BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 670 In stock
USD 997 In stock

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Cited by 52 Publications

10 Customer Reviews

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

    Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

  • J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

    Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

Purity & Quality Control

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
PI3Kα [1]
(Cell-free assay)
Met [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM 2.407 μM 4.754 μM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3;FNmlEPTB;MD6wNFc4PiEQvF2= NFTTRo9USU6JRWK=
ACN NXe5fohkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3KTWM2OD1yLkCwPFQ{KM7:TR?= M1jjfnNCVkeHUh?=
TE-8 M{LCdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMEC5OFEh|ryP MX7TRW5ITVJ?
LC-2-ad M37Hdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMEGwPVMh|ryP MmP3V2FPT0WU
ALL-PO NFzuUIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEGzJO69VQ>? M{P2WnNCVkeHUh?=
EW-16 NXPBOIhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfZTWM2OD1yLkCxN|M3KM7:TR?= Mor2V2FPT0WU
KM12 NXTvNGU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2i2V2lEPTB;MD6wNVM1QCEQvF2= MWnTRW5ITVJ?
GI-1 NVXz[lF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3e4XmlEPTB;MD6wNVM5OyEQvF2= NHP1c2pUSU6JRWK=
LS-411N NUTWR256T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjTW3p3UUN3ME2wMlAyPDB5IN88US=> MUfTRW5ITVJ?
ES8 NXnmXHdYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInYeVVKSzVyPUCuNFE1QTRizszN NVLiWFZIW0GQR1XS
SNU-C2B MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjJdmZnUUN3ME2wMlAyPTJ4IN88US=> NGGzOolUSU6JRWK=
CESS MnrVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1GwXmlEPTB;MD6wNVYxOiEQvF2= MYPTRW5ITVJ?
697 NFTBWZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEG2Olgh|ryP MkG4V2FPT0WU
NCI-H1963 NFO0NZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mof2TWM2OD1yLkCxOlc{KM7:TR?= M3nxWnNCVkeHUh?=
IA-LM NY\WfGh7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEG2PFgh|ryP MoPwV2FPT0WU
SW954 MmC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwMEG3NFUh|ryP NH7xflhUSU6JRWK=
RL95-2 NIDRfo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkH0TWM2OD1yLkCxO|M5KM7:TR?= Ml3wV2FPT0WU
LXF-289 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPMbIk3UUN3ME2wMlAyPzdizszN MnixV2FPT0WU
OCUB-M M4DjT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE[wSoFKSzVyPUCuNFE5OjZizszN MYLTRW5ITVJ?
RKO NEHjcWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\GTWM2OD1yLkCxPVg4KM7:TR?= NXrrWppVW0GQR1XS
LOUCY NGSwSnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmX1TWM2OD1yLkCyNFUh|ryP NHXIUFRUSU6JRWK=
NOS-1 M{XYVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfiTWM2OD1yLkCyNFk{KM7:TR?= MoX3V2FPT0WU
A4-Fuk MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMEKyNVgh|ryP MYXTRW5ITVJ?
A388 Mn7JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlzqTWM2OD1yLkCyNlI4KM7:TR?= NVizbphIW0GQR1XS
TE-9 NFXybYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPBbYVKSzVyPUCuNFIzPjFizszN NWLGT45qW0GQR1XS
KURAMOCHI NEj2dJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXufJpFUUN3ME2wMlAzOjh3IN88US=> NIPLfm1USU6JRWK=
KALS-1 M2DlNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLMTWM2OD1yLkCyN|M5KM7:TR?= M{XHR3NCVkeHUh?=
HOP-62 NYPkcZVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTVeWl3UUN3ME2wMlAzPDJizszN NVzFO2hUW0GQR1XS
RPMI-8402 NV;McnRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEXDPIJKSzVyPUCuNFI2ODhizszN MnG2V2FPT0WU
TE-1 M32y[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPLTWM2OD1yLkCyOVEzKM7:TR?= MVjTRW5ITVJ?
CCRF-CEM MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TBWWlEPTB;MD6wNlU1OyEQvF2= M1n4eXNCVkeHUh?=
HUTU-80 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;vUItzUUN3ME2wMlAzPjJ2IN88US=> NHrSS3ZUSU6JRWK=
NCI-H1648 NWLXSZF1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjvTWM2OD1yLkCyOlQ4KM7:TR?= NIf1fYNUSU6JRWK=
HCE-4 M1ThfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX74WHFWUUN3ME2wMlAzPjh{IN88US=> MXnTRW5ITVJ?
ETK-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMEK3N|Yh|ryP MXfTRW5ITVJ?
TE-15 M1LmNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHz4Z2pKSzVyPUCuNFI4OzhizszN NELwUphUSU6JRWK=
BE-13 Mn;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMEK3OEDPxE1? MXLTRW5ITVJ?
KE-37 NUjW[pE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLQbVRyUUN3ME2wMlAzPzRzIN88US=> MYLTRW5ITVJ?
NCI-H1355 M2CzSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFu0TIFKSzVyPUCuNFI4QDNizszN MYjTRW5ITVJ?
TE-11 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMEK4NFkh|ryP MlTGV2FPT0WU
BL-70 NYe4W|dTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMEK4OVch|ryP MYfTRW5ITVJ?
ES6 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\pfWlEPTB;MD6wNlg5OSEQvF2= NXLV[HJlW0GQR1XS
GT3TKB Mk\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13LcGlEPTB;MD6wNlk2OyEQvF2= MX;TRW5ITVJ?
LB647-SCLC NYPYeWFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4H2eWlEPTB;MD6wN|E6PSEQvF2= M4DRcHNCVkeHUh?=
NB13 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;JcJpKSzVyPUCuNFM{OTZizszN MU\TRW5ITVJ?
ST486 NEDaSGhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\aPWcxUUN3ME2wMlA{OzN5IN88US=> NWPuPHh2W0GQR1XS
NCI-H82 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEXJRYRKSzVyPUCuNFM{PDNizszN MUnTRW5ITVJ?
NTERA-S-cl-D1 NXjVT4FsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXrMc3NZUUN3ME2wMlA{Ozl7IN88US=> MmTCV2FPT0WU
ES4 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkP1TWM2OD1yLkCzOFY{KM7:TR?= MYLTRW5ITVJ?
SK-NEP-1 MmXKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTCSWlmUUN3ME2wMlA{PDl7IN88US=> MonaV2FPT0WU
Becker M1fOcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17o[mlEPTB;MD6wN|U2PSEQvF2= MX7TRW5ITVJ?
