BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
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USD 210 In stock
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Cited by 53 Publications

11 Customer Reviews

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

  • Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

  • Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 NX;5dm1LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LDcmlEPTB;MD6wNFc4PiEQvF2= NUfqXoc4W0GQR1XS
ACN NGKzbpBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWjJR|UxRTBwMEC4OFMh|ryP NH3JSZBUSU6JRWK=
TE-8 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFXYSWdKSzVyPUCuNFA6PDFizszN MUfTRW5ITVJ?
LC-2-ad MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLwOmVvUUN3ME2wMlAyODl|IN88US=> M2HsZ3NCVkeHUh?=
ALL-PO MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMEGzJO69VQ>? NIDpcFdUSU6JRWK=
EW-16 MmH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2K0dGlEPTB;MD6wNVM{PiEQvF2= NHOzUHJUSU6JRWK=
KM12 M3\CTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnncGM6UUN3ME2wMlAyOzR6IN88US=> MoX5V2FPT0WU
GI-1 M{LJbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX3JR|UxRTBwMEGzPFMh|ryP NH3qXHhUSU6JRWK=
LS-411N MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTyXW1KSzVyPUCuNFE1ODdizszN M3X4PXNCVkeHUh?=
ES8 M3qyUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYnKc3J4UUN3ME2wMlAyPDl2IN88US=> M{DjSHNCVkeHUh?=
SNU-C2B M2q3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7BTWM2OD1yLkCxOVI3KM7:TR?= MlnpV2FPT0WU
CESS NXPzWpl7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMEG2NFIh|ryP MV\TRW5ITVJ?
697 MoDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHX5VGlKSzVyPUCuNFE3PjhizszN M1;hW3NCVkeHUh?=
NCI-H1963 M4jPNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2m1c2lEPTB;MD6wNVY4OyEQvF2= Mn7pV2FPT0WU
IA-LM NUPKWHJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPiTWM2OD1yLkCxOlg5KM7:TR?= NFnsWnBUSU6JRWK=
SW954 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH64cpNKSzVyPUCuNFE4ODVizszN M3Plc3NCVkeHUh?=
RL95-2 NEi3eHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorwTWM2OD1yLkCxO|M5KM7:TR?= M1vMNHNCVkeHUh?=
LXF-289 NVnCOnFOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT1TWM2OD1yLkCxO|ch|ryP M3e5OnNCVkeHUh?=
OCUB-M M2DBdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHG3fXFKSzVyPUCuNFE5OjZizszN NEPLN2JUSU6JRWK=
RKO M13mfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInhXXJKSzVyPUCuNFE6QDdizszN NWDVfFJVW0GQR1XS
LOUCY MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3i2T2lEPTB;MD6wNlA2KM7:TR?= M{\hb3NCVkeHUh?=
NOS-1 MlX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUe5bnhbUUN3ME2wMlAzODl|IN88US=> M1L3VXNCVkeHUh?=
A4-Fuk M{nvbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMEKyNVgh|ryP MVnTRW5ITVJ?
A388 Mk\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NU\2UnlZUUN3ME2wMlAzOjJ5IN88US=> NFn1SY1USU6JRWK=
TE-9 Mn;VS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXvTWM2OD1yLkCyNlYyKM7:TR?= MmDNV2FPT0WU
KURAMOCHI NIrMO3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2jJOWlEPTB;MD6wNlI5PSEQvF2= NIXzXGdUSU6JRWK=
KALS-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMEKzN|gh|ryP MXnTRW5ITVJ?
HOP-62 Mo\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfJcYE1UUN3ME2wMlAzPDJizszN Mki1V2FPT0WU
RPMI-8402 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfPTWM2OD1yLkCyOVA5KM7:TR?= NFTmTXhUSU6JRWK=
TE-1 M{j3UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjVTWM2OD1yLkCyOVEzKM7:TR?= M{m5fnNCVkeHUh?=
CCRF-CEM M4S0d2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3CTWM2OD1yLkCyOVQ{KM7:TR?= M1fjVHNCVkeHUh?=
HUTU-80 MkXDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVHJR|UxRTBwMEK2NlQh|ryP Mof3V2FPT0WU
NCI-H1648 NFnxOWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwMEK2OFch|ryP NVS0d4c4W0GQR1XS
HCE-4 NU[1SHRTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jLU2lEPTB;MD6wNlY5OiEQvF2= NGnZZVBUSU6JRWK=
ETK-1 NYSyRmVOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1X4dmlEPTB;MD6wNlc{PiEQvF2= NXv4TYh6W0GQR1XS
TE-15 M{nkRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnXrTWM2OD1yLkCyO|M5KM7:TR?= Mn2yV2FPT0WU
BE-13 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXLJR|UxRTBwMEK3OEDPxE1? MmCzV2FPT0WU
KE-37 MoWwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1f3V2lEPTB;MD6wNlc1OSEQvF2= NHPEe4pUSU6JRWK=
NCI-H1355 NYTnS3pFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEK3PFMh|ryP Mle0V2FPT0WU
TE-11 M1jsO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTKdZB7UUN3ME2wMlAzQDB7IN88US=> MVfTRW5ITVJ?
BL-70 MmOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMEK4OVch|ryP NHG2eJNUSU6JRWK=
ES6 MlzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLUTWM2OD1yLkCyPFgyKM7:TR?= MkmyV2FPT0WU
GT3TKB MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEK5OVMh|ryP MnXlV2FPT0WU
LB647-SCLC NUniW|VkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrtTWM2OD1yLkCzNVk2KM7:TR?= MoO1V2FPT0WU
NB13 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXKzXG1XUUN3ME2wMlA{OzF4IN88US=> NYTM[IxZW0GQR1XS
ST486 MofyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYqzdVJRUUN3ME2wMlA{OzN5IN88US=> M{XUR3NCVkeHUh?=
NCI-H82 MorWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nITGlEPTB;MD6wN|M1OyEQvF2= MlTnV2FPT0WU
NTERA-S-cl-D1 NXHtOpA6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4mwN2lEPTB;MD6wN|M6QSEQvF2= MWDTRW5ITVJ?
ES4 NXjzVoVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoP1TWM2OD1yLkCzOFY{KM7:TR?= MWjTRW5ITVJ?
SK-NEP-1 M{S2Xmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHzTWM2OD1yLkCzOFk6KM7:TR?= NIHVOpdUSU6JRWK=
Becker MnPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofFTWM2OD1yLkCzOVU2KM7:TR?= Mn60V2FPT0WU
A101D MoH2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITRT|ZKSzVyPUCuNFM4PDhizszN M4DFVHNCVkeHUh?=
SK-UT-1 NGnSTo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnyPVRjUUN3ME2wMlA{Pzd2IN88US=> NX:xb3FEW0GQR1XS
SW982 NYntdnRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1i3emlEPTB;MD6wN|c6KM7:TR?= NITPOlZUSU6JRWK=
TE-10 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnf5TWM2OD1yLkC0NFQ3KM7:TR?= NV2yZW5rW0GQR1XS
OVCAR-4 NWnw[4R4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXH4NYVZUUN3ME2wMlA1ODV7IN88US=> NFvuc3VUSU6JRWK=
KP-N-YS M{\ETGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mke1TWM2OD1yLkC0NFg2KM7:TR?= NXrGTmRkW0GQR1XS
BL-41 NF;BbpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTaNVBKSzVyPUCuNFQyOjVizszN M2jrRXNCVkeHUh?=
MZ1-PC NEjyd4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4S1VGlEPTB;MD6wOFEzPyEQvF2= NFTpV4VUSU6JRWK=
PF-382 M3XmVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvCTWM2OD1yLkC0NVk5KM7:TR?= M3PvW3NCVkeHUh?=
MOLT-13 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjwcGRKSzVyPUCuNFQzOzhizszN MWjTRW5ITVJ?
HCC1599 M1PqRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml3qTWM2OD1yLkC0NlU5KM7:TR?= MlHiV2FPT0WU
IST-MEL1 MlrUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mni0TWM2OD1yLkC0OFQzKM7:TR?= MlG4V2FPT0WU
LU-139 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1L4XmlEPTB;MD6wOFQ1OiEQvF2= M3jlZ3NCVkeHUh?=
MS-1 NYLFTml3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MorUTWM2OD1yLkC0O|AyKM7:TR?= NIDyR49USU6JRWK=
MFH-ino NHnxZopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jaNWlEPTB;MD6wOVAxOyEQvF2= Mm[2V2FPT0WU
IMR-5 MonFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYHJR|UxRTBwMEWwNlEh|ryP NV\6WWtuW0GQR1XS
TE-5 NH3xTZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4T1b2lEPTB;MD6wOVA3OyEQvF2= NUTEPGV7W0GQR1XS
DJM-1 NF\0SFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnEbng2UUN3ME2wMlA2OTR{IN88US=> M4XKTnNCVkeHUh?=
NB17 NHjkN3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDOd2hxUUN3ME2wMlA2OjB5IN88US=> NWHj[lUyW0GQR1XS
KARPAS-45 NH3FeXhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEWzOVgh|ryP NULjSJBlW0GQR1XS
TGBC1TKB NYfnWZVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIXUUXBKSzVyPUCuNFU1ODVizszN MoLOV2FPT0WU
ML-2 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PGfWlEPTB;MD6wOVQyPCEQvF2= NFTzWlRUSU6JRWK=
no-10 MonrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETlepNKSzVyPUCuNFU1PzRizszN MVTTRW5ITVJ?
CTV-1 NX\O[oRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFfTfWdKSzVyPUCuNFU2ODJizszN Ml7wV2FPT0WU
SJSA-1 MlLkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWLJR|UxRTBwMEW1NkDPxE1? NYTKS5FXW0GQR1XS
HC-1 NG\SbFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfmN3BWUUN3ME2wMlA2PTl5IN88US=> NVPYRW8zW0GQR1XS
TE-12 M3L0Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTBwMEW2NVMh|ryP MoHuV2FPT0WU
KY821 NHnRfpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfZTWM2OD1yLkC1OlMzKM7:TR?= NY\WR41{W0GQR1XS
TALL-1 NVXTNnp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;5N41vUUN3ME2wMlA2PzB6IN88US=> NELrN|BUSU6JRWK=
DEL NF[zW21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPqNZpKSzVyPUCuNFU4ODlizszN NEnaTIxUSU6JRWK=
TE-6 NIPEcFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYHUOo14UUN3ME2wMlA2PzJ{IN88US=> M4PNOXNCVkeHUh?=
SK-LMS-1 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTBwMEW4NFUh|ryP NWnYVFBpW0GQR1XS
EW-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlzUTWM2OD1yLkC1PFM4KM7:TR?= M2TnTXNCVkeHUh?=
8-MG-BA MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fkNmlEPTB;MD6wOVg2OSEQvF2= M1[1cnNCVkeHUh?=
NALM-6 NGHvUmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXvsXFNuUUN3ME2wMlA2QTd|IN88US=> NHHzXG1USU6JRWK=
LB771-HNC Ml;zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LhemlEPTB;MD6wOVk4QSEQvF2= MYLTRW5ITVJ?
HT-144 MmnjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHzhNGhKSzVyPUCuNFYyOyEQvF2= M3PtRnNCVkeHUh?=
KM-H2 MnvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlO2TWM2OD1yLkC2NlIyKM7:TR?= MVvTRW5ITVJ?
SF268 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF;ySGpKSzVyPUCuNFYzQDZizszN MWHTRW5ITVJ?
RS4-11 NU\6RnZET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3K4dWlEPTB;MD6wOlMxPCEQvF2= M3TWSHNCVkeHUh?=
MHH-PREB-1 M2TONWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWT3Z5FwUUN3ME2wMlA3OzF7IN88US=> MXzTRW5ITVJ?
ATN-1 MnXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwME[zOFUh|ryP M3z5dXNCVkeHUh?=
BB30-HNC Mlz2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILNNXVKSzVyPUCuNFY1OzZizszN MlGwV2FPT0WU
CPC-N NUfZ[lRMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\GTWM2OD1yLkC2OVI1KM7:TR?= MY\TRW5ITVJ?
NB1 NHf6ZnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwME[2NVMh|ryP NWnTdVJWW0GQR1XS
KS-1 M4\RcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHKTWM2OD1yLkC2O|Q5KM7:TR?= MYXTRW5ITVJ?
RXF393 Mn3US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LUdmlEPTB;MD6wOlc3PCEQvF2= NHe3VXRUSU6JRWK=
IST-SL2 MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvBTWM2OD1yLkC3NFA1KM7:TR?= Mn23V2FPT0WU
GI-ME-N M3PrNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvFTWM2OD1yLkC3Nlg3KM7:TR?= NXTSeotqW0GQR1XS
VA-ES-BJ M4\FUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLIfYtkUUN3ME2wMlA4PDd3IN88US=> NVS1SJprW0GQR1XS
NCI-H1581 MorlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LsdmlEPTB;MD6wO|Q4QCEQvF2= NEPLdGtUSU6JRWK=
U-266 MmnyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEXGWnRKSzVyPUCuNFc1QTdizszN NYTWeoRMW0GQR1XS
DMS-114 NH7ycmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7oeYFKSzVyPUCuNFc2OjhizszN NYDjRlJzW0GQR1XS
NCI-H187 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTBwMEe3NlYh|ryP NXfaeIJ3W0GQR1XS
SW962 NVnEPFBPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFr5bnBKSzVyPUCuNFc5OzlizszN M1\wcHNCVkeHUh?=
MONO-MAC-6 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;wZo9KSzVyPUCuNFc6QDZizszN MUjTRW5ITVJ?
MOLT-16 NIHIR2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXTuTXN[UUN3ME2wMlA5OTJzIN88US=> MWDTRW5ITVJ?
KNS-42 NGCxeXBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfETWM2OD1yLkC4NVYyKM7:TR?= MX3TRW5ITVJ?
CMK NUX4eWNGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEiyNlUh|ryP MnnXV2FPT0WU
Ramos-2G6-4C10 M1W4fWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M363dmlEPTB;MD6wPFIzPSEQvF2= NWfpSHhGW0GQR1XS
Daudi MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEiyOVYh|ryP MYXTRW5ITVJ?
NCI-H510A NXP5OZh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2POUWlEPTB;MD6wPFM{PiEQvF2= NWrQcol1W0GQR1XS
LB831-BLC NIDSN2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFqxT4hKSzVyPUCuNFg2PjFizszN M4Hn[3NCVkeHUh?=
HEL NEW2SZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXGwbVFTUUN3ME2wMlA5PjZ6IN88US=> MYDTRW5ITVJ?
LU-134-A MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXvoO2l3UUN3ME2wMlA5PzB6IN88US=> NYXKN49VW0GQR1XS
NCI-H1694 NULzeFRJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEi3OFQh|ryP NEj3VYRUSU6JRWK=
KGN NXPRb25lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jId2lEPTB;MD6wPFc2QSEQvF2= NF;zbodUSU6JRWK=
A253 M3Tre2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrofZlKSzVyPUCuNFg5OjJizszN MnK0V2FPT0WU
DG-75 MkPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYTJR|UxRTBwMEi5NlIh|ryP NHXCV4ZUSU6JRWK=
MOLT-4 NEXod|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPTRm1mUUN3ME2wMlA5QTh|IN88US=> MV7TRW5ITVJ?
NCI-SNU-5 NXrreGp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlP4TWM2OD1yLkC5NlU5KM7:TR?= NYHZTXRTW0GQR1XS
ONS-76 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmH0TWM2OD1yLkC5Nlc3KM7:TR?= MVLTRW5ITVJ?
NCI-H446 MlH6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX;JR|UxRTBwMEm0OlIh|ryP MoLhV2FPT0WU
COR-L279 NEK3SIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlP1TWM2OD1yLkC5OVU3KM7:TR?= MYXTRW5ITVJ?
Calu-6 M3\oXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIKycIFKSzVyPUCuNFk2QThizszN NYjUW3p1W0GQR1XS
BC-3 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1v0[mlEPTB;MD6wPVY3OiEQvF2= MmXqV2FPT0WU
NCI-H2126 M{m1[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDvfJVMUUN3ME2wMlA6PzlzIN88US=> MVXTRW5ITVJ?
NCI-H1882 NWDUPHJQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnnT2dCUUN3ME2wMlA6QDB7IN88US=> MUDTRW5ITVJ?
BB65-RCC M3vnU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jJdWlEPTB;MD6xNFI6PCEQvF2= NX24RnlJW0GQR1XS
DU-4475 NWC1WI9JT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\rOIhGUUN3ME2wMlExPDB5IN88US=> MXXTRW5ITVJ?
NCI-H526 MmPzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXtTWM2OD1yLkGwOFQh|ryP NHnp[pJUSU6JRWK=
NEC8 M2jseGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\jXXZRUUN3ME2wMlExPTJ3IN88US=> Mn;NV2FPT0WU
NCI-H1304 NW\BcIpbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfsUY1wUUN3ME2wMlExPTl2IN88US=> M2nJ[3NCVkeHUh?=
L-540 Mk\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMUC3NFgh|ryP NI\aNFNUSU6JRWK=
NCI-SNU-16 NXz6WodoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXexVY1DUUN3ME2wMlExPzR{IN88US=> NIjKUndUSU6JRWK=
HD-MY-Z MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH:1Z3hKSzVyPUCuNVA5PTZizszN MlvDV2FPT0WU
K-562 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3e3VGlEPTB;MD6xNFg2QCEQvF2= MWLTRW5ITVJ?
JAR MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMUC5NlUh|ryP NInnemxUSU6JRWK=
MZ2-MEL MmfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlvsTWM2OD1yLkGxNFUh|ryP NVLJe3d6W0GQR1XS
L-363 M4DPSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWLJR|UxRTBwMUGwO|kh|ryP Mle0V2FPT0WU
BV-173 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{PRSmlEPTB;MD6xNVI1OyEQvF2= MlPXV2FPT0WU
NCI-H524 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX76eGoyUUN3ME2wMlEyOjd2IN88US=> NWjlZnJtW0GQR1XS
EoL-1-cell NWXBcXdPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;SdGlEPTB;MD6xNVY4OiEQvF2= NYq2dYpEW0GQR1XS
K052 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4DuS2lEPTB;MD6xNVcyOiEQvF2= NEL2dlRUSU6JRWK=
TK10 NY[2PGFtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVXDXJVkUUN3ME2wMlEyPzJ6IN88US=> NGnkfItUSU6JRWK=
KU812 Mnm5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGr4VpBKSzVyPUCuNVIxPDRizszN MkDuV2FPT0WU
RPMI-8226 NGT0SG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkjyTWM2OD1yLkGyNFUzKM7:TR?= MUPTRW5ITVJ?
MZ7-mel MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3H0ZmlEPTB;MD6xNlI{PyEQvF2= NES4O3RUSU6JRWK=
SK-PN-DW MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWfJR|UxRTBwMUKyPFch|ryP M4jvZnNCVkeHUh?=
SR MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrnTWM2OD1yLkGyOFQyKM7:TR?= MmL4V2FPT0WU
RPMI-6666 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU[z[YFGUUN3ME2wMlEzPzR|IN88US=> MWfTRW5ITVJ?
no-11 NEXENpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMUK4Olkh|ryP NX;WSlI4W0GQR1XS
EW-3 M{nrWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEC1fndKSzVyPUCuNVI5QTNizszN NI[zcYZUSU6JRWK=
LAMA-84 M3PFdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mkf4TWM2OD1yLkGzNVg4KM7:TR?= NEPhOHZUSU6JRWK=
HT MkL5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknjTWM2OD1yLkGzOVc1KM7:TR?= NX7HPYljW0GQR1XS
KP-N-RT-BM-1 NHnvOpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[wTWM2OD1yLkGzOlEzKM7:TR?= MUTTRW5ITVJ?
NCI-H747 NUDBbmxrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4DC[mlEPTB;MD6xN|ch|ryP M1XhdXNCVkeHUh?=
NCCIT MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\tfmlEPTB;MD6xN|k{QSEQvF2= NF7mNnJUSU6JRWK=
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LP-1 NHHNNlhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMUSyOEDPxE1? MmPoV2FPT0WU
CAL-148 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXHJR|UxRTBwMUS0PFMh|ryP NEDOO5JUSU6JRWK=
GB-1 NGPFV3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHP5OWxKSzVyPUCuNVQ2OjZizszN NIjRbo5USU6JRWK=
COR-L88 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{TLN2lEPTB;MD6xOFgxOiEQvF2= M3;YOnNCVkeHUh?=
NKM-1 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmi4TWM2OD1yLkG0PVA3KM7:TR?= MkPDV2FPT0WU
NB5 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwMUW0OlIh|ryP M3jURnNCVkeHUh?=
SH-4 NVjKRZZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHXFemZKSzVyPUCuNVU1PjZizszN NH6xVmNUSU6JRWK=
EM-2 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMUW0Olch|ryP M1zC[3NCVkeHUh?=
TGBC24TKB MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHrBd4dKSzVyPUCuNVU3PTlizszN M2D5enNCVkeHUh?=
SCLC-21H NUX0bVNYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHmS2o2UUN3ME2wMlE2PzB{IN88US=> MXLTRW5ITVJ?
COLO-684 Mm\4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMUW3NlEh|ryP NIDwVnBUSU6JRWK=
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LS-123 NHO2TmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWToVXpVUUN3ME2wMlE2QTF5IN88US=> M2iwXXNCVkeHUh?=
MC116 NXLobW9uT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nTWmlEPTB;MD6xOlE2QCEQvF2= M1O2cXNCVkeHUh?=
SU-DHL-1 NHXVdXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnWTWM2OD1yLkG2NlA3KM7:TR?= NGDCZ3lUSU6JRWK=
NCI-H64 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjPVGxKSzVyPUCuNVY{PDdizszN NXjObYdHW0GQR1XS
HCE-T MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoD4TWM2OD1yLkG2OVA1KM7:TR?= MWjTRW5ITVJ?
LOXIMVI NX2xbINOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMU[5OFkh|ryP MoPqV2FPT0WU
ARH-77 MkLnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\BTWM2OD1yLkG3N|c6KM7:TR?= MVnTRW5ITVJ?
DOHH-2 M37aXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMUe2O|Ih|ryP MnPOV2FPT0WU
COLO-320-HSR MnjuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\WdXQxUUN3ME2wMlE5OTV2IN88US=> MofuV2FPT0WU
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SNB75 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVGw[4s1UUN3ME2wMlE5QDJ2IN88US=> NFe4W|lUSU6JRWK=
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KARPAS-299 NU\3U5RrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vEfGlEPTB;MD6xPVI1OSEQvF2= NYP6cI42W0GQR1XS
LC4-1 NIXt[ZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PoTWlEPTB;MD6xPVUxOiEQvF2= M1iwVnNCVkeHUh?=
UACC-257 M13GPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1:1dGlEPTB;MD6xPVk1PyEQvF2= NF63TFBUSU6JRWK=
EVSA-T MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXKTWM2OD1yLkKwN|EzKM7:TR?= NV3ZNnpvW0GQR1XS
JiyoyeP-2003 NIL4dnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3tSWlHUUN3ME2wMlIxPDd5IN88US=> M4\vdXNCVkeHUh?=
NCI-H720 NXnPPWF7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMkC1NlUh|ryP NWLrSY9LW0GQR1XS
GAK MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnJR|UxRTBwMkGxPFkh|ryP Mn\2V2FPT0WU
HH NFjpcGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV;5V25nUUN3ME2wMlIyPDB3IN88US=> MUHTRW5ITVJ?
NCI-H1436 M13VZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLBb|JWUUN3ME2wMlIyPDZ2IN88US=> M4TPUXNCVkeHUh?=
GR-ST MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3UTWM2OD1yLkKxOFg5KM7:TR?= MoD5V2FPT0WU
BC-1 NFTJPHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LDUGlEPTB;MD6yNlYyPiEQvF2= M1;3TXNCVkeHUh?=
SIG-M5 NYfmdIRkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMkK3Nlch|ryP NHzUe29USU6JRWK=
NCI-H345 M37VVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfacnlKSzVyPUCuNlM5ODVizszN NVvtenpPW0GQR1XS
OPM-2 NIDVTWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH\pVmFKSzVyPUCuNlM5QDJizszN MVTTRW5ITVJ?
LB1047-RCC M4fpNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MU\JR|UxRTBwMkS0NUDPxE1? M17IOHNCVkeHUh?=
CTB-1 NID3Z2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4X1OmlEPTB;MD6yOFQ6OyEQvF2= MnLMV2FPT0WU
A3-KAW MmnVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkToTWM2OD1yLkK1N|QyKM7:TR?= NE\4SIhUSU6JRWK=
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KARPAS-422 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTDcnFQUUN3ME2wMlI2PDN3IN88US=> M4W3NnNCVkeHUh?=
MEG-01 M3TCfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml:5TWM2OD1yLkK1Olc{KM7:TR?= NXe1SJc5W0GQR1XS
NCI-H209 NEjHSGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MonxTWM2OD1yLkK2N|c1KM7:TR?= MkPvV2FPT0WU
SBC-1 M2XMVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFO5VGxKSzVyPUCuNlY2KM7:TR?= MmPwV2FPT0WU
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QIMR-WIL M{HrSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3ux[WlEPTB;MD6yO|E2PSEQvF2= MXfTRW5ITVJ?
NMC-G1 NEiwUWRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWnnNI1wUUN3ME2wMlI5OjF5IN88US=> MoroV2FPT0WU
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SW684 M4fwfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV7JR|UxRTBwM{CwOFch|ryP MlLmV2FPT0WU
MV-4-11 NGG4fFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHKTWM2OD1yLkOwO|g5KM7:TR?= NIjuPWJUSU6JRWK=
LAN-6 NI[1doNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3;pW2lEPTB;MD6zNVU4OiEQvF2= MnW2V2FPT0WU
RH-1 NFHyTndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDwdGZZUUN3ME2wMlMyQDdzIN88US=> M4DJcnNCVkeHUh?=
CP66-MEL MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4fVTGlEPTB;MD6zNVg4QCEQvF2= MYrTRW5ITVJ?
EC-GI-10 M1G0[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGfHXJBKSzVyPUCuN|I6QDdizszN M2H6fnNCVkeHUh?=
GDM-1 NW\KNo84T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{m5S2lEPTB;MD6zN|A2QSEQvF2= NVr6SYxoW0GQR1XS
IST-SL1 NHPwcWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFHr[21KSzVyPUCuN|Q6OTRizszN MojBV2FPT0WU
KMOE-2 Mn3aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYG2TXh6UUN3ME2wMlM2OTd3IN88US=> MkC0V2FPT0WU
OS-RC-2 NW\LcZZUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvwTWM2OD1yLkO1OVQ1KM7:TR?= NW\aZYtFW0GQR1XS
HDLM-2 NWK1OIxHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{C3T2lEPTB;MD6zO|gyPCEQvF2= NFvKcpRUSU6JRWK=
DSH1 NHG2R|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT5TWM2OD1yLkO4OlMyKM7:TR?= NVziU5ZyW0GQR1XS
LS-1034 NFywSnRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1r4UmlEPTB;MD6zPFk2PCEQvF2= M3:5WnNCVkeHUh?=
LB373-MEL-D MnHHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGj5flRKSzVyPUCuN|kyQTdizszN MULTRW5ITVJ?
GOTO M37MXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHmwZ3RKSzVyPUCuOFIyOThizszN NHLQPHdUSU6JRWK=
MRK-nu-1 M4XQUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljvTWM2OD1yLkSyNlA2KM7:TR?= Ml3vV2FPT0WU
SK-MM-2 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUHFVHVIUUN3ME2wMlQ{PDR{IN88US=> NEDBOYRUSU6JRWK=
BOKU NFS2fG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlzkTWM2OD1yLkSzO|kzKM7:TR?= M4\6OXNCVkeHUh?=
NOMO-1 MmPNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIq4Wm9KSzVyPUCuOFM5PiEQvF2= M{XTNnNCVkeHUh?=
J-RT3-T3-5 M3zBZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\vfGlEPTB;MD60OFg4QCEQvF2= MorLV2FPT0WU
COLO-668 NXvtOYRvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn21TWM2OD1yLkS1OlY5KM7:TR?= MlPiV2FPT0WU
SF539 MnrOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwNEi2PFQh|ryP NFvWUmhUSU6JRWK=
LB2518-MEL MnPrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHH3WopKSzVyPUCuOFk4ODNizszN MnnyV2FPT0WU
TE-441-T NEf6WGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf4TWM2OD1yLkWwNVIh|ryP MlrEV2FPT0WU
MDA-MB-134-VI NWfZeVU3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo[2TWM2OD1yLkWwPVIyKM7:TR?= NWrjPFZ5W0GQR1XS
SCC-3 NEHTWIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwNUG4O|Mh|ryP M1XwUXNCVkeHUh?=
KLE Ml\tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHoRVVKSzVyPUCuOVIyPzFizszN MXLTRW5ITVJ?
LB2241-RCC MkjaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[3cGlEPTB;MD61NlUzPSEQvF2= NWLB[WR2W0GQR1XS
NCI-H1417 M1yxNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH1TWM2OD1yLkWzOFM2KM7:TR?= M3\GcXNCVkeHUh?=
NCI-H2081 M1\4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHHfJlKSzVyPUCuOVg3OTFizszN NFjMNVRUSU6JRWK=
NCI-H1522 NHS0UHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoqzTWM2OD1yLkW5N|g{KM7:TR?= M4XoRnNCVkeHUh?=
NCI-H889 NHTId4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jHcmlEPTB;MD61PVg1PCEQvF2= M1;LS3NCVkeHUh?=
CGTH-W-1 MnPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nqeGlEPTB;MD62NFc2PSEQvF2= M2myOXNCVkeHUh?=
EB-3 NF22eHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2SyUWlEPTB;MD62NVE2OyEQvF2= M3TVOnNCVkeHUh?=
D-336MG M2LIRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zjVWlEPTB;MD62NVc6OSEQvF2= NX3vU4QzW0GQR1XS
LC-1F MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmP3TWM2OD1yLk[yOVkzKM7:TR?= M3jaZnNCVkeHUh?=
MHH-NB-11 NXL3XlJWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{jD[GlEPTB;MD62N|gxOSEQvF2= MmHUV2FPT0WU
SK-N-FI MoLjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DK[2lEPTB;MD62N|kyKM7:TR?= Mm[yV2FPT0WU
NCI-H69 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHHObWNKSzVyPUCuOlQ5PzlizszN M2PGUnNCVkeHUh?=
SCH M3HQPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofFTWM2OD1yLk[2NFI{KM7:TR?= M4nXdHNCVkeHUh?=
LS-513 NFy1VI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrib4lKSzVyPUCuOlczPTlizszN NYWxcFZTW0GQR1XS
CP67-MEL MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1Loc2lEPTB;MD62O|U6PiEQvF2= NHf6XnpUSU6JRWK=
GCIY MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWrJR|UxRTBwN{CzOlMh|ryP M4n5Z3NCVkeHUh?=
SHP-77 NF23RWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7R[WZyUUN3ME2wMlcxPzN2IN88US=> MUDTRW5ITVJ?
EHEB NFvJTGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkLqTWM2OD1yLkexPFU1KM7:TR?= NWnXT2pwW0GQR1XS
D-247MG NFTxTVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NG[1dFRKSzVyPUCuO|MzOzJizszN MWTTRW5ITVJ?
Raji MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjhWo1YUUN3ME2wMlc1QTh7IN88US=> MlnYV2FPT0WU
MPP-89 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\5SGdKSzVyPUCuO|U6PzhizszN MoLWV2FPT0WU
EKVX NYLXOWR1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XmfGlEPTB;MD63PVA4OyEQvF2= Mkn0V2FPT0WU
HCC2218 NYLadWF6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHNbFdKSzVyPUCuO|kyOzFizszN MWfTRW5ITVJ?
KNS-81-FD M2Hwe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX36Smw5UUN3ME2wMlgyODFzIN88US=> MoHpV2FPT0WU
HCC2157 NYfVUmdiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fx[WlEPTB;MD64OFk2OSEQvF2= MVfTRW5ITVJ?
BT-474 NYjyUY1sT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTkWWxvUUN3ME2wMlg5QDV2IN88US=> MVPTRW5ITVJ?
NCI-H748 M1G2UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PpUGlEPTB;MD65NVIh|ryP NY\Gb3o{W0GQR1XS
EW-24 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DwRmlEPTB;MD65NlAxOiEQvF2= NGTqXGtUSU6JRWK=
D-263MG M{XlPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEK4W5JKSzVyPUCuPVQ2OTJizszN M1XGbnNCVkeHUh?=
OMC-1 NWfz[HZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLMeWFRUUN3ME2wMlk3Ozd|IN88US=> NWLWcIhWW0GQR1XS
NCI-H2196 Mn\FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M131O2lEPTB;MD65O|c4PyEQvF2= NYDQeJN4W0GQR1XS
HAL-01 NILrOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfGV2dwUUN3ME2wMlk6QDd{IN88US=> M376[3NCVkeHUh?=
NCI-H2107 NU\YVWtuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTWOopVUUN3ME2xMlAyQDV2IN88US=> NGrGVYxUSU6JRWK=
LB996-RCC NWTwbmk2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLOTIV[UUN3ME2xMlA5ODVzIN88US=> MkLDV2FPT0WU
NCI-H1395 NYHQXZBHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXXW[WNQUUN3ME2xMlExPjdizszN MUnTRW5ITVJ?
CHP-126 NV7hNHppT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm0TWM2OD1zLkG2NVk6KM7:TR?= NEDZfIhUSU6JRWK=
NB69 M4TLbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnuxTWM2OD1zLkK2NVQ5KM7:TR?= MX\TRW5ITVJ?
CAS-1 M1TKZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV33TmZsUUN3ME2xMlM1OjNzIN88US=> NH\GZ25USU6JRWK=
JVM-3 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkSzTWM2OD1zLkS3PFU2KM7:TR?= NXfzNHY4W0GQR1XS
DMS-153 MnXmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUO4[ZBQUUN3ME2xMlU4Pjd2IN88US=> MoDhV2FPT0WU
SK-MEL-2 NWfDS2tET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mnf3TWM2OD1zLkexO|g6KM7:TR?= MlTvV2FPT0WU
NCI-H1155 MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37ldGlEPTB;MT63N|Y4PiEQvF2= MlH4V2FPT0WU
NCI-H1092 NF7qOHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEf0T|RKSzVyPUGuO|YyQDJizszN NWDQOXNtW0GQR1XS
LU-165 NULPWFZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rDSmlEPTB;MT64OlQ4PiEQvF2= NU\YO5RQW0GQR1XS
HL-60 M4naSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTFwOUm5NFgh|ryP MU\TRW5ITVJ?
REH NFnlO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTlcVgxUUN3ME2yMlAxPTh{IN88US=> MVPTRW5ITVJ?
JVM-2 M3y5SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1jRRWlEPTB;Mj6wOlE{PSEQvF2= M4TTN3NCVkeHUh?=
MN-60 M2f0T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1XsZWlEPTB;Mj6xO|MxQCEQvF2= NIrE[nNUSU6JRWK=
SCC-15 NFnsfpZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJwMkCyO{DPxE1? NXPkd5A5W0GQR1XS
SNU-C1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnmcVhjUUN3ME2yMlIyOzR|IN88US=> NX\pS49kW0GQR1XS
SK-MEL-1 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTJwM{KwOFch|ryP M{LGTXNCVkeHUh?=
TGW NXnySHFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\CXWlEPTB;Mj6zOVAzPyEQvF2= MXTTRW5ITVJ?
CA46 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTxTWM2OD1{Lke1PVY4KM7:TR?= M2XjW3NCVkeHUh?=
NCI-H23 NV\Vd2FjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzZdI0zUUN3ME2yMlgxPzlzIN88US=> MYLTRW5ITVJ?
MMAC-SF NVvnUplsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fybGlEPTB;Mj64OlYzQCEQvF2= MkPYV2FPT0WU
NCI-H2171 NHe1VZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HnfGlEPTB;Mz6wN|Q1QCEQvF2= NGO5OpVUSU6JRWK=
A704 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnK4TWM2OD1|LkG0NVk1KM7:TR?= MkOxV2FPT0WU
DB MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWDxXpB2UUN3ME2zMlI2PTd4IN88US=> M4D4PHNCVkeHUh?=
NCI-H719 NHXzPWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTNwM{CzPFQh|ryP NIntZXNUSU6JRWK=
MC-CAR MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzifHdKSzVyPUOuOVQ5OTdizszN NFW0TmdUSU6JRWK=
SIMA M3zLTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfIVWxIUUN3ME2zMlU5PDF4IN88US=> MnjCV2FPT0WU
SW872 NUfFVVBFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXXJR|UxRTNwN{ixNFEh|ryP MWDTRW5ITVJ?
HCC1187 NEjHV4FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzMTWM2OD1|Lke4N|E2KM7:TR?= NVy2SmtOW0GQR1XS
EW-13 MofCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1HUNGlEPTB;Mz64N|QyPyEQvF2= MWrTRW5ITVJ?
NCI-SNU-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTRwMkG5PVkh|ryP MkfBV2FPT0WU
NCI-H226 NVjGTXlrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn\qTWM2OD12LkOzOlA3KM7:TR?= M3\STnNCVkeHUh?=
RPMI-8866 NYDnZXZDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NE\rXVdKSzVyPUSuN|YxOjlizszN NXfpUnJYW0GQR1XS
OCI-AML2 NE\UUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1z6T2lEPTB;ND61OVI{KM7:TR?= NFLsTFNUSU6JRWK=
LU-65 MlfRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{m4NWlEPTB;ND65N|A{OyEQvF2= NGnWTnRUSU6JRWK=
SK-N-DZ MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzu[2Z3UUN3ME21MlY{PDZ3IN88US=> MnLyV2FPT0WU
NB14 NX;0cFFET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NI\sdFFKSzVyPUWuPVcyOzVizszN M3nUe3NCVkeHUh?=
COLO-829 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjiXHNTUUN3ME22MlM{OzV7IN88US=> M3SySXNCVkeHUh?=
MHH-CALL-2 MoLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlSyTWM2OD14LkWxOVA5KM7:TR?= NVO5VXhVW0GQR1XS
NCI-H1770 NVf2b2pmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTZwNk[5NFQh|ryP MUnTRW5ITVJ?
ECC4 NGXIe4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3nPW2lEPTB;Nj64NlE4QSEQvF2= MWjTRW5ITVJ?
A498 NHfrTHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkTMTWM2OD14Lki3NVkzKM7:TR?= Mlr6V2FPT0WU
DMS-79 NIjF[VBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{nRfmlEPTB;Nz6wOFUyOiEQvF2= MnfRV2FPT0WU
P30-OHK NYnhd2J{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDjTWM2OD15LkKxPVA3KM7:TR?= Mn\IV2FPT0WU
D-502MG NX\WNIh1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUHBVmpYUUN3ME23Mlk5OzZizszN MlTHV2FPT0WU
RCC10RGB NG\LSZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\WfZlFUUN3ME24MlA3OjhizszN NW\BNlY1W0GQR1XS
U-698-M NWHCOXNPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRThwMkmyNlYh|ryP M1XaeXNCVkeHUh?=
BB49-HNC NImwcmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3T4O2lEPTB;OT60NlI3PSEQvF2= MnzmV2FPT0WU
ES1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrCdGJKSzVyPUmuOlg6PTZizszN MWDTRW5ITVJ?
MFM-223 NI\nTmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYjJR|UxRTFyLkm5Nlch|ryP M{Sx[nNCVkeHUh?=
C2BBe1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGW5S5hKSzVyPUGxMlM2OjNizszN NGK2dHlUSU6JRWK=
EB2 M1rGemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml7WTWM2OD1zMj62PFgyKM7:TR?= MVHTRW5ITVJ?
C8166 NEXxWFVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\ZOIdkUUN3ME2xN{45OzB|IN88US=> M1zSWXNCVkeHUh?=
ES3 NFe3eZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2mx[WlEPTB;MUOuPVk4PyEQvF2= NH3lRmxUSU6JRWK=
NCI-H1650 NXXofYZ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTF4LkO3OlUh|ryP M3HLVHNCVkeHUh?=
Mo-T MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVnuW4xkUUN3ME2xO{41ODJ7IN88US=> MXXTRW5ITVJ?
NB7 NWr4[YI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV;qRZNiUUN3ME2xO{44PDZ5IN88US=> NWrmWlNkW0GQR1XS
ES7 MoHIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfIc5RKSzVyPUG5MlU2ODdizszN Mof5V2FPT0WU
ES5 NIjlWppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFrwbmhKSzVyPUKxMlc3PzFizszN NELLUFJUSU6JRWK=
MSTO-211H MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3v4XGlEPTB;MkGuPFg2QCEQvF2= MmjnV2FPT0WU
U-87-MG NVPX[WlpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTJ3LkG5OlYh|ryP M4T2bXNCVkeHUh?=
THP-1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmrxTWM2OD1{OT63NlAyKM7:TR?= NXLhUZFZW0GQR1XS
NB10 NHj2N5dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrRVWxXUUN3ME2zNE4zPjl2IN88US=> NY\VbYlrW0GQR1XS
NH-12 NGjxdFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\lSGlEPTB;M{OuNlAyPyEQvF2= MV;TRW5ITVJ?
COLO-824 NFPmcZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fHN2lEPTB;M{SuNVAxPiEQvF2= MYjTRW5ITVJ?
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OVCAR-8 NIDSdoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXzCZoRSUUN3ME23MlE6KMLzIEOuOlAhdk1? MnTjNlM6PjJ2NEW=
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... Click to View More Cell Line Experimental Data

In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
+ Expand
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
In vivo Add solvents individually and in order:
30% PEG 400+0.5% Tween 80+5% Propylene glycol
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID