Name: Imipenem
Brand: Selleck Chemicals
SKU: S3667
Availability: InStock
Rating: 5 (1 reviews)

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Quality Control

Batch: Purity: 99.79%

99.79

Related Targets	Integrase Bacterial Antibiotics Anti-infection Fungal Antiviral COVID-19 Parasite Reverse Transcriptase HIV
Other β-lactamase Inhibitors	Sultamicillin Clavulanic acid

Solubility

In vitro
Batch:

Water : 63 mg/mL

DMSO : 1 mg/mL (3.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.050mg/ml (0.16mM)	Taking the 1 mL working solution as an example, add 50 μL of 1 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.050mg/ml (0.16mM)	Taking the 1 mL working solution as an example, add 50 μL of 1 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	317.36	Formula	C₁₂H₁₇N₃O₄S.H₂O	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	74431-23-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCN=CN)O.O

Mechanism of Action

Targets/IC₅₀/Ki	AmpC β-lactamase
In vitro	Imipenem, a β-lactam antibiotic, binds to penicillin binding protein 2 with the highest affinity and produces rounded cells. The binding of this compound causes cells to lyse quickly and thereby to release less free endotoxin.
In vivo	Imipenem has a very short half-life. This compound has antimycobacterial activity both in a mouse model and in humans at high risk for failure of treatment for MDR (multiple-drug-resistant) tuberculosis.
References	[1] https://pubmed.ncbi.nlm.nih.gov/24687492/ [2] https://pubmed.ncbi.nlm.nih.gov/15980354/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT05561764	Recruiting	Cystic Fibrosis\|Pneumonia Bacterial	Hartford Hospital\|Merck Sharp & Dohme LLC\|Q2 Solutions\|Connecticut Children''s Medical Center\|St. Christopher''s Hospital for Children\|University of Texas Southwestern Medical Center\|University of Pittsburgh Medical Center\|Indiana University Health Methodist Hospital\|James Whitcomb Riley Hospital for Children	January 3 2023	Phase 4
NCT05146154	Enrolling by invitation	Obesity\|Critical Illness	University of Illinois at Chicago\|Merck Sharp & Dohme LLC	January 1 2023	Phase 4
NCT05516433	Recruiting	Enterobacteriaceae Infections	Fondation Hôpital Saint-Joseph	January 23 2023	--
NCT05285046	Unknown status	Bacterial Infections\|Antibiotic Resistant Infection	D''Or Institute for Research and Education	April 1 2022	--
NCT04802863	Completed	Bacterial Infections	Evopoint Biosciences Inc.	March 25 2021	Phase 1
NCT04801043	Completed	Bacterial Infections	Evopoint Biosciences Inc.	March 2 2021	Phase 1

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Imipenem β-lactamase inhibitor

Chemical Structure

Molecular Weight: 317.36