A101D NULwUVJjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMEO3OFgh|ryP MVLTRW5ITVJ?
SK-UT-1 NXLvWI1yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMEO3O|Qh|ryP MkjkV2FPT0WU
SW982 M1LSbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;PTWM2OD1yLkCzO|kh|ryP MUjTRW5ITVJ?
TE-10 NXvRSZJ[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMESwOFYh|ryP MYDTRW5ITVJ?
OVCAR-4 NFjucZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIj6d2dKSzVyPUCuNFQxPTlizszN NUHm[YN5W0GQR1XS
KP-N-YS NIHuSXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\1b2lEPTB;MD6wOFA5PSEQvF2= MlL3V2FPT0WU
BL-41 M4DkT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTD[292UUN3ME2wMlA1OTJ3IN88US=> MlvHV2FPT0WU
MZ1-PC MnW4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NInr[Y9KSzVyPUCuNFQyOjdizszN M2HIcXNCVkeHUh?=
PF-382 MoPXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXK5UXhUUUN3ME2wMlA1OTl6IN88US=> Mo\sV2FPT0WU
MOLT-13 NV21Z|JVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXrJR|UxRTBwMESyN|gh|ryP NGm2eXpUSU6JRWK=
HCC1599 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\WZ2lEPTB;MD6wOFI2QCEQvF2= M3TPNHNCVkeHUh?=
IST-MEL1 MoXJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnUPVM1UUN3ME2wMlA1PDR{IN88US=> MYPTRW5ITVJ?
LU-139 M170b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULoZZBHUUN3ME2wMlA1PDR{IN88US=> NGjINXlUSU6JRWK=
MS-1 NHntVINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHMNY1rUUN3ME2wMlA1PzBzIN88US=> MYPTRW5ITVJ?
MFH-ino MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HCUmlEPTB;MD6wOVAxOyEQvF2= M1\1V3NCVkeHUh?=
IMR-5 NHjzZYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMEWwNlEh|ryP NH7NNlJUSU6JRWK=
TE-5 M{DuUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlTHTWM2OD1yLkC1NFY{KM7:TR?= NWH1XFVOW0GQR1XS
DJM-1 NYjsTHA1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVm3XWNiUUN3ME2wMlA2OTR{IN88US=> NXrDWXdDW0GQR1XS
NB17 NHL6c21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXexVHU3UUN3ME2wMlA2OjB5IN88US=> M4D6PHNCVkeHUh?=
KARPAS-45 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnJUmVKSzVyPUCuNFU{PThizszN NIm5cIVUSU6JRWK=
TGBC1TKB MlPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHmwSYpKSzVyPUCuNFU1ODVizszN MUDTRW5ITVJ?
ML-2 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jq[GlEPTB;MD6wOVQyPCEQvF2= MkjiV2FPT0WU
no-10 M3S1Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjYR5FKSzVyPUCuNFU1PzRizszN M2i0RXNCVkeHUh?=
CTV-1 NXvLOItMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLN[XlJUUN3ME2wMlA2PTB{IN88US=> MoG3V2FPT0WU
SJSA-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwMEW1NkDPxE1? MnTtV2FPT0WU
HC-1 M2DVOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH70OGpKSzVyPUCuNFU2QTdizszN NULVZ|VSW0GQR1XS
TE-12 NHHGVHlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXvUIlKSzVyPUCuNFU3OTNizszN NXqxTWRqW0GQR1XS
KY821 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;pfZhKSzVyPUCuNFU3OzJizszN M2PUenNCVkeHUh?=
TALL-1 MmrDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHRSJVKSzVyPUCuNFU4ODhizszN Mo\pV2FPT0WU
DEL NHT2RYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PsfGlEPTB;MD6wOVcxQSEQvF2= MojlV2FPT0WU
TE-6 NVznVXRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHjTWM2OD1yLkC1O|IzKM7:TR?= M{DGcnNCVkeHUh?=
SK-LMS-1 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTBwMEW4NFUh|ryP NFTldXlUSU6JRWK=
EW-1 NYDBfmRUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGH3OnNKSzVyPUCuNFU5OzdizszN NHPOR|ZUSU6JRWK=
8-MG-BA MnLIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFzaS4hKSzVyPUCuNFU5PTFizszN NXnyWIJsW0GQR1XS
NALM-6 NHnNc2tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4P3TmlEPTB;MD6wOVk4OyEQvF2= M3rQWnNCVkeHUh?=
LB771-HNC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MonnTWM2OD1yLkC1PVc6KM7:TR?= M2n0cXNCVkeHUh?=
HT-144 NVnRfJc4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkP0TWM2OD1yLkC2NVMh|ryP M3ftN3NCVkeHUh?=
KM-H2 M{\tdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHvE[IdKSzVyPUCuNFYzOjFizszN NX7FWYpLW0GQR1XS
SF268 NHHOflFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mm\jTWM2OD1yLkC2Nlg3KM7:TR?= NUTxbJdRW0GQR1XS
RS4-11 M3f0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDQWpJ4UUN3ME2wMlA3OzB2IN88US=> MVrTRW5ITVJ?
MHH-PREB-1 M1n5fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDHPHdWUUN3ME2wMlA3OzF7IN88US=> NULvbIR5W0GQR1XS
ATN-1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHQVJpKSzVyPUCuNFY{PDVizszN M3HDTnNCVkeHUh?=
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CPC-N MlTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLuVYxsUUN3ME2wMlA3PTJ2IN88US=> NIG0e4tUSU6JRWK=
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VA-ES-BJ MljNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X3eGlEPTB;MD6wO|Q4PSEQvF2= M{LEWHNCVkeHUh?=
NCI-H1581 NYDDeoRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXxWGhDUUN3ME2wMlA4PDd6IN88US=> NXTIfXFlW0GQR1XS
U-266 NEnTN2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfnTWM2OD1yLkC3OFk4KM7:TR?= MWXTRW5ITVJ?
DMS-114 M3[3eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMEe1Nlgh|ryP MnzPV2FPT0WU
NCI-H187 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwMEe3NlYh|ryP MVLTRW5ITVJ?
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MONO-MAC-6 MoLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMEe5PFYh|ryP MYTTRW5ITVJ?
MOLT-16 M1vFTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEHwUGJKSzVyPUCuNFgyOjFizszN MX7TRW5ITVJ?
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CMK NIXFcmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXGOY1WUUN3ME2wMlA5OjJ3IN88US=> MWLTRW5ITVJ?
Ramos-2G6-4C10 NULjcm9ST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HFemlEPTB;MD6wPFIzPSEQvF2= NUntRZNVW0GQR1XS
Daudi NX\xUoFoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYLJR|UxRTBwMEiyOVYh|ryP M3npU3NCVkeHUh?=
NCI-H510A NE\5eIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1OzZmlEPTB;MD6wPFM{PiEQvF2= MWHTRW5ITVJ?
LB831-BLC NWDERYdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnSxTWM2OD1yLkC4OVYyKM7:TR?= NVj5b|hlW0GQR1XS
HEL MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoX3TWM2OD1yLkC4OlY5KM7:TR?= NG[xfmhUSU6JRWK=
LU-134-A MlrkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLrTWM2OD1yLkC4O|A5KM7:TR?= NVfHRmtvW0GQR1XS
NCI-H1694 NIHxdYdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrwRXB1UUN3ME2wMlA5PzR2IN88US=> NILHeFZUSU6JRWK=
KGN MmGzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nzXGlEPTB;MD6wPFc2QSEQvF2= MYTTRW5ITVJ?
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DG-75 M4PRZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUKzTVN{UUN3ME2wMlA5QTJ{IN88US=> MonIV2FPT0WU
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NCI-SNU-5 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWOyT4hmUUN3ME2wMlA6OjV6IN88US=> MYXTRW5ITVJ?
ONS-76 NVz5NJVET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7Rb|VKSzVyPUCuNFkzPzZizszN NETON25USU6JRWK=
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COR-L279 M1jXSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUDJR|UxRTBwMEm1OVYh|ryP NXPx[JVsW0GQR1XS
Calu-6 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjzW|hKSzVyPUCuNFk2QThizszN M1nwOHNCVkeHUh?=
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NCI-H2126 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PGRmlEPTB;MD6wPVc6OSEQvF2= NVXWZ|JFW0GQR1XS
NCI-H1882 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV63dpBFUUN3ME2wMlA6QDB7IN88US=> NVfKcoQyW0GQR1XS
BB65-RCC Mn7xS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NELCSW1KSzVyPUCuNVAzQTRizszN NIDLdVdUSU6JRWK=
DU-4475 NH21RVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkPRTWM2OD1yLkGwOFA4KM7:TR?= MmPJV2FPT0WU
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NCI-H1304 MoL1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrPTWM2OD1yLkGwOVk1KM7:TR?= NGDXcYFUSU6JRWK=
L-540 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwMUC3NFgh|ryP NHW2SJZUSU6JRWK=
NCI-SNU-16 M2TI[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVXxWZJqUUN3ME2wMlExPzR{IN88US=> NVjObmdrW0GQR1XS
HD-MY-Z NG\mOWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2[2WWlEPTB;MD6xNFg2PiEQvF2= NV7jbFRSW0GQR1XS
K-562 MnXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMUC4OVgh|ryP NYnxSWVOW0GQR1XS
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MZ2-MEL M1GxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYjPOpYxUUN3ME2wMlEyODVizszN M{LCUXNCVkeHUh?=
L-363 MkLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXzJR|UxRTBwMUGwO|kh|ryP NXrzcVJLW0GQR1XS
BV-173 M3fV[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMUGyOFMh|ryP NIjpdoFUSU6JRWK=
NCI-H524 M4HFTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnznTWM2OD1yLkGxNlc1KM7:TR?= Ml24V2FPT0WU
EoL-1-cell NWnDWW9MT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NU\D[Hl1UUN3ME2wMlEyPjd{IN88US=> Mo[5V2FPT0WU
K052 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTLZYhKSzVyPUCuNVE4OTJizszN M{TUNnNCVkeHUh?=
TK10 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnSwTWM2OD1yLkGxO|I5KM7:TR?= MnjEV2FPT0WU
KU812 MlnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3hOllRUUN3ME2wMlEzODR2IN88US=> NF7qO4dUSU6JRWK=
RPMI-8226 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPYS2VuUUN3ME2wMlEzODV{IN88US=> M3v4UnNCVkeHUh?=
MZ7-mel NV\5fI5FT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLvW2dmUUN3ME2wMlEzOjN5IN88US=> M3rGXXNCVkeHUh?=
SK-PN-DW M17FVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LYZWlEPTB;MD6xNlI5PyEQvF2= NWHlXlF7W0GQR1XS
SR M16xdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\qTWM2OD1yLkGyOFQyKM7:TR?= MUPTRW5ITVJ?
RPMI-6666 Mn;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWfJR|UxRTBwMUK3OFMh|ryP NI\CPXZUSU6JRWK=
no-11 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkT6TWM2OD1yLkGyPFY6KM7:TR?= M2HKSHNCVkeHUh?=
EW-3 M2jpbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2WxVWlEPTB;MD6xNlg6OyEQvF2= M{jWeXNCVkeHUh?=
LAMA-84 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMUOxPFch|ryP Mk\aV2FPT0WU
HT Mm\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TkOmlEPTB;MD6xN|U4PCEQvF2= Mm\VV2FPT0WU
KP-N-RT-BM-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTBwMUO2NVIh|ryP NELncHdUSU6JRWK=
NCI-H747 NGTGVWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\4PIdKSzVyPUCuNVM4KM7:TR?= NGfYPZJUSU6JRWK=
NCCIT NHfyRWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[zTWM2OD1yLkGzPVM6KM7:TR?= MV3TRW5ITVJ?
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LP-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmO3TWM2OD1yLkG0NlQh|ryP MWXTRW5ITVJ?
CAL-148 NFu3VW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrj[4VqUUN3ME2wMlE1PDh|IN88US=> M363[HNCVkeHUh?=
GB-1 M3PZNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nUcWlEPTB;MD6xOFUzPiEQvF2= Ml7yV2FPT0WU
COR-L88 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37ZdGlEPTB;MD6xOFgxOiEQvF2= NGX0c45USU6JRWK=
NKM-1 M3;vWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWnVfmdsUUN3ME2wMlE1QTB4IN88US=> MV7TRW5ITVJ?
NB5 NXfHVmtTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMUW0OlIh|ryP MV\TRW5ITVJ?
SH-4 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWHjcVNTUUN3ME2wMlE2PDZ4IN88US=> MVPTRW5ITVJ?
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TGBC24TKB MlzkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HIUGlEPTB;MD6xOVY2QSEQvF2= MnfyV2FPT0WU
SCLC-21H M1znSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\4WFRKSzVyPUCuNVU4ODJizszN Mn\qV2FPT0WU
COLO-684 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4Ti[2lEPTB;MD6xOVczOSEQvF2= MVHTRW5ITVJ?
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LS-123 M4fFfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\ITGJQUUN3ME2wMlE2QTF5IN88US=> MmPvV2FPT0WU
MC116 NEH4NpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPLXmpZUUN3ME2wMlE3OTV6IN88US=> NFrxdHVUSU6JRWK=
SU-DHL-1 MmC3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{G3UGlEPTB;MD6xOlIxPiEQvF2= MXfTRW5ITVJ?
NCI-H64 NF7BcY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnMSHFKSzVyPUCuNVY{PDdizszN Ml3BV2FPT0WU
HCE-T MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\sW2lKSzVyPUCuNVY2ODRizszN Ml7MV2FPT0WU
LOXIMVI MmLBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkPrTWM2OD1yLkG2PVQ6KM7:TR?= MVfTRW5ITVJ?
ARH-77 M3jMNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE\DOopKSzVyPUCuNVc{PzlizszN NEfhS|dUSU6JRWK=
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COLO-320-HSR M4nSd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYq3OnpLUUN3ME2wMlE5OTV2IN88US=> M2jwUXNCVkeHUh?=
NB6 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4XlR2lEPTB;MD6xPFU3PiEQvF2= MkjrV2FPT0WU
L-428 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLyNlFKSzVyPUCuNVg5OTNizszN M1S1bHNCVkeHUh?=
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NCI-H2141 NXq2[XYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnCdlZKSzVyPUCuNVkxOTFizszN MVzTRW5ITVJ?
KARPAS-299 M{HMOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nlcGlEPTB;MD6xPVI1OSEQvF2= NYLFSIZ{W0GQR1XS
LC4-1 NIXGZmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXWTWM2OD1yLkG5OVAzKM7:TR?= NHPkW2dUSU6JRWK=
UACC-257 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV\Obmd3UUN3ME2wMlE6QTR5IN88US=> M4rtUHNCVkeHUh?=
EVSA-T M2P1cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMkCzNVIh|ryP MlXMV2FPT0WU
JiyoyeP-2003 NHnpVZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\K[GlEPTB;MD6yNFQ4PyEQvF2= Ml3vV2FPT0WU
NCI-H720 NV3CZnQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMkC1NlUh|ryP NWTIUpZQW0GQR1XS
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NCI-H1436 M3y2dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMkG0OlQh|ryP NW\GXHpyW0GQR1XS
GR-ST M1W5e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rWbWlEPTB;MD6yNVQ5QCEQvF2= M33lPXNCVkeHUh?=
BC-1 NYXRcZRYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkXrTWM2OD1yLkKyOlE3KM7:TR?= Ml3YV2FPT0WU
SIG-M5 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3P0OWlEPTB;MD6yNlczPyEQvF2= M1XzZnNCVkeHUh?=
NCI-H345 NU\rS3FQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU\JR|UxRTBwMkO4NFUh|ryP MYjTRW5ITVJ?
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LB1047-RCC MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnToTWM2OD1yLkK0OFEh|ryP MnzUV2FPT0WU
CTB-1 NXGyWoxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlqwTWM2OD1yLkK0OFk{KM7:TR?= NXn2OXRYW0GQR1XS
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SF126 M3uwUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljRTWM2OD1yLkK1N|g{KM7:TR?= MUHTRW5ITVJ?
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MEG-01 NGDYfFRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml7lTWM2OD1yLkK1Olc{KM7:TR?= M1zDOHNCVkeHUh?=
NCI-H209 NF\H[GRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVH6c3AyUUN3ME2wMlI3Ozd2IN88US=> MWPTRW5ITVJ?
SBC-1 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\acYJyUUN3ME2wMlI3PSEQvF2= MljhV2FPT0WU
K5 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3nTWM2OD1yLkK2PVg1KM7:TR?= M17BR3NCVkeHUh?=
QIMR-WIL NHT1Sm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nNb2lEPTB;MD6yO|E2PSEQvF2= MYnTRW5ITVJ?
NMC-G1 NULQXFhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nEcmlEPTB;MD6yPFIyPyEQvF2= M3LoSnNCVkeHUh?=
IST-MES1 NWrB[nR2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTBwMkmyN|gh|ryP MXTTRW5ITVJ?
SW684 NEXSN2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlvXTWM2OD1yLkOwNFQ4KM7:TR?= Ml;vV2FPT0WU
MV-4-11 NVy2RldqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmC3TWM2OD1yLkOwO|g5KM7:TR?= NWnue2FkW0GQR1XS
LAN-6 M4fRPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4G0ZmlEPTB;MD6zNVU4OiEQvF2= M13kVHNCVkeHUh?=
RH-1 NFPMWW9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2qy[GlEPTB;MD6zNVg4OSEQvF2= Mn;yV2FPT0WU
CP66-MEL MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTBwM{G4O|gh|ryP NF7sfIRUSU6JRWK=
EC-GI-10 M4\Y[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\I[mhKSzVyPUCuN|I6QDdizszN MUXTRW5ITVJ?
GDM-1 M4Cy[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIn5NZFKSzVyPUCuN|MxPTlizszN MWLTRW5ITVJ?
IST-SL1 M4LNeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzGTWM2OD1yLkO0PVE1KM7:TR?= Ml7RV2FPT0WU
KMOE-2 NWHRNVd[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjTTWM2OD1yLkO1NVc2KM7:TR?= MnmwV2FPT0WU
OS-RC-2 NX\3R4pDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwM{W1OFQh|ryP MoX0V2FPT0WU
HDLM-2 Mmq0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYn2[XVJUUN3ME2wMlM4QDF2IN88US=> NFvjfGlUSU6JRWK=
DSH1 NWOzfmpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwM{i2N|Eh|ryP MlHNV2FPT0WU
LS-1034 M3\teGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlPzTWM2OD1yLkO4PVU1KM7:TR?= NHvPSlBUSU6JRWK=
LB373-MEL-D NF3wc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTBwM{mxPVch|ryP MWLTRW5ITVJ?
