BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
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USD 210 In stock
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Cited by 53 Publications

11 Customer Reviews

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

  • Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

  • Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

Purity & Quality Control

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Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
PI3Kα [1]
(Cell-free assay)
Met [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM 2.407 μM 4.754 μM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 Mk\0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT1TWM2OD1yLkCwO|c3KM7:TR?= NULmR4NZW0GQR1XS
ACN MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXTJR|UxRTBwMEC4OFMh|ryP NFG3OnFUSU6JRWK=
TE-8 NG\jU2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGr5UnRKSzVyPUCuNFA6PDFizszN MVzTRW5ITVJ?
LC-2-ad M2LKemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlexTWM2OD1yLkCxNFk{KM7:TR?= M4nzVnNCVkeHUh?=
ALL-PO MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\5TWM2OD1yLkCxN{DPxE1? MWPTRW5ITVJ?
EW-16 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnfxTWM2OD1yLkCxN|M3KM7:TR?= NFfPb|RUSU6JRWK=
KM12 NVT3U28zT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwMEGzOFgh|ryP NInRSnRUSU6JRWK=
GI-1 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMEGzPFMh|ryP M4nNPHNCVkeHUh?=
LS-411N M4fwd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMEG0NFch|ryP NV;UfIdYW0GQR1XS
ES8 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVWy[5BVUUN3ME2wMlAyPDl2IN88US=> NFjrdmVUSU6JRWK=
SNU-C2B MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEG1NlYh|ryP M3HaTnNCVkeHUh?=
CESS NFvzcXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2G5eWlEPTB;MD6wNVYxOiEQvF2= M4TQTXNCVkeHUh?=
697 MofuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwMEG2Olgh|ryP NYToenY1W0GQR1XS
NCI-H1963 M{XJdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmDuTWM2OD1yLkCxOlc{KM7:TR?= MXXTRW5ITVJ?
IA-LM MkDmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMEG2PFgh|ryP MXrTRW5ITVJ?
SW954 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDWd3JUUUN3ME2wMlAyPzB3IN88US=> M4DRTnNCVkeHUh?=
RL95-2 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlXTTWM2OD1yLkCxO|M5KM7:TR?= NFfHN5VUSU6JRWK=
LXF-289 MmXQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnOxTWM2OD1yLkCxO|ch|ryP M4HGdHNCVkeHUh?=
OCUB-M MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXrJR|UxRTBwMEG4NlYh|ryP M{D0WXNCVkeHUh?=
RKO MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4\Q[mlEPTB;MD6wNVk5PyEQvF2= MVzTRW5ITVJ?
LOUCY MnXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\4bGlEPTB;MD6wNlA2KM7:TR?= NFzuWXBUSU6JRWK=
NOS-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoixTWM2OD1yLkCyNFk{KM7:TR?= NVziPZR7W0GQR1XS
A4-Fuk M4fTcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlnZTWM2OD1yLkCyNlE5KM7:TR?= MW\TRW5ITVJ?
A388 M4Pu[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMEKyNlch|ryP NH;re3RUSU6JRWK=
TE-9 NF;3T3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlnWTWM2OD1yLkCyNlYyKM7:TR?= NIT2SYpUSU6JRWK=
KURAMOCHI Mof0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlOwTWM2OD1yLkCyNlg2KM7:TR?= Mkm4V2FPT0WU
KALS-1 NGjKV21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUSwNHhOUUN3ME2wMlAzOzN6IN88US=> NVHRZYZLW0GQR1XS
HOP-62 M{jjdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWj6VpJ[UUN3ME2wMlAzPDJizszN MUHTRW5ITVJ?
RPMI-8402 M3TQRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MljUTWM2OD1yLkCyOVA5KM7:TR?= NHTqPZNUSU6JRWK=
TE-1 M3LBU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwMEK1NVIh|ryP M2rpPHNCVkeHUh?=
CCRF-CEM MnzSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jRWGlEPTB;MD6wNlU1OyEQvF2= MVHTRW5ITVJ?
HUTU-80 M{TyfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;teXliUUN3ME2wMlAzPjJ2IN88US=> NEm3SFJUSU6JRWK=
NCI-H1648 MmjHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmnBTWM2OD1yLkCyOlQ4KM7:TR?= MYPTRW5ITVJ?
HCE-4 MoHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7mb3d7UUN3ME2wMlAzPjh{IN88US=> MnzTV2FPT0WU
ETK-1 MkHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWntV|BIUUN3ME2wMlAzPzN4IN88US=> MkT4V2FPT0WU
TE-15 M3PpPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDV[IpoUUN3ME2wMlAzPzN6IN88US=> NV;ETHFlW0GQR1XS
BE-13 NUXtRYJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUC1OHVNUUN3ME2wMlAzPzRizszN Mo\xV2FPT0WU
KE-37 MofXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrB[mxVUUN3ME2wMlAzPzRzIN88US=> Mlf5V2FPT0WU
NCI-H1355 Mn\uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrwTWM2OD1yLkCyO|g{KM7:TR?= NVT4UFY{W0GQR1XS
TE-11 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEK4NFkh|ryP MVrTRW5ITVJ?
BL-70 NEDEO4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnMOHBRUUN3ME2wMlAzQDV5IN88US=> NEHQT5BUSU6JRWK=
ES6 NIHsfoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEK4PFEh|ryP M1viW3NCVkeHUh?=
GT3TKB MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Kyb2lEPTB;MD6wNlk2OyEQvF2= MXTTRW5ITVJ?
LB647-SCLC MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2nxPGlEPTB;MD6wN|E6PSEQvF2= MVXTRW5ITVJ?
NB13 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjVTWM2OD1yLkCzN|E3KM7:TR?= NEDRPHlUSU6JRWK=
ST486 M2XnVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vsT2lEPTB;MD6wN|M{PyEQvF2= NV3ybIluW0GQR1XS
NCI-H82 M3PuXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYG2dXNmUUN3ME2wMlA{OzR|IN88US=> NE\TSWRUSU6JRWK=
NTERA-S-cl-D1 M3f3V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYDJR|UxRTBwMEOzPVkh|ryP MV3TRW5ITVJ?
ES4 NVnQb4tQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXV[25KSzVyPUCuNFM1PjNizszN MUjTRW5ITVJ?
SK-NEP-1 M2n0bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3O0N2lEPTB;MD6wN|Q6QSEQvF2= NYnETGJHW0GQR1XS
Becker NV\ZT4s2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrLTWM2OD1yLkCzOVU2KM7:TR?= MW\TRW5ITVJ?
A101D M17RV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PBdWlEPTB;MD6wN|c1QCEQvF2= M33JW3NCVkeHUh?=
SK-UT-1 NGe4SolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVK3e41pUUN3ME2wMlA{Pzd2IN88US=> MX7TRW5ITVJ?
SW982 NGLMfIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUXZcYpXUUN3ME2wMlA{PzlizszN MnXIV2FPT0WU
TE-10 Mnr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnuZpdPUUN3ME2wMlA1ODR4IN88US=> M3vlfHNCVkeHUh?=
OVCAR-4 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTiTWM2OD1yLkC0NFU6KM7:TR?= NInWV2RUSU6JRWK=
KP-N-YS Mkj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjOXJE{UUN3ME2wMlA1ODh3IN88US=> MWHTRW5ITVJ?
BL-41 Mn\HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nST2lEPTB;MD6wOFEzPSEQvF2= NWjFS|ZKW0GQR1XS
MZ1-PC NGH5bVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMESxNlch|ryP MlrrV2FPT0WU
PF-382 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1S1W2lEPTB;MD6wOFE6QCEQvF2= NGTwWoRUSU6JRWK=
MOLT-13 NUW3WIJxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrlXXpKSzVyPUCuNFQzOzhizszN MYPTRW5ITVJ?
HCC1599 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXXV|drUUN3ME2wMlA1OjV6IN88US=> MknDV2FPT0WU
IST-MEL1 NIHz[INIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XTWGlEPTB;MD6wOFQ1OiEQvF2= NUnlOo93W0GQR1XS
LU-139 NHWxfI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\KSZNWUUN3ME2wMlA1PDR{IN88US=> M3;oO3NCVkeHUh?=
MS-1 NV\jS5Q{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M324TWlEPTB;MD6wOFcxOSEQvF2= M3HkdHNCVkeHUh?=
MFH-ino NH3uNIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWHPN3cyUUN3ME2wMlA2ODB|IN88US=> MXPTRW5ITVJ?
IMR-5 M1noW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEfXeXBKSzVyPUCuNFUxOjFizszN NGrsUGZUSU6JRWK=
TE-5 M3fsNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLWTWM2OD1yLkC1NFY{KM7:TR?= NHjxSHVUSU6JRWK=
DJM-1 NV\tbopqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvsTWM2OD1yLkC1NVQzKM7:TR?= NY[zTZQ1W0GQR1XS
NB17 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfOTWM2OD1yLkC1NlA4KM7:TR?= M{HZWHNCVkeHUh?=
KARPAS-45 NF\JNmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4i3UGlEPTB;MD6wOVM2QCEQvF2= NFHNXnJUSU6JRWK=
TGBC1TKB NGX6W|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2PFWGlEPTB;MD6wOVQxPSEQvF2= NHP4U5FUSU6JRWK=
ML-2 MmHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4PKZ2lEPTB;MD6wOVQyPCEQvF2= NGO0V5pUSU6JRWK=
no-10 M{G4eGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzOTWM2OD1yLkC1OFc1KM7:TR?= M{DNXnNCVkeHUh?=
CTV-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkXGTWM2OD1yLkC1OVAzKM7:TR?= Ml3rV2FPT0WU
SJSA-1 NFTXOY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XOPWlEPTB;MD6wOVUzKM7:TR?= NYjhbZZSW0GQR1XS
HC-1 NVHRblhnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4q0XWlEPTB;MD6wOVU6PyEQvF2= MljwV2FPT0WU
TE-12 M4fTdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3K1dWlEPTB;MD6wOVYyOyEQvF2= NFPZS3ZUSU6JRWK=
KY821 NFrZclJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGfEdGRKSzVyPUCuNFU3OzJizszN NILRTVRUSU6JRWK=
TALL-1 Mm\QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHv3WHRKSzVyPUCuNFU4ODhizszN MoOxV2FPT0WU
DEL MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1SwW2lEPTB;MD6wOVcxQSEQvF2= NXHaNYRnW0GQR1XS
TE-6 NVTo[|JTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYjJR|UxRTBwMEW3NlIh|ryP MlvwV2FPT0WU
SK-LMS-1 NEDBbnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwMEW4NFUh|ryP MUnTRW5ITVJ?
EW-1 NFvs[JBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\lTWM2OD1yLkC1PFM4KM7:TR?= MW\TRW5ITVJ?
8-MG-BA NH\QXFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWrJR|UxRTBwMEW4OVEh|ryP MnXRV2FPT0WU
NALM-6 NF7QXZJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1P4XGlEPTB;MD6wOVk4OyEQvF2= NG\FdJlUSU6JRWK=
LB771-HNC M4r0Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWPJR|UxRTBwMEW5O|kh|ryP NEnVTJVUSU6JRWK=
HT-144 M{PmXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Ml\VTWM2OD1yLkC2NVMh|ryP NGm1OWxUSU6JRWK=
KM-H2 NGjMSlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGK0[WNKSzVyPUCuNFYzOjFizszN NGDlUZRUSU6JRWK=
SF268 NGX2NFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LLRWlEPTB;MD6wOlI5PiEQvF2= NXLNWHIxW0GQR1XS
RS4-11 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DZVGlEPTB;MD6wOlMxPCEQvF2= Mm\0V2FPT0WU
MHH-PREB-1 M2\DZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvlTWM2OD1yLkC2N|E6KM7:TR?= NH\PW|RUSU6JRWK=
ATN-1 NEP3W3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTQTWM2OD1yLkC2N|Q2KM7:TR?= NIHOXXZUSU6JRWK=
BB30-HNC MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7HTWM2OD1yLkC2OFM3KM7:TR?= NWWxblRiW0GQR1XS
CPC-N M{HIXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\6TWM2OD1yLkC2OVI1KM7:TR?= NH7wU3JUSU6JRWK=
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KS-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\LTWM2OD1yLkC2O|Q5KM7:TR?= NUf1fINuW0GQR1XS
RXF393 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPmc|djUUN3ME2wMlA3PzZ2IN88US=> MmDQV2FPT0WU
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GI-ME-N NYru[|FQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvZUG1KSzVyPUCuNFczQDZizszN M4PLNXNCVkeHUh?=
VA-ES-BJ NWDiUnVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{H6VWlEPTB;MD6wO|Q4PSEQvF2= NXroVpc4W0GQR1XS
NCI-H1581 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF\NPIZKSzVyPUCuNFc1PzhizszN MWXTRW5ITVJ?
U-266 NEfSdWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3YUpRKSzVyPUCuNFc1QTdizszN NGfXdnpUSU6JRWK=
DMS-114 MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfTXlNKSzVyPUCuNFc2OjhizszN MmLPV2FPT0WU
NCI-H187 NVm1O4Q2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\GTWM2OD1yLkC3O|I3KM7:TR?= NFKyZ3JUSU6JRWK=
SW962 NIDlV3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3XLRWlEPTB;MD6wO|g{QSEQvF2= Mm\WV2FPT0WU
MONO-MAC-6 NYnSUnpQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmTFTWM2OD1yLkC3PVg3KM7:TR?= NXjt[ll6W0GQR1XS
MOLT-16 NUC0RnZzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3VTWM2OD1yLkC4NVIyKM7:TR?= MUjTRW5ITVJ?
KNS-42 M3;OTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{LhWGlEPTB;MD6wPFE3OSEQvF2= MWDTRW5ITVJ?
CMK M4fTS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFrIRYxKSzVyPUCuNFgzOjVizszN MXTTRW5ITVJ?
Ramos-2G6-4C10 MmTGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofYTWM2OD1yLkC4NlI2KM7:TR?= MVjTRW5ITVJ?
Daudi M4XoSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYfJR|UxRTBwMEiyOVYh|ryP NETYT3JUSU6JRWK=
NCI-H510A NX;s[5pST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHMZ3hKSzVyPUCuNFg{OzZizszN NFKwfZFUSU6JRWK=
LB831-BLC NV3oWWtFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\veXRyUUN3ME2wMlA5PTZzIN88US=> MUHTRW5ITVJ?
HEL NUjxeHF{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwMEi2Olgh|ryP NX7obFJzW0GQR1XS
LU-134-A NG\vOZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fzWWlEPTB;MD6wPFcxQCEQvF2= MVLTRW5ITVJ?
NCI-H1694 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXPVIpKSzVyPUCuNFg4PDRizszN Mne4V2FPT0WU
KGN M4riXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYTYZo46UUN3ME2wMlA5PzV7IN88US=> MlXIV2FPT0WU
A253 MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXLJR|UxRTBwMEi4NlIh|ryP M3rsOXNCVkeHUh?=
DG-75 NGLiRnZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfBZodKSzVyPUCuNFg6OjJizszN MUPTRW5ITVJ?
MOLT-4 Mof2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXXJR|UxRTBwMEi5PFMh|ryP M2i1dXNCVkeHUh?=
NCI-SNU-5 NFXOWGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3HbnpMUUN3ME2wMlA6OjV6IN88US=> M1HkfHNCVkeHUh?=
ONS-76 M3e0dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPZWZpyUUN3ME2wMlA6Ojd4IN88US=> NH3TVndUSU6JRWK=
NCI-H446 MnLWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEW5OHNKSzVyPUCuNFk1PjJizszN NWjxZpV[W0GQR1XS
COR-L279 NX[5U|JnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHjTWM2OD1yLkC5OVU3KM7:TR?= MmnvV2FPT0WU
Calu-6 M33MXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3j1TGlEPTB;MD6wPVU6QCEQvF2= MVzTRW5ITVJ?
BC-3 MmDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XY[2lEPTB;MD6wPVY3OiEQvF2= MlroV2FPT0WU
NCI-H2126 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1f5eWlEPTB;MD6wPVc6OSEQvF2= MlXCV2FPT0WU
NCI-H1882 NVS1THB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MW\JR|UxRTBwMEm4NFkh|ryP Mn\FV2FPT0WU
BB65-RCC Ml3sS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMUCyPVQh|ryP MX\TRW5ITVJ?
DU-4475 MkTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPkXmY{UUN3ME2wMlExPDB5IN88US=> M{X3c3NCVkeHUh?=
NCI-H526 M1L2bGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFzK[VFKSzVyPUCuNVA1PCEQvF2= MVvTRW5ITVJ?
NEC8 M2DQOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzIOVQxUUN3ME2wMlExPTJ3IN88US=> NWr4PIUyW0GQR1XS
NCI-H1304 NY[zdnh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwMUC1PVQh|ryP M2LJTHNCVkeHUh?=
L-540 NFmxWoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMUC3NFgh|ryP NGnXVHBUSU6JRWK=
NCI-SNU-16 M{j5VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwMUC3OFIh|ryP MmXCV2FPT0WU
HD-MY-Z NVPTempGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlO5TWM2OD1yLkGwPFU3KM7:TR?= MmPLV2FPT0WU
K-562 M{ezTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4O1e2lEPTB;MD6xNFg2QCEQvF2= MmjtV2FPT0WU
JAR M4m1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLZTWM2OD1yLkGwPVI2KM7:TR?= MYXTRW5ITVJ?
MZ2-MEL NYP4OHJzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYfJR|UxRTBwMUGwOUDPxE1? M3Tyd3NCVkeHUh?=
L-363 NFXURWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLaXphCUUN3ME2wMlEyODd7IN88US=> NHTvO5hUSU6JRWK=
BV-173 NF7WUldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3jBXmlEPTB;MD6xNVI1OyEQvF2= MVPTRW5ITVJ?
NCI-H524 M3H0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVLJR|UxRTBwMUGyO|Qh|ryP NX7FbGJNW0GQR1XS
EoL-1-cell MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwMUG2O|Ih|ryP M3\mTHNCVkeHUh?=
K052 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHT[otKSzVyPUCuNVE4OTJizszN M{\VT3NCVkeHUh?=
TK10 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\WTWM2OD1yLkGxO|I5KM7:TR?= MkC2V2FPT0WU
KU812 NWe3[nB4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\VWoZrUUN3ME2wMlEzODR2IN88US=> NETFeJVUSU6JRWK=
RPMI-8226 M2nJVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\1TWM2OD1yLkGyNFUzKM7:TR?= NWr0bWh1W0GQR1XS
MZ7-mel M1HNSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMUKyN|ch|ryP MoO2V2FPT0WU
SK-PN-DW MlrBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTBwMUKyPFch|ryP MlrCV2FPT0WU
SR MomwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHfafHdKSzVyPUCuNVI1PDFizszN MWfTRW5ITVJ?
RPMI-6666 NGTHTHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2\MTmlEPTB;MD6xNlc1OyEQvF2= NWfaTZloW0GQR1XS
no-11 M2DZeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUXjOZR6UUN3ME2wMlEzQDZ7IN88US=> NXH1O5NDW0GQR1XS
EW-3 NH7VT5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVLJR|UxRTBwMUK4PVMh|ryP NEjhbXJUSU6JRWK=
LAMA-84 NXr1fFJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkj3TWM2OD1yLkGzNVg4KM7:TR?= NYTzZplmW0GQR1XS
HT NX30fFByT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInQVHJKSzVyPUCuNVM2PzRizszN M2\vWXNCVkeHUh?=
KP-N-RT-BM-1 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVv0cYFuUUN3ME2wMlE{PjF{IN88US=> Ml;PV2FPT0WU
NCI-H747 M3f5N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIj2N2FKSzVyPUCuNVM4KM7:TR?= MnHkV2FPT0WU
NCCIT NH3LS3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGLUe3BKSzVyPUCuNVM6OzlizszN M2j5eXNCVkeHUh?=
MLMA NF\3TohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjMeWxKSzVyPUCuNVQyPjdizszN MUPTRW5ITVJ?
LP-1 NHGxTIpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMUSyOEDPxE1? NXyxe2poW0GQR1XS
CAL-148 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnETWM2OD1yLkG0OFg{KM7:TR?= NX3SfVdXW0GQR1XS
GB-1 NGq4PXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\PdWlEPTB;MD6xOFUzPiEQvF2= NHK4c3hUSU6JRWK=
COR-L88 NYXyXYNUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfDTWM2OD1yLkG0PFAzKM7:TR?= MmroV2FPT0WU
NKM-1 MlPhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4XqNmlEPTB;MD6xOFkxPiEQvF2= NV3ybVZzW0GQR1XS
NB5 MkL6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NETicXRKSzVyPUCuNVU1PjJizszN NIr3doJUSU6JRWK=
SH-4 NFPEN4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnXZTWM2OD1yLkG1OFY3KM7:TR?= NV6x[FR1W0GQR1XS
EM-2 NGjzVI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMUW0Olch|ryP M2nRVHNCVkeHUh?=
TGBC24TKB NF32T|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGTIepJKSzVyPUCuNVU3PTlizszN MnK0V2FPT0WU
SCLC-21H NV7rbI9iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMUW3NFIh|ryP M4PNWXNCVkeHUh?=
COLO-684 M3rBVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIT4flZKSzVyPUCuNVU4OjFizszN MoGxV2FPT0WU
KINGS-1 M4rUXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwMUW5NUDPxE1? NF\GOG1USU6JRWK=
LS-123 NYTEWnFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPDTWM2OD1yLkG1PVE4KM7:TR?= Mm\qV2FPT0WU
MC116 M2DwPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMU[xOVgh|ryP MnK2V2FPT0WU
SU-DHL-1 M4PrNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HiUmlEPTB;MD6xOlIxPiEQvF2= M2TPPXNCVkeHUh?=
NCI-H64 M1Sy[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwMU[zOFch|ryP NXnsUYlMW0GQR1XS
HCE-T NXfU[okyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4nSOGlEPTB;MD6xOlUxPCEQvF2= MWnTRW5ITVJ?
LOXIMVI M2TUO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofkTWM2OD1yLkG2PVQ6KM7:TR?= M2r6d3NCVkeHUh?=
ARH-77 NWi4ephwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPBTWM2OD1yLkG3N|c6KM7:TR?= NHXUUFFUSU6JRWK=
DOHH-2 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHETWM2OD1yLkG3OlczKM7:TR?= MWXTRW5ITVJ?
COLO-320-HSR MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY\JR|UxRTBwMUixOVQh|ryP NV\0O4ZNW0GQR1XS
NB6 NHzh[3dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPiWppKSzVyPUCuNVg2PjZizszN NXfH[2lMW0GQR1XS
L-428 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1nQXmlEPTB;MD6xPFgyOyEQvF2= Mmq3V2FPT0WU
SNB75 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMUi4NlQh|ryP M{\2b3NCVkeHUh?=
NCI-H2141 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMUmwNVEh|ryP MVLTRW5ITVJ?
KARPAS-299 NUfzfVMxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjuTWM2OD1yLkG5NlQyKM7:TR?= M{LUTnNCVkeHUh?=
LC4-1 NH[3[4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NY\xN21LUUN3ME2wMlE6PTB{IN88US=> NUW3fHJkW0GQR1XS
UACC-257 NVnMTVQ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVjJR|UxRTBwMUm5OFch|ryP MUXTRW5ITVJ?
EVSA-T NYfj[FBvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmjQTWM2OD1yLkKwN|EzKM7:TR?= M3j6b3NCVkeHUh?=
JiyoyeP-2003 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVHM[Yk{UUN3ME2wMlIxPDd5IN88US=> NVPmUXNUW0GQR1XS
NCI-H720 NH3obYtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MofhTWM2OD1yLkKwOVI2KM7:TR?= MkDjV2FPT0WU
GAK NEC0fnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHmTWM2OD1yLkKxNVg6KM7:TR?= MWXTRW5ITVJ?
HH MofNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMkG0NFUh|ryP M32zOHNCVkeHUh?=
NCI-H1436 MljzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjmT21KSzVyPUCuNlE1PjRizszN NYrWe2ZjW0GQR1XS
GR-ST NE[yW|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUO0OVc2UUN3ME2wMlIyPDh6IN88US=> NGLBPVBUSU6JRWK=
BC-1 NWrhdWM4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1jqW2lEPTB;MD6yNlYyPiEQvF2= M1n4[3NCVkeHUh?=
SIG-M5 M2LZ[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3jQdmlEPTB;MD6yNlczPyEQvF2= MYPTRW5ITVJ?
NCI-H345 NX7pb3VmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nFWGlEPTB;MD6yN|gxPSEQvF2= NULa[IRrW0GQR1XS
OPM-2 NVPKUXp5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\jU5pKSzVyPUCuNlM5QDJizszN NYnQcJplW0GQR1XS
LB1047-RCC NGPtWHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn71TWM2OD1yLkK0OFEh|ryP Mnu3V2FPT0WU
CTB-1 NH7RR|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2LNe2lEPTB;MD6yOFQ6OyEQvF2= NXzMPFJbW0GQR1XS
A3-KAW M4Habmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUD4SGp2UUN3ME2wMlI2OzRzIN88US=> NELzOJRUSU6JRWK=
SF126 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1y1WmlEPTB;MD6yOVM5OyEQvF2= M4rVSXNCVkeHUh?=
KARPAS-422 NVHGbFUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMkW0N|Uh|ryP NXi2NGgyW0GQR1XS
MEG-01 NVnDbYlST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PPfGlEPTB;MD6yOVY4OyEQvF2= M1\WW3NCVkeHUh?=
NCI-H209 NVrIZ2R1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFXid5ZKSzVyPUCuNlY{PzRizszN NYK4[5NOW0GQR1XS
SBC-1 NFu1fmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFPMT3RKSzVyPUCuNlY2KM7:TR?= M2D5NnNCVkeHUh?=
K5 Mo\1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkLYTWM2OD1yLkK2PVg1KM7:TR?= Mn7FV2FPT0WU
QIMR-WIL NXzJNIdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVzaVINDUUN3ME2wMlI4OTV3IN88US=> MYDTRW5ITVJ?
NMC-G1 MnOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PPWmlEPTB;MD6yPFIyPyEQvF2= NVWxOZE5W0GQR1XS
IST-MES1 Mo\ES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTCWo1KSzVyPUCuNlkzOzhizszN NFXRU4lUSU6JRWK=
SW684 NEe4RVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nre2lEPTB;MD6zNFA1PyEQvF2= M3fBe3NCVkeHUh?=
MV-4-11 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{DmVGlEPTB;MD6zNFc5QCEQvF2= NVvBR4xHW0GQR1XS
LAN-6 M4fXPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwM{G1O|Ih|ryP MlLzV2FPT0WU
RH-1 M1n3c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3DTWM2OD1yLkOxPFcyKM7:TR?= M1TCWXNCVkeHUh?=
CP66-MEL MojXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4LX[GlEPTB;MD6zNVg4QCEQvF2= NIDQR|RUSU6JRWK=
EC-GI-10 MlHGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYPJR|UxRTBwM{K5PFch|ryP NFTxbpRUSU6JRWK=
GDM-1 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf1U|F2UUN3ME2wMlM{ODV7IN88US=> NULme|VJW0GQR1XS
IST-SL1 M1joS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTBwM{S5NVQh|ryP NVL5Uo5kW0GQR1XS
KMOE-2 Mo[5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1X1R2lEPTB;MD6zOVE4PSEQvF2= NXrkVJZNW0GQR1XS
OS-RC-2 NVGzXW5TT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUXrOWNTUUN3ME2wMlM2PTR2IN88US=> NUnOTXoxW0GQR1XS
HDLM-2 NHKxcolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrSR2VDUUN3ME2wMlM4QDF2IN88US=> M4HrWHNCVkeHUh?=
DSH1 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\ZUmlEPTB;MD6zPFY{OSEQvF2= NGjzWVRUSU6JRWK=
LS-1034 NESzbYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{G4RWlEPTB;MD6zPFk2PCEQvF2= MVnTRW5ITVJ?
LB373-MEL-D MmW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NITZXYpKSzVyPUCuN|kyQTdizszN M1nuTHNCVkeHUh?=
GOTO M1TNdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwNEKxNVgh|ryP M2DBOnNCVkeHUh?=
MRK-nu-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwNEKyNFUh|ryP MoPvV2FPT0WU
SK-MM-2 MorOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDzZm03UUN3ME2wMlQ{PDR{IN88US=> M1S4WXNCVkeHUh?=
BOKU MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwNEO3PVIh|ryP NYTrSHNRW0GQR1XS
NOMO-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XFb2lEPTB;MD60N|g3KM7:TR?= M4\wbnNCVkeHUh?=
J-RT3-T3-5 NEjEPZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLLTWM2OD1yLkS0PFc5KM7:TR?= MknoV2FPT0WU
COLO-668 NV7lV3FET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPreoNlUUN3ME2wMlQ2PjZ6IN88US=> MnfYV2FPT0WU
SF539 M3HKe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILBT2hKSzVyPUCuOFg3QDRizszN Mnf1V2FPT0WU
LB2518-MEL MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2T6bWlEPTB;MD60PVcxOyEQvF2= NFnJd2lUSU6JRWK=
TE-441-T NHjId5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIPhenNKSzVyPUCuOVAyOiEQvF2= MoG4V2FPT0WU
MDA-MB-134-VI MoWyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTOdGpKSzVyPUCuOVA6OjFizszN Mn3wV2FPT0WU
SCC-3 NYq5OXNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFjlTWZKSzVyPUCuOVE5PzNizszN MVHTRW5ITVJ?
KLE M3T4VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2HqfGlEPTB;MD61NlE4OSEQvF2= MmfDV2FPT0WU
LB2241-RCC NXP6fpliT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnrzTWM2OD1yLkWyOVI2KM7:TR?= M3nzRXNCVkeHUh?=
NCI-H1417 MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NI\ON2xKSzVyPUCuOVM1OzVizszN NWq2UHZsW0GQR1XS
NCI-H2081 M{XYb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVnMO3dyUUN3ME2wMlU5PjFzIN88US=> MXvTRW5ITVJ?
NCI-H1522 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\2TWM2OD1yLkW5N|g{KM7:TR?= M{PKT3NCVkeHUh?=
NCI-H889 NFzJZmxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmD3TWM2OD1yLkW5PFQ1KM7:TR?= M4[5NnNCVkeHUh?=
CGTH-W-1 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXjJR|UxRTBwNkC3OVUh|ryP MoixV2FPT0WU
EB-3 NGC0dVNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjQXYFKSzVyPUCuOlEyPTNizszN MlfxV2FPT0WU
D-336MG NEP4WXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3j0eWlEPTB;MD62NVc6OSEQvF2= MnXlV2FPT0WU
LC-1F MoTUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHrfodKSzVyPUCuOlI2QTJizszN NWPUT4hiW0GQR1XS
MHH-NB-11 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2\KWGlEPTB;MD62N|gxOSEQvF2= NVr6TWJ5W0GQR1XS
SK-N-FI MlnOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlf0TWM2OD1yLk[zPVEh|ryP NHPSdnRUSU6JRWK=
NCI-H69 NUf6T2R6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWLZTHVRUUN3ME2wMlY1QDd7IN88US=> M4f3R3NCVkeHUh?=
SCH NF;sRmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH7SdlZKSzVyPUCuOlYxOjNizszN MoWzV2FPT0WU
LS-513 NYLYZpU4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvQTWM2OD1yLk[3NlU6KM7:TR?= Ml3sV2FPT0WU
CP67-MEL M3LJO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnNZoNKSzVyPUCuOlc2QTZizszN M1zUTXNCVkeHUh?=
GCIY NEe1W|BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXJTWM2OD1yLkewN|Y{KM7:TR?= M3fN[HNCVkeHUh?=
SHP-77 NX;sW2lbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkfNTWM2OD1yLkewO|M1KM7:TR?= NFfaZYNUSU6JRWK=
EHEB Ml\mS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTtZWNKSzVyPUCuO|E5PTRizszN M3vkTnNCVkeHUh?=
D-247MG MoHpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHTNOWVKSzVyPUCuO|MzOzJizszN NWXKelhQW0GQR1XS
Raji NXSyOVN1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF[1dXRKSzVyPUCuO|Q6QDlizszN M1TGdXNCVkeHUh?=
MPP-89 MlX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkD4TWM2OD1yLke1PVc5KM7:TR?= MoGxV2FPT0WU
EKVX NUHLVnJJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzqTWM2OD1yLke5NFc{KM7:TR?= NYLvWlFEW0GQR1XS
HCC2218 NUjOWYhpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\ZTWM2OD1yLke5NVMyKM7:TR?= NELHeI1USU6JRWK=
KNS-81-FD MlP5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjyOHpKSzVyPUCuPFExOTFizszN MWHTRW5ITVJ?
HCC2157 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVz4U20yUUN3ME2wMlg1QTVzIN88US=> MUnTRW5ITVJ?
BT-474 MljaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPjOYlFUUN3ME2wMlg5QDV2IN88US=> NWXpZmNrW0GQR1XS
NCI-H748 MonSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4Tje2lEPTB;MD65NVIh|ryP NWXoWo5sW0GQR1XS
EW-24 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2LaOGlEPTB;MD65NlAxOiEQvF2= MUPTRW5ITVJ?
D-263MG NYniO3hET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTQfVVCUUN3ME2wMlk1PTF{IN88US=> M1LY[3NCVkeHUh?=
OMC-1 NYTwXWx3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHvK[GJKSzVyPUCuPVY{PzNizszN NE\4U45USU6JRWK=
NCI-H2196 MkfLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHP0e5NKSzVyPUCuPVc4PzdizszN NWnSO5F[W0GQR1XS
HAL-01 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoHnTWM2OD1yLkm5PFczKM7:TR?= M3zDc3NCVkeHUh?=
NCI-H2107 MnXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIXIVWxKSzVyPUGuNFE5PTRizszN M3fvVHNCVkeHUh?=
LB996-RCC Mnn2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTFwMEiwOVEh|ryP NELnVmlUSU6JRWK=
NCI-H1395 MkD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFX5fYlKSzVyPUGuNVA3PyEQvF2= NVr2cZp3W0GQR1XS
CHP-126 M{HPdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTFwMU[xPVkh|ryP MkXVV2FPT0WU
NB69 NV7wd45ET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml;yTWM2OD1zLkK2NVQ5KM7:TR?= M3\0VHNCVkeHUh?=
CAS-1 M{njNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTFwM{SyN|Eh|ryP MonoV2FPT0WU
JVM-3 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTFwNEe4OVUh|ryP MU\TRW5ITVJ?
DMS-153 M2W3WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{fkSmlEPTB;MT61O|Y4PCEQvF2= NEDLZnlUSU6JRWK=
SK-MEL-2 MmrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NESweHpKSzVyPUGuO|E4QDlizszN MWrTRW5ITVJ?
NCI-H1155 M3ntfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NETjc4tKSzVyPUGuO|M3PzZizszN MnPpV2FPT0WU
NCI-H1092 NGHWcotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH61UJZKSzVyPUGuO|YyQDJizszN NUHaZWZ2W0GQR1XS
LU-165 NInWOoVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEXuRlFKSzVyPUGuPFY1PzZizszN M{PwW3NCVkeHUh?=
HL-60 NEj5ZmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoOzTWM2OD1zLkm5PVA5KM7:TR?= M3\mZnNCVkeHUh?=
REH NF:xUHFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkXZTWM2OD1{LkCwOVgzKM7:TR?= MoDYV2FPT0WU
JVM-2 NHTlcY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1\ZeWlEPTB;Mj6wOlE{PSEQvF2= MmDiV2FPT0WU
MN-60 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTJwMUezNFgh|ryP MX;TRW5ITVJ?
SCC-15 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTJwMkCyO{DPxE1? NVjtSYoxW0GQR1XS
SNU-C1 NVLYZ2ROT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTJwMkGzOFMh|ryP NFnnXJdUSU6JRWK=
SK-MEL-1 NVfOV25iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLaTWM2OD1{LkOyNFQ4KM7:TR?= NWXzSVA3W0GQR1XS
TGW NIezSYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTFTWM2OD1{LkO1NFI4KM7:TR?= Mm\tV2FPT0WU
CA46 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYTJR|UxRTJwN{W5Olch|ryP NXeyfXZGW0GQR1XS
NCI-H23 M{HxVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfoOpB[UUN3ME2yMlgxPzlzIN88US=> MW\TRW5ITVJ?
MMAC-SF M1fFWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTJwOE[2Nlgh|ryP MYDTRW5ITVJ?
NCI-H2171 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\4fYl{UUN3ME2zMlA{PDR6IN88US=> M3jQenNCVkeHUh?=
A704 NGXmT2xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIjzZVNKSzVyPUOuNVQyQTRizszN NVTBbZBHW0GQR1XS
DB M1;heWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTNwMkW1O|Yh|ryP M{jSSHNCVkeHUh?=
NCI-H719 NWDNc5Y6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P6cmlEPTB;Mz6zNFM5PCEQvF2= M2TvcnNCVkeHUh?=
MC-CAR NWXYZY1ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnsbZhMUUN3ME2zMlU1QDF5IN88US=> NWLE[o97W0GQR1XS
SIMA NVjrSpp6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fER2lEPTB;Mz61PFQyPiEQvF2= MWHTRW5ITVJ?
SW872 M4\lXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfLPJBKSzVyPUOuO|gyODFizszN MlzrV2FPT0WU
HCC1187 M2LodGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrNTWM2OD1|Lke4N|E2KM7:TR?= MWjTRW5ITVJ?
EW-13 M{D3UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\Re2lEPTB;Mz64N|QyPyEQvF2= NXXibY1DW0GQR1XS
NCI-SNU-1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHfvU2tKSzVyPUSuNlE6QTlizszN MVHTRW5ITVJ?
NCI-H226 NED0VFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTRwM{O2NFYh|ryP NELLPIFUSU6JRWK=
RPMI-8866 M4XqUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LnTWlEPTB;ND6zOlAzQSEQvF2= NGPDOFNUSU6JRWK=
OCI-AML2 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1LVNGlEPTB;ND61OVI{KM7:TR?= NV\OOFJPW0GQR1XS
LU-65 NUHkPXdDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTRwOUOwN|Mh|ryP MmqxV2FPT0WU
SK-N-DZ MlHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfCTWM2OD13Lk[zOFY2KM7:TR?= MnLBV2FPT0WU
NB14 NGjRVFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1TsWGlEPTB;NT65O|E{PSEQvF2= M2rrO3NCVkeHUh?=
COLO-829 NF;Ceo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1znfmlEPTB;Nj6zN|M2QSEQvF2= MXXTRW5ITVJ?
MHH-CALL-2 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTZwNUG1NFgh|ryP MUTTRW5ITVJ?
NCI-H1770 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7MV|dKSzVyPU[uOlY6ODRizszN M2Wwb3NCVkeHUh?=
ECC4 MnXMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPDUpFQUUN3ME22MlgzOTd7IN88US=> MojIV2FPT0WU
A498 NH\mXZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfsTWM2OD14Lki3NVkzKM7:TR?= NY\vTFFFW0GQR1XS
DMS-79 NWfieZhST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVLJSGVrUUN3ME23MlA1PTF{IN88US=> MUHTRW5ITVJ?
P30-OHK MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXPJR|UxRTdwMkG5NFYh|ryP Mnz4V2FPT0WU
D-502MG NILleoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTdwOUizOkDPxE1? NYX1OXA4W0GQR1XS
RCC10RGB MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HZV2lEPTB;OD6wOlI5KM7:TR?= MWXTRW5ITVJ?
U-698-M M4TIUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonLTWM2OD16LkK5NlI3KM7:TR?= MkPTV2FPT0WU
BB49-HNC NEXRc5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTBTWM2OD17LkSyNlY2KM7:TR?= NYDFSplCW0GQR1XS
ES1 NFHLcnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7OcJBpUUN3ME25MlY5QTV4IN88US=> M3vMN3NCVkeHUh?=
MFM-223 Mn3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFH6RZhKSzVyPUGwMlk6OjdizszN MljBV2FPT0WU
C2BBe1 NYjYRm5KT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{SzU2lEPTB;MUGuN|UzOyEQvF2= M3nDXXNCVkeHUh?=
EB2 NUDxemNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTF{Lk[4PFEh|ryP M4W0RnNCVkeHUh?=
C8166 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGXzUHNKSzVyPUGzMlg{ODNizszN NYi4PWFxW0GQR1XS
ES3 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{LIZmlEPTB;MUOuPVk4PyEQvF2= NITSdGFUSU6JRWK=
NCI-H1650 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHkeopLUUN3ME2xOk4{PzZ3IN88US=> MnjGV2FPT0WU
Mo-T NF3HT4VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHTWbHlKSzVyPUG3MlQxOjlizszN NWDPRnpWW0GQR1XS
NB7 NGSwc|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEm2VI9KSzVyPUG3Mlc1PjdizszN MkPpV2FPT0WU
ES7 MmTWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWn2O2tqUUN3ME2xPU42PTB5IN88US=> NIjoNmtUSU6JRWK=
ES5 MoPCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LwdGlEPTB;MkGuO|Y4OSEQvF2= MYXTRW5ITVJ?
MSTO-211H M2LFWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfVTodKSzVyPUKxMlg5PThizszN NFXvZ2ZUSU6JRWK=
U-87-MG MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTJ3LkG5OlYh|ryP M{jDbnNCVkeHUh?=
THP-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUDJR|UxRTJ7LkeyNFEh|ryP M4nXPHNCVkeHUh?=
NB10 NEfjSWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnWTWM2OD1|MD6yOlk1KM7:TR?= MnjqV2FPT0WU
NH-12 MnvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnMTWM2OD1|Mz6yNFE4KM7:TR?= MkXqV2FPT0WU
COLO-824 M4D6PGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnGzTWM2OD1|ND6xNFA3KM7:TR?= MmT0V2FPT0WU
SKM-1 MnP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn\ITWM2OD1|Nz64OFIzKM7:TR?= MVHTRW5ITVJ?
NCI-H1838 NF\mNoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTN6LkO3PVch|ryP M3jxSnNCVkeHUh?=
RL MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHxTWM2OD1|OT6yOFc4KM7:TR?= MWrTRW5ITVJ?
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KG-1 NUjwboFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fMe2lEPTB;NECuPFk2PSEQvF2= NYXnO|EzW0GQR1XS
TUR MmDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVH5NoE4UUN3ME20NU43Ozl7IN88US=> NI\0OVRUSU6JRWK=
LNCaP-Clone-FGC M4[xSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXBTWM2OD12MT65NFE4KM7:TR?= NX76NJVMW0GQR1XS
NCI-H322M NVGxbGRsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX24c3l{UUN3ME20Nk42QTh2IN88US=> NXzKbIRrW0GQR1XS
LNCaP  MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXMS45MUUN3ME25NU4{KG6P MU[yOVUxPTF5NB?=
C4-2 NVXVT4ZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13mcGlEPTB;ODDuUS=> MnLhNlU2ODVzN{S=
JURKAT NUC2Z3RkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYeyOEBp NFzOXHVKSzVyPUSxOk43PiCwTR?= NEe4UVczPDVzOUm5OS=>
MOLT-4 NG[5WHpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWWyOEBp MoPRTWM2OD1{OEWzMlUhdk1? NIfuemMzPDVzOUm5OS=>
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NALM-6 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MljGNlQhcA>? M3nsdGlEPTB;M{SzN|Ahdk1? NHvWeFQzPDVzOUm5OS=>
RS 4;11 NFHjdW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYjOenk3OjRiaB?= MWLJR|UxRTVzOT6wOUBvVQ>? M{PjVFI1PTF7OUm1
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SIL-ALL M332Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGDSSFgzPCCq MUDJR|UxRTF7OT63O{BvVQ>? NYLtZlZ4OjR3MUm5PVU>
CEM NFPOWYhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;MNlQhcA>? M2TwOWlEPTB;NUKuNVghdk1? NX\UcmROOjR3MUm5PVU>
P12 NVzrWllWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWOyOEBp NHX2UoJKSzVyPUO5MlI4KG6P MoPBNlQ2OTl7OUW=
NALM-16 NG\MNpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4jKR|I1KGh? NGG3T25KSzVyPUm2MlI5KG6P MnS5NlQ2OTl7OUW=
JURKAT MojHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUH3UGlpPDhiaB?= NGjF[opKSzVyPUG0Mlg1KG6P MljONlQ2OTl7OUW=
MOLT-4 NGPFNZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUC0PEBp MUPJR|UxRTJ4Lk[gcm0> M2m0b|I1PTF7OUm1
REH MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\VWZI1QCCq NE\V[WlKSzVyPUS0MlcyKG6P MYeyOFUyQTl7NR?=
NALM-6 M1fENWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYG0PEBp MV;JR|UxRTJ|LkK2JI5O M4TNc|I1PTF7OUm1
RS 4;11 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn3GOFghcA>? MVLJR|UxRTF4ND6yPEBvVQ>? M4jwc|I1PTF7OUm1
697 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXjTZVQPDhiaB?= M3jub2lEPTB;M{C1MlMhdk1? MXqyOFUyQTl7NR?=
SIL-ALL Mm\LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVe0PEBp M13lWmlEPTB;N{SuOlIhdk1? M2P1UFI1PTF7OUm1
CEM MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX[0PEBp NHq1VohKSzVyPUK0MlU2KG6P NVnsfYhLOjR3MUm5PVU>
P12 MoXUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV35Z|czPDhiaB?= MlnSTWM2OD1zOD60OkBvVQ>? NVXVU|FrOjR3MUm5PVU>
NALM-16 MkfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVm0PEBp MnfSTWM2OD14Mz6yOEBvVQ>? NG\PVJEzPDVzOUm5OS=>
JURKAT MkXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGTyTJk4OiCq MW\JR|UxRTNwNkWgcm0> NWHGRVdUOjR3MUm5PVU>
MOLT-4 NXq3S4tLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3YO|IhcA>? NHLPcXZKSzVyPUeuN|khdk1? M1\EcVI1PTF7OUm1
REH NH7KPFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrU[FMyPzJiaB?= M1G0fGlEPTB;MU[uNFEhdk1? NVqweWVkOjR3MUm5PVU>
NALM-6 Ml3pS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{HSWlczKGh? MluzTWM2OD1zLke4JI5O MUeyOFUyQTl7NR?=
RS 4;11 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NU\1RnJ6PzJiaB?= Mn\wTWM2OD12LkO4JI5O M3XZflI1PTF7OUm1
697 NUn6b2RzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXtO|IhcA>? MnThTWM2OD15ND6yPEBvVQ>? M4jyTlI1PTF7OUm1
SIL-ALL NUXNNVV1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HVO|czKGh? Ml\UTWM2OD15LkKgcm0> NHH0fIUzPDVzOUm5OS=>
CEM MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVXoeIhJPzJiaB?= NFPvfHhKSzVyPUWuOFIhdk1? NILadmozPDVzOUm5OS=>
P12 M1rtbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPze3Y4OiCq MlTBTWM2OD14LkO3JI5O NHqwc|UzPDVzOUm5OS=>
NALM-16 NXj2OVVST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHOwRlU4OiCq MmrvTWM2OD15Nz63N{BvVQ>? NGO4clkzPDVzOUm5OS=>
Y79 MWTBdI9xfG:|aYOgRZN{[Xl? NVvPTYdvOS13MDDuUS=> NUO3OZZXOTJxMkSgbC=> M1T1cGROW09? M4LrPYlv\HWlZXSgZZBweHSxc3nzJJdpcWOqIHPhckBj\SCnbnjhcoNm\CCkeTDIWC=> NUnZUHBMOjR|Nk[2OlU>
WER-Rb-1 MV\BdI9xfG:|aYOgRZN{[Xl? NWPWbYtlOS13MDDuUS=> NUDXeHV{OTJxMkSgbC=> M{LTXGROW09? NFHpdJhqdmS3Y3XkJIFxd3C2b4Ppd{B4cGmlaDDjZY4h[mViZX7oZY5k\WRiYomgTHQ> NYHRR3hqOjR|Nk[2OlU>
G7 NGjBeolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXX0U457UUN3ME2zMlMhdk1? MV[yOFIxPDd|Mx?=
G166 NHLBXFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTdwMDDuUS=> MV2yOFIxPDd|Mx?=
CB660 NF;icoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYi2PG5CUUN3ME22MlQhdk1? MX[yOFIxPDd|Mx?=
CB1117 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXm4dWJmUUN3ME2xOU43KG6P NX;5fVJDOjR{MES3N|M>
KB-3-1 NIS2S41Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkf2TWM2OD1zLkS4JOKyKDBwNUOgcm0> M{\2SVI{QTZ{NES1
KB-8-5-11 NHr2doFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2m3V2lEPTB;NT6wNUDDuSB{LkCxJI5O MVWyN|k3OjR2NR?=
KB-C-1 NVHmS5N3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmPyTWM2OD1zNj63OkDDuSB2LkWxJI5O M1\QUVI{QTZ{NES1
KB-V-1 NFz0d2NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoX0TWM2OD1{OEGuNlQhyrFiM{GuOVchdk1? NH;MNIwzOzl4MkS0OS=>
OVCAR-8 Mnf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrFXXZzUUN3ME23MlE6KMLzIEOuOlAhdk1? NW[4[ZBqOjN7NkK0OFU>
NCI-ADR-RES MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTF{N{OuN|AhyrFiMUmxMlIxKG6P MkHwNlM6PjJ2NEW=
MCF7 Mm\XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmXVTWM2OD13LkGxJOKyKDFwNEegcm0> NXXmcndXOjN7NkK0OFU>
MCF7-FLV1000 M33WUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWjyeIFIUUN3ME2zPVMvOThiwsGgO|QvQDNibl2= NV22cnZrOjN7NkK0OFU>
S1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MomwTWM2OD1{ND6zNEDDuSB2Lke1JI5O MnfuNlM6PjJ2NEW=
S1-M1-80 M1jVcWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3qwemlEPTB;Mk[xMlA3KMLzIES4MlI2KG6P MViyN|k3OjR2NR?=
CORL-23/P NFTYNINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTRwM{igxtEhOS5{NTDuUS=> M3LCO|I{QTZ{NES1
CORL-23/R NXnHPGo2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\5TWM2OD13LkG2JOKyKDFwOEOgcm0> M4D6[|I{QTZ{NES1
NIH3T3 M3jrV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGr1foNKSzVyPUSwMlYxKMLzIESuPVchdk1? MmHsNlM6PjJ2NEW=
NIH3T3-G185 M4q4bWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTJ2MUOuOFAhyrFiNEKzMlY3KG6P Mk\LNlM6PjJ2NEW=
pcDNA-HEK293 M1vob2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvpPGl3UUN3ME2yMlc2KMLzIECuOlchdk1? MXWyN|k3OjR2NR?=
MDR19-HEK293 M3zxUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvITFBYUUN3ME24OU42OCEEsTCxN{43PyCwTR?= M1vZU|I{QTZ{NES1
R482-HEK293 MmWxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33SOmlEPTB;MkWuPVchyrFiND65OUBvVQ>? NXLRSG45OjN7NkK0OFU>
MRP1-HEK293 NWXS[WVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LmXGlEPTB;Mj65PUDDuSBzLkS5JI5O MV2yN|k3OjR2NR?=
SF188 M3vOZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW[xNE0yODBibl2= NWW5eWF1OjRvOU[gbC=> Mn33SG1UVw>? MmHobY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEB1cW2nLTDhcoQh[2:wY3XueJJifGmxbj2g[IVx\WSnboSgcYFvdmW{ NFPJZVUzOzh6N{[0OS=>
T98G MlHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFjK[G8yOC1zMECgcm0> NHPrT4ozPC17NjDo NWnTe5VlTE2VTx?= M33FUIlvcGmkaYTzJINmdGxiZ4Lve5RpKGmwIHPvcoNmdnS{YYTpc44uKGSncHXk[Y51KG2jbn7ldi=> MkLqNlM5QDd4NEW=
DU145 M{HIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2TON2ROW09? MUHJR|Ux6oj:NkCgcm0> NF3CeHYzOzh6NESyPC=>
LNCaP  NXXVb5ozT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVf5Z5ltTE2VTx?= Ml71TWM2OOLKvEe1JI5O NYW3VZJzOjN6OES0Nlg>
PC3 M3j5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEnSSmtFVVOR MXfJR|Ux6oj:MUe1JI5O MorRNlM5QDR2Mki=
RT4 MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfkTWM2OD1{Nz6yNUBvVQ>? NYPjTnFiOjN5OUK2N|k>
5637 NYDDS4Y5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEHPW3VKSzVyPUS1MlQ4KG6P NVzYeWlFOjN5OUK2N|k>
T24 NYnSbIxiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVe2VodrUUN3ME23PU4yOiCwTR?= M4jablI{Pzl{NkO5
MCF7  NFj5NXJHfW6ldHnvckBCe3OjeR?= MV:xNFAhdk1? MmDXNUBp MlvCSG1UVw>? NGPMOoRz\WS3Y3XzJJRp\SCrbnT1Z5Rqd25ib3dCpGdz\WJzLNMgV4dsOS{EoGDzNkzDqFOncoDpcoE{NCCjbnVCpHdqe3B{ NW\LbYp{OjN5N{CyOFQ>
KB-V1  NGXGbm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVjVfIhLUUN3ME2zMlkzKM7:TR?= NVu5flVrOjN3OUOxPVY>
Hec50co MojLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHyzWG9KSzVyPUWgcm0> M1jDPVI{OTR4Nki3
MDA-MB-468 MornRZBweHSxc3nzJGF{e2G7 Ml;ENU82NzFyIH7N M3nuVFI1NzR6L{eyJIg> NXrhPWJ6TE2VTx?= MUTpcoR2[2W|IHHwc5B1d3OrczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= Ml;BNlMyPDR{OUS=
MCF10A M3O1XWFxd3C2b4Ppd{BCe3OjeR?= NYfWSGRKOS93L{GwJI5O NV7jfZBoOjRxNEivO|IhcA>? NXX1OYpTTE2VTx?= NIHuUmVqdmS3Y3XzJIFxd3C2b4Ppd{BqdiCjIHTvd4Uu\GWyZX7k[Y51KG2jbn7ldi=> MVmyN|E1PDJ7NB?=
Huh-7 NVfTd|Z1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;EdlEwOTBxMUCwM|ExODBibl2= NGntT2g1QCCq Ml;s[IVkemWjc3XzJJRp\SClZXzsJJZq[WKrbHn0fUBld3OnLXTldIVv\GWwdHz5 NGHUSIUzOjd2NUW4Oy=>
Daoy  MnnGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXflWmtrOS56N{WtNlQxKG6P M4TsZ|czKGh? M2PxbWROW09? NFLmR4ZKSzVyPUWgcm0> NUG5cWhXOjJ|OUCyO|k>
ONS-76 NEfjOZNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnHcWhXOS56N{WtNlQxKG6P NWTD[|loPzJiaB?= MonWSG1UVw>? M{j1U2lEPTB;Nz61JI5O MXGyNlM6ODJ5OR?=
SUM 149 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1K1fVAuOTByIH7N NFj4cJo4OiCq MlPpbY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy MXuyNlMxQTl|OR?=
MDA-MB-231 MmjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWCybm9rOC1zMECgcm0> NInJOXA4OiCq MoTubY5pcWKrdIOgeIhmKGOnbHygeoli[mmuaYT5JIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnHy MWGyNlMxQTl|OR?=
HR5 M{X6c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYDyTpA5OC1zMECgcm0> M3\NTFczKGh? MYjpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= NXTWTpBKOjJ|MEm5N|k>
BT-474-M1 NHH3XmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;4cnRyOC1zMECgcm0> M{fKW|czKGh? MVTpcohq[mm2czD0bIUh[2WubDD2bYFjcWyrdImgbY4h[SCmb4PlMYRmeGWwZHXueEBu[W6wYYK= NEXOPYgzOjNyOUmzPS=>
AU565 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUOwMVExOCCwTR?= NY\Q[4ZSPzJiaB?= NW\xVJl2cW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz NFf4c3czOjNyOUmzPS=>
T47D MmDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWWwMVExOCCwTR?= NGr6O|g4OiCq NHHWeotqdmirYnn0d{B1cGViY3XscEB3cWGkaXzpeJkhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7uZZI> M3TJeVIzOzB7OUO5
MCF7 Mo\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoHYNE0yODBibl2= MojFO|IhcA>? NX:5[5lLcW6qaXLpeJMhfGinIHPlcIwhfmmjYnnsbZR6KGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoFz NYHQTJlZOjJ|MEm5N|k>
HCT116p53(+/+) NH3NdXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlHxNVAuOTByMDDuUS=> Mk\1NlQwPDhiaB?= M{DsZYlvcGmkaYTzJINmdGxicILvcIln\XKjdHnvckBkd22ybHX0[Yx6KGG2IEK1JI5O NXrUboc5OjJ{NkKxO|E>
HCT116p53(-/-) Mon6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnFW3BIOTBvMUCwNEBvVQ>? MV6yOE81QCCq MYHpcohq[mm2czDj[YxtKHC{b3zp[oVz[XSrb36gZ49ueGyndHXsfUBifCB{NTDuUS=> MYGyNlI3OjF5MR?=
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GB-CL-1 NF7pdmZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHZcHk{PzJiaB?= MWHJR|UxRTVwMkKgcm0> MUiyNVk3PTd|OR?=
Mz-ChA-2 NWrl[Ws3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnLN5IzPzJiaB?= NGnsbWlKSzVyPUOuN|Ehdk1? MYWyNVk3PTd|OR?=
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... Click to View More Cell Line Experimental Data

In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
+ Expand
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water <1 mg/mL
In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 15mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID