FLI-06

Catalog No.S7399

FLI-06 Chemical Structure

Molecular Weight(MW): 438.52

FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.

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1 Customer Review

  • G. In the presence of FLI-06, wound healing assay was conducted to evaluate the cell motility after transfection. Scale bar represents 200 μm. H. In the presence of FLI-06, invasion assay was conducted to evaluate the cell invasiveness after transfection. Data were from three independent experiments and were Mean ± SD. **p < 0.01 compared to cells transfected with vector, ##p < 0.01 compared to cells transfected with ACTG2. Scale bar represents 100 μm.

    Biochem Biophys Res Commun, 2016. FLI-06 purchased from Selleck.

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Biological Activity

Description FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM.
Targets
Notch [1]
(Cell-based assay)
2.3 μM(EC50)
In vitro

In HeLa NotchΔE-eGFP cells, FLI-06 blocks Notch trafficking and processing. FLI-06 changes the maturation pattern of APP and abolishes the shedding of APPs in HEK293 cells stably expressing a mutated APP that yields robust amounts of amyloid β. FLI-06 disrupt the Golgi apparatus, and inhibits general secretion at a step before exit from the endoplasmic reticulum (ER), which is accompanied by a tubule-to-sheet morphological transition of the ER. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
human MDA-MB-231 cells NVP4XWlJS3m2b4TvfIlkcXS7IHHzd4F6 MmC1R5l1d3SxeHnjbZR6KGGpYXnud5QhcHWvYX6gUWRCNU2ELUKzNUBk\WyuczygTWM2OD12IN88US=> MmGwNlYyOTV3N{G=

... Click to View More Cell Line Experimental Data

In vivo FLI-06 (50 μM) inhibits endogenous Notch signaling in zebrafish embryos. [1]

Protocol

Animal Research:

[1]

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  • Animal Models: Zebrafish embryos.
  • Formulation: DMSO
  • Dosages: 50 μM
  • Administration: --
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 88 mg/mL (200.67 mM)
Ethanol 8 mg/mL (18.24 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 438.52
Formula

C25H30N2O5

CAS No. 313967-18-9
Storage powder
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID