Research Area
Product Type
United States ( Change Country )
Bleomycin sulfate Chemical Structure
Cisplatin
Potent anticancer agent that blocks DNA synthesis.
Nelarabine (Arranon)
Nelarabine(Arranon) performes growth inhibitory activity (IC50= 1.61 μM) against MOLT-4 cells
Carboplatin
This drug performed growth inhibitory activity in IGROV1 and OAW42 cells(IC50 of 25 and 30 mg/l,respectively).
Clafen (Cyclophosphamide)
This agent inhibited cell proliferation of NCI-H727 with IC50 at 9.3 nM.
Clofarabine
Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase
Oxaliplatin (Eloxatin)
Oxaliplatin (Eloxatin) is a 1,2-diaminocyclohexane (DACH) carrier ligand-based groups of platinum antitumor agent with IC50 of median 1.3, 6.2 and 1.5 mM for SW480 DLD1, HT29, respectively.
CCT239065
CCT239065 is a novel, selective, and efficacious nanomolar pyridopyrazinone V600E BRAF and LCK inhibitor with IC50 of 13 nM and 6 nM, respectively.
NSC-207895 (XI-006)
NSC-207895 (XI-006) is a derivative of nitrobenzofuroxan and an anticancer agent with an EC50 of 1 μM.
CX-5461
CX-5461 is a potent small-molecule rRNA synthesis inhibitor with an IC50 of 0.11 μM.
BSI-201
BSI-201 is a potent PARP1 inhibitor with strong anti-neoplastic effect.
Biological Activity
Bleomycin, known as an chemotherapy agent, is a glycopeptide antibiotic produced by the bacterium Streptomyces verticillus. This drug is used in the treatment of Hodgkin lymphoma, squamous cell carcinomas, and testicular cancer, as well as in the treatment of pleurodesis and plantar warts. [1]
Bleomycin sulfate forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. [2]
Product Information
| Molecular Weight (WM): | 1512.62 |
|---|---|
| Formula: | C55H85N17O25S4 |
| CAS No.: | 9041-93-4 |
| Synonyms: |
Blenoxane
|
| Dissolve in (25°C): | DMSO ≥153mg/mL |
| Water ≥302mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
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