Hypoxia, EGFR signaling VEGF P ericyte recr uitment Necrotic core T umor rim T umor cells PDGF a c V ascular disr uption d Hypoxia, EGFR signaling VEGF P ericyte recr uitment Necrotic core T umor rim T umor cells PDGF a c V ascular disr uption d Hypoxia, EGFR signaling VEGF P ericyte recr uitment T umor cells PDGF a c Abnormal Tumor VascularNetwork with Poor Perfusion,High Interstitial Fluid Pressureand Areas of Hypoxia Necrotic Central Core Decreased Nascent Vessel Number Improved blood flow leading to improved delivery of chemotherapeutic agents Abnormal Bulges Blind Ends Remaining rim of viable cells that can be targeted with chemotherapeutic agents and radiation Small Molecules: e.g., DMXAA, NPI-2358Ligand-based: e.g., antibody-toxin, antibody-IL12, ‘naked’ antibodies, VEGF-gelonin Direct Endothelial Cell EffectsVascular Disruption Anti-VEGF EffectsInitial Vascular Normalization Anti-Angiogenic Agents P {{ board.text }} {{ board.text }} {{ board.text }} {{ board.text }} {{ group.title }} {{ text.text }}