BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
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USD 210 In stock
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Cited by 53 Publications

11 Customer Reviews

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

  • Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

  • Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 MlS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfSNWlKSzVyPUCuNFA4PzZizszN NWfNcnJvW0GQR1XS
ACN NETmWFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3rCZ2lEPTB;MD6wNFg1OyEQvF2= MXPTRW5ITVJ?
TE-8 M2TrZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnFW|RZUUN3ME2wMlAxQTRzIN88US=> M2PBWHNCVkeHUh?=
LC-2-ad M{PRUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XRRWlEPTB;MD6wNVA6OyEQvF2= Ml;2V2FPT0WU
ALL-PO M4\aUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPqdlA3UUN3ME2wMlAyOyEQvF2= M1;xVnNCVkeHUh?=
EW-16 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIjtfFFKSzVyPUCuNFE{OzZizszN NH3XfIxUSU6JRWK=
KM12 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HiV2lEPTB;MD6wNVM1QCEQvF2= MYnTRW5ITVJ?
GI-1 M1jSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEGzPFMh|ryP M37meXNCVkeHUh?=
LS-411N NUjRbndDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHBbHpKSzVyPUCuNFE1ODdizszN Mly2V2FPT0WU
ES8 NIDJOYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVrpcWxGUUN3ME2wMlAyPDl2IN88US=> NHPzW5BUSU6JRWK=
SNU-C2B M{K4Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1X3[2lEPTB;MD6wNVUzPiEQvF2= MXTTRW5ITVJ?
CESS NXLFRllsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGPwUGdKSzVyPUCuNFE3ODJizszN MVnTRW5ITVJ?
697 NFiwUoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fpUmlEPTB;MD6wNVY3QCEQvF2= NUC0ZXNJW0GQR1XS
NCI-H1963 M2PiTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVPJR|UxRTBwMEG2O|Mh|ryP MWjTRW5ITVJ?
IA-LM NHLFbFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMEG2PFgh|ryP NV\MdHZoW0GQR1XS
SW954 M2XjVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMEG3NFUh|ryP MmDZV2FPT0WU
RL95-2 M2HmXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn:4TWM2OD1yLkCxO|M5KM7:TR?= Mk\3V2FPT0WU
LXF-289 NH6xRoFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NInkW5pKSzVyPUCuNFE4PyEQvF2= MY\TRW5ITVJ?
OCUB-M MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnjpTWM2OD1yLkCxPFI3KM7:TR?= NYPRZYpIW0GQR1XS
RKO Mnr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3u5TWlEPTB;MD6wNVk5PyEQvF2= M1HsVXNCVkeHUh?=
LOUCY MmnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXu5N4NrUUN3ME2wMlAzODVizszN NWL3OnFrW0GQR1XS
NOS-1 M3fvbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMEKwPVMh|ryP NVPyepVsW0GQR1XS
A4-Fuk M3ryeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Moi3TWM2OD1yLkCyNlE5KM7:TR?= MXPTRW5ITVJ?
A388 M2HVNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M33ZfmlEPTB;MD6wNlIzPyEQvF2= NVjqdFlIW0GQR1XS
TE-9 NFO2NpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXjJR|UxRTBwMEKyOlEh|ryP MYXTRW5ITVJ?
KURAMOCHI MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPCZ5NKUUN3ME2wMlAzOjh3IN88US=> MnrNV2FPT0WU
KALS-1 NG\NdVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrvV5lKSzVyPUCuNFI{OzhizszN MVvTRW5ITVJ?
