| S9698 |
Ezatiostat
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Ezatiostat, a tripeptide analog of glutathione, is a peptidomimetic inhibitor of Glutathione S-transferase P1-1 (GSTP1-1). This compound activates c-Jun NH2 terminal kinase (JNK1) and ERK1/ERK2 and induces apoptosis.
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| S5561 |
Ethacrynic Acid
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Ethacrynic Acid is a loop or high ceiling diuretic used for the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.
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J Pharm Anal, 2024, 14(5):100923
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Journal of Pharmaceutical Analysis, 2023, 10.1016/j.jpha.2023.12.013
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| S4686 |
Vitamin E
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Vitamin E (D-alpha-Tocopherol) is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.
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Elife, 2025, 13RP94169
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Cancer Drug Resist, 2025, 8:45
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Signal Transduct Target Ther, 2024, 9(1):109
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| S2541 |
Clomipramine HCl
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Clomipramine HCl is a tricyclic antidepressant acting as a potent inhibitor of 5-HT reuptake with an IC50 value of 1.5 nM. Clomipramine hydrochloride is used in research on depression, anxiety, and obsessive-compulsive disorder (OCD).
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Biomed Pharmacother, 2022, 153:113328
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bioRxiv, 2020, 2020/9/20.4.7.30734
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| S0970 |
Curzerene
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Curzerene, a sesquiterpene isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity, inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression and induces cell apoptosis.
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