Histone deacetylase (HDAC); activates Nrf2 pathway and supresses the activation of NF-κB. Curcumin induces mitophagy, autophagy, apoptosis, and cell cycle arrest with antitumor activity. Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death. Curcumin exhibits anti-infective properties against various human pathogens like the influenza virus, hepatitis C virus, HIV and so on.
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J Biol Chem, 2025, 301(7):110305
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Mol Pain, 2025, 21:17448069251323668
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BMC Immunol, 2025, 26(1):67
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| S7975 |
Favipiravir (T-705)
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Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.
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PLoS Pathog, 2025, 21(8):e1013401
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Front Pharmacol, 2025, 16:1491150
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Vet World, 2025, 18(9):2785-2797
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| S2597 |
Oseltamivir Phosphate
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Oseltamivir Phosphate(Tamiflu) is a potent and selective inhibitor of the neuraminidase that is essential for replication of influenza A and B viruses, used to prevent influenza.
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Nat Commun, 2025, 16(1):6271
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Int J Biol Macromol, 2025, 330(Pt 3):148150
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Clin Immunol, 2024, 262:110178
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| S2716 |
Peramivir Trihydrate
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Peramivir Trihydrate (BCX-1812, RWJ-270201, S-021812) is a trihydrate of the anti-infection agent peramivir which is a transition-state analogue and a potent, specific influenza viral neuraminidase inhibitor with an IC50 of median 0.09 nM.
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Viruses, 2024, 16(9)1467
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Emerg Microbes Infect, 2014, 3(11):e78
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Emerg Microbes Infec, 2014, 3, e78
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| S3007 |
Zanamivir
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Zanamivir (GG167,GR 121167X) is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.
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Front Immunol, 2019, 10:2575
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Emerg Microbes Infect, 2014, 3(11):e78
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Emerg Microbes Infec, 2014, 3, e78
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| S0289 |
KIN1148
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KIN1148 is an agonist of interferon regulatory factor 3 (IRF3) that induces dose-dependent IRF3 nuclear translocation and specific activation of IRF3-responsive promoters. This compound is an influenza vaccine adjuvant that enhances flu vaccine efficacy.
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J Allergy Clin Immunol, 2022, S0091-6749(22)01423-3
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| S6854 |
Triazavirin (TZV)
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Triazavirin (TZV) is a novel antiviral drug, a nucleoside analogue of nucleic acid that inhibits the synthesis of viral RNA and DNA and replication of genomic fragments. It is active against influenza and a number of other viruses, and is an effective protective agent on the transmission stage of influenza.
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Nature, 2022, 604(7904):120-126
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| S0861 |
Laninamivir Octanoate
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Laninamivir octanoate (CS-8958, R-118958, Inavir, LANI), a prodrug of Laninamivir (R-125489), is a long-acting neuraminidase (NA) inhibitor with superior anti-influenza virus activity.
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| E3128 |
Isatidis Folium Extract
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Isatidis Folium Extract is obtained from the dry leaves of Isatis indigotica Fort. (family Cruciferae), has been commonly applied in orient countries for centuries as antipyretic, antiviral, anti-inflammatory, anti-influenza, and anti-cancer agents.
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