Sigma Receptor Antagonists

Cat.No.	Product Name	Information	Product Use Citations
S0106	BD-1047 dihydrobromide	BD-1047 dihydrobromide (HBr) is a selective functional antagonist of sigma-1 (σ1) receptor, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.	Phytotherapy Research, 2025, Online ahead of print Brain Res, 2024, 1838:149011 Authorea Preprints, 2023,
S6754	S1RA	S1RA (E-52862) is a selective sigma-1 receptor (σ1R) antagonist with a reported binding affinity of Ki = 17.0 ± 7.0 nM for human σ1 receptor , selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels.	Int Immunopharmacol, 2024, 128:111524
E0388	WQ 1	WQ 1 is a high affinity and selective σ1 receptor antagonist with pKi values of 10.85, 6.53 and 5.80 at σ1, σ2 receptors and dopamine transporter (DAT), displaying σ1/σ2 selectivity ratio of 20893.
S0191	BD1063 2HCL	BD1063 2HCL (BD1063 dihydrochloride) is a potent and selective sigma-1 receptor (σ1R) antagonist with Ki of 4.43 nM.