HLCL-61 HCL

Catalog No.S8209 Synonyms: HLCL61

HLCL-61 HCL Chemical Structure

Molecular Weight(MW): 380.91

HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.

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Choose Selective Histone Methyltransferase Inhibitors

Biological Activity

Description HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.
Targets
PRMT5 [1]
(In THP-1 cells)
16.74 μM
In vitro

HLCL-61 shows no inhibitory activity against the type I (PRMT1 and PRMT4) and type II (PRMT7) PRMT family members. HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples.Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also results in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h[1].

Protocol

Cell Research:[1]
+ Expand
  • Cell lines: AML cell lines
  • Concentrations: 25,50uM
  • Incubation Time: 48h
  • Method: CD11b expression is tested by flow cytometry on cells treated with DMSO or HLCL-61 (25 and 50 μM) for 48 h.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 76 mg/mL (199.52 mM)
Ethanol 76 mg/mL (199.52 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 380.91
Formula

C23H24N2O.HCl

CAS No. 1158279-20-9
Storage powder
Synonyms HLCL61

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Related Antibodies

Histone Methyltransferase Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID