Calcineurin

Other Neuronal Signaling Related Inhibitors

Secretase GluR GABA Receptor Dopamine Receptor 5-HT Receptor P2 Receptor AChR Histamine Receptor MAO Beta Amyloid

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S5003	FK506 (Tacrolimus)	Tacrolimus (FK506) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.	Proc Natl Acad Sci U S A, 2025, 122(4):e2418317122 J Nanobiotechnology, 2025, 23(1):32 PLoS Pathog, 2025, 21(1):e1012872
S2286	Cyclosporin A	Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model.Cyclosporin A (NSC 290193) can be used to induce animal models of Chronic Rejection of Liver Transplantation.	Signal Transduct Target Ther, 2025, 10(1):81 Signal Transduct Target Ther, 2025, 10(1):167 Adv Sci (Weinh), 2025, 12(36):e06150

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S5003

FK506 (Tacrolimus)

Tacrolimus (FK506) is a 23-membered macrolide lactone, it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. Tacrolimus also inhibits the phosphatase activity of calcineurin. Tacrolimus induces vascular endothelial autophagy.

Proc Natl Acad Sci U S A, 2025, 122(4):e2418317122

J Nanobiotechnology, 2025, 23(1):32

PLoS Pathog, 2025, 21(1):e1012872

Verified customer review of FK506 (Tacrolimus)

S2286

Cyclosporin A

Cyclosporin A, a non-polar cyclic oligopeptide, is an immunosuppressive agent that binds to cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay. Cyclosporin A is generally given following transplant surgery to prevent rejection and has been used to test its toxic effect on a perfused 3D proximal tubule model.Cyclosporin A (NSC 290193) can be used to induce animal models of Chronic Rejection of Liver Transplantation.

Signal Transduct Target Ther, 2025, 10(1):81

Signal Transduct Target Ther, 2025, 10(1):167

Adv Sci (Weinh), 2025, 12(36):e06150

Verified customer review of Cyclosporin A