GOTO MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVW5O21NUUN3ME2wMlQzOTF6IN88US=> NV:y[YpzW0GQR1XS
MRK-nu-1 NUXnfXhrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoLPTWM2OD1yLkSyNlA2KM7:TR?= NXS3doNDW0GQR1XS
SK-MM-2 NY[zPXE3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwNEO0OFIh|ryP NUjiZmRDW0GQR1XS
BOKU Mn\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoDzTWM2OD1yLkSzO|kzKM7:TR?= M37JdnNCVkeHUh?=
NOMO-1 MkLrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXrTWM2OD1yLkSzPFYh|ryP NWm2SIhoW0GQR1XS
J-RT3-T3-5 NHvQVIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn21TWM2OD1yLkS0PFc5KM7:TR?= M1HIVHNCVkeHUh?=
COLO-668 Mnf1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjhTWM2OD1yLkS1OlY5KM7:TR?= NXvTTZl3W0GQR1XS
SF539 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3PWWVtUUN3ME2wMlQ5Pjh2IN88US=> MXPTRW5ITVJ?
LB2518-MEL MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwNEm3NFMh|ryP MoO0V2FPT0WU
TE-441-T NF;ISZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ruXGlEPTB;MD61NFEzKM7:TR?= MXTTRW5ITVJ?
MDA-MB-134-VI NUnFSnVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NILMeIlKSzVyPUCuOVA6OjFizszN NYjXe4lxW0GQR1XS
SCC-3 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPweXM3UUN3ME2wMlUyQDd|IN88US=> MkTqV2FPT0WU
KLE M{jFVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jLXGlEPTB;MD61NlE4OSEQvF2= M2XVSHNCVkeHUh?=
LB2241-RCC NHr4cWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwNUK1NlUh|ryP NGjEdXpUSU6JRWK=
NCI-H1417 NEDQd2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHvTWM2OD1yLkWzOFM2KM7:TR?= MVjTRW5ITVJ?
NCI-H2081 Mmm0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jXcmlEPTB;MD61PFYyOSEQvF2= MkfXV2FPT0WU
NCI-H1522 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HzSWlEPTB;MD61PVM5OyEQvF2= M4S1V3NCVkeHUh?=
NCI-H889 NG\F[YVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PYdWlEPTB;MD61PVg1PCEQvF2= MXHTRW5ITVJ?
CGTH-W-1 NWnZTlVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwNkC3OVUh|ryP NXXlT|kzW0GQR1XS
EB-3 NEnpd5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTHT3ExUUN3ME2wMlYyOTV|IN88US=> MkLIV2FPT0WU
D-336MG NG\vN5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnuTWM2OD1yLk[xO|kyKM7:TR?= M3r1enNCVkeHUh?=
LC-1F M4T2RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwNkK1PVIh|ryP MWjTRW5ITVJ?
MHH-NB-11 NFrzNGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwNkO4NFEh|ryP MUDTRW5ITVJ?
SK-N-FI MmXoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlmzTWM2OD1yLk[zPVEh|ryP NH[zcGJUSU6JRWK=
NCI-H69 NVjpXoF5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfRTWM2OD1yLk[0PFc6KM7:TR?= Mnn1V2FPT0WU
SCH MmjtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\OSI9KSzVyPUCuOlYxOjNizszN MY\TRW5ITVJ?
LS-513 NHi0PG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\QS5NTUUN3ME2wMlY4OjV7IN88US=> NFLxdGFUSU6JRWK=
CP67-MEL M1zmVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fYc2lEPTB;MD62O|U6PiEQvF2= NFz2cpRUSU6JRWK=
GCIY MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fHSWlEPTB;MD63NFM3OyEQvF2= NV3h[lljW0GQR1XS
SHP-77 NG\iVnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[yTWM2OD1yLkewO|M1KM7:TR?= NWnlVHQ1W0GQR1XS
EHEB M{fkNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYGwUldDUUN3ME2wMlcyQDV2IN88US=> M1;IVXNCVkeHUh?=
D-247MG NYDwSVVoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVfLUpcyUUN3ME2wMlc{OjN{IN88US=> M2LVfXNCVkeHUh?=
Raji MmnYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwN{S5PFkh|ryP MkXpV2FPT0WU
MPP-89 NG\4e2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYLXR|drUUN3ME2wMlc2QTd6IN88US=> NHvxWWdUSU6JRWK=
EKVX NVG5V3h7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwN{mwO|Mh|ryP NYXVS3M4W0GQR1XS
HCC2218 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j4eGlEPTB;MD63PVE{OSEQvF2= NH7KZpJUSU6JRWK=
KNS-81-FD NGS3PJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEewPVFKSzVyPUCuPFExOTFizszN MVPTRW5ITVJ?
HCC2157 NV7BeWR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfRbmlKSzVyPUCuPFQ6PTFizszN M2LuXHNCVkeHUh?=
BT-474 MkToS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF7RXmNKSzVyPUCuPFg5PTRizszN M123O3NCVkeHUh?=
NCI-H748 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3rXemlEPTB;MD65NVIh|ryP MUXTRW5ITVJ?
EW-24 MlfnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXq1TlF3UUN3ME2wMlkzODB{IN88US=> NHOxZ4FUSU6JRWK=
D-263MG NXziUWtPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWTJR|UxRTBwOUS1NVIh|ryP NVq4SHhNW0GQR1XS
OMC-1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fXU2lEPTB;MD65OlM4OyEQvF2= NUjId3BJW0GQR1XS
NCI-H2196 M3XYcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFixVoxKSzVyPUCuPVc4PzdizszN MXTTRW5ITVJ?
HAL-01 NUGyVIh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1L0NWlEPTB;MD65PVg4OiEQvF2= M2DYVnNCVkeHUh?=
NCI-H2107 MmnzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4m4d2lEPTB;MT6wNVg2PCEQvF2= MlTHV2FPT0WU
LB996-RCC MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\OTWM2OD1zLkC4NFUyKM7:TR?= MYHTRW5ITVJ?
NCI-H1395 M4jkS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkC0TWM2OD1zLkGwOlch|ryP MWHTRW5ITVJ?
CHP-126 MkHnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2CyRWlEPTB;MT6xOlE6QSEQvF2= MVrTRW5ITVJ?
