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Calcineurin

Neuronal Signaling

GluR AMPA Receptor-kainate Receptor-NMDA Receptor Gamma-secretase Dopamine Receptor 5-HT Receptor P2 Receptor AChR Histamine Receptor MAO Beta Amyloid Substance P BACE CaMK NMDAR GlyT Neurotrophin Notch BChE Adenosine Kinase Adenosine Deaminase Neurotensin Receptor Serotonin Transporter Secretase Calcineurin Ion Channel
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Cat.No. Product Name Information Product Use Citations Product Validations
S2286 Cyclosporin A Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model.Cyclosporin A (NSC 290193) can be used to induce animal models of Chronic Rejection of Liver Transplantation.
Signal Transduct Target Ther, 2025, 10(1):81
Signal Transduct Target Ther, 2025, 10(1):167
Adv Sci (Weinh), 2025, 12(36):e06150
Verified customer review of Cyclosporin A
S5003 Tacrolimus (FK506) Tacrolimus (FK506) is a 23-membered macrolide lactone that reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) to create a new complex. It also inhibits the phosphatase activity of calcineurin and induces vascular endothelial autophagy.
Proc Natl Acad Sci U S A, 2025, 122(4):e2418317122
J Nanobiotechnology, 2025, 23(1):32
PLoS Pathog, 2025, 21(1):e1012872
Verified customer review of Tacrolimus (FK506)
S2286 Cyclosporin A Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model.Cyclosporin A (NSC 290193) can be used to induce animal models of Chronic Rejection of Liver Transplantation.
Signal Transduct Target Ther, 2025, 10(1):81
Signal Transduct Target Ther, 2025, 10(1):167
Adv Sci (Weinh), 2025, 12(36):e06150
 Verified customer review of Cyclosporin A
S5003 Tacrolimus (FK506) Tacrolimus (FK506) is a 23-membered macrolide lactone that reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) to create a new complex. It also inhibits the phosphatase activity of calcineurin and induces vascular endothelial autophagy.
Proc Natl Acad Sci U S A, 2025, 122(4):e2418317122
J Nanobiotechnology, 2025, 23(1):32
PLoS Pathog, 2025, 21(1):e1012872
 Verified customer review of Tacrolimus (FK506)