HOP-62 NXvNXXBWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEK0NkDPxE1? NU\jS3NiW0GQR1XS
RPMI-8402 M37QNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DaN2lEPTB;MD6wNlUxQCEQvF2= M3rLcXNCVkeHUh?=
TE-1 MlPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnZTWM2OD1yLkCyOVEzKM7:TR?= M{naXnNCVkeHUh?=
CCRF-CEM MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkfiTWM2OD1yLkCyOVQ{KM7:TR?= M2LlT3NCVkeHUh?=
HUTU-80 M1HHTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml[1TWM2OD1yLkCyOlI1KM7:TR?= M2XUeXNCVkeHUh?=
NCI-H1648 NXrpcIlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIrMTohKSzVyPUCuNFI3PDdizszN NEn3TpZUSU6JRWK=
HCE-4 M4\VNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nqZWlEPTB;MD6wNlY5OiEQvF2= MoDvV2FPT0WU
ETK-1 M12yU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVKwcY9PUUN3ME2wMlAzPzN4IN88US=> NFPyTHVUSU6JRWK=
TE-15 M2fzTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIDsOJlKSzVyPUCuNFI4OzhizszN NV7IbXo6W0GQR1XS
BE-13 M{LYPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrDZ3hKSzVyPUCuNFI4PCEQvF2= MoTUV2FPT0WU
KE-37 NYrneYhzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXPJR|UxRTBwMEK3OFEh|ryP NGmyTWVUSU6JRWK=
NCI-H1355 NWDvRnlRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vodGlEPTB;MD6wNlc5OyEQvF2= M4HDbHNCVkeHUh?=
TE-11 M{foXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nHdmlEPTB;MD6wNlgxQSEQvF2= MVHTRW5ITVJ?
BL-70 NVW3cJdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUm4fpdoUUN3ME2wMlAzQDV5IN88US=> MnL0V2FPT0WU
ES6 NV3aNZM2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7HW|VKSzVyPUCuNFI5QDFizszN Ml30V2FPT0WU
GT3TKB MlTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml6wTWM2OD1yLkCyPVU{KM7:TR?= NGDNN|BUSU6JRWK=
LB647-SCLC MkXxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMEOxPVUh|ryP NXfUcmdTW0GQR1XS
NB13 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkOyTWM2OD1yLkCzN|E3KM7:TR?= NXLuT3BxW0GQR1XS
ST486 M2DUPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3BS4tKSzVyPUCuNFM{OzdizszN MULTRW5ITVJ?
NCI-H82 NH\kNVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor3TWM2OD1yLkCzN|Q{KM7:TR?= M1\vXXNCVkeHUh?=
NTERA-S-cl-D1 M3vVWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnkTWM2OD1yLkCzN|k6KM7:TR?= NYT3WYNKW0GQR1XS
ES4 M3nGVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMEO0OlMh|ryP M1rlXXNCVkeHUh?=
SK-NEP-1 MkfwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwMEO0PVkh|ryP MYXTRW5ITVJ?
Becker MnTmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4[5NWlEPTB;MD6wN|U2PSEQvF2= MUXTRW5ITVJ?
A101D M4LhO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnDWpBKSzVyPUCuNFM4PDhizszN M4ToTHNCVkeHUh?=
SK-UT-1 NHi4SGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml30TWM2OD1yLkCzO|c1KM7:TR?= M2XPbHNCVkeHUh?=
SW982 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzyTWM2OD1yLkCzO|kh|ryP MXPTRW5ITVJ?
TE-10 NYq3[HhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzENIlKSzVyPUCuNFQxPDZizszN NVLibnRFW0GQR1XS
OVCAR-4 MknXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HUPGlEPTB;MD6wOFA2QSEQvF2= NYnUV3NYW0GQR1XS
KP-N-YS M1LSb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTBWFd7UUN3ME2wMlA1ODh3IN88US=> MYrTRW5ITVJ?
BL-41 NHLEV25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\BcXdKSzVyPUCuNFQyOjVizszN NGDIfWlUSU6JRWK=
MZ1-PC MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMESxNlch|ryP NGfBcnFUSU6JRWK=
PF-382 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XVeGlEPTB;MD6wOFE6QCEQvF2= M1rROnNCVkeHUh?=
MOLT-13 NGD4W3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{[2PWlEPTB;MD6wOFI{QCEQvF2= NV3lcWo{W0GQR1XS
HCC1599 NF;VeWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHxUWlEUUN3ME2wMlA1OjV6IN88US=> MVTTRW5ITVJ?
IST-MEL1 NIDJfJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwMES0OFIh|ryP MYjTRW5ITVJ?
LU-139 NYG5cnl{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfzdZZKSzVyPUCuNFQ1PDJizszN M13CVXNCVkeHUh?=
MS-1 NWXTOGx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vFfmlEPTB;MD6wOFcxOSEQvF2= NFHoRWdUSU6JRWK=
MFH-ino NEDi[VNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDjS|lXUUN3ME2wMlA2ODB|IN88US=> MoPhV2FPT0WU
IMR-5 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTBwMEWwNlEh|ryP NXzPXoNJW0GQR1XS
TE-5 NEjsOI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYG0OGRYUUN3ME2wMlA2ODZ|IN88US=> NGizNVFUSU6JRWK=
DJM-1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknSTWM2OD1yLkC1NVQzKM7:TR?= NFGy[lZUSU6JRWK=
NB17 NIfLdZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWSxUI9RUUN3ME2wMlA2OjB5IN88US=> MVrTRW5ITVJ?
KARPAS-45 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwMEWzOVgh|ryP M1XTXnNCVkeHUh?=
TGBC1TKB MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk[zTWM2OD1yLkC1OFA2KM7:TR?= NHvFSnVUSU6JRWK=
ML-2 NEDuT5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGHiUmlKSzVyPUCuNFU1OTRizszN NISxU4RUSU6JRWK=
no-10 M3LyRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXmN4FKSzVyPUCuNFU1PzRizszN M2nMNnNCVkeHUh?=
CTV-1 NVjzRoViT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vKTmlEPTB;MD6wOVUxOiEQvF2= NFfrWZFUSU6JRWK=
SJSA-1 NEDqO|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXXjN4pwUUN3ME2wMlA2PTJizszN M1Xh[XNCVkeHUh?=
HC-1 NXfuOnhoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2\mfWlEPTB;MD6wOVU6PyEQvF2= Ml2xV2FPT0WU
TE-12 M1W0OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LPbGlEPTB;MD6wOVYyOyEQvF2= NELvfpZUSU6JRWK=
KY821 NVW1TGxkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEW2N|Ih|ryP M3n6e3NCVkeHUh?=
TALL-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrjTWM2OD1yLkC1O|A5KM7:TR?= NV;XUHFMW0GQR1XS
DEL NFzwb|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnuTWM2OD1yLkC1O|A6KM7:TR?= MXjTRW5ITVJ?
TE-6 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjVdplKSzVyPUCuNFU4OjJizszN M1exRXNCVkeHUh?=
SK-LMS-1 NVzUWm51T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\rTWM2OD1yLkC1PFA2KM7:TR?= NHHPPGJUSU6JRWK=
EW-1 M3znWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PNT2lEPTB;MD6wOVg{PyEQvF2= NWjlTo5IW0GQR1XS
8-MG-BA MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlnrTWM2OD1yLkC1PFUyKM7:TR?= MUfTRW5ITVJ?
NALM-6 NGjZRXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\ybpNKSzVyPUCuNFU6PzNizszN MVfTRW5ITVJ?
LB771-HNC NVnaNmExT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEW5O|kh|ryP MYTTRW5ITVJ?
HT-144 NWSyWm1JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUnFOGt5UUN3ME2wMlA3OTNizszN M1P1OHNCVkeHUh?=
KM-H2 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrUVXBbUUN3ME2wMlA3OjJzIN88US=> NV;SXlM6W0GQR1XS
SF268 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TpNmlEPTB;MD6wOlI5PiEQvF2= NIrLZpFUSU6JRWK=
RS4-11 NV\Zc|BkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mlq5TWM2OD1yLkC2N|A1KM7:TR?= MXXTRW5ITVJ?
MHH-PREB-1 M4fQT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XsfWlEPTB;MD6wOlMyQSEQvF2= M4DJdXNCVkeHUh?=
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LAN-6 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;qe4lKSzVyPUCuN|E2PzJizszN M3zCOHNCVkeHUh?=
RH-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGn4SWZKSzVyPUCuN|E5PzFizszN MVLTRW5ITVJ?
CP66-MEL NYq0b3p2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{TKWGlEPTB;MD6zNVg4QCEQvF2= NIrhNllUSU6JRWK=
EC-GI-10 NXqwPFhHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NImzc2pKSzVyPUCuN|I6QDdizszN MoDPV2FPT0WU
GDM-1 MnXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlfjTWM2OD1yLkOzNFU6KM7:TR?= NYmySJk2W0GQR1XS
IST-SL1 NVLGUVh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwM{S5NVQh|ryP NVr1ZnhZW0GQR1XS
KMOE-2 M3THbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NG\KSYVKSzVyPUCuN|UyPzVizszN MV7TRW5ITVJ?
OS-RC-2 NWS4U24yT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwM{W1OFQh|ryP NFzyXlFUSU6JRWK=
HDLM-2 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4m3dGlEPTB;MD6zO|gyPCEQvF2= MnrhV2FPT0WU
DSH1 MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWr6OJNZUUN3ME2wMlM5PjNzIN88US=> NHS5dnRUSU6JRWK=
LS-1034 NEPHdZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTEbIxKSzVyPUCuN|g6PTRizszN NHvEdGNUSU6JRWK=
LB373-MEL-D Ml[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVi2e3FrUUN3ME2wMlM6OTl5IN88US=> M3vsfXNCVkeHUh?=
GOTO M3qzTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfY[lZKSzVyPUCuOFIyOThizszN MYrTRW5ITVJ?
MRK-nu-1 M176RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XkW2lEPTB;MD60NlIxPSEQvF2= M4fhe3NCVkeHUh?=
SK-MM-2 NYLIWldET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3UTWM2OD1yLkSzOFQzKM7:TR?= NWLnZ4oyW0GQR1XS
BOKU NVv2WlBbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4n4[GlEPTB;MD60N|c6OiEQvF2= M3HLN3NCVkeHUh?=
NOMO-1 NIWzTW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T3TGlEPTB;MD60N|g3KM7:TR?= NFv0TZNUSU6JRWK=
J-RT3-T3-5 NGjTZWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwNES4O|gh|ryP Mn;oV2FPT0WU
COLO-668 Mn;SS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3jjVWlEPTB;MD60OVY3QCEQvF2= M{Duc3NCVkeHUh?=
SF539 MnrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlXGTWM2OD1yLkS4Olg1KM7:TR?= M{j1bHNCVkeHUh?=
LB2518-MEL M2nKOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDib2xEUUN3ME2wMlQ6PzB|IN88US=> NXz4flhoW0GQR1XS
TE-441-T MnuxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXjK[YdUUUN3ME2wMlUxOTJizszN NFrvWVVUSU6JRWK=
MDA-MB-134-VI NXr3c|lyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF63cFNKSzVyPUCuOVA6OjFizszN NFPrTINUSU6JRWK=
SCC-3 NUPwc2F4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVviO3VJUUN3ME2wMlUyQDd|IN88US=> NUT0dGZMW0GQR1XS
KLE MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4K2W2lEPTB;MD61NlE4OSEQvF2= NYXIbIlOW0GQR1XS
LB2241-RCC NYfhdJQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYnJR|UxRTBwNUK1NlUh|ryP NX7xNlI6W0GQR1XS
NCI-H1417 MoDkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVfJR|UxRTBwNUO0N|Uh|ryP MmPyV2FPT0WU
NCI-H2081 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3:ye2lEPTB;MD61PFYyOSEQvF2= NYjXSHZSW0GQR1XS
NCI-H1522 NIe5dVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;IOGlEPTB;MD61PVM5OyEQvF2= MoPtV2FPT0WU
NCI-H889 MlHVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwNUm4OFQh|ryP M{HCWXNCVkeHUh?=
CGTH-W-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\l[WNKSzVyPUCuOlA4PTVizszN M4X6d3NCVkeHUh?=
EB-3 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TwRmlEPTB;MD62NVE2OyEQvF2= Mk\OV2FPT0WU
D-336MG NHyzRpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYm0cJVrUUN3ME2wMlYyPzlzIN88US=> MWDTRW5ITVJ?
LC-1F NV\0R|J4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDJTWM2OD1yLk[yOVkzKM7:TR?= NFLIbYxUSU6JRWK=
MHH-NB-11 MnrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3;kNWlEPTB;MD62N|gxOSEQvF2= NFj5OIRUSU6JRWK=
SK-N-FI MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwNkO5NUDPxE1? MlXsV2FPT0WU
NCI-H69 NYj6UVlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\LTWM2OD1yLk[0PFc6KM7:TR?= MYrTRW5ITVJ?
SCH NWDEdVVrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGLtVFFKSzVyPUCuOlYxOjNizszN MmDMV2FPT0WU
LS-513 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm3coFMUUN3ME2wMlY4OjV7IN88US=> NIrJPXRUSU6JRWK=
CP67-MEL NYPhZo5QT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3rYfmlEPTB;MD62O|U6PiEQvF2= NHzSXWRUSU6JRWK=
GCIY Mlz3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTBwN{CzOlMh|ryP MXPTRW5ITVJ?
SHP-77 NHG1OmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWjacZlbUUN3ME2wMlcxPzN2IN88US=> Moq2V2FPT0WU
EHEB MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX\TfItqUUN3ME2wMlcyQDV2IN88US=> MYDTRW5ITVJ?
D-247MG MnPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHjVJhKSzVyPUCuO|MzOzJizszN Mm[wV2FPT0WU
Raji NHPJZodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITZVHRKSzVyPUCuO|Q6QDlizszN M3fuOXNCVkeHUh?=
MPP-89 NY\JdG1WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MofFTWM2OD1yLke1PVc5KM7:TR?= NFXDU2hUSU6JRWK=
EKVX MlHKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWnpeoo5UUN3ME2wMlc6ODd|IN88US=> NHzsT|ZUSU6JRWK=
HCC2218 NIHR[2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwN{mxN|Eh|ryP NGCyW4tUSU6JRWK=
KNS-81-FD MmPaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mof3TWM2OD1yLkixNFEyKM7:TR?= NEfJXWJUSU6JRWK=
HCC2157 Ml\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3fSZ2lEPTB;MD64OFk2OSEQvF2= NH7VWndUSU6JRWK=
BT-474 M1ixdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfyblQxUUN3ME2wMlg5QDV2IN88US=> NEDlc|VUSU6JRWK=
NCI-H748 MkPKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGT4TVBKSzVyPUCuPVEzKM7:TR?= MV\TRW5ITVJ?
EW-24 M{HYUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwOUKwNFIh|ryP NYGwPGl[W0GQR1XS
D-263MG Mn7TS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PEO2lEPTB;MD65OFUyOiEQvF2= NYLIbmxEW0GQR1XS
OMC-1 MnfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjKeGRKSzVyPUCuPVY{PzNizszN MoniV2FPT0WU
NCI-H2196 M2e0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwOUe3O|ch|ryP Mn;HV2FPT0WU
HAL-01 NFnVR2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P3bWlEPTB;MD65PVg4OiEQvF2= NXPvfJFVW0GQR1XS
NCI-H2107 NEX3UJVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv4SlFKSzVyPUGuNFE5PTRizszN MVLTRW5ITVJ?
LB996-RCC MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVrJR|UxRTFwMEiwOVEh|ryP MonrV2FPT0WU
NCI-H1395 NH\ETIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPVTWM2OD1zLkGwOlch|ryP MmXTV2FPT0WU
CHP-126 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrzTWM2OD1zLkG2NVk6KM7:TR?= NEnNendUSU6JRWK=
NB69 NEXaWnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFvHbmtKSzVyPUGuNlYyPDhizszN NY\wd41SW0GQR1XS
CAS-1 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlyxTWM2OD1zLkO0NlMyKM7:TR?= MYDTRW5ITVJ?
JVM-3 M3Gwemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnFZoVKSzVyPUGuOFc5PTVizszN M3W3e3NCVkeHUh?=
DMS-153 NUHBeXhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPo[IJKSzVyPUGuOVc3PzRizszN NYrFe3RLW0GQR1XS
SK-MEL-2 M2\5ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTFwN{G3PFkh|ryP M4jYZXNCVkeHUh?=
NCI-H1155 NUj2NZN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3ToW2lEPTB;MT63N|Y4PiEQvF2= NEXJSnhUSU6JRWK=
NCI-H1092 NHTMOHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{KwbWlEPTB;MT63OlE5OiEQvF2= Ml3rV2FPT0WU
LU-165 NEDHV2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPz[HhKSzVyPUGuPFY1PzZizszN MYPTRW5ITVJ?
HL-60 MmTiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTFwOUm5NFgh|ryP M13QZnNCVkeHUh?=
REH MnXhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mkm4TWM2OD1{LkCwOVgzKM7:TR?= MnftV2FPT0WU
JVM-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTJwME[xN|Uh|ryP M4j1cHNCVkeHUh?=
MN-60 M2O0emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nabmlEPTB;Mj6xO|MxQCEQvF2= MWnTRW5ITVJ?
SCC-15 Mn\lS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHyyfWhKSzVyPUKuNlAzPyEQvF2= NYDtZXdrW0GQR1XS
SNU-C1 MnXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjh[lJUUUN3ME2yMlIyOzR|IN88US=> Mn;6V2FPT0WU
SK-MEL-1 MoDRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXoTWM2OD1{LkOyNFQ4KM7:TR?= NX7lTm84W0GQR1XS
TGW MkK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1f0b2lEPTB;Mj6zOVAzPyEQvF2= MVvTRW5ITVJ?
CA46 MlfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXT6NY9lUUN3ME2yMlc2QTZ5IN88US=> M1jtSHNCVkeHUh?=
NCI-H23 M37xSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTJwOEC3PVEh|ryP MYLTRW5ITVJ?
MMAC-SF MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHtS3BKSzVyPUKuPFY3OjhizszN M37hNnNCVkeHUh?=
NCI-H2171 NH7jZ|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPYOXFyUUN3ME2zMlA{PDR6IN88US=> MX3TRW5ITVJ?
A704 NXv1XVVMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV\JR|UxRTNwMUSxPVQh|ryP MorQV2FPT0WU
DB NU\sZoRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLRPZpKSzVyPUOuNlU2PzZizszN NGHxVINUSU6JRWK=
NCI-H719 M2\yOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XGbmlEPTB;Mz6zNFM5PCEQvF2= NITlTYZUSU6JRWK=
MC-CAR M{nobmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3VTWM2OD1|LkW0PFE4KM7:TR?= MVXTRW5ITVJ?
SIMA NYOxdpQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXkO3NyUUN3ME2zMlU5PDF4IN88US=> NFiyV4RUSU6JRWK=
SW872 MkThS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIK1XJBKSzVyPUOuO|gyODFizszN NHXOblJUSU6JRWK=
HCC1187 M3;6dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2iyVmlEPTB;Mz63PFMyPSEQvF2= NHz6dHZUSU6JRWK=
EW-13 M{Hvc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTNwOEO0NVch|ryP M3;ONXNCVkeHUh?=
NCI-SNU-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmDuTWM2OD12LkKxPVk6KM7:TR?= M3jYSXNCVkeHUh?=
NCI-H226 NWnPNXBkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTRwM{O2NFYh|ryP MYfTRW5ITVJ?
RPMI-8866 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\FO2lEPTB;ND6zOlAzQSEQvF2= NYfMTldZW0GQR1XS
OCI-AML2 NEW3XYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTRwNUWyN{DPxE1? MWLTRW5ITVJ?
LU-65 MkKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPZW2JxUUN3ME20Mlk{ODN|IN88US=> MlqwV2FPT0WU
SK-N-DZ Ml:wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoK2TWM2OD13Lk[zOFY2KM7:TR?= NVHpSHJxW0GQR1XS
NB14 MoTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTVwOUexN|Uh|ryP M1vaUXNCVkeHUh?=
COLO-829 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{f1UWlEPTB;Nj6zN|M2QSEQvF2= NXTIfYNpW0GQR1XS
MHH-CALL-2 Mo\CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTZwNUG1NFgh|ryP MUPTRW5ITVJ?
NCI-H1770 NFXTTGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DJXWlEPTB;Nj62OlkxPCEQvF2= Mn:xV2FPT0WU
ECC4 NEDqRXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;TdWpFUUN3ME22MlgzOTd7IN88US=> MUnTRW5ITVJ?
A498 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPiTWM2OD14Lki3NVkzKM7:TR?= MlriV2FPT0WU
DMS-79 M4rhcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jVcGlEPTB;Nz6wOFUyOiEQvF2= NIjUUHJUSU6JRWK=
P30-OHK M37NVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzWWlRKSzVyPUeuNlE6ODZizszN NUDOU2ZPW0GQR1XS
D-502MG NU\4TmhqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkjLTWM2OD15Lkm4N|Yh|ryP NXK1XVR6W0GQR1XS
RCC10RGB M174S2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\INWlEPTB;OD6wOlI5KM7:TR?= NVr5fJZvW0GQR1XS
U-698-M M1u0TWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWGxNYozUUN3ME24MlI6OjJ4IN88US=> NF\HZ3VUSU6JRWK=
BB49-HNC NGrR[opIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3vTWM2OD17LkSyNlY2KM7:TR?= NIjVN4ZUSU6JRWK=
ES1 NH30TFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV\MfVFQUUN3ME25MlY5QTV4IN88US=> M2PLenNCVkeHUh?=
MFM-223 NW[5VlY5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7qeohKSzVyPUGwMlk6OjdizszN NVH5Z2dGW0GQR1XS
C2BBe1 MnjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTFzLkO1NlMh|ryP M4nkbnNCVkeHUh?=
EB2 NEjIfI5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;rZWlEPTB;MUKuOlg5OSEQvF2= Mne5V2FPT0WU
C8166 NGP0TWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVzoeVFXUUN3ME2xN{45OzB|IN88US=> MV\TRW5ITVJ?
ES3 MnvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTF|Lkm5O|ch|ryP NIXMTGxUSU6JRWK=
NCI-H1650 NHLMXldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXNOJRKSzVyPUG2MlM4PjVizszN M4HST3NCVkeHUh?=
Mo-T MkXFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnpTWM2OD1zNz60NFI6KM7:TR?= NHzTVJlUSU6JRWK=
NB7 M1POUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTF5Lke0Olch|ryP MXLTRW5ITVJ?
ES7 M4LVc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTF7LkW1NFch|ryP MVPTRW5ITVJ?
ES5 NYnTdodNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\4[IpKSzVyPUKxMlc3PzFizszN NXzNVWZDW0GQR1XS
MSTO-211H NIW1T3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4DYZ2lEPTB;MkGuPFg2QCEQvF2= NXu1dZR7W0GQR1XS
U-87-MG NHX3V5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTJVYZKSzVyPUK1MlE6PjZizszN NHzhSW9USU6JRWK=
THP-1 M3O3VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTJ7LkeyNFEh|ryP NGPNSZRUSU6JRWK=
NB10 NYm1ZVRWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGnK[lFKSzVyPUOwMlI3QTRizszN NV3i[FVRW0GQR1XS
NH-12 MmPYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DsTGlEPTB;M{OuNlAyPyEQvF2= NVjJcXI{W0GQR1XS
COLO-824 MmrCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4rp[GlEPTB;M{SuNVAxPiEQvF2= NIrlZo1USU6JRWK=
SKM-1 M17rSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXNPIVyUUN3ME2zO{45PDJ{IN88US=> M3;kW3NCVkeHUh?=
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NALM-6 NFO2bFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXm0PEBp NHTFeXdKSzVyPUKzMlI3KG6P MkjaNlQ2OTl7OUW=
RS 4;11 NH\3UmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjBTHljPDhiaB?= NYX1[GFzUUN3ME2xOlQvOjhibl2= M1rjOFI1PTF7OUm1
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SIL-ALL M1HnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1nERlQ5KGh? NF;Zfo9KSzVyPUe0MlYzKG6P NGXHU3UzPDVzOUm5OS=>
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SIL-ALL MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1eyZVczKGh? MYrJR|UxRTdwMjDuUS=> NIXHPIszPDVzOUm5OS=>
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NALM-16 NETj[pdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\MVJY4OiCq NFe2TYFKSzVyPUe3Mlc{KG6P MV:yOFUyQTl7NR?=
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KB-8-5-11 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEX0XWJKSzVyPUWuNFEhyrFiMj6wNUBvVQ>? NXHDSGdpOjN7NkK0OFU>
KB-C-1 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{[5NGlEPTB;MU[uO|YhyrFiND61NUBvVQ>? NX3Kbol{OjN7NkK0OFU>
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OVCAR-8 M4jUSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWfrUHZKUUN3ME23MlE6KMLzIEOuOlAhdk1? MVyyN|k3OjR2NR?=
NCI-ADR-RES MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTF{N{OuN|AhyrFiMUmxMlIxKG6P MV2yN|k3OjR2NR?=
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LNCaP  NIPIeHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHe1XW9FVVOR MXvJR|Ux6oj:N{Wgcm0> M1eycFI{QDh2NEK4
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MCF7  MnztSpVv[3Srb36gRZN{[Xl? NVLJ[VBKOTByIH7N NG[xR5QyKGh? M4rtcWROW09? NYTIcGFLemWmdXPld{B1cGViaX7keYN1cW:wIH;mxsBIemWkMT|CpHNoczFuwrDQd|ItyqCVZYLwbY5iOyxiYX7kxsBYcXOyMh?= M376XlI{PzdyMkS0
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Hec50co M3Xwemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fuWmlEPTB;NTDuUS=> M4XxXFI{OTR4Nki3
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... Click to View More Cell Line Experimental Data

In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
+ Expand
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
30% PEG 400+0.5% Tween 80+5% Propylene glycol
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID