Fluocinonide
Catalog No.S2608
Molecular Weight(MW): 494.52
Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
Purity & Quality Control
Choose Selective Glucocorticoid Receptor Inhibitors
Biological Activity
| Description | Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema. | |
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| Targets |
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| In vitro |
Fluocinonide cream has a lower potential to produce atrophic changes of the skin than either clobetasol cream or clobetasol propionate foam. [1] |
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| In vivo | Fluocinonide causes prompt and sustains pituitary-adrenocortical suppression in healthy dogs. Fluocinonide results in significant reduction of plasma cortisol and iACTH concentrations by day 2 of treatment in healthy dog, and the lower concentrations continued to day 5. One week after the last application of Fluocinonide, plasma iACTH concentrations in the corticosteroid-treated dogs has returned to the range of values for the control dogs; however, pre- and post-ACTH cortisol concentrations remains suppressed in Fluocinonide treated dogs. Two weeks after the last treatment, the pre-ACTH plasma cortisol concentrations of corticosteroid-treated dogs returns to those of the control dogs, but the post-ACTH plasma cortisol concentrations remains suppressed. [2] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 99 mg/mL (200.19 mM) |
|---|---|---|
| Water | Insoluble | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 494.52 |
|---|---|
| Formula | C26H32F2O7 |
| CAS No. | 356-12-7 |
| Storage | powder |
| Synonyms | N/A |
Bio Calculators
Molarity Calculator
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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).
Dilution Calculator
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.
Molarity Calculator
Clinical Trial Information
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT02301494 | Not yet recruiting | Mycosis Fungoides | Rochester General Hospital|Valeant Pharmaceuticals International, Inc.|Rochester Skin Lymphoma Medical Group, PLLC | June 2017 | -- |
| NCT02176148 | Recruiting | Cutaneous Lupus | Wake Forest University Health Sciences | December 2014 | Early Phase 1 |
| NCT01802580 | Completed | Psoriasis | Wake Forest University|Wake Forest University Health Sciences | October 2012 | -- |
| NCT01469767 | Recruiting | Atopic Dermatitis | Wake Forest University|Medicis Pharmaceutical Corporation|Wake Forest University Health Sciences | November 2011 | -- |
| NCT01422408 | Completed | Breast Carcinoma | OHSU Knight Cancer Institute|National Cancer Institute (NCI) | September 2011 | Phase 2 |
| NCT01049243 | Completed | Atopic Dermatitis | Wake Forest University|Medicis Pharmaceutical Corporation|Wake Forest University Health Sciences | March 2009 | Phase 4 |
Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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