Deflazacort

Catalog No.S1888 Synonyms: MDL 458

Deflazacort  Chemical Structure

Molecular Weight(MW): 441.52

Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.

Size Price Stock Quantity  
In DMSO USD 130 In stock
USD 97 In stock
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Choose Selective Glucocorticoid Receptor Inhibitors

Biological Activity

Description Deflazacort is a glucocorticoid used as an anti-inflammatory and immunosuppressant.
Targets
Glucocorticoid receptor [1]
()
In vivo Deflazacort results in a significant and equal decrease of thymus weight, indicating a marked reduction in total immunogenic tissue in rats. [1] Deflazacort reduces thymus weight and Daily weight gain in rats. Deflazacort lowers liver IFG-I and GHR mRNA in rats. [2] Deflazacort (DFC) is a heterocyclic glucocorticoid with anti-inflammatory activity but with decreased side effects. Deflazacort and [3H]dexamethasone (DEX) similarly induce in vivo ornithine decarboxylase activity in hippocampus and liver, although body weight loss after chronic treatment is significantly less for DFC. [3] Deflazacort induces dose-dependent decreases in osteocalcin (OC) plasma production rate (PPR). Deflazacort and prednisolone increase both postabsorptive plasma glucose and plasma calcium levels in sheep, but there are no significant differences between their effects. [4] Deflazacort, especially combined with L-arginine, spares quadriceps muscle from injury-induced regeneration (myf5 expression) compared with placebo treatment, despite an increase in membrane permeability immediately after exercise. Deflazacort alone prevents the typical progressive loss of function (measured as voluntary distance run over 24 hours) that is observed 3 months later in placebo-treated mice. [5] Deflazacort causes a less significant alteration in the pattern of GH secretion and does not negatively affect the overall amount of GH secreted. [6]

Protocol

Solubility (25°C)

In vitro DMSO 88 mg/mL (199.31 mM)
Ethanol 12 mg/mL (27.17 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 441.52
Formula

C25H31NO6

CAS No. 14484-47-0
Storage powder
Synonyms MDL 458

Bio Calculators

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT02485431 Completed Healthy Volunteers Marathon Pharmaceuticals, LLC|ICON Development Solutions, LLC June 2015 Phase 1
NCT02251600 Completed Duchenne Muscular Dystrophy Marathon Pharmaceuticals, LLC December 2014 Phase 1
NCT02286622 Completed Renal Impairment Marathon Pharmaceuticals, LLC December 2014 Phase 1
NCT02286609 Completed Hepatic Impairment Marathon Pharmaceuticals, LLC December 2014 Phase 1
NCT02295748 Active, not recruiting Duchenne Muscular Dystrophy Marathon Pharmaceuticals, LLC December 2014 Phase 1
NCT02286635 Completed Healthy Volunteers Marathon Pharmaceuticals, LLC November 2014 Phase 1

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID