BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 670 In stock
USD 997 In stock

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Cited by 52 Publications

10 Customer Reviews

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

    Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

  • J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

    Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

Purity & Quality Control

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
PI3Kα [1]
(Cell-free assay)
Met [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM 2.407 μM 4.754 μM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 NH[0SW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nlcWlEPTB;MD6wNFc4PiEQvF2= M3r4RXNCVkeHUh?=
ACN NIG3O|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13rTmlEPTB;MD6wNFg1OyEQvF2= MUDTRW5ITVJ?
TE-8 M1LZZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMEC5OFEh|ryP MkXKV2FPT0WU
LC-2-ad M1\Cfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWC4bW5OUUN3ME2wMlAyODl|IN88US=> NUP3U29vW0GQR1XS
ALL-PO Mo\qS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mo\lTWM2OD1yLkCxN{DPxE1? M2PN[HNCVkeHUh?=
EW-16 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwMEGzN|Yh|ryP MkHWV2FPT0WU
KM12 NF;neWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrHTWM2OD1yLkCxN|Q5KM7:TR?= M4e4b3NCVkeHUh?=
GI-1 MoXwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUfLV4tGUUN3ME2wMlAyOzh|IN88US=> M1TsNnNCVkeHUh?=
LS-411N NY\kdHpHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\WeGlEPTB;MD6wNVQxPyEQvF2= MYjTRW5ITVJ?
ES8 NEPjUoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXzJR|UxRTBwMEG0PVQh|ryP NGfBZY1USU6JRWK=
SNU-C2B Mli5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4fUSmlEPTB;MD6wNVUzPiEQvF2= NXzBOot{W0GQR1XS
CESS MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjzSFJjUUN3ME2wMlAyPjB{IN88US=> M2HQSXNCVkeHUh?=
697 NWn1fWZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVHWWmZsUUN3ME2wMlAyPjZ6IN88US=> NEm0OldUSU6JRWK=
NCI-H1963 M3rWbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMEG2O|Mh|ryP NHfLSZlUSU6JRWK=
IA-LM MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3[xXWlEPTB;MD6wNVY5QCEQvF2= MmnBV2FPT0WU
SW954 NYfFPVlHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HkeGlEPTB;MD6wNVcxPSEQvF2= MW\TRW5ITVJ?
RL95-2 NHTuboVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjBU3ZKSzVyPUCuNFE4OzhizszN Mlr2V2FPT0WU
LXF-289 MlvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGiyWmhKSzVyPUCuNFE4PyEQvF2= NUXQdHM3W0GQR1XS
OCUB-M NHHq[45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIfueFdKSzVyPUCuNFE5OjZizszN NUDvV2U{W0GQR1XS
RKO MlTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjCXG5KSzVyPUCuNFE6QDdizszN NGHqfHFUSU6JRWK=
LOUCY MkDQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHmTWM2OD1yLkCyNFUh|ryP MVPTRW5ITVJ?
NOS-1 NI\NVXdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRTBwMEKwPVMh|ryP NELBUm1USU6JRWK=
A4-Fuk NI\yZ45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVy2OmJQUUN3ME2wMlAzOjF6IN88US=> MVTTRW5ITVJ?
A388 NXzqS|k1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFLNXmhKSzVyPUCuNFIzOjdizszN NGHW[pZUSU6JRWK=
TE-9 NEnJO2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV\JR|UxRTBwMEKyOlEh|ryP M{nzSXNCVkeHUh?=
KURAMOCHI MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1P6OmlEPTB;MD6wNlI5PSEQvF2= MUPTRW5ITVJ?
KALS-1 MlPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnLTWM2OD1yLkCyN|M5KM7:TR?= M4TXOnNCVkeHUh?=
HOP-62 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXvJR|UxRTBwMEK0NkDPxE1? MWnTRW5ITVJ?
RPMI-8402 NGjVeHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEK1NFgh|ryP MVPTRW5ITVJ?
TE-1 NFHrc4pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\xTWM2OD1yLkCyOVEzKM7:TR?= Moq5V2FPT0WU
CCRF-CEM MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEHqSWtKSzVyPUCuNFI2PDNizszN M36wWnNCVkeHUh?=
HUTU-80 M1TSbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvpTWM2OD1yLkCyOlI1KM7:TR?= Ml:yV2FPT0WU
NCI-H1648 M3fUNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XESmlEPTB;MD6wNlY1PyEQvF2= M160V3NCVkeHUh?=
HCE-4 M171WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVjJR|UxRTBwMEK2PFIh|ryP Mn;ZV2FPT0WU
ETK-1 NXvTcpdmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3;Cb2lEPTB;MD6wNlc{PiEQvF2= NHnzTHdUSU6JRWK=
TE-15 NH[4XIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXLNZlFxUUN3ME2wMlAzPzN6IN88US=> NX\yRWxLW0GQR1XS
BE-13 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXPxcGZOUUN3ME2wMlAzPzRizszN NYL6cHVFW0GQR1XS
KE-37 NVzjTngyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFu3dZpKSzVyPUCuNFI4PDFizszN NFry[FhUSU6JRWK=
NCI-H1355 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTBwMEK3PFMh|ryP MnfaV2FPT0WU
TE-11 Mle4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXTJR|UxRTBwMEK4NFkh|ryP NUPT[pNEW0GQR1XS
BL-70 MnfvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3zBbGlEPTB;MD6wNlg2PyEQvF2= Mn;aV2FPT0WU
ES6 Mo[3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nzWWlEPTB;MD6wNlg5OSEQvF2= NYHoPXl2W0GQR1XS
GT3TKB MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF3kOnRKSzVyPUCuNFI6PTNizszN M2XhUnNCVkeHUh?=
LB647-SCLC M3fmTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3LJcGlEPTB;MD6wN|E6PSEQvF2= M2\4bHNCVkeHUh?=
NB13 NYXZWYx1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\ITWM2OD1yLkCzN|E3KM7:TR?= NFXre2tUSU6JRWK=
ST486 NVK1dW5WT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYXS[olWUUN3ME2wMlA{OzN5IN88US=> M{n1WnNCVkeHUh?=
NCI-H82 M3K5Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIX5eZFKSzVyPUCuNFM{PDNizszN NIn5VZpUSU6JRWK=
NTERA-S-cl-D1 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzHd|lOUUN3ME2wMlA{Ozl7IN88US=> NVK1WI42W0GQR1XS
ES4 NFPiTnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoS1TWM2OD1yLkCzOFY{KM7:TR?= NY[5UIZoW0GQR1XS
SK-NEP-1 NUnyW2lrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG2RldKSzVyPUCuNFM1QTlizszN MlS5V2FPT0WU
Becker NH7aVJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMEO1OVUh|ryP MV7TRW5ITVJ?
A101D NGLX[2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXPJR|UxRTBwMEO3OFgh|ryP NVXVSm9IW0GQR1XS
SK-UT-1 NGHESmFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUfJR|UxRTBwMEO3O|Qh|ryP MkLpV2FPT0WU
SW982 M2rLN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmH1TWM2OD1yLkCzO|kh|ryP NWfwVphKW0GQR1XS
TE-10 Mk\zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2\tNWlEPTB;MD6wOFA1PiEQvF2= MlyzV2FPT0WU
OVCAR-4 MmTDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGfqSm1KSzVyPUCuNFQxPTlizszN MUfTRW5ITVJ?
KP-N-YS NHfwUFlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMESwPFUh|ryP MlTJV2FPT0WU
BL-41 MlHkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMESxNlUh|ryP MXHTRW5ITVJ?
MZ1-PC MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYHzSYVKUUN3ME2wMlA1OTJ5IN88US=> Mmf3V2FPT0WU
PF-382 M4\LSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMESxPVgh|ryP NUH5VZp6W0GQR1XS
MOLT-13 Mnj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2PZdWlEPTB;MD6wOFI{QCEQvF2= M{PLT3NCVkeHUh?=
HCC1599 MoqwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nJZ2lEPTB;MD6wOFI2QCEQvF2= NWjZ[FFDW0GQR1XS
IST-MEL1 NVPHNmtuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFHiXINKSzVyPUCuNFQ1PDJizszN NYXKXFBGW0GQR1XS
LU-139 MlLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MofXTWM2OD1yLkC0OFQzKM7:TR?= MmjTV2FPT0WU
MS-1 MmfNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT6[WxKSzVyPUCuNFQ4ODFizszN M1rCVHNCVkeHUh?=
MFH-ino NX;ucFJYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHkU5FKSzVyPUCuNFUxODNizszN NF\oUHNUSU6JRWK=
IMR-5 M1uySGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVzJR|UxRTBwMEWwNlEh|ryP M1m5enNCVkeHUh?=
TE-5 NFXXZY5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\2SWlEPTB;MD6wOVA3OyEQvF2= NWHIVXcxW0GQR1XS
DJM-1 M3z5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4mz[GlEPTB;MD6wOVE1OiEQvF2= NGi0dHlUSU6JRWK=
NB17 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGHHU5RKSzVyPUCuNFUzODdizszN M2PJUHNCVkeHUh?=
KARPAS-45 M2PXdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDYTWM2OD1yLkC1N|U5KM7:TR?= MU\TRW5ITVJ?
TGBC1TKB MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\uTWM2OD1yLkC1OFA2KM7:TR?= MlXrV2FPT0WU
ML-2 NWW5[2J3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwMEW0NVQh|ryP NXfkTJByW0GQR1XS
no-10 M33xemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWTJR|UxRTBwMEW0O|Qh|ryP MnHjV2FPT0WU
CTV-1 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUnJR|UxRTBwMEW1NFIh|ryP M3;leXNCVkeHUh?=
SJSA-1 NIr0WmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnkdZN7UUN3ME2wMlA2PTJizszN NELLN5VUSU6JRWK=
HC-1 M1SzXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1\tbGlEPTB;MD6wOVU6PyEQvF2= NHP4bHRUSU6JRWK=
TE-12 NVjhcItpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGC3dGpKSzVyPUCuNFU3OTNizszN NHnWcpBUSU6JRWK=
KY821 NXH5OnJ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHPTWM2OD1yLkC1OlMzKM7:TR?= NXLCcnNwW0GQR1XS
TALL-1 Mo\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2KyPGlEPTB;MD6wOVcxQCEQvF2= M3jVTHNCVkeHUh?=
DEL NGH4WI1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGC5UmRKSzVyPUCuNFU4ODlizszN NIjTcXNUSU6JRWK=
TE-6 NV7UVJhUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3Dd5VKSzVyPUCuNFU4OjJizszN NW[zOYNoW0GQR1XS
SK-LMS-1 NYXwUWhET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnjyTWM2OD1yLkC1PFA2KM7:TR?= M{eyOHNCVkeHUh?=
EW-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXLXUZJVUUN3ME2wMlA2QDN5IN88US=> NFfLZlVUSU6JRWK=
8-MG-BA MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1vkWmlEPTB;MD6wOVg2OSEQvF2= M2C1WnNCVkeHUh?=
NALM-6 M{jE[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEW5O|Mh|ryP MYnTRW5ITVJ?
LB771-HNC NUThNnhZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTBwMEW5O|kh|ryP MoP2V2FPT0WU
HT-144 M3nhTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPue49YUUN3ME2wMlA3OTNizszN MX;TRW5ITVJ?
KM-H2 MnXpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHWVlVKSzVyPUCuNFYzOjFizszN NHqxZpZUSU6JRWK=
SF268 NI\sendIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX7tSpM5UUN3ME2wMlA3Ojh4IN88US=> M1;aSHNCVkeHUh?=
RS4-11 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTBwME[zNFQh|ryP M4q3fnNCVkeHUh?=
MHH-PREB-1 NY\J[lczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzaTWM2OD1yLkC2N|E6KM7:TR?= M4Hk[HNCVkeHUh?=
ATN-1 M{nIR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwME[zOFUh|ryP MkPRV2FPT0WU
BB30-HNC NETPPGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHf1OHdKSzVyPUCuNFY1OzZizszN MXvTRW5ITVJ?
CPC-N Mn;uS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm\qTWM2OD1yLkC2OVI1KM7:TR?= M1\OOnNCVkeHUh?=
NB1 NWPlZnJVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLyXnFKSzVyPUCuNFY3OTNizszN NXTxdllpW0GQR1XS
KS-1 NYLWdVhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwME[3OFgh|ryP MXvTRW5ITVJ?
RXF393 M3n5bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwME[3OlQh|ryP MV7TRW5ITVJ?
IST-SL2 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NEfXXmdKSzVyPUCuNFcxODRizszN MUnTRW5ITVJ?
GI-ME-N MnfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfDTpBKSzVyPUCuNFczQDZizszN M{D5NXNCVkeHUh?=
VA-ES-BJ NWXpWVBJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInRWoZKSzVyPUCuNFc1PzVizszN MU\TRW5ITVJ?
NCI-H1581 NEDLRYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnfwTWM2OD1yLkC3OFc5KM7:TR?= Mk[zV2FPT0WU
U-266 NWHQUJdZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7pTWM2OD1yLkC3OFk4KM7:TR?= MWTTRW5ITVJ?
DMS-114 M1fUXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnLclVKSzVyPUCuNFc2OjhizszN MYrTRW5ITVJ?
NCI-H187 NGDQUJFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT0TWM2OD1yLkC3O|I3KM7:TR?= MX3TRW5ITVJ?
SW962 NFnuZo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnHITWM2OD1yLkC3PFM6KM7:TR?= MWLTRW5ITVJ?
MONO-MAC-6 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHjIPWdKSzVyPUCuNFc6QDZizszN NUfSUVJGW0GQR1XS
MOLT-16 NWfjbHluT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUL0bFlvUUN3ME2wMlA5OTJzIN88US=> MUHTRW5ITVJ?
KNS-42 M4O4T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LQPWlEPTB;MD6wPFE3OSEQvF2= NHi3SopUSU6JRWK=
CMK NG\aT2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{LEXmlEPTB;MD6wPFIzPSEQvF2= M2TyVnNCVkeHUh?=
Ramos-2G6-4C10 NHL2VWNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVfJR|UxRTBwMEiyNlUh|ryP MlL3V2FPT0WU
Daudi M3nkemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXL4N5I1UUN3ME2wMlA5OjV4IN88US=> MlL0V2FPT0WU
NCI-H510A MnfhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFTQUIZKSzVyPUCuNFg{OzZizszN MXXTRW5ITVJ?
LB831-BLC NVTKeWlCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEi1OlEh|ryP NWrLWJR[W0GQR1XS
HEL NIPoTplIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWXJR|UxRTBwMEi2Olgh|ryP NH\ze3ZUSU6JRWK=
LU-134-A MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PR[2lEPTB;MD6wPFcxQCEQvF2= MoPDV2FPT0WU
NCI-H1694 M1n2eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3PSYFKSzVyPUCuNFg4PDRizszN MYXTRW5ITVJ?
KGN NYr4T2VIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nvcWlEPTB;MD6wPFc2QSEQvF2= NYjXfnhRW0GQR1XS
A253 M3LpPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLZTWM2OD1yLkC4PFIzKM7:TR?= MUHTRW5ITVJ?
DG-75 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTBwMEi5NlIh|ryP MVzTRW5ITVJ?
MOLT-4 M1HnZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXXJR|UxRTBwMEi5PFMh|ryP MYrTRW5ITVJ?
NCI-SNU-5 Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHpWHZKSzVyPUCuNFkzPThizszN MV3TRW5ITVJ?
ONS-76 NXrSZ5ZXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnmTVJPUUN3ME2wMlA6Ojd4IN88US=> NYSwXZVEW0GQR1XS
NCI-H446 M2S1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Ppb2lEPTB;MD6wPVQ3OiEQvF2= MV;TRW5ITVJ?
COR-L279 NXy5eYpoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGi0bG5KSzVyPUCuNFk2PTZizszN Mk\4V2FPT0WU
Calu-6 NFvjSYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[xdY5KSzVyPUCuNFk2QThizszN M1i0c3NCVkeHUh?=
BC-3 NXuzN4Z3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMEm2OlIh|ryP NV2wcZpNW0GQR1XS
NCI-H2126 NF;jN3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXP6WGkxUUN3ME2wMlA6PzlzIN88US=> MnfnV2FPT0WU
NCI-H1882 NYrP[2hxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXzHPWgzUUN3ME2wMlA6QDB7IN88US=> NIPxNFFUSU6JRWK=
BB65-RCC NXnvUlJHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjlb4pSUUN3ME2wMlExOjl2IN88US=> M{\Sb3NCVkeHUh?=
DU-4475 MkfKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTBwMUC0NFch|ryP NYnPZolYW0GQR1XS
NCI-H526 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2HQZWlEPTB;MD6xNFQ1KM7:TR?= M4LUUnNCVkeHUh?=
NEC8 Mmf3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILqeJdKSzVyPUCuNVA2OjVizszN MWTTRW5ITVJ?
NCI-H1304 Mn:zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTqTWM2OD1yLkGwOVk1KM7:TR?= MYHTRW5ITVJ?
L-540 M2jH[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMUC3NFgh|ryP M3OzVXNCVkeHUh?=
NCI-SNU-16 NYjnc2pRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTVZZM3UUN3ME2wMlExPzR{IN88US=> MUDTRW5ITVJ?
HD-MY-Z NX7IfI1YT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXITWM2OD1yLkGwPFU3KM7:TR?= NW\GXpUzW0GQR1XS
K-562 MlX3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLBTWM2OD1yLkGwPFU5KM7:TR?= MYrTRW5ITVJ?
JAR M4DWT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3yN2xKSzVyPUCuNVA6OjVizszN NFHHUFJUSU6JRWK=
MZ2-MEL MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfiTWM2OD1yLkGxNFUh|ryP MXLTRW5ITVJ?
L-363 M37UeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMUGwO|kh|ryP MXvTRW5ITVJ?
BV-173 Mn;iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoW2TWM2OD1yLkGxNlQ{KM7:TR?= M2ruU3NCVkeHUh?=
NCI-H524 MojmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGPt[GxKSzVyPUCuNVEzPzRizszN MVrTRW5ITVJ?
EoL-1-cell NF3Vc25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXxTWM2OD1yLkGxOlczKM7:TR?= M2fuR3NCVkeHUh?=
K052 NEjLS5pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmjpTWM2OD1yLkGxO|EzKM7:TR?= NV\mT45zW0GQR1XS
TK10 M4O0b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMUG3Nlgh|ryP NYjmWWdjW0GQR1XS
KU812 NXL1d|BwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3[zOmlEPTB;MD6xNlA1PCEQvF2= NWjNemlvW0GQR1XS
RPMI-8226 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPRbHZQUUN3ME2wMlEzODV{IN88US=> MULTRW5ITVJ?
MZ7-mel NVLBV4N4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zwOWlEPTB;MD6xNlI{PyEQvF2= M36xOHNCVkeHUh?=
SK-PN-DW M1zqN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHnIXllKSzVyPUCuNVIzQDdizszN MWfTRW5ITVJ?
SR MkPBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmO4TWM2OD1yLkGyOFQyKM7:TR?= NGfzXXJUSU6JRWK=
RPMI-6666 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTBwMUK3OFMh|ryP NXvXW|NIW0GQR1XS
no-11 NWLweHNFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXGTWM2OD1yLkGyPFY6KM7:TR?= NWHDN4RJW0GQR1XS
EW-3 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjJeWFXUUN3ME2wMlEzQDl|IN88US=> M1XGU3NCVkeHUh?=
LAMA-84 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIi3UWdKSzVyPUCuNVMyQDdizszN NUfXVI9xW0GQR1XS
HT MnftS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\UTWM2OD1yLkGzOVc1KM7:TR?= M1PZU3NCVkeHUh?=
KP-N-RT-BM-1 Mle5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4C1c2lEPTB;MD6xN|YyOiEQvF2= M4GyTHNCVkeHUh?=
NCI-H747 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUDVSZdMUUN3ME2wMlE{PyEQvF2= MmXWV2FPT0WU
NCCIT NGGwXYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoS0TWM2OD1yLkGzPVM6KM7:TR?= NH;HS3VUSU6JRWK=
MLMA M1TjT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rYSGlEPTB;MD6xOFE3PyEQvF2= M{fuTXNCVkeHUh?=
LP-1 M{jVe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HVU2lEPTB;MD6xOFI1KM7:TR?= Ml\hV2FPT0WU
CAL-148 NYPCTnZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH6zRYxKSzVyPUCuNVQ1QDNizszN Mn6zV2FPT0WU
GB-1 NIrRRoxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHKTWM2OD1yLkG0OVI3KM7:TR?= NV7nfpc5W0GQR1XS
COR-L88 MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HEZWlEPTB;MD6xOFgxOiEQvF2= NVq4bJpTW0GQR1XS
NKM-1 M3LobGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1f6U2lEPTB;MD6xOFkxPiEQvF2= M2LaW3NCVkeHUh?=
NB5 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHLSFRKSzVyPUCuNVU1PjJizszN M4HlXnNCVkeHUh?=
SH-4 MmX5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{m2bWlEPTB;MD6xOVQ3PiEQvF2= MUfTRW5ITVJ?
EM-2 NHzvTZZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTBwMUW0Olch|ryP MXjTRW5ITVJ?
TGBC24TKB Mor4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwMUW2OVkh|ryP MWDTRW5ITVJ?
SCLC-21H NHLScJlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknSTWM2OD1yLkG1O|AzKM7:TR?= NWHhPYdvW0GQR1XS
COLO-684 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYPOWFhMUUN3ME2wMlE2PzJzIN88US=> M4XEN3NCVkeHUh?=
KINGS-1 MnvyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVjJR|UxRTBwMUW5NUDPxE1? MV7TRW5ITVJ?
