Fluticasone propionate

Catalog No.S1992 Synonyms: CCI-187881

Fluticasone propionate  Chemical Structure

Molecular Weight(MW): 500.57

Fluticasone Propionate is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.

Size Price Stock Quantity  
In DMSO USD 120 In stock
USD 90 In stock
USD 270 In stock
USD 570 In stock
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Biological Activity

Description Fluticasone Propionate is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.
Targets
Glucocorticoid receptor [1]
()
In vitro

Fluticasone propionate (1 pM) inhibits the constitutive and TGF-beta-induced expression of alpha-SMA in human lung myofibroblasts. Fluticasone propionate blocks the TNF-alpha-induced nuclear translocation of the pro-inflammatory transcription factor NF-kappaB in human lung myofibroblasts. [1] Fluticasone propionate inhibits in lung myofibroblasts, at a very early stage of differentiation, the activation of Janus kinase/STAT pathways induced by IL-13 (tyrosine kinase 2, STAT1, STAT3, STAT6, mitogen-activated protein kinase). Fluticasone propionate still displays a potential anti-inflammatory activity even if it only inhibits tyrosine kinase 2 phosphorylation in mildly or fully differentiated myofibroblastic cultures. Fluticasone propionate inhibits constitutive and TGF-beta-induced expression of alpha-smooth muscle actin, the main marker of myofibroblastic differentiation, both in very early and in mild differentiated myofibroblasts. Fluticasone propionate displays an additional powerful anti-inflammatory effect, decreasing nuclear translocation of NF-kappaB independent of the degree of myofibroblastic differentiation. [2] Fluticasone propionate inhibits allergen-induced T-cell proliferation, expression of IL-3, IL-5 and GM-CSF mRNA, and secretion of the corresponding proteins in a concentration-dependent fashion. Fluticasone propionate has the potential markedly to inhibit allergen-induced T-cell production of asthma-relevant cytokines. [3]

In vivo Fluticasone propionate administrated after induction of a severe heaves exacerbation results in complete resolution of clinical signs, normalization of pulmonary function tests, and significant decrease in bronchoalveolar lavage (BAL) neutrophilia in horse. [4]

Protocol

Solubility (25°C)

In vitro DMSO 100 mg/mL (199.77 mM)
Ethanol 5 mg/mL (9.98 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 500.57
Formula

C25H31F3O5S

CAS No. 80474-14-2
Storage powder
Synonyms CCI-187881

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03004131 Recruiting Seasonal Allergic Rhinitis MEDA Pharma GmbH & Co. KG January 7, 2017 Phase 4
NCT02873468 Not yet recruiting Eosinophilic Esophagitis EMS July 2017 Phase 2|Phase 3
NCT03040596 Not yet recruiting Vocal Fold Nodules University of Pittsburgh February 2017 Phase 1
NCT02991859 Not yet recruiting Asthma GlaxoSmithKline February 2017 Phase 2
NCT03012061 Recruiting Asthma GlaxoSmithKline January 2017 Phase 2
NCT02953106 Not yet recruiting Asthma, Allergic|Rhinitis,Allergic|Allergy University of Dundee December 2016 Phase 4

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID