Catalog No.S1992 Synonyms: CCI-187881
Molecular Weight(MW): 500.57
Fluticasone Propionate is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.
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|Description||Fluticasone Propionate is a synthetic glucocorticoid, used to treat non-allergic and allergic rhinitis.|
Fluticasone propionate (1 pM) inhibits the constitutive and TGF-beta-induced expression of alpha-SMA in human lung myofibroblasts. Fluticasone propionate blocks the TNF-alpha-induced nuclear translocation of the pro-inflammatory transcription factor NF-kappaB in human lung myofibroblasts.  Fluticasone propionate inhibits in lung myofibroblasts, at a very early stage of differentiation, the activation of Janus kinase/STAT pathways induced by IL-13 (tyrosine kinase 2, STAT1, STAT3, STAT6, mitogen-activated protein kinase). Fluticasone propionate still displays a potential anti-inflammatory activity even if it only inhibits tyrosine kinase 2 phosphorylation in mildly or fully differentiated myofibroblastic cultures. Fluticasone propionate inhibits constitutive and TGF-beta-induced expression of alpha-smooth muscle actin, the main marker of myofibroblastic differentiation, both in very early and in mild differentiated myofibroblasts. Fluticasone propionate displays an additional powerful anti-inflammatory effect, decreasing nuclear translocation of NF-kappaB independent of the degree of myofibroblastic differentiation.  Fluticasone propionate inhibits allergen-induced T-cell proliferation, expression of IL-3, IL-5 and GM-CSF mRNA, and secretion of the corresponding proteins in a concentration-dependent fashion. Fluticasone propionate has the potential markedly to inhibit allergen-induced T-cell production of asthma-relevant cytokines. 
|In vivo||Fluticasone propionate administrated after induction of a severe heaves exacerbation results in complete resolution of clinical signs, normalization of pulmonary function tests, and significant decrease in bronchoalveolar lavage (BAL) neutrophilia in horse. |
|In vitro||DMSO||100 mg/mL (199.77 mM)|
|Ethanol||5 mg/mL (9.98 mM)|
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Clinical Trial Information
|NCT Number||Recruitment||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT03273946||Recruiting||Asthma||GlaxoSmithKline||January 9 2018||--|
|NCT02991859||Recruiting||Asthma||GlaxoSmithKline||February 9 2017||Phase 2|
|NCT02446418||Completed||Asthma||GlaxoSmithKline||July 9 2015||Phase 3|
|NCT00843193||Completed||Asthma||GlaxoSmithKline||December 9 2008||Phase 2|
|NCT00273026||Terminated||Asthma||GlaxoSmithKline||November 8 2004||Phase 4|
|NCT03363191||Withdrawn||Asthma||GlaxoSmithKline|Parexel||March 7 2018||Phase 4|
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