Name: Desonide
Brand: Selleck Chemicals
SKU: S1701
Availability: InStock
Rating: 5 (3 reviews)

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Quality Control

Batch: Purity: 99.71%

99.71

Related Targets	Adrenergic Receptor Estrogen/progestogen Receptor GPR Androgen Receptor ACE RAAS Progesterone Receptor Opioid Receptor THR PGES
Other Glucocorticoid Receptor Inhibitors	Relacorilant (CORT125134) Corticosterone AL082D06 (20S)-Protopanaxatriol Cortodoxone

Solubility

In vitro
Batch:

DMSO : 83 mg/mL (199.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 41 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

%

% Tween 80

% ddH₂O

% DMSO

+

%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	416.51	Formula	C₂₄H₃₂O₆	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	638-94-8	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			SMILES	CC1(OC2CC3C4CCC5=CC(=O)C=CC5(C4C(CC3(C2(O1)C(=O)CO)C)O)C)C

Read more about storage stability stock solution CAS number SMILES

Mechanism of Action

Targets/IC₅₀/Ki	Glucocorticoid receptor
References	[1] https://pubmed.ncbi.nlm.nih.gov/18549345/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-02-20)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT03437005	RECRUITING	Healthy	University of California, Davis	2013-01-28	PHASE1
NCT03758365	COMPLETED	Vasoconstriction	MC2 Therapeutics	2018-11-05	PHASE1
NCT03386032	COMPLETED	Atopic Dermatitis Eczema	Procter and Gamble	2017-11-27	PHASE3
NCT02732314	COMPLETED	Dermatitis, Atopic; Eczema	Procter & Gamble Beauty	2016-03	PHASE4
NCT02624544	WITHDRAWN	Psoriasis	EMS	2016-01	PHASE4
NCT02286700	UNKNOWN	Dermatitis, Atopic; Eczema	NeoStrata Company, Inc.	2014-11	PHASE3

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Desonide Glucocorticoid Receptor agonist

Chemical Structure

Molecular Weight: 416.51