NB69 NEWzToZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTFwMk[xOFgh|ryP MmPzV2FPT0WU
CAS-1 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjTXFJ6UUN3ME2xMlM1OjNzIN88US=> NYjzWFVQW0GQR1XS
JVM-3 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1[yTGlEPTB;MT60O|g2PSEQvF2= NUTZNYNLW0GQR1XS
DMS-153 NHvMcXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{n4SWlEPTB;MT61O|Y4PCEQvF2= M4DxS3NCVkeHUh?=
SK-MEL-2 M1ryNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVi5R21MUUN3ME2xMlcyPzh7IN88US=> NInQUHdUSU6JRWK=
NCI-H1155 NITZPWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTiWFVoUUN3ME2xMlc{Pjd4IN88US=> NILTVmZUSU6JRWK=
NCI-H1092 NUTaeWM{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTFwN{[xPFIh|ryP MofUV2FPT0WU
LU-165 NIDjR3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjJTWM2OD1zLki2OFc3KM7:TR?= MVfTRW5ITVJ?
HL-60 M4WwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2jZNmlEPTB;MT65PVkxQCEQvF2= M2XQNHNCVkeHUh?=
REH MnnPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;mNIpKSzVyPUKuNFA2QDJizszN NIHBWYVUSU6JRWK=
JVM-2 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPpTIk4UUN3ME2yMlA3OTN3IN88US=> NHnNTGFUSU6JRWK=
MN-60 NVfFVHNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzYfm5KSzVyPUKuNVc{ODhizszN Mm\mV2FPT0WU
SCC-15 NEDkdWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTJwMkCyO{DPxE1? MmjzV2FPT0WU
SNU-C1 M1KwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTJwMkGzOFMh|ryP NFHxZlZUSU6JRWK=
SK-MEL-1 MknRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{P4bmlEPTB;Mj6zNlA1PyEQvF2= NHfObXNUSU6JRWK=
TGW NUTBeopoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTJTWM2OD1{LkO1NFI4KM7:TR?= NGP1SpZUSU6JRWK=
CA46 MmD0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEf1VohKSzVyPUKuO|U6PjdizszN NHvhdVlUSU6JRWK=
NCI-H23 MljGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnUd3QzUUN3ME2yMlgxPzlzIN88US=> MorKV2FPT0WU
MMAC-SF MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;QeGN4UUN3ME2yMlg3PjJ6IN88US=> NGX5cZJUSU6JRWK=
NCI-H2171 M3i0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXn5UY9IUUN3ME2zMlA{PDR6IN88US=> NEjP[HJUSU6JRWK=
A704 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXrWRnRjUUN3ME2zMlE1OTl2IN88US=> NELNendUSU6JRWK=
DB NFexN2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1e3bWlEPTB;Mz6yOVU4PiEQvF2= Mom3V2FPT0WU
NCI-H719 M4\lbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv5WXdKSzVyPUOuN|A{QDRizszN M4fUe3NCVkeHUh?=
MC-CAR MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGrOU4ZKSzVyPUOuOVQ5OTdizszN NV\xfYJLW0GQR1XS
SIMA Ml35S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3\OZWlEPTB;Mz61PFQyPiEQvF2= NIm2fFRUSU6JRWK=
SW872 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjkTWM2OD1|Lke4NVAyKM7:TR?= MVPTRW5ITVJ?
HCC1187 MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXyWVFKSzVyPUOuO|g{OTVizszN M3G5S3NCVkeHUh?=
EW-13 Mn\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jrOGlEPTB;Mz64N|QyPyEQvF2= NXThZmhFW0GQR1XS
NCI-SNU-1 MlPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTRwMkG5PVkh|ryP MnXWV2FPT0WU
NCI-H226 NV\KbplVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3T1eGlEPTB;ND6zN|YxPiEQvF2= NELlUWJUSU6JRWK=
RPMI-8866 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjKeVI1UUN3ME20MlM3ODJ7IN88US=> M2\uUXNCVkeHUh?=
OCI-AML2 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PBc2lEPTB;ND61OVI{KM7:TR?= MlnoV2FPT0WU
LU-65 NVPvbo1xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYGzfZV4UUN3ME20Mlk{ODN|IN88US=> NYnl[JBKW0GQR1XS
SK-N-DZ M1fWfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTVwNkO0OlUh|ryP M{TYS3NCVkeHUh?=
NB14 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTVwOUexN|Uh|ryP M1PnfnNCVkeHUh?=
COLO-829 NISwO4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTZwM{OzOVkh|ryP Ml\6V2FPT0WU
MHH-CALL-2 NHPGOWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLITWM2OD14LkWxOVA5KM7:TR?= MWfTRW5ITVJ?
NCI-H1770 NWToW5JtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEjH[nhKSzVyPU[uOlY6ODRizszN Mmf6V2FPT0WU
ECC4 NX;SbYl1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTZwOEKxO|kh|ryP MknaV2FPT0WU
A498 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTZwOEexPVIh|ryP NWHnUlRmW0GQR1XS
DMS-79 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DROGlEPTB;Nz6wOFUyOiEQvF2= NFnvS4pUSU6JRWK=
P30-OHK MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XwR2lEPTB;Nz6yNVkxPiEQvF2= NIj4UmpUSU6JRWK=
D-502MG MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUC3eZRsUUN3ME23Mlk5OzZizszN MkK3V2FPT0WU
RCC10RGB NVSyfFlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvDTWM2OD16LkC2Nlgh|ryP NXi4Z41OW0GQR1XS
U-698-M NUfVUmhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRThwMkmyNlYh|ryP MYjTRW5ITVJ?
BB49-HNC NUPvNFdFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MknPTWM2OD17LkSyNlY2KM7:TR?= NHXITYNUSU6JRWK=
ES1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NELCOGRKSzVyPUmuOlg6PTZizszN M1\hfnNCVkeHUh?=
MFM-223 MmfPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTFyLkm5Nlch|ryP MVvTRW5ITVJ?
C2BBe1 MnfxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWXJR|UxRTFzLkO1NlMh|ryP MWTTRW5ITVJ?
EB2 M2\WVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYHpNZhnUUN3ME2xNk43QDhzIN88US=> MlLaV2FPT0WU
C8166 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIG0VFZKSzVyPUGzMlg{ODNizszN NFH2ZZlUSU6JRWK=
ES3 NFfQcoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;wR4NJUUN3ME2xN{46QTd5IN88US=> NEDlTY5USU6JRWK=
NCI-H1650 NF;lcpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEPTcYZKSzVyPUG2MlM4PjVizszN NXG0UGs5W0GQR1XS
Mo-T MlvIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX35Oo9HUUN3ME2xO{41ODJ7IN88US=> NHnodJNUSU6JRWK=
NB7 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPYXmY5UUN3ME2xO{44PDZ5IN88US=> MlrvV2FPT0WU
ES7 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1i0fGlEPTB;MUmuOVUxPyEQvF2= M{fXe3NCVkeHUh?=
ES5 NVfTUWdnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYDJR|UxRTJzLke2O|Eh|ryP MVvTRW5ITVJ?
MSTO-211H M4[zTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlXFTWM2OD1{MT64PFU5KM7:TR?= NFvrTJVUSU6JRWK=
U-87-MG MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2eyTmlEPTB;MkWuNVk3PiEQvF2= Mof3V2FPT0WU
THP-1 MnHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETvN|RKSzVyPUK5MlczODFizszN M{PkVnNCVkeHUh?=
NB10 M1;ROWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTNyLkK2PVQh|ryP NHy1SVJUSU6JRWK=
NH-12 NYHsfXFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2HifmlEPTB;M{OuNlAyPyEQvF2= NHT2Z41USU6JRWK=
COLO-824 NGHnV5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;3NmlEPTB;M{SuNVAxPiEQvF2= MULTRW5ITVJ?
SKM-1 NF3ZNItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFK0WWhKSzVyPUO3Mlg1OjJizszN NIXrdpJUSU6JRWK=
NCI-H1838 M372TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\0cYZTUUN3ME2zPE4{Pzl5IN88US=> MWrTRW5ITVJ?
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COLO-800 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17tXWlEPTB;NECuNFc4OyEQvF2= MXLTRW5ITVJ?
KG-1 NEH0SoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml\TTWM2OD12MD64PVU2KM7:TR?= MX7TRW5ITVJ?
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LNCaP-Clone-FGC NHz1W3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjnd2tuUUN3ME20NU46ODF5IN88US=> MXzTRW5ITVJ?
NCI-H322M MlHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTR{LkW5PFQh|ryP MX\TRW5ITVJ?
LNCaP  M3HheWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nQfWlEPTB;OUGuN{BvVQ>? M4H3NVI2PTB3MUe0
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SIL-ALL M3zkdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUOyOEBp MmnuTWM2OD1zOUmuO|chdk1? MWCyOFUyQTl7NR?=
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NALM-16 M1LONGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXSNlQhcA>? MnTyTWM2OD17Nj6yPEBvVQ>? M4n5WlI1PTF7OUm1
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MOLT-4 MnHaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\GOFghcA>? MWfJR|UxRTJ4Lk[gcm0> NYLtT4w1OjR3MUm5PVU>
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RS 4;11 NXfEUGdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;3PHd5PDhiaB?= MnPqTWM2OD1zNkSuNlghdk1? M2DhUFI1PTF7OUm1
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SIL-ALL MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHIZ4w1QCCq M330Z2lEPTB;N{SuOlIhdk1? M1z1clI1PTF7OUm1
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NALM-16 M3TaPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXm0PEBp NHzUXnJKSzVyPU[zMlI1KG6P MXOyOFUyQTl7NR?=
JURKAT MoDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVi3NkBp MmPPTWM2OD1|Lk[1JI5O MnrZNlQ2OTl7OUW=
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NALM-6 MmfDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrmO|IhcA>? M3HZZmlEPTB;MT63PEBvVQ>? Moq3NlQ2OTl7OUW=
RS 4;11 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkm0O|IhcA>? NEnQfFVKSzVyPUSuN|ghdk1? MnfYNlQ2OTl7OUW=
697 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWi3NkBp M1\uNmlEPTB;N{SuNlghdk1? NU[zWlg3OjR3MUm5PVU>
SIL-ALL NVfZTWxOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWG3NkBp MkfYTWM2OD15LkKgcm0> M1yxclI1PTF7OUm1
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NALM-16 MlTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonBO|IhcA>? Ml7tTWM2OD15Nz63N{BvVQ>? MoPzNlQ2OTl7OUW=
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WER-Rb-1 MX;BdI9xfG:|aYOgRZN{[Xl? M{K4d|EuPTBibl2= M3:5NlEzNzJ2IHi= NHT6U25FVVOR MWPpcoR2[2WmIHHwc5B1d3OrczD3bIlkcCClYX6gZoUh\W6qYX7j[YQh[nliSGS= NXHle5FmOjR|Nk[2OlU>
G7 NVjlZVZnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUnJR|UxRTNwMzDuUS=> MYSyOFIxPDd|Mx?=
G166 M4qzSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzNO|lKSzVyPUeuNEBvVQ>? NW\4NHdJOjR{MES3N|M>
CB660 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXzJR|UxRTZwNDDuUS=> M{jMNlI1OjB2N{Oz
CB1117 M1HtW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;hbWlEPTB;MUWuOkBvVQ>? MkTnNlQzODR5M{O=
KB-3-1 NEnUeGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTFwNEigxtEhOC53MzDuUS=> MlfZNlM6PjJ2NEW=
KB-8-5-11 M{S3XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MY\JR|UxRTVwMEGgxtEhOi5yMTDuUS=> MWmyN|k3OjR2NR?=
KB-C-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4W3dGlEPTB;MU[uO|YhyrFiND61NUBvVQ>? NGO5engzOzl4MkS0OS=>
KB-V-1 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXfJR|UxRTJ6MT6yOEDDuSB|MT61O{BvVQ>? NGi0Z48zOzl4MkS0OS=>
OVCAR-8 NEn6TYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mmn0TWM2OD15LkG5JOKyKDNwNkCgcm0> M4XTSlI{QTZ{NES1
NCI-ADR-RES M4PKSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkP3TWM2OD1zMkezMlMxKMLzIEG5NU4zOCCwTR?= NHvH[2ozOzl4MkS0OS=>
MCF7 M330U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\MTWM2OD13LkGxJOKyKDFwNEegcm0> NVjjd4hDOjN7NkK0OFU>
MCF7-FLV1000 NUnofXBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2[4VGlEPTB;M{mzMlE5KMLzIEe0Mlg{KG6P M3flcFI{QTZ{NES1
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CORL-23/P NF7rXmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Ox[2lEPTB;ND6zPEDDuSBzLkK1JI5O NXTSfph5OjN7NkK0OFU>
CORL-23/R MmT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFH2XWpKSzVyPUWuNVYhyrFiMT64N{BvVQ>? M4HwXFI{QTZ{NES1
NIH3T3 NX3GWVNsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTRyLk[wJOKyKDRwOUegcm0> MW[yN|k3OjR2NR?=
NIH3T3-G185 NGftfXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnqXXN2UUN3ME2yOFE{NjRyINMxJFQzOy54NjDuUS=> NUj1PJBlOjN7NkK0OFU>
pcDNA-HEK293 MlvZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\LcWlEPTB;Mj63OUDDuSByLk[3JI5O NGTkVIIzOzl4MkS0OS=>
MDR19-HEK293 M3fOcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPQPJg5UUN3ME24OU42OCEEsTCxN{43PyCwTR?= NHnrS4wzOzl4MkS0OS=>
R482-HEK293 NYPS[HJ7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3mxbmlEPTB;MkWuPVchyrFiND65OUBvVQ>? NV70OIhpOjN7NkK0OFU>
MRP1-HEK293 NV\wWoZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlmwTWM2OD1{Lkm5JOKyKDFwNEmgcm0> NH\TPFgzOzl4MkS0OS=>
SF188 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:weoYyOC1zMECgcm0> MYCyOE06PiCq NH:ydIFFVVOR NWTybmt4cW6qaXLpeJMh[2WubDDndo94fGhiaX6gZo91cCC2aX3lMUBidmRiY3;uZ4VvfHKjdHnvck0h\GWyZXTlcpQhdWGwbnXy NHjFUZUzOzh6N{[0OS=>
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DU145 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4q4O2ROW09? MYnJR|Ux6oj:NkCgcm0> NYj2N5JCOjN6OES0Nlg>
LNCaP  MnvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\mfWROW09? NVixc4JMUUN3MPMIwFc2KG6P MWeyN|g5PDR{OB?=
PC3 NFXJXmpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVi0Z45XTE2VTx?= MVzJR|Ux6oj:MUe1JI5O MVmyN|g5PDR{OB?=
RT4 NXXZTFZmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\vVGlEPTB;MkeuNlEhdk1? M2XnVVI{Pzl{NkO5
5637 M3HHWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDBTWM2OD12NT60O{BvVQ>? MXmyN|c6OjZ|OR?=
T24 M4LXNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnyO4ZKSzVyPUe5MlEzKG6P NFTFd3EzOzd7Mk[zPS=>
MCF7  M2GyPGZ2dmO2aX;uJGF{e2G7 MU[xNFAhdk1? NX;PcYdOOSCq MlfPSG1UVw>? MYfy[YR2[2W|IITo[UBqdmS3Y4Tpc44hd2cEoFfy[YIyNMLiU3frNUzDqFC|Mj|CpHNmenCrbnGzMEBidmUEoGfpd5Az MmjlNlM4PzB{NES=
KB-V1  NEjuOZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGK1TpJKSzVyPUOuPVIh|ryP MUOyN|U6OzF7Nh?=
Hec50co MmLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml3mTWM2OD13IH7N MmTyNlMyPDZ4OEe=
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Huh-7 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLLNU8yOC9zMECvNVAxOCCwTR?= M1fFcVQ5KGh? NIfNbGhl\WO{ZXHz[ZMhfGinIHPlcIwhfmmjYnnsbZR6KGSxc3Wt[IVx\W6mZX70cJk> M1XoOFIzPzR3NUi3
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SUM 149 MlThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEPYWoMxNTFyMDDuUS=> NHz4W|c4OiCq M3TNfYlvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> MWmyNlMxQTl|OR?=
MDA-MB-231 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVmwMVExOCCwTR?= NFrOUnY4OiCq MoW3bY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy M1f2bVIzOzB7OUO5
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BT-474-M1 NIC1RmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjqUJo4OC1zMECgcm0> MU[3NkBp M3rVb4lvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> Ml3uNlI{ODl7M{m=
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T47D NYTu[5VTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M335SFAuOTByIH7N M2rPXVczKGh? M17sXYlvcGmkaYTzJJRp\SClZXzsJJZq[WKrbHn0fUBqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7hdi=> MX2yNlMxQTl|OR?=
MCF7 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXOwMVExOCCwTR?= NHjsWG44OiCq MWTpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= Mmj6NlI{ODl7M{m=
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GB-CL-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzXO|IhcA>? NFzJ[5ZKSzVyPUWuNlIhdk1? NYe3PZVuOjF7NkW3N|k>
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TGBC1-TKB NFrEcIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\D[WkyPDRiaB?= MXnJR|UxRTZwN{Kgcm0> NUPiV41rOjF7NkW3N|k>
Wittier NXTHOYRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTQcIR1PzJiaB?= NVf5T2NHUUN3ME2zMlI3KG6P NEP5T2MzOTl4NUezPS=>
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HMC-1.2 M1SwTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUnYbmJmOS1zMECwJI5O NXfW[lRHPzJiaB?= MXPpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> M2P4ZVIyOjR{MUi5
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CHP-212 M1PwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j4VFEuOTJ3IH7N M1TvTFI1NTF{MDDo NUP0VFRUcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> MnftNlEyPjl{NEK=
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SH-EP MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX:xMVEzPSCwTR?= NVvkZoFqOjRvMUKwJIg> NFvhTGlqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MlPkNlEyPjl{NEK=
SH-SY5Y MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjQUo0yNTF{NTDuUS=> NYDlNHE2OjRvMUKwJIg> NW[0[YlxcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> Mln0NlEyPjl{NEK=
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KG1 MmD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWqxM|ExNzFyMDDuUS=> NUn1VnNnPzJiaB?= NY\5WGYxTE2VTx?= NGmwdVRqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MUWxPVQ2QDN3OB?=
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CAL62 NWnLZZFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoHNNE4yNTFyMDDuUS=> MY[3NkBp NEezVVNFVVOR M3uzU2VEPTB;MT60JI5O NVTrTmc3OTl{MkO1OVM>
OCUT-1 MmLqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7pfVkxNjFvMUCwJI5O NHvad3c4OiCq NUf0Om1PTE2VTx?= M1;PU2VEPTB;Mj6zJI5O NFu3VnkyQTJ{M{W1Ny=>
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SW1736 MnLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3SdnYxNjFvMUCwJI5O NET0cI04OiCq M3PhRmROW09? MYXFR|UxRTVwNjDuUS=> NW[2[Xp2OTl{MkO1OVM>

... Click to View More Cell Line Experimental Data

In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay
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Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research
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  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research
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  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water <1 mg/mL
In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 15mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID