IPI-3063

Catalog No.S7335

IPI-3063 Chemical Structure

Molecular Weight(MW): 455.51

IPI-3063 is a potent and selective p110δ inhibitor with biochemical IC50 of 2.5 ± 1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.

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Biological Activity

Description IPI-3063 is a potent and selective p110δ inhibitor with biochemical IC50 of 2.5 ± 1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.
Targets
p110δ [1]
(Cell-free assay)
2.5 nM
In vitro

IPI-3063 is a p110δ selective compound with an IC50 = 0.1 nM in p110δ-specific cell-based assays and cellular IC50 values for the other class I PI3K isoforms are at least 1,000-fold higher. IPI-3063 potently reduces mouse B cell proliferation, survival, and plasmablast differentiation[1].

In vivo IPI-3063 has good pharmacokinetics in mice[1].

Protocol

Cell Research:

[1]

+ Expand
  • Cell lines: purified mouse B cells
  • Concentrations: 0.01, 0.1, 1, 10, 30, 100 nM
  • Incubation Time: 48 h
  • Method:

    Purified mouse B cells are incubated for 48 h in either B-cell activating factor (BAFF) or interleukin-4 (IL-4) with various concentrations of IPI-3063 and IPI-443.


    (Only for Reference)
Animal Research:

[2]

+ Expand
  • Animal Models: Brown Norway rats
  • Formulation: 0.5% carboxymethylcellulose, 0.05% Tween 80 in ultra-pure water
  • Dosages: 50 mg/kg
  • Administration: oral administration
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 91 mg/mL (199.77 mM)
Ethanol 12 mg/mL (26.34 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 455.51
Formula

C25H25N7O2

CAS No. 1425043-73-7
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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PI3K Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID