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Methylmalonate

Name: Methylmalonate
Brand: Selleck Chemicals
SKU: S3683
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.S3683

Methylmalonate (Methylmalonic acid, Isosuccinic Acid, NSC 25201, MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A (methylmalonyl-CoA).

Chemical Structure

Molecular Weight: 118.09

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Quality Control

Batch: S368301 DMSO]23 mg/mL]false]Water]23 mg/mL]false]Ethanol]23 mg/mL]false Purity: 98.89%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS
Datasheet

98.89

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Solubility

In vitro
Batch:

DMSO : 23 mg/mL (194.76 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 23 mg/mL

Ethanol : 23 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	118.09	Formula	C₄H₆O₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	516-05-2	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Methylmalonic acid, Isosuccinic Acid, NSC 25201, MMA			Smiles	CC(C(=O)O)C(=O)O

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06323538	Not yet recruiting	Dietary Exposure\|Diabetes Mellitus Type 2\|Cardiovascular Diseases\|Bone Loss\|Sustainability\|Exposure\|Obesity\|Vitamin Deficiency\|Mineral Deficiency	German Federal Institute for Risk Assessment\|Max Rubner-Institut\|University of Bonn\|Research Institute for Plant-Based Nutrition\|University of Jena\|University of Regensburg\|Heidelberg University\|University of Vienna	April 1 2024	--
NCT06242483	Not yet recruiting	Hypertension	Hospital Israelita Albert Einstein\|Elfie Pte. Ltd.	April 1 2024	Not Applicable
NCT05949580	Not yet recruiting	Relapsing Remitting Multiple Sclerosis	Hoffmann-La Roche\|icometrix	April 30 2024	--
NCT06117722	Not yet recruiting	Chronic Heart Failure	Elpen Pharmaceutical Co. Inc.	March 1 2024	--

Tech Support

Handling Instructions

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