Home Metabolism NPC1L1 chemical L-Citrulline

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L-Citrulline NPC1L1 chemical

Cat.No.S3798

L-citrulline is a substance called a non-essential amino acid that is used as a sports performance and cardiovascular health supplement.
L-Citrulline NPC1L1 chemical Chemical Structure

Chemical Structure

Molecular Weight: 175.19

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Quality Control

Batch: Purity: 99.89%
99.89

Solubility

In vitro
Batch:

Water : 35 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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In vivo
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Chemical Information, Storage & Stability

Molecular Weight 175.19 Formula

C6H13N3O3

 Storage (From the date of receipt)
CAS No. 372-75-8 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles C(CC(C(=O)O)N)CNC(=O)N

Mechanism of Action

In vitro
L-Citrulline restores nitric oxide/reactive oxygen species balance and barrier function in high glucose-treated monolayers of human glomerular endothelial cells. Moreover, this compound also has the ability to establish an anti-inflammatory profile, characterized by increased IL-10 and reduced IL-1β and IL-12(p70) generation in the human proximal tubular cells.
In vivo
Oral l-cit (precursor of l-arg) augments NO-dependent signaling, not only by means of increasing l-arg synthesis, but also by decreasing l-arg catabolism, as such increasing circulating l-arg levels. This compound exerts protective effects in kidneys of STZ-rats, and markedly reduces urinary albumin excretion, tubulo-interstitial fibrosis, and kidney hypertrophy, observed in untreated diabetic mice. Its supplementation also strengthens vascular endothelium function and attenuates stress-induced cold hypersensitivity by improving blood circulation.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06207461 Not yet recruiting
Traditional Chinese Acupoint Message|Intestinal Barrier|Gastrointestinal Dysfunction
Wuhan Union Hospital China
 February 15 2024 --
NCT05636397 Recruiting
BPD - Bronchopulmonary Dysplasia|Pulmonary Hypertension|NEC
The Hospital for Sick Children
 November 1 2023 Not Applicable
NCT06092476 Not yet recruiting
Diabetes Mellitus Type 2
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|Fractyl Health Inc.
 November 1 2023 Not Applicable
NCT06025383 Recruiting
Menopause|Hypertension
Texas Tech University
 July 20 2023 Not Applicable
NCT05590117 Enrolling by invitation
Colo-rectal Cancer|Neuropathy;Peripheral|Mucositis
Tanta University
 October 11 2022 Early Phase 1

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