SorLA/SORL1 Antibody [G6C20]

Catalog No.: F3454

    Home Primary Antibodies SorLA/SORL1 Antibody [G6C20]

    For research use only.

    Application: Reactivity:

    Usage Information

    Dilution
    1:1000 - 1:10000
    1:500 - 1:1000
    Application
    WB, IHC
    Reactivity
    Rat, Human
    Source
    Rabbit Monoclonal Antibody
    Storage Buffer
    PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
    Storage (from the date of receipt)
    -20°C (avoid freeze-thaw cycles), 2 years
    Predicted MW
    248 kDa

    Datasheet & SDS

    Biological Description

    Specificity
    SorLA/SORL1 Antibody [G6C20] detects endogenous levels of total SorLA/SORL1 protein.
    Clone
    G6C20
    Synonym(s)
    C11orf32; SORL1; Sortilin-related receptor; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; SorLA-1; Sorting protein-related receptor containing LDLR class A repeats; LR11; SorLA
    Background
    SorLA, also known as SORL1 or sortilin-related receptor 1, is a large (~250 kDa) multi-domain type I transmembrane protein belonging to the vacuolar protein sorting 10 protein (Vps10p) domain receptor family. Its extracellular region is composed of a VPS10p domain responsible for ligand binding, a YWTD β-propeller domain, a cluster of 11 complement-type repeat (CR) domains crucial for interacting with ligands such as amyloid precursor protein (APP), and a cassette of fibronectin type-III domains. The cytoplasmic tail contains motifs essential for binding cytosolic adaptor proteins involved in intracellular trafficking. SorLA acts as a sorting receptor that regulates the intracellular trafficking and processing of proteins, cycling between the trans-Golgi network (TGN), endosomes, and the cell surface. While predominantly expressed in neurons, SorLA is also present in other tissues such as the heart and kidney. It plays a critical role in mediating the trafficking and processing of APP, reducing amyloid-beta peptide production by retaining APP in the Golgi and influencing its post-translational modifications, such as O-linked glycosylation, thereby impacting Alzheimer’s disease pathology. SorLA also interacts with lipoprotein receptors like LRP1 and apolipoproteins, linking it to lipoprotein metabolism and cardiovascular disease. Its recycling and endocytosis depend on cytoplasmic tail motifs that engage adaptor proteins such as AP2 and PACS1, enabling efficient retrograde trafficking from endosomes to the Golgi.
    References
    • https://pubmed.ncbi.nlm.nih.gov/25525276/
    • https://pubmed.ncbi.nlm.nih.gov/27832290/

    Tech Support

    Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

    Handling Instructions

    Tel: +1-832-582-8158 Ext:3
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