LS-123 MmnZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1PZeWlEPTB;MD6xOVkyPyEQvF2= NYrH[253W0GQR1XS
MC116 NGO3dIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NILTd2JKSzVyPUCuNVYyPThizszN MlXCV2FPT0WU
SU-DHL-1 MnPOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUD0dFRKUUN3ME2wMlE3OjB4IN88US=> MmDWV2FPT0WU
NCI-H64 NF\UcnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HmbmlEPTB;MD6xOlM1PyEQvF2= M1TpU3NCVkeHUh?=
HCE-T Mlr3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW[5XGZNUUN3ME2wMlE3PTB2IN88US=> NXm3d2pFW0GQR1XS
LOXIMVI MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDzTWM2OD1yLkG2PVQ6KM7:TR?= NVnmR2hJW0GQR1XS
ARH-77 NGrPV4tIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoK5TWM2OD1yLkG3N|c6KM7:TR?= NWjpU2txW0GQR1XS
DOHH-2 MnHiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVq1cWplUUN3ME2wMlE4Pjd{IN88US=> M2LYfnNCVkeHUh?=
COLO-320-HSR NYrDSHZVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF23SHBKSzVyPUCuNVgyPTRizszN M{j4NnNCVkeHUh?=
NB6 M4fQNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMUi1OlYh|ryP NEjVdlRUSU6JRWK=
L-428 NV\VXpNST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWfpVGFKUUN3ME2wMlE5QDF|IN88US=> NUPSS2l5W0GQR1XS
SNB75 MojWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVnJR|UxRTBwMUi4NlQh|ryP NVrTOGhHW0GQR1XS
NCI-H2141 NETrO2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn5TWM2OD1yLkG5NFEyKM7:TR?= MWfTRW5ITVJ?
KARPAS-299 NVfGcnpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVG2O4J5UUN3ME2wMlE6OjRzIN88US=> MXjTRW5ITVJ?
LC4-1 MkHqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIfGWFRKSzVyPUCuNVk2ODJizszN M13QSnNCVkeHUh?=
UACC-257 M{f3U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMUm5OFch|ryP MVTTRW5ITVJ?
EVSA-T NUDBcXdlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkPXTWM2OD1yLkKwN|EzKM7:TR?= NH[4UpNUSU6JRWK=
JiyoyeP-2003 NUG0dG9ZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPvTWM2OD1yLkKwOFc4KM7:TR?= MYTTRW5ITVJ?
NCI-H720 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVTkWFNGUUN3ME2wMlIxPTJ3IN88US=> M1HBfHNCVkeHUh?=
GAK NU[zeHNxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Moi4TWM2OD1yLkKxNVg6KM7:TR?= NIjoWY1USU6JRWK=
HH NF36WoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfLS3FKSzVyPUCuNlE1ODVizszN MXjTRW5ITVJ?
NCI-H1436 M2DuV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DrN2lEPTB;MD6yNVQ3PCEQvF2= MoexV2FPT0WU
GR-ST NHXy[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nIOGlEPTB;MD6yNVQ5QCEQvF2= NXXORVd1W0GQR1XS
BC-1 NFzRUHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NU\2NWlZUUN3ME2wMlIzPjF4IN88US=> NFPpfFRUSU6JRWK=
SIG-M5 MoqxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LCTWlEPTB;MD6yNlczPyEQvF2= MmLsV2FPT0WU
NCI-H345 NYS2VYNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX35UZpPUUN3ME2wMlI{QDB3IN88US=> M{P2dHNCVkeHUh?=
OPM-2 MkOzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1[xWWlEPTB;MD6yN|g5OiEQvF2= NH\5enhUSU6JRWK=
LB1047-RCC M2nzbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TyPWlEPTB;MD6yOFQyKM7:TR?= NUHafpgxW0GQR1XS
CTB-1 MnKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMkS0PVMh|ryP NUTsWXMxW0GQR1XS
A3-KAW MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLFW2xxUUN3ME2wMlI2OzRzIN88US=> MnS5V2FPT0WU
SF126 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTBwMkWzPFMh|ryP MYPTRW5ITVJ?
KARPAS-422 NGLicI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\SdGlEPTB;MD6yOVQ{PSEQvF2= NGDZUVdUSU6JRWK=
MEG-01 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGf0NWtKSzVyPUCuNlU3PzNizszN MX;TRW5ITVJ?
NCI-H209 M4PwWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUXJR|UxRTBwMk[zO|Qh|ryP NFvXRWlUSU6JRWK=
SBC-1 NWK3VlRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3P[WVKSzVyPUCuNlY2KM7:TR?= M{ftbnNCVkeHUh?=
K5 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV;JR|UxRTBwMk[5PFQh|ryP NVHXSW1iW0GQR1XS
QIMR-WIL NWPnSGhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2LncWlEPTB;MD6yO|E2PSEQvF2= MlzPV2FPT0WU
NMC-G1 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHvTWM2OD1yLkK4NlE4KM7:TR?= NIiwNW1USU6JRWK=
IST-MES1 MmTXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMkmyN|gh|ryP NHHMRZRUSU6JRWK=
SW684 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHPMZmVKSzVyPUCuN|AxPDdizszN MnHjV2FPT0WU
MV-4-11 NHLSWopIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwM{C3PFgh|ryP NUPiXnVMW0GQR1XS
LAN-6 MmLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTiXXAzUUN3ME2wMlMyPTd{IN88US=> NF;ZW5JUSU6JRWK=
RH-1 M371UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\u[lFpUUN3ME2wMlMyQDdzIN88US=> NFq3c4tUSU6JRWK=
CP66-MEL NGO1SG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYf5Z3VVUUN3ME2wMlMyQDd6IN88US=> MkDZV2FPT0WU
EC-GI-10 MlT2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXxdHYyUUN3ME2wMlMzQTh5IN88US=> NF34U3NUSU6JRWK=
GDM-1 NXvhbop7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwM{OwOVkh|ryP NVTsfVA4W0GQR1XS
IST-SL1 M1PGd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXRTWM2OD1yLkO0PVE1KM7:TR?= MmX2V2FPT0WU
KMOE-2 NEnScnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVLYcpZJUUN3ME2wMlM2OTd3IN88US=> M1nqNXNCVkeHUh?=
OS-RC-2 NWfsRlVDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mkm2TWM2OD1yLkO1OVQ1KM7:TR?= NYjTe4tNW0GQR1XS
HDLM-2 MmjVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEjQcW1KSzVyPUCuN|c5OTRizszN NXrwTG14W0GQR1XS
DSH1 NEnkbVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[2ZmlEPTB;MD6zPFY{OSEQvF2= MUnTRW5ITVJ?
LS-1034 NVL6TZd6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWLJR|UxRTBwM{i5OVQh|ryP MU\TRW5ITVJ?
LB373-MEL-D NIrVUppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYrUZXljUUN3ME2wMlM6OTl5IN88US=> MUPTRW5ITVJ?
GOTO MlG4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDLZ49OUUN3ME2wMlQzOTF6IN88US=> NXXTZYJuW0GQR1XS
MRK-nu-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwNEKyNFUh|ryP MWHTRW5ITVJ?
SK-MM-2 NGPhTolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr2VW9KSzVyPUCuOFM1PDJizszN M3ntfXNCVkeHUh?=
BOKU MoPES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWPJR|UxRTBwNEO3PVIh|ryP MUnTRW5ITVJ?
NOMO-1 MkXrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnVTWM2OD1yLkSzPFYh|ryP NFi2TZNUSU6JRWK=
J-RT3-T3-5 NFG5dWJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3NZ2pIUUN3ME2wMlQ1QDd6IN88US=> Ml7nV2FPT0WU
COLO-668 NFjKcFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHYTWM2OD1yLkS1OlY5KM7:TR?= NWPnXGpjW0GQR1XS
SF539 NWi5UWlYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7GfZlKSzVyPUCuOFg3QDRizszN M3TsXXNCVkeHUh?=
LB2518-MEL M3GzOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\LNGlEPTB;MD60PVcxOyEQvF2= NELGPGpUSU6JRWK=
TE-441-T MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYDaSVg4UUN3ME2wMlUxOTJizszN M4iwNnNCVkeHUh?=
MDA-MB-134-VI NYXJenVkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mni2TWM2OD1yLkWwPVIyKM7:TR?= Mn7qV2FPT0WU
SCC-3 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrqTWM2OD1yLkWxPFc{KM7:TR?= MXjTRW5ITVJ?
KLE MoPJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MorOTWM2OD1yLkWyNVcyKM7:TR?= MYjTRW5ITVJ?
LB2241-RCC NWnmV|BlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGK4UYVKSzVyPUCuOVI2OjVizszN NHj0eY5USU6JRWK=
NCI-H1417 MnzLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXfJR|UxRTBwNUO0N|Uh|ryP NGj2S5JUSU6JRWK=
NCI-H2081 NFfiTm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoLRTWM2OD1yLkW4OlEyKM7:TR?= MYXTRW5ITVJ?
NCI-H1522 NU[4OmlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXDTWM2OD1yLkW5N|g{KM7:TR?= NXewdWVEW0GQR1XS
NCI-H889 M3rQSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\SXIZKSzVyPUCuOVk5PDRizszN NYnnRmVrW0GQR1XS
CGTH-W-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\sfmlEPTB;MD62NFc2PSEQvF2= NH32Z4pUSU6JRWK=
EB-3 NH7XSHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXHJR|UxRTBwNkGxOVMh|ryP M1XPV3NCVkeHUh?=
D-336MG M{\afmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIiweIZKSzVyPUCuOlE4QTFizszN MUPTRW5ITVJ?
LC-1F MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWm1OVF5UUN3ME2wMlYzPTl{IN88US=> NV\lVmxDW0GQR1XS
MHH-NB-11 NGrjVnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrxTWM2OD1yLk[zPFAyKM7:TR?= NHv2N2hUSU6JRWK=
SK-N-FI NGrPZXRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYnJR|UxRTBwNkO5NUDPxE1? MUnTRW5ITVJ?
NCI-H69 NUm1RXZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2jNT2lEPTB;MD62OFg4QSEQvF2= NFHscXJUSU6JRWK=
SCH Mny5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmizTWM2OD1yLk[2NFI{KM7:TR?= MVjTRW5ITVJ?
LS-513 M4\YUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnjnTWM2OD1yLk[3NlU6KM7:TR?= M2fGe3NCVkeHUh?=
CP67-MEL NHm5d49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYP0fXJQUUN3ME2wMlY4PTl4IN88US=> NVSyOo1XW0GQR1XS
GCIY MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2TzTWlEPTB;MD63NFM3OyEQvF2= MV7TRW5ITVJ?
SHP-77 M3Tl[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{nm[GlEPTB;MD63NFc{PCEQvF2= MY\TRW5ITVJ?
EHEB MkjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jYfGlEPTB;MD63NVg2PCEQvF2= MVXTRW5ITVJ?
D-247MG MmjOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwN{OyN|Ih|ryP MkX0V2FPT0WU
Raji MlrMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PY[GlEPTB;MD63OFk5QSEQvF2= Ml7WV2FPT0WU
MPP-89 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkjJTWM2OD1yLke1PVc5KM7:TR?= NVrhc5JMW0GQR1XS
EKVX NYrHNllOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnSO|NvUUN3ME2wMlc6ODd|IN88US=> M3KxbnNCVkeHUh?=
HCC2218 NFPuRm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfmZnVWUUN3ME2wMlc6OTNzIN88US=> Ml3HV2FPT0WU
KNS-81-FD MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIP2Z|FKSzVyPUCuPFExOTFizszN M{e4VnNCVkeHUh?=
HCC2157 MofxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NW\nblZEUUN3ME2wMlg1QTVzIN88US=> MonIV2FPT0WU
BT-474 MkD4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmn3TWM2OD1yLki4PFU1KM7:TR?= Mkj0V2FPT0WU
NCI-H748 M3P0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1zEdmlEPTB;MD65NVIh|ryP MXzTRW5ITVJ?
EW-24 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrQTWM2OD1yLkmyNFAzKM7:TR?= NEnBOZpUSU6JRWK=
D-263MG MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfW[oRwUUN3ME2wMlk1PTF{IN88US=> M2jCXXNCVkeHUh?=
OMC-1 MnrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUPJR|UxRTBwOU[zO|Mh|ryP NGH5XGpUSU6JRWK=
NCI-H2196 M{O2Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS1OoRKSzVyPUCuPVc4PzdizszN MnviV2FPT0WU
HAL-01 M4HD[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWPPV3g{UUN3ME2wMlk6QDd{IN88US=> NEDCe|RUSU6JRWK=
NCI-H2107 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4TEdGlEPTB;MT6wNVg2PCEQvF2= MVXTRW5ITVJ?
LB996-RCC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUPsVHlVUUN3ME2xMlA5ODVzIN88US=> NFjNR2tUSU6JRWK=
NCI-H1395 NF7oRYJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vicWlEPTB;MT6xNFY4KM7:TR?= M{LkTXNCVkeHUh?=
CHP-126 M2\oUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofhTWM2OD1zLkG2NVk6KM7:TR?= NXHtcpNMW0GQR1XS
NB69 Mk[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn65TWM2OD1zLkK2NVQ5KM7:TR?= M1LF[nNCVkeHUh?=
CAS-1 NHXxUFNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlfiTWM2OD1zLkO0NlMyKM7:TR?= MYjTRW5ITVJ?
JVM-3 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWTJR|UxRTFwNEe4OVUh|ryP MnHvV2FPT0WU
DMS-153 M2PhcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2i4[GlEPTB;MT61O|Y4PCEQvF2= MoiwV2FPT0WU
SK-MEL-2 M3P3bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXT6NJFkUUN3ME2xMlcyPzh7IN88US=> NYroUHY{W0GQR1XS
NCI-H1155 M2HPSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLRNHZiUUN3ME2xMlc{Pjd4IN88US=> MofoV2FPT0WU
NCI-H1092 NITsdZhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIX3PJFKSzVyPUGuO|YyQDJizszN NHrPd|hUSU6JRWK=
LU-165 M3PxSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkfiTWM2OD1zLki2OFc3KM7:TR?= M33SZnNCVkeHUh?=
HL-60 MmLvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnqxTWM2OD1zLkm5PVA5KM7:TR?= NXTKWZVyW0GQR1XS
REH M1OxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlzhTWM2OD1{LkCwOVgzKM7:TR?= NX75dlRlW0GQR1XS
JVM-2 MnPQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoPNTWM2OD1{LkC2NVM2KM7:TR?= M{j2bnNCVkeHUh?=
MN-60 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVjmXlFmUUN3ME2yMlE4OzB6IN88US=> MmjlV2FPT0WU
SCC-15 NYPHZlNbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn3jTWM2OD1{LkKwNlch|ryP NHjOO49USU6JRWK=
SNU-C1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUPJR|UxRTJwMkGzOFMh|ryP M2Dwd3NCVkeHUh?=
SK-MEL-1 M2jQbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HCVWlEPTB;Mj6zNlA1PyEQvF2= M3nKd3NCVkeHUh?=
TGW NI[0dYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1v5VWlEPTB;Mj6zOVAzPyEQvF2= NX71bnNUW0GQR1XS
CA46 NVPDdWpmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXHX[HFUUUN3ME2yMlc2QTZ5IN88US=> M{nNO3NCVkeHUh?=
NCI-H23 NFHGN2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfnT3NlUUN3ME2yMlgxPzlzIN88US=> MXHTRW5ITVJ?
MMAC-SF NXi0ZWVQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWS4cXFlUUN3ME2yMlg3PjJ6IN88US=> NV\1fo1HW0GQR1XS
NCI-H2171 M2r4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYe1OWJUUUN3ME2zMlA{PDR6IN88US=> NELNcpZUSU6JRWK=
A704 NYjqcYhXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fHT2lEPTB;Mz6xOFE6PCEQvF2= MVPTRW5ITVJ?
DB M3nKUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPGU5pKSzVyPUOuNlU2PzZizszN Moi1V2FPT0WU
NCI-H719 MkfpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3vLcmlEPTB;Mz6zNFM5PCEQvF2= NUDzOXRwW0GQR1XS
MC-CAR MlHES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTNwNUS4NVch|ryP M4XxR3NCVkeHUh?=
SIMA M13DPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkWyTWM2OD1|LkW4OFE3KM7:TR?= NW\DVFhEW0GQR1XS
SW872 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnkWotZUUN3ME2zMlc5OTBzIN88US=> NI[3UpFUSU6JRWK=
HCC1187 M1jTTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXvCUFJMUUN3ME2zMlc5OzF3IN88US=> NVGxbGZZW0GQR1XS
EW-13 M1\RSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHOO5BmUUN3ME2zMlg{PDF5IN88US=> NYS3WlZ1W0GQR1XS
NCI-SNU-1 M3TV[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVj3fpc4UUN3ME20MlIyQTl7IN88US=> MnPuV2FPT0WU
NCI-H226 NV31[Hh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojCTWM2OD12LkOzOlA3KM7:TR?= MmS1V2FPT0WU
RPMI-8866 MnPyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmfOTWM2OD12LkO2NFI6KM7:TR?= NEjw[W9USU6JRWK=
OCI-AML2 M1z4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\1R4xKSzVyPUSuOVUzOyEQvF2= NXHJS5c{W0GQR1XS
LU-65 NYHvOYVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUfJR|UxRTRwOUOwN|Mh|ryP M{H4V3NCVkeHUh?=
SK-N-DZ MmrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYLJR|UxRTVwNkO0OlUh|ryP MV7TRW5ITVJ?
NB14 NIS2eIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFmxNmJKSzVyPUWuPVcyOzVizszN M1XFXnNCVkeHUh?=
COLO-829 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M333fWlEPTB;Nj6zN|M2QSEQvF2= MkG3V2FPT0WU
MHH-CALL-2 M2DUUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nSWGlEPTB;Nj61NVUxQCEQvF2= MoXiV2FPT0WU
NCI-H1770 M2iycWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1fnN2lEPTB;Nj62OlkxPCEQvF2= M3TBdnNCVkeHUh?=
ECC4 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjhTFlKSzVyPU[uPFIyPzlizszN MYXTRW5ITVJ?
A498 M{XHXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTZwOEexPVIh|ryP NVjaclh1W0GQR1XS
DMS-79 Mmr5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLzSXdKSzVyPUeuNFQ2OTJizszN M2C5ZXNCVkeHUh?=
P30-OHK MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIHzdXFKSzVyPUeuNlE6ODZizszN MXzTRW5ITVJ?
D-502MG MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;TNI1TUUN3ME23Mlk5OzZizszN NHGwbpdUSU6JRWK=
RCC10RGB NEWyTIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUm4dG9HUUN3ME24MlA3OjhizszN MojNV2FPT0WU
U-698-M MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NG\O[ZNKSzVyPUiuNlkzOjZizszN MXnTRW5ITVJ?
BB49-HNC NV7FZYh6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\O[G1KSzVyPUmuOFIzPjVizszN M2\EOXNCVkeHUh?=
ES1 M1P5fmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYLmSoRwUUN3ME25MlY5QTV4IN88US=> MV7TRW5ITVJ?
MFM-223 M1rlXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\MTWM2OD1zMD65PVI4KM7:TR?= NVXlcVd7W0GQR1XS
C2BBe1 M2TrUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTFzLkO1NlMh|ryP M{TZVnNCVkeHUh?=
EB2 MlTxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnvOTWM2OD1zMj62PFgyKM7:TR?= NWXTZ3NpW0GQR1XS
C8166 MlP6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFHid2tKSzVyPUGzMlg{ODNizszN M1fzO3NCVkeHUh?=
ES3 Mnm3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXtco5uUUN3ME2xN{46QTd5IN88US=> MlTvV2FPT0WU
NCI-H1650 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXzlWnR7UUN3ME2xOk4{PzZ3IN88US=> MUTTRW5ITVJ?
Mo-T MnnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWDVfWU{UUN3ME2xO{41ODJ7IN88US=> MXLTRW5ITVJ?
NB7 MlzOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlW5TWM2OD1zNz63OFY4KM7:TR?= Ml\xV2FPT0WU
ES7 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3HvfWlEPTB;MUmuOVUxPyEQvF2= NVLLO4EyW0GQR1XS
ES5 M3vIdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3PiPWlEPTB;MkGuO|Y4OSEQvF2= NXrWUFJDW0GQR1XS
MSTO-211H M165WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXrJR|UxRTJzLki4OVgh|ryP NXzuc2ZjW0GQR1XS
U-87-MG Ml;HS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHDbJpvUUN3ME2yOU4yQTZ4IN88US=> NYraXJJKW0GQR1XS
THP-1 MmG1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoO5TWM2OD1{OT63NlAyKM7:TR?= NYrQfmxrW0GQR1XS
NB10 NVHK[21LT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1zNXGlEPTB;M{CuNlY6PCEQvF2= M3;pWXNCVkeHUh?=
NH-12 MkfoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTuOog6UUN3ME2zN{4zODF5IN88US=> NGrCfphUSU6JRWK=
COLO-824 NFKzO3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFqwSIZKSzVyPUO0MlExODZizszN MVfTRW5ITVJ?
SKM-1 Moi5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFG0TWpKSzVyPUO3Mlg1OjJizszN MX\TRW5ITVJ?
NCI-H1838 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYjtellqUUN3ME2zPE4{Pzl5IN88US=> NVzqU3B{W0GQR1XS
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SH-EP NGTiboRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1jSflEuOTJ3IH7N NYe3[IVvOjRvMUKwJIg> M334ZolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MojmNlEyPjl{NEK=
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... Click to View More Cell Line Experimental Data

In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
+ Expand
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water <1 mg/mL
In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 15mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID