Fluocinonide

Catalog No.S2608

Fluocinonide  Chemical Structure

Molecular Weight(MW): 494.52

Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.

Size Price Stock Quantity  
In DMSO USD 90 In stock
USD 110 In stock
USD 370 In stock
Bulk Discount

Free Overnight Delivery on orders over $ 500
Next day delivery by 10:00 a.m. Order now.

Purity & Quality Control

Choose Selective Glucocorticoid Receptor Inhibitors

Biological Activity

Description Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders such as eczema.
Targets
Glucocorticoid receptor [1]
()
In vitro

Fluocinonide cream has a lower potential to produce atrophic changes of the skin than either clobetasol cream or clobetasol propionate foam. [1]

In vivo Fluocinonide causes prompt and sustains pituitary-adrenocortical suppression in healthy dogs. Fluocinonide results in significant reduction of plasma cortisol and iACTH concentrations by day 2 of treatment in healthy dog, and the lower concentrations continued to day 5. One week after the last application of Fluocinonide, plasma iACTH concentrations in the corticosteroid-treated dogs has returned to the range of values for the control dogs; however, pre- and post-ACTH cortisol concentrations remains suppressed in Fluocinonide treated dogs. Two weeks after the last treatment, the pre-ACTH plasma cortisol concentrations of corticosteroid-treated dogs returns to those of the control dogs, but the post-ACTH plasma cortisol concentrations remains suppressed. [2]

Protocol

Solubility (25°C)

In vitro DMSO 99 mg/mL (200.19 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 494.52
Formula

C26H32F2O7

CAS No. 356-12-7
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02301494 Not yet recruiting Mycosis Fungoides Rochester General Hospital|Valeant Pharmaceuticals International, Inc.|Rochester Skin Lymphoma Medical Group, PLLC June 2017 --
NCT02176148 Recruiting Cutaneous Lupus Wake Forest University Health Sciences December 2014 Early Phase 1
NCT01802580 Completed Psoriasis Wake Forest University|Wake Forest University Health Sciences October 2012 --
NCT01469767 Recruiting Atopic Dermatitis Wake Forest University|Medicis Pharmaceutical Corporation|Wake Forest University Health Sciences November 2011 --
NCT01422408 Completed Breast Carcinoma OHSU Knight Cancer Institute|National Cancer Institute (NCI) September 2011 Phase 2
NCT01049243 Completed Atopic Dermatitis Wake Forest University|Medicis Pharmaceutical Corporation|Wake Forest University Health Sciences March 2009 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field
Tags: buy Fluocinonide | Fluocinonide ic50 | Fluocinonide price | Fluocinonide cost | Fluocinonide solubility dmso | Fluocinonide purchase | Fluocinonide manufacturer | Fluocinonide research buy | Fluocinonide order | Fluocinonide mouse | Fluocinonide chemical structure | Fluocinonide mw | Fluocinonide molecular weight | Fluocinonide datasheet | Fluocinonide supplier | Fluocinonide in vitro | Fluocinonide cell line | Fluocinonide concentration | Fluocinonide nmr
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID