BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 670 In stock
USD 997 In stock

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Cited by 53 Publications

11 Customer Reviews

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

  • Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

  • Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

Purity & Quality Control

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Notes:

2. For more details, such as half maximal inhibitory concentrations (IC50s) and working concentrations of each inhibitor, please click on the link of the inhibitor of interest.
3. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation.
4. Orange "√" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
PI3Kα [1]
(Cell-free assay)
Met [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM 2.407 μM 4.754 μM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 NHftSVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3mwVGlEPTB;MD6wNFc4PiEQvF2= MUfTRW5ITVJ?
ACN NHK5bG9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3fzZWlEPTB;MD6wNFg1OyEQvF2= NGnCWZhUSU6JRWK=
TE-8 NIHye|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXTJR|UxRTBwMEC5OFEh|ryP M2DNZXNCVkeHUh?=
LC-2-ad MoOxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEHnXYlKSzVyPUCuNFExQTNizszN NEO1NVlUSU6JRWK=
ALL-PO NH\ZNYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXvJR|UxRTBwMEGzJO69VQ>? NGThbmJUSU6JRWK=
EW-16 NGL5RodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWixeWxNUUN3ME2wMlAyOzN4IN88US=> M3mz[3NCVkeHUh?=
KM12 NYTtXFBXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXLkfVVQUUN3ME2wMlAyOzR6IN88US=> MYTTRW5ITVJ?
GI-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVvJR|UxRTBwMEGzPFMh|ryP M2TLTXNCVkeHUh?=
LS-411N MkTvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkK4TWM2OD1yLkCxOFA4KM7:TR?= NIPqeFFUSU6JRWK=
ES8 NWfVNW9{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVP2[3hRUUN3ME2wMlAyPDl2IN88US=> NEHTO4RUSU6JRWK=
SNU-C2B M33pc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWDaOFJVUUN3ME2wMlAyPTJ4IN88US=> NXrVNGh7W0GQR1XS
CESS NUfEUGQxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1vXPWlEPTB;MD6wNVYxOiEQvF2= MVHTRW5ITVJ?
697 NYXWb3JlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUC4fVlwUUN3ME2wMlAyPjZ6IN88US=> M3HVS3NCVkeHUh?=
NCI-H1963 NGfIc3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEG2O|Mh|ryP MlHtV2FPT0WU
IA-LM NHvLSW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVzJR|UxRTBwMEG2PFgh|ryP M{m1NHNCVkeHUh?=
SW954 M3jhb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;X[HJOUUN3ME2wMlAyPzB3IN88US=> NHni[YRUSU6JRWK=
RL95-2 NEPme|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVPJR|UxRTBwMEG3N|gh|ryP MmW5V2FPT0WU
LXF-289 NEDFUYZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3wTWM2OD1yLkCxO|ch|ryP MmruV2FPT0WU
OCUB-M MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnkTWM2OD1yLkCxPFI3KM7:TR?= MUHTRW5ITVJ?
RKO NEDXOGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DDcGlEPTB;MD6wNVk5PyEQvF2= MlnQV2FPT0WU
LOUCY NVu5WWNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWi5XWFQUUN3ME2wMlAzODVizszN M4PKOnNCVkeHUh?=
NOS-1 NXLyWVZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEKwPVMh|ryP Moq5V2FPT0WU
A4-Fuk NVroTJRxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\FTWM2OD1yLkCyNlE5KM7:TR?= M{fTTXNCVkeHUh?=
A388 M4DKVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTMRmVnUUN3ME2wMlAzOjJ5IN88US=> M2ixOHNCVkeHUh?=
TE-9 MljjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MknGTWM2OD1yLkCyNlYyKM7:TR?= M{LQTXNCVkeHUh?=
KURAMOCHI M4[4fGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\UTmlEPTB;MD6wNlI5PSEQvF2= MXfTRW5ITVJ?
KALS-1 MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\LTWM2OD1yLkCyN|M5KM7:TR?= NXTLO2tTW0GQR1XS
HOP-62 NXf0NXc{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2fVcGlEPTB;MD6wNlQzKM7:TR?= MkDrV2FPT0WU
RPMI-8402 MojaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkH5TWM2OD1yLkCyOVA5KM7:TR?= NF7KSHZUSU6JRWK=
TE-1 NXnsOHJbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NELub5pKSzVyPUCuNFI2OTJizszN M2Gx[nNCVkeHUh?=
CCRF-CEM NIrxfoZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmP1TWM2OD1yLkCyOVQ{KM7:TR?= NVnlWXYxW0GQR1XS
HUTU-80 NH\tRVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVnJR|UxRTBwMEK2NlQh|ryP MYjTRW5ITVJ?
NCI-H1648 MnLpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{CzNWlEPTB;MD6wNlY1PyEQvF2= NYDROo9NW0GQR1XS
HCE-4 NVOwSHYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PiVWlEPTB;MD6wNlY5OiEQvF2= MUTTRW5ITVJ?
ETK-1 MlPFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3rrN2lEPTB;MD6wNlc{PiEQvF2= MWDTRW5ITVJ?
TE-15 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfKc4lKSzVyPUCuNFI4OzhizszN M2jBc3NCVkeHUh?=
BE-13 M1\rc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXjJR|UxRTBwMEK3OEDPxE1? NFLR[5NUSU6JRWK=
KE-37 M4OwR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmHjTWM2OD1yLkCyO|QyKM7:TR?= MVHTRW5ITVJ?
NCI-H1355 NFPreXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWnJR|UxRTBwMEK3PFMh|ryP MkGwV2FPT0WU
TE-11 NYnsTWs6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHuTWM2OD1yLkCyPFA6KM7:TR?= MYfTRW5ITVJ?
BL-70 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWC3bFAxUUN3ME2wMlAzQDV5IN88US=> MXjTRW5ITVJ?
ES6 M3\tfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4rReWlEPTB;MD6wNlg5OSEQvF2= MXTTRW5ITVJ?
GT3TKB NI[zU5NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX:4T2hDUUN3ME2wMlAzQTV|IN88US=> M1XrdHNCVkeHUh?=
LB647-SCLC MnLYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LCdWlEPTB;MD6wN|E6PSEQvF2= NFTudXBUSU6JRWK=
NB13 NHjMb25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHITWM2OD1yLkCzN|E3KM7:TR?= MWrTRW5ITVJ?
ST486 NX64WJFmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2H1[GlEPTB;MD6wN|M{PyEQvF2= MnTlV2FPT0WU
NCI-H82 NFjtVWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nqbmlEPTB;MD6wN|M1OyEQvF2= M4TCR3NCVkeHUh?=
NTERA-S-cl-D1 MkjQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMEOzPVkh|ryP M3nIPXNCVkeHUh?=
ES4 M2DG[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1mzOmlEPTB;MD6wN|Q3OyEQvF2= MorSV2FPT0WU
SK-NEP-1 NYHFNmRQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DjXGlEPTB;MD6wN|Q6QSEQvF2= MYDTRW5ITVJ?
Becker M3exNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVTJR|UxRTBwMEO1OVUh|ryP M3WxdHNCVkeHUh?=
A101D M1H2e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwMEO3OFgh|ryP M{XTV3NCVkeHUh?=
SK-UT-1 MorvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIjpToJKSzVyPUCuNFM4PzRizszN MXnTRW5ITVJ?
SW982 MkjvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV\JR|UxRTBwMEO3PUDPxE1? NWXwcXJZW0GQR1XS
TE-10 M335WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFSwcotKSzVyPUCuNFQxPDZizszN NFfS[ZFUSU6JRWK=
OVCAR-4 NUX3WYRCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMESwOVkh|ryP Mor4V2FPT0WU
KP-N-YS NVzEemg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4rETmlEPTB;MD6wOFA5PSEQvF2= NVO5T2JSW0GQR1XS
BL-41 M2TBVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn;VTWM2OD1yLkC0NVI2KM7:TR?= NUPBUIxtW0GQR1XS
MZ1-PC NInE[mdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnmxTWM2OD1yLkC0NVI4KM7:TR?= NIrjWZpUSU6JRWK=
PF-382 M3\QXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUfJR|UxRTBwMESxPVgh|ryP M2H4TnNCVkeHUh?=
MOLT-13 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPTeGt[UUN3ME2wMlA1OjN6IN88US=> NWH1c5loW0GQR1XS
HCC1599 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPOTWM2OD1yLkC0NlU5KM7:TR?= NWrx[o9rW0GQR1XS
IST-MEL1 M3TLUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MniwTWM2OD1yLkC0OFQzKM7:TR?= MkL5V2FPT0WU
LU-139 MkTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlrvTWM2OD1yLkC0OFQzKM7:TR?= NITIc3BUSU6JRWK=
MS-1 NFzNfHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYDJR|UxRTBwMES3NFEh|ryP NHjmTXlUSU6JRWK=
MFH-ino NWe3bok3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{XJOmlEPTB;MD6wOVAxOyEQvF2= MlfKV2FPT0WU
IMR-5 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLhTWM2OD1yLkC1NFIyKM7:TR?= NGnUd2NUSU6JRWK=
TE-5 MnXTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\mXWFKSzVyPUCuNFUxPjNizszN NHT0eZJUSU6JRWK=
DJM-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLHTpdKSzVyPUCuNFUyPDJizszN MnXlV2FPT0WU
NB17 M3jQNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HBSWlEPTB;MD6wOVIxPyEQvF2= MVzTRW5ITVJ?
KARPAS-45 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY[wOJBwUUN3ME2wMlA2OzV6IN88US=> NH\UXXJUSU6JRWK=
TGBC1TKB MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fxR2lEPTB;MD6wOVQxPSEQvF2= M{LO[HNCVkeHUh?=
ML-2 Mli4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLiWmRKSzVyPUCuNFU1OTRizszN MmDPV2FPT0WU
no-10 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUXXOWRpUUN3ME2wMlA2PDd2IN88US=> MkHpV2FPT0WU
CTV-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml76TWM2OD1yLkC1OVAzKM7:TR?= NXXCb|AyW0GQR1XS
SJSA-1 NX3jXnpMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX;MSohZUUN3ME2wMlA2PTJizszN Mn22V2FPT0WU
HC-1 NXWzdHdrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPNRXUzUUN3ME2wMlA2PTl5IN88US=> MUfTRW5ITVJ?
TE-12 M{DOe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnruTWM2OD1yLkC1OlE{KM7:TR?= MmPDV2FPT0WU
KY821 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFy0N|dKSzVyPUCuNFU3OzJizszN M3ywNHNCVkeHUh?=
TALL-1 NYGyb|l6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV;JR|UxRTBwMEW3NFgh|ryP MWPTRW5ITVJ?
DEL NUHOTG06T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3j1R2lEPTB;MD6wOVcxQSEQvF2= M1LoZnNCVkeHUh?=
TE-6 M3zs[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHYNJNKSzVyPUCuNFU4OjJizszN NGSyR41USU6JRWK=
SK-LMS-1 NYfwRmJIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3LiSmlEPTB;MD6wOVgxPSEQvF2= NVjz[lkxW0GQR1XS
EW-1 NVr1XlhsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXjJR|UxRTBwMEW4N|ch|ryP NXrVWm9ZW0GQR1XS
8-MG-BA NEjoPIdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUPJR|UxRTBwMEW4OVEh|ryP NYH1ZY5mW0GQR1XS
NALM-6 MoDMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33vd2lEPTB;MD6wOVk4OyEQvF2= MkmyV2FPT0WU
LB771-HNC M1jK[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHHLNJpKSzVyPUCuNFU6PzlizszN M3zjN3NCVkeHUh?=
HT-144 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUm1TGR2UUN3ME2wMlA3OTNizszN MX3TRW5ITVJ?
KM-H2 NYDGNGR4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUXJR|UxRTBwME[yNlEh|ryP MUTTRW5ITVJ?
SF268 MnS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrJdWdtUUN3ME2wMlA3Ojh4IN88US=> NVjUVZJSW0GQR1XS
RS4-11 MmO2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mk\4TWM2OD1yLkC2N|A1KM7:TR?= Ml7TV2FPT0WU
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LAN-6 MlnxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwM{G1O|Ih|ryP NFvSSoxUSU6JRWK=
RH-1 MnvrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmTkTWM2OD1yLkOxPFcyKM7:TR?= NYPCfpRUW0GQR1XS
CP66-MEL Mn7aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1q2NmlEPTB;MD6zNVg4QCEQvF2= Ml\sV2FPT0WU
EC-GI-10 M1r4OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmPzTWM2OD1yLkOyPVg4KM7:TR?= MlSzV2FPT0WU
GDM-1 NYPpXVE{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmDETWM2OD1yLkOzNFU6KM7:TR?= NGPNT2RUSU6JRWK=
IST-SL1 NWi0[5FJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWC1WHB{UUN3ME2wMlM1QTF2IN88US=> MXnTRW5ITVJ?
KMOE-2 M3HHXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwM{WxO|Uh|ryP M4TnbnNCVkeHUh?=
OS-RC-2 NYfETnpzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFnMdYlKSzVyPUCuN|U2PDRizszN NHzweoNUSU6JRWK=
HDLM-2 M3rWZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3m2d2lEPTB;MD6zO|gyPCEQvF2= NUjRTnlzW0GQR1XS
DSH1 M1m1T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;xWWlEPTB;MD6zPFY{OSEQvF2= Mm\KV2FPT0WU
LS-1034 NHXGc3hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDGTWM2OD1yLkO4PVU1KM7:TR?= NGnZR2dUSU6JRWK=
LB373-MEL-D NV\w[pd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\EdJdEUUN3ME2wMlM6OTl5IN88US=> NUDHeY9JW0GQR1XS
GOTO NWfkSWhIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\WVGlEPTB;MD60NlEyQCEQvF2= M13aO3NCVkeHUh?=
MRK-nu-1 Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXPWdGVTUUN3ME2wMlQzOjB3IN88US=> NV21blRuW0GQR1XS
SK-MM-2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPvRW9UUUN3ME2wMlQ{PDR{IN88US=> Mo\vV2FPT0WU
BOKU NIfwOJBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDKOohEUUN3ME2wMlQ{Pzl{IN88US=> MYDTRW5ITVJ?
NOMO-1 M4HoSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvITWM2OD1yLkSzPFYh|ryP NGe4UmhUSU6JRWK=
J-RT3-T3-5 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3zKO2lEPTB;MD60OFg4QCEQvF2= NYfhVWRHW0GQR1XS
COLO-668 MmDGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLjTWM2OD1yLkS1OlY5KM7:TR?= MoXYV2FPT0WU
SF539 M3nyUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmLJTWM2OD1yLkS4Olg1KM7:TR?= NG\4ZmFUSU6JRWK=
LB2518-MEL MlX6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfDTWM2OD1yLkS5O|A{KM7:TR?= MYrTRW5ITVJ?
TE-441-T NV3m[nI4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUW3OVd[UUN3ME2wMlUxOTJizszN NX3tW3AyW0GQR1XS
MDA-MB-134-VI NIfFSpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3HrNWlEPTB;MD61NFkzOSEQvF2= NXHWTIR7W0GQR1XS
SCC-3 NWLwVJdxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWD6Sld6UUN3ME2wMlUyQDd|IN88US=> NUPGPFZ3W0GQR1XS
KLE M2j0dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnTETWM2OD1yLkWyNVcyKM7:TR?= M1rCeXNCVkeHUh?=
LB2241-RCC M4Lv[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF3iXGxKSzVyPUCuOVI2OjVizszN NEPOTmZUSU6JRWK=
NCI-H1417 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwNUO0N|Uh|ryP M{DvXnNCVkeHUh?=
NCI-H2081 MmnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml7ITWM2OD1yLkW4OlEyKM7:TR?= MUTTRW5ITVJ?
NCI-H1522 M1\RfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn7GTWM2OD1yLkW5N|g{KM7:TR?= M4fLO3NCVkeHUh?=
NCI-H889 NUfxdXIzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{m0TWlEPTB;MD61PVg1PCEQvF2= NFyydIpUSU6JRWK=
CGTH-W-1 M{DZWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4OwZ2lEPTB;MD62NFc2PSEQvF2= MlfsV2FPT0WU
EB-3 NIKxU3JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwNkGxOVMh|ryP NFTQVZZUSU6JRWK=
D-336MG NWHkXlQ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwNkG3PVEh|ryP M2\peHNCVkeHUh?=
LC-1F NWfYd4pzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{\nNWlEPTB;MD62NlU6OiEQvF2= M37X[nNCVkeHUh?=
MHH-NB-11 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFOxUndKSzVyPUCuOlM5ODFizszN MUTTRW5ITVJ?
SK-N-FI M3HndGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVPrSGFPUUN3ME2wMlY{QTFizszN NEn1OoRUSU6JRWK=
NCI-H69 NH7lOYpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHFTWM2OD1yLk[0PFc6KM7:TR?= MUHTRW5ITVJ?
SCH NV;OeFZFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojjTWM2OD1yLk[2NFI{KM7:TR?= NIfJTYNUSU6JRWK=
LS-513 NUfXNGR7T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTBwNkeyOVkh|ryP MYfTRW5ITVJ?
CP67-MEL MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXTGWVlrUUN3ME2wMlY4PTl4IN88US=> NH3PZVdUSU6JRWK=
GCIY MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLuZWlKSzVyPUCuO|A{PjNizszN NWPMb5U{W0GQR1XS
SHP-77 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnLZTWM2OD1yLkewO|M1KM7:TR?= NXWyNWlvW0GQR1XS
EHEB NUP3OG9HT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPEVWhKSzVyPUCuO|E5PTRizszN Ml\YV2FPT0WU
D-247MG MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3XoTWlEPTB;MD63N|I{OiEQvF2= M4H4U3NCVkeHUh?=
Raji NUTDR5RpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml22TWM2OD1yLke0PVg6KM7:TR?= MXnTRW5ITVJ?
MPP-89 NW[yZ3hHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEfSWYFKSzVyPUCuO|U6PzhizszN M1[wSHNCVkeHUh?=
EKVX Mk\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGe5dmhKSzVyPUCuO|kxPzNizszN MnLHV2FPT0WU
HCC2218 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwN{mxN|Eh|ryP MXfTRW5ITVJ?
KNS-81-FD M{P1UGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHKz[5hKSzVyPUCuPFExOTFizszN MkHyV2FPT0WU
HCC2157 M1;Be2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1S0bmlEPTB;MD64OFk2OSEQvF2= M{jLWXNCVkeHUh?=
BT-474 NF3weFZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoD3TWM2OD1yLki4PFU1KM7:TR?= MV3TRW5ITVJ?
NCI-H748 NVnNRpk3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwOUGyJO69VQ>? NFXPW3RUSU6JRWK=
EW-24 M3HLcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nVNmlEPTB;MD65NlAxOiEQvF2= Mn64V2FPT0WU
D-263MG NWDWTZRKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk\rTWM2OD1yLkm0OVEzKM7:TR?= NVrGXXl5W0GQR1XS
OMC-1 NYCxWY5lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4fyd2lEPTB;MD65OlM4OyEQvF2= MWDTRW5ITVJ?
NCI-H2196 NUPvbHlOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwOUe3O|ch|ryP MlrqV2FPT0WU
HAL-01 M{jIVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkjjTWM2OD1yLkm5PFczKM7:TR?= NXLnRVk3W0GQR1XS
NCI-H2107 NIryS2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoDHTWM2OD1zLkCxPFU1KM7:TR?= M32wRXNCVkeHUh?=
LB996-RCC MmXBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfHXpVuUUN3ME2xMlA5ODVzIN88US=> M3Lsc3NCVkeHUh?=
NCI-H1395 MlrjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTFwMUC2O{DPxE1? M3rhXXNCVkeHUh?=
CHP-126 M1e0WGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NW\SN5lrUUN3ME2xMlE3OTl7IN88US=> MUHTRW5ITVJ?
NB69 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn;STWM2OD1zLkK2NVQ5KM7:TR?= NGn2NoJUSU6JRWK=
CAS-1 NX[3e2RLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF73VnVKSzVyPUGuN|QzOzFizszN M2TBUnNCVkeHUh?=
JVM-3 MlHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPGZW57UUN3ME2xMlQ4QDV3IN88US=> NUO4NHY6W0GQR1XS
DMS-153 M4DKfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7SSWNKSzVyPUGuOVc3PzRizszN MXzTRW5ITVJ?
SK-MEL-2 NWjyWmNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DxTWlEPTB;MT63NVc5QSEQvF2= NUTvOG13W0GQR1XS
NCI-H1155 M2fSe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4f2bGlEPTB;MT63N|Y4PiEQvF2= MX7TRW5ITVJ?
NCI-H1092 NUT1bnVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfHTWM2OD1zLke2NVgzKM7:TR?= M2WxVnNCVkeHUh?=
LU-165 M1LlOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jE[2lEPTB;MT64OlQ4PiEQvF2= MljnV2FPT0WU
HL-60 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnG3TWM2OD1zLkm5PVA5KM7:TR?= M4HJUHNCVkeHUh?=
REH M17vS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny0TWM2OD1{LkCwOVgzKM7:TR?= M4PFcHNCVkeHUh?=
JVM-2 NGLjdZRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmTUTWM2OD1{LkC2NVM2KM7:TR?= Mom4V2FPT0WU
MN-60 M3vRUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTJwMUezNFgh|ryP Mn30V2FPT0WU
SCC-15 MlfrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmj4TWM2OD1{LkKwNlch|ryP NXP2WmpPW0GQR1XS
SNU-C1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknTTWM2OD1{LkKxN|Q{KM7:TR?= MmLOV2FPT0WU
SK-MEL-1 NEDDZ2RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTJwM{KwOFch|ryP M{eyUHNCVkeHUh?=
TGW NH7hcphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEjXWY9KSzVyPUKuN|UxOjdizszN MlPZV2FPT0WU
CA46 M4rOSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI\MTXhKSzVyPUKuO|U6PjdizszN NXi0TVRuW0GQR1XS
NCI-H23 NWftZ3V5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF3lVJhKSzVyPUKuPFA4QTFizszN MkHJV2FPT0WU
MMAC-SF MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4jZUmlEPTB;Mj64OlYzQCEQvF2= NHLneZdUSU6JRWK=
NCI-H2171 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVvEbGhEUUN3ME2zMlA{PDR6IN88US=> MlzlV2FPT0WU
A704 NX3XOYdUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrESG05UUN3ME2zMlE1OTl2IN88US=> NEW4eZNUSU6JRWK=
DB MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI\mXlRKSzVyPUOuNlU2PzZizszN M3vqPXNCVkeHUh?=
NCI-H719 MlTCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV3JR|UxRTNwM{CzPFQh|ryP M4DmfHNCVkeHUh?=
MC-CAR Ml3CS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTNwNUS4NVch|ryP M3OxRXNCVkeHUh?=
SIMA MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLUXIlEUUN3ME2zMlU5PDF4IN88US=> MkDRV2FPT0WU
SW872 NYm3cXlJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M125O2lEPTB;Mz63PFExOSEQvF2= NYfhS5huW0GQR1XS
HCC1187 Mn7LS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3TtPGlEPTB;Mz63PFMyPSEQvF2= NYHXZ|EzW0GQR1XS
EW-13 MofoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{X3N2lEPTB;Mz64N|QyPyEQvF2= M1LXWHNCVkeHUh?=
NCI-SNU-1 M2TvUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MonZTWM2OD12LkKxPVk6KM7:TR?= NXPi[5c{W0GQR1XS
NCI-H226 NWPhWIVWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MonDTWM2OD12LkOzOlA3KM7:TR?= Mn[2V2FPT0WU
RPMI-8866 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;QTWM2OD12LkO2NFI6KM7:TR?= MYLTRW5ITVJ?
OCI-AML2 M4ezVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHXUYNyUUN3ME20MlU2OjNizszN MVPTRW5ITVJ?
LU-65 M1H4U2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWi2RoxEUUN3ME20Mlk{ODN|IN88US=> MVzTRW5ITVJ?
SK-N-DZ MmTrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml;uTWM2OD13Lk[zOFY2KM7:TR?= MWXTRW5ITVJ?
NB14 Mn;yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmL0TWM2OD13Lkm3NVM2KM7:TR?= M{P0O3NCVkeHUh?=
COLO-829 M4LKbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NInzdHZKSzVyPU[uN|M{PTlizszN NFj6Um5USU6JRWK=
MHH-CALL-2 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTZwNUG1NFgh|ryP MUnTRW5ITVJ?
NCI-H1770 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH3IeI9KSzVyPU[uOlY6ODRizszN M2njUnNCVkeHUh?=
ECC4 NIDFTpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYrJR|UxRTZwOEKxO|kh|ryP NWDkW|BkW0GQR1XS
A498 NH72cGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rBT2lEPTB;Nj64O|E6OiEQvF2= M{\abXNCVkeHUh?=
DMS-79 NWPXVWQzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LZNWlEPTB;Nz6wOFUyOiEQvF2= NVnzTWVTW0GQR1XS
P30-OHK M3izV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLuTWM2OD15LkKxPVA3KM7:TR?= MkT1V2FPT0WU
D-502MG MnXRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnkdZoyUUN3ME23Mlk5OzZizszN NYrrdmhqW0GQR1XS
RCC10RGB NH7CclJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1v4dWlEPTB;OD6wOlI5KM7:TR?= MmLJV2FPT0WU
U-698-M NWSwXGI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LqN2lEPTB;OD6yPVIzPiEQvF2= Moe1V2FPT0WU
BB49-HNC M37ub2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLvTWM2OD17LkSyNlY2KM7:TR?= NHzDToxUSU6JRWK=
ES1 NGXte5lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIrGXm5KSzVyPUmuOlg6PTZizszN M4jicHNCVkeHUh?=
MFM-223 NUTTOY95T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HKfWlEPTB;MUCuPVkzPyEQvF2= NUHHZoRDW0GQR1XS
C2BBe1 M1:z[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYPNflFUUUN3ME2xNU4{PTJ|IN88US=> Mn\SV2FPT0WU
EB2 M2fvRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFix[29KSzVyPUGyMlY5QDFizszN MnnEV2FPT0WU
C8166 NYXHeJlnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFrzeW5KSzVyPUGzMlg{ODNizszN NU\CN4loW0GQR1XS
ES3 NELxVY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TSeWlEPTB;MUOuPVk4PyEQvF2= MmCzV2FPT0WU
NCI-H1650 NGXNWWxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYfSV|BFUUN3ME2xOk4{PzZ3IN88US=> NE\l[lRUSU6JRWK=
Mo-T M2TDW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH3YPI1KSzVyPUG3MlQxOjlizszN MVTTRW5ITVJ?
NB7 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTF5Lke0Olch|ryP NUHhW5JYW0GQR1XS
ES7 NIP0S4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUn3VoZwUUN3ME2xPU42PTB5IN88US=> MYDTRW5ITVJ?
ES5 NW\zNIxTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXTlUZdLUUN3ME2yNU44PjdzIN88US=> MWHTRW5ITVJ?
MSTO-211H MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTJzLki4OVgh|ryP M{Xl[3NCVkeHUh?=
U-87-MG NGfHfFhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjIdIxKSzVyPUK1MlE6PjZizszN MoP3V2FPT0WU
THP-1 MknjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWC1cW1UUUN3ME2yPU44OjBzIN88US=> MWXTRW5ITVJ?
NB10 NWDlNIRRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHVc2RKSzVyPUOwMlI3QTRizszN NXPI[VJGW0GQR1XS
NH-12 NHLXTllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXyWHdpUUN3ME2zN{4zODF5IN88US=> MYLTRW5ITVJ?
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SIL-ALL NWL4RoZLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2nTbVI1KGh? MmPJTWM2OD1zOUmuO|chdk1? MVKyOFUyQTl7NR?=
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NALM-6 M1e3[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYK0PEBp NEjxdppKSzVyPUKzMlI3KG6P NGHaWJkzPDVzOUm5OS=>
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SIL-ALL M3TjcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M12xeVQ5KGh? NUHrVow3UUN3ME23OE43OiCwTR?= M162OVI1PTF7OUm1
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MOLT-4 M1XhN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3\KdVczKGh? NWjCWY0{UUN3ME23MlM6KG6P MoG4NlQ2OTl7OUW=
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NALM-6 MmC1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHH2UnI4OiCq NVzkS2FrUUN3ME2xMlc5KG6P Mn;ENlQ2OTl7OUW=
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SIL-ALL MoXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13zblczKGh? MnvtTWM2OD15LkKgcm0> MUSyOFUyQTl7NR?=
CEM MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjlRo44OiCq MXfJR|UxRTVwNEKgcm0> NUC3fXNoOjR3MUm5PVU>
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G166 M2[xU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTdwMDDuUS=> MVeyOFIxPDd|Mx?=
CB660 MkfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYT3NHJvUUN3ME22MlQhdk1? MkLvNlQzODR5M{O=
CB1117 NHjM[WhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2rvcmlEPTB;MUWuOkBvVQ>? MojnNlQzODR5M{O=
KB-3-1 NGryXIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4\UVmlEPTB;MT60PEDDuSByLkWzJI5O MoHJNlM6PjJ2NEW=
KB-8-5-11 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWn5RotjUUN3ME21MlAyKMLzIEKuNFEhdk1? NIrsUmYzOzl4MkS0OS=>
KB-C-1 NILQUpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfSOVVKUUN3ME2xOk44PiEEsTC0MlUyKG6P Mo[5NlM6PjJ2NEW=
KB-V-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmLpTWM2OD1{OEGuNlQhyrFiM{GuOVchdk1? MlPINlM6PjJ2NEW=
OVCAR-8 NV\l[2dWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnT6TWM2OD15LkG5JOKyKDNwNkCgcm0> NVvF[445OjN7NkK0OFU>
NCI-ADR-RES MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGD6XWNKSzVyPUGyO|MvOzBiwsGgNVkyNjJyIH7N MmLDNlM6PjJ2NEW=
MCF7 MoS3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXHJR|UxRTVwMUGgxtEhOS52NzDuUS=> MkftNlM6PjJ2NEW=
MCF7-FLV1000 NVr1W243T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH;0RnNKSzVyPUO5N{4yQCEEsTC3OE45OyCwTR?= NF;LV5czOzl4MkS0OS=>
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CORL-23/R NH3z[otIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHfo[ZJKSzVyPUWuNVYhyrFiMT64N{BvVQ>? MWmyN|k3OjR2NR?=
NIH3T3 M4XHWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV\JR|UxRTRyLk[wJOKyKDRwOUegcm0> MlXtNlM6PjJ2NEW=
NIH3T3-G185 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTJ2MUOuOFAhyrFiNEKzMlY3KG6P NI\kR5IzOzl4MkS0OS=>
pcDNA-HEK293 NYrxOXc6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{mxVmlEPTB;Mj63OUDDuSByLk[3JI5O NILHeFYzOzl4MkS0OS=>
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R482-HEK293 M37w[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn2TWM2OD1{NT65O{DDuSB2Lkm1JI5O M3Tqb|I{QTZ{NES1
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SF188 MnjWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjoNVAuOTByIH7N MUCyOE06PiCq MXTEUXNQ MUfpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWVvIHHu[EBkd26lZX70doF1cW:wLTDk[ZBm\GWwdDDtZY5v\XJ? M{i2SFI{QDh5NkS1
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DU145 NF\2R3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LKeGROW09? Mlj6TWM2OOLKvE[wJI5O M17iT|I{QDh2NEK4
LNCaP  Mm\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlPESG1UVw>? NFTUbZVKSzVy4pk8O|Uhdk1? Mn7wNlM5QDR2Mki=
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5637 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTR3LkS3JI5O NYjiS4hEOjN5OUK2N|k>
T24 NHTzeYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3r3UWlEPTB;N{muNVIhdk1? MY[yN|c6OjZ|OR?=
MCF7  NWfy[nMyTnWwY4Tpc44hSXO|YYm= NUjzfVM3OTByIH7N M4fIRlEhcA>? NHXYdmhFVVOR NHXsVJNz\WS3Y3XzJJRp\SCrbnT1Z5Rqd25ib3dCpGdz\WJzLNMgV4dsOS{EoGDzNkzDqFOncoDpcoE{NCCjbnVCpHdqe3B{ MWCyN|c4ODJ2NB?=
KB-V1  Ml70S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{CxfWlEPTB;Mz65NkDPxE1? MoTxNlM2QTNzOU[=
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MDA-MB-468 MV3BdI9xfG:|aYOgRZN{[Xl? M3\RdlEwPS9zMDDuUS=> NUDZSnZEOjRxNEivO|IhcA>? NHT5SGlFVVOR NXftRnlGcW6mdXPld{BieG:ydH;zbZMhcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> MlvxNlMyPDR{OUS=
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Huh-7 NIq3bWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVnDeHY4OS9zMD:xNFAwOTByMDDuUS=> NFTqSng1QCCq Mn3L[IVkemWjc3XzJJRp\SClZXzsJJZq[WKrbHn0fUBld3OnLXTldIVv\GWwdHz5 MmHJNlI4PDV3OEe=
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... Click to View More Cell Line Experimental Data

In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
+ Expand
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water <1 mg/mL
In vivo 30% PEG 400+0.5% Tween 80+5% Propylene glycol 15mg/mL

* 1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID