BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 670 In stock
USD 997 In stock
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Cited by 54 Publications

12 Customer Reviews

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

  • Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like cells after treatment with BI 2536 for 24 and 48 hours, respectively.

    Oncotarget, 2017, 8(23):37633-37645. BI 2536 purchased from Selleck.

    Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

  • J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

    Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 Mo\ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvI[4VUUUN3ME2wMlAxPzd4IN88US=> NHzQOmxUSU6JRWK=
ACN M2DoTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVz6No1LUUN3ME2wMlAxQDR|IN88US=> NGn3XlBUSU6JRWK=
TE-8 NYi3NZhDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TiTmlEPTB;MD6wNFk1OSEQvF2= NWP0e4hnW0GQR1XS
LC-2-ad MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnnRTWM2OD1yLkCxNFk{KM7:TR?= NHywPGFUSU6JRWK=
ALL-PO NIXkTWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nVTWlEPTB;MD6wNVMh|ryP MXzTRW5ITVJ?
EW-16 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2j4UmlEPTB;MD6wNVM{PiEQvF2= M4PSTHNCVkeHUh?=
KM12 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV\JR|UxRTBwMEGzOFgh|ryP MmHzV2FPT0WU
GI-1 NG\Kc5FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NULOWpc4UUN3ME2wMlAyOzh|IN88US=> MnyxV2FPT0WU
LS-411N NXjmOIJpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUTHTVlxUUN3ME2wMlAyPDB5IN88US=> MWHTRW5ITVJ?
ES8 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGX6d5dKSzVyPUCuNFE1QTRizszN MlHZV2FPT0WU
SNU-C2B NX\SW3RoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1TM[GlEPTB;MD6wNVUzPiEQvF2= NE\YXHdUSU6JRWK=
CESS MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkLOTWM2OD1yLkCxOlAzKM7:TR?= NUP0dYtDW0GQR1XS
697 NGnyfXNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHT6cZpKSzVyPUCuNFE3PjhizszN MmPVV2FPT0WU
NCI-H1963 M2Hp[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mo\zTWM2OD1yLkCxOlc{KM7:TR?= MU\TRW5ITVJ?
IA-LM NHO0co5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX\qNGdwUUN3ME2wMlAyPjh6IN88US=> MonGV2FPT0WU
SW954 NHz2eGVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVTJR|UxRTBwMEG3NFUh|ryP MWHTRW5ITVJ?
RL95-2 NHzBZWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn2xTWM2OD1yLkCxO|M5KM7:TR?= M4WyNXNCVkeHUh?=
LXF-289 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3vWNGlEPTB;MD6wNVc4KM7:TR?= Mo\jV2FPT0WU
OCUB-M NXvSRYpDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEG4NlYh|ryP NYDpd4h3W0GQR1XS
RKO NV\Fd2g4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYD5RWRIUUN3ME2wMlAyQTh5IN88US=> NELhfmRUSU6JRWK=
LOUCY MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVrPbVdFUUN3ME2wMlAzODVizszN NILmT4pUSU6JRWK=
NOS-1 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;y[|NjUUN3ME2wMlAzODl|IN88US=> NGrIT3BUSU6JRWK=
A4-Fuk MknmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYXBZVZxUUN3ME2wMlAzOjF6IN88US=> MVHTRW5ITVJ?
A388 MnX2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M33JUGlEPTB;MD6wNlIzPyEQvF2= NEnHc|lUSU6JRWK=
TE-9 MmnUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIT0fYRKSzVyPUCuNFIzPjFizszN NIDlWZBUSU6JRWK=
KURAMOCHI NVXWbmhWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlfDTWM2OD1yLkCyNlg2KM7:TR?= NF2xZ4NUSU6JRWK=
KALS-1 MnfUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUDxXW9SUUN3ME2wMlAzOzN6IN88US=> NFHoW4dUSU6JRWK=
HOP-62 Ml:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFz2dWxKSzVyPUCuNFI1OiEQvF2= M1jyNnNCVkeHUh?=
RPMI-8402 M161eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPGfFNvUUN3ME2wMlAzPTB6IN88US=> MXzTRW5ITVJ?
TE-1 NUT6dmJqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwMEK1NVIh|ryP MkL2V2FPT0WU
CCRF-CEM MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{jiW2lEPTB;MD6wNlU1OyEQvF2= NUDEXVNGW0GQR1XS
HUTU-80 NYXNR4RCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEK2NlQh|ryP NX7QR5ZsW0GQR1XS
NCI-H1648 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4LVfmlEPTB;MD6wNlY1PyEQvF2= NVHwS3d1W0GQR1XS
HCE-4 NWLEdHN3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVXJR|UxRTBwMEK2PFIh|ryP NHXBNlZUSU6JRWK=
ETK-1 M3:wbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\DOpN1UUN3ME2wMlAzPzN4IN88US=> NYHXT4xJW0GQR1XS
TE-15 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NET0NXJKSzVyPUCuNFI4OzhizszN M3OwVnNCVkeHUh?=
BE-13 NFXlelNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWfsbo5PUUN3ME2wMlAzPzRizszN NFno[XNUSU6JRWK=
KE-37 NED5cpVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXnJR|UxRTBwMEK3OFEh|ryP Ml:wV2FPT0WU
NCI-H1355 NYrjSoFCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NULYdVlWUUN3ME2wMlAzPzh|IN88US=> Mm\MV2FPT0WU
TE-11 NV3FZZRFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYHJR|UxRTBwMEK4NFkh|ryP NGn3b21USU6JRWK=
BL-70 NW\4N2dIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4X1SmlEPTB;MD6wNlg2PyEQvF2= NUDxVWI3W0GQR1XS
ES6 NUXyPYZ{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDqdWtDUUN3ME2wMlAzQDhzIN88US=> MVrTRW5ITVJ?
GT3TKB M2nQU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGjvUZRKSzVyPUCuNFI6PTNizszN NGficlVUSU6JRWK=
LB647-SCLC NI\4e2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1KzbWlEPTB;MD6wN|E6PSEQvF2= NWD0SmtjW0GQR1XS
NB13 NWnaUWpZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUjJR|UxRTBwMEOzNVYh|ryP MmDMV2FPT0WU
ST486 NUHNN5hqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEOzN|ch|ryP NYTBdW1iW0GQR1XS
NCI-H82 NVzFdlFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1\1fmlEPTB;MD6wN|M1OyEQvF2= M{nVUHNCVkeHUh?=
NTERA-S-cl-D1 MoTsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NED2T2tKSzVyPUCuNFM{QTlizszN NUXEfFNzW0GQR1XS
ES4 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVPJR|UxRTBwMEO0OlMh|ryP NYDDUHVuW0GQR1XS
SK-NEP-1 NWi3c29pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3vkS2lEPTB;MD6wN|Q6QSEQvF2= NFPabWNUSU6JRWK=
Becker MmTkS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fPbWlEPTB;MD6wN|U2PSEQvF2= NVjS[oNLW0GQR1XS
A101D NYftWXJ3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEO3OFgh|ryP NHm5UZFUSU6JRWK=
SK-UT-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\DUZdiUUN3ME2wMlA{Pzd2IN88US=> NXHF[WRYW0GQR1XS
SW982 NFHpSGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHy2TW5KSzVyPUCuNFM4QSEQvF2= NWDORphGW0GQR1XS
TE-10 M2DSc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1vzeWlEPTB;MD6wOFA1PiEQvF2= NGe4ZlhUSU6JRWK=
OVCAR-4 Mle4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnH2TWM2OD1yLkC0NFU6KM7:TR?= NXrtV5FsW0GQR1XS
KP-N-YS NI\sPXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWT5eZhMUUN3ME2wMlA1ODh3IN88US=> M4jxenNCVkeHUh?=
BL-41 Mn[0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MULJR|UxRTBwMESxNlUh|ryP NXPQTpdDW0GQR1XS
MZ1-PC NIP5W4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2TIbWlEPTB;MD6wOFEzPyEQvF2= M1TH[HNCVkeHUh?=
PF-382 NHfEclhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF2zbY5KSzVyPUCuNFQyQThizszN NF;ofnlUSU6JRWK=
MOLT-13 NFPmSWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMESyN|gh|ryP M3;0e3NCVkeHUh?=
HCC1599 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2XIbGlEPTB;MD6wOFI2QCEQvF2= NInlbmtUSU6JRWK=
IST-MEL1 M1jGNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX\5c5BTUUN3ME2wMlA1PDR{IN88US=> NVrUXG5[W0GQR1XS
LU-139 NInJSZBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPwTo9qUUN3ME2wMlA1PDR{IN88US=> MmTUV2FPT0WU
MS-1 NGDQR25Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TwVmlEPTB;MD6wOFcxOSEQvF2= M{\BeXNCVkeHUh?=
MFH-ino NGexO2dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHoTWM2OD1yLkC1NFA{KM7:TR?= NYTLcZhtW0GQR1XS
IMR-5 NV7IZ4FZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn75TWM2OD1yLkC1NFIyKM7:TR?= NHW1T3RUSU6JRWK=
TE-5 M3fSdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjHTWdtUUN3ME2wMlA2ODZ|IN88US=> NHezPFlUSU6JRWK=
DJM-1 NWfWNnlUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPONGRKSzVyPUCuNFUyPDJizszN NXr1VIhrW0GQR1XS
NB17 NH\LNIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHuxbIhKSzVyPUCuNFUzODdizszN NXzQVohKW0GQR1XS
KARPAS-45 NVfPTnpkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVizPVgxUUN3ME2wMlA2OzV6IN88US=> Ml\pV2FPT0WU
TGBC1TKB NUWxVJVzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;6cIhKSzVyPUCuNFU1ODVizszN NVnrT5J{W0GQR1XS
ML-2 M{Cxb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfMZW9tUUN3ME2wMlA2PDF2IN88US=> NV\Tc3RDW0GQR1XS
no-10 M3PRSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMEW0O|Qh|ryP MVHTRW5ITVJ?
CTV-1 M{G0Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2PvRmlEPTB;MD6wOVUxOiEQvF2= MYjTRW5ITVJ?
SJSA-1 M37EVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NULQXoNnUUN3ME2wMlA2PTJizszN MkPLV2FPT0WU
HC-1 NGf1[JFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkexTWM2OD1yLkC1OVk4KM7:TR?= NUL6SXZMW0GQR1XS
TE-12 NIXhUYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXnsZm9iUUN3ME2wMlA2PjF|IN88US=> MnLDV2FPT0WU
KY821 M4DqUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\zZ5lKSzVyPUCuNFU3OzJizszN MVvTRW5ITVJ?
TALL-1 MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlOwTWM2OD1yLkC1O|A5KM7:TR?= NWDnbJp{W0GQR1XS
DEL NUDxfnJrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{WzbWlEPTB;MD6wOVcxQSEQvF2= MUPTRW5ITVJ?
TE-6 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnkZWJEUUN3ME2wMlA2PzJ{IN88US=> NY\tcYtpW0GQR1XS
SK-LMS-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn4TWM2OD1yLkC1PFA2KM7:TR?= MWrTRW5ITVJ?
EW-1 M37OTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1LBVmlEPTB;MD6wOVg{PyEQvF2= M{nhbXNCVkeHUh?=
8-MG-BA NICwSYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDoZ2t7UUN3ME2wMlA2QDVzIN88US=> NF7EN45USU6JRWK=
NALM-6 NXuyW4gyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWnQN2l4UUN3ME2wMlA2QTd|IN88US=> NFPEeHlUSU6JRWK=
LB771-HNC MoLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TwW2lEPTB;MD6wOVk4QSEQvF2= M3PhbXNCVkeHUh?=
HT-144 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHLXSVBKSzVyPUCuNFYyOyEQvF2= NIjk[4RUSU6JRWK=
KM-H2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkTUTWM2OD1yLkC2NlIyKM7:TR?= NHW0SFdUSU6JRWK=
SF268 NGLBcnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MULJR|UxRTBwME[yPFYh|ryP MlzEV2FPT0WU
RS4-11 MlPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3mycWlEPTB;MD6wOlMxPCEQvF2= NFzJcIFUSU6JRWK=
MHH-PREB-1 NX7nXWh2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HBb2lEPTB;MD6wOlMyQSEQvF2= M3fDN3NCVkeHUh?=
ATN-1 MmrhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwME[zOFUh|ryP NVTpPHkyW0GQR1XS
BB30-HNC M2\DOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\MPGlEPTB;MD6wOlQ{PiEQvF2= MoLoV2FPT0WU
CPC-N MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIiyWI1KSzVyPUCuNFY2OjRizszN NUn1dHc5W0GQR1XS
NB1 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwME[2NVMh|ryP MVnTRW5ITVJ?
KS-1 NXX0TXRoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrPTWM2OD1yLkC2O|Q5KM7:TR?= MWfTRW5ITVJ?
RXF393 MnvtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\0e5BKUUN3ME2wMlA3PzZ2IN88US=> NG\ITVlUSU6JRWK=
IST-SL2 MojjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7jXIh3UUN3ME2wMlA4ODB2IN88US=> NX\3eVRRW0GQR1XS
GI-ME-N NHLHVVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTBwMEeyPFYh|ryP MVzTRW5ITVJ?
VA-ES-BJ NVXUeIZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfNdo9KSzVyPUCuNFc1PzVizszN MUfTRW5ITVJ?
NCI-H1581 M4X5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX;BdldEUUN3ME2wMlA4PDd6IN88US=> Mlv0V2FPT0WU
U-266 MU\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWGwNlhUUUN3ME2wMlA4PDl5IN88US=> MlvIV2FPT0WU
DMS-114 M2\hbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHrNV3pKSzVyPUCuNFc2OjhizszN NGXlVVRUSU6JRWK=
NCI-H187 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4PVW2lEPTB;MD6wO|czPiEQvF2= MnL0V2FPT0WU
SW962 MoDXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jzc2lEPTB;MD6wO|g{QSEQvF2= Mn;XV2FPT0WU
MONO-MAC-6 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMEe5PFYh|ryP M4DQSHNCVkeHUh?=
MOLT-16 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\2b2lEPTB;MD6wPFEzOSEQvF2= NWPkS3p7W0GQR1XS
KNS-42 NWD2ZXZKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVLJR|UxRTBwMEixOlEh|ryP NHfwZpFUSU6JRWK=
CMK M1vkR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVfsco1YUUN3ME2wMlA5OjJ3IN88US=> NX22SoM6W0GQR1XS
Ramos-2G6-4C10 NHfKcnFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzMTWM2OD1yLkC4NlI2KM7:TR?= MlHNV2FPT0WU
Daudi M4nFW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2\ObWlEPTB;MD6wPFI2PiEQvF2= MULTRW5ITVJ?
NCI-H510A Ml3QS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2jyb2lEPTB;MD6wPFM{PiEQvF2= M2PR[HNCVkeHUh?=
LB831-BLC NFXMXG5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1nFeGlEPTB;MD6wPFU3OSEQvF2= NY\udJFCW0GQR1XS
HEL M{PvT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2XBfGlEPTB;MD6wPFY3QCEQvF2= MVvTRW5ITVJ?
LU-134-A MoC5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVTJR|UxRTBwMEi3NFgh|ryP NFX1[pFUSU6JRWK=
NCI-H1694 NHnPfHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGnnZVRKSzVyPUCuNFg4PDRizszN NV7O[YRWW0GQR1XS
KGN MnnRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrE[4NKSzVyPUCuNFg4PTlizszN M4D6V3NCVkeHUh?=
A253 M2jINmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;0U|dQUUN3ME2wMlA5QDJ{IN88US=> MX7TRW5ITVJ?
DG-75 M363SGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEi5NlIh|ryP MofyV2FPT0WU
MOLT-4 MmnDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwMEi5PFMh|ryP NXTJd2pSW0GQR1XS
NCI-SNU-5 M4\y[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEntVJlKSzVyPUCuNFkzPThizszN MlXvV2FPT0WU
ONS-76 MmDjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPBbINKSzVyPUCuNFkzPzZizszN MlH2V2FPT0WU
NCI-H446 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml\qTWM2OD1yLkC5OFYzKM7:TR?= MWrTRW5ITVJ?
COR-L279 NHvGdHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoXSTWM2OD1yLkC5OVU3KM7:TR?= MV;TRW5ITVJ?
Calu-6 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGDTWZdKSzVyPUCuNFk2QThizszN NF71eVZUSU6JRWK=
BC-3 M1jLSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjsfoxqUUN3ME2wMlA6PjZ{IN88US=> M4PmTXNCVkeHUh?=
NCI-H2126 NGHKWnhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rCcmlEPTB;MD6wPVc6OSEQvF2= M{\5SXNCVkeHUh?=
NCI-H1882 NVjENXBqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEm4NFkh|ryP M172[XNCVkeHUh?=
BB65-RCC NVSyO3I2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMUCyPVQh|ryP NVrJVmp{W0GQR1XS
DU-4475 M2jxd2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mk\kTWM2OD1yLkGwOFA4KM7:TR?= MoHIV2FPT0WU
NCI-H526 NY\yc2xoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWPJR|UxRTBwMUC0OEDPxE1? MnHTV2FPT0WU
NEC8 Ml\iS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjlT5hzUUN3ME2wMlExPTJ3IN88US=> NUS2WGFZW0GQR1XS
NCI-H1304 NIPXSWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{\ibGlEPTB;MD6xNFU6PCEQvF2= M1m5THNCVkeHUh?=
L-540 NXXrOmljT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PX[2lEPTB;MD6xNFcxQCEQvF2= NEexeVFUSU6JRWK=
NCI-SNU-16 NFHDZZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{HM[GlEPTB;MD6xNFc1OiEQvF2= NYH4T49wW0GQR1XS
HD-MY-Z NU\KdI9pT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPXN3FUUUN3ME2wMlExQDV4IN88US=> NFLtPXpUSU6JRWK=
K-562 NHqwXVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3GTWM2OD1yLkGwPFU5KM7:TR?= M1nGSnNCVkeHUh?=
JAR NHH4VZpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjsb|ZVUUN3ME2wMlExQTJ3IN88US=> NXjTO25xW0GQR1XS
MZ2-MEL M4TIPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnGyTWM2OD1yLkGxNFUh|ryP M3LuenNCVkeHUh?=
L-363 MljHS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{O0[GlEPTB;MD6xNVA4QSEQvF2= Ml60V2FPT0WU
BV-173 NX;p[WxRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml6wTWM2OD1yLkGxNlQ{KM7:TR?= MUTTRW5ITVJ?
NCI-H524 NXP5[nhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NG\VToJKSzVyPUCuNVEzPzRizszN MXLTRW5ITVJ?
EoL-1-cell MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwMUG2O|Ih|ryP NWTwZng{W0GQR1XS
K052 M36xRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlT6TWM2OD1yLkGxO|EzKM7:TR?= MVjTRW5ITVJ?
TK10 NXPweHNwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnzvTWM2OD1yLkGxO|I5KM7:TR?= MlW5V2FPT0WU
KU812 MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\tTWM2OD1yLkGyNFQ1KM7:TR?= MX7TRW5ITVJ?
RPMI-8226 M170SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYXJR|UxRTBwMUKwOVIh|ryP NUfUVG9OW0GQR1XS
MZ7-mel M1XWUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{na[mlEPTB;MD6xNlI{PyEQvF2= M1u1PHNCVkeHUh?=
SK-PN-DW Mnv2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnXSmxOUUN3ME2wMlEzOjh5IN88US=> NYPxZoo4W0GQR1XS
SR NV3V[Fg6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnizTWM2OD1yLkGyOFQyKM7:TR?= M{jFO3NCVkeHUh?=
RPMI-6666 MmrRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX7he5hJUUN3ME2wMlEzPzR|IN88US=> M2jPS3NCVkeHUh?=
no-11 MmLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmL1TWM2OD1yLkGyPFY6KM7:TR?= NHjn[oNUSU6JRWK=
EW-3 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMUK4PVMh|ryP NFPkOG5USU6JRWK=
LAMA-84 NGPHTYFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVjJR|UxRTBwMUOxPFch|ryP MV7TRW5ITVJ?
HT NH73eJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFXEW|BKSzVyPUCuNVM2PzRizszN M3e1eXNCVkeHUh?=
KP-N-RT-BM-1 NWDMVGlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGfK[WNKSzVyPUCuNVM3OTJizszN M4HQR3NCVkeHUh?=
NCI-H747 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrmcpN{UUN3ME2wMlE{PyEQvF2= MljwV2FPT0WU
NCCIT Mm\jS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXzmb4tMUUN3ME2wMlE{QTN7IN88US=> MUfTRW5ITVJ?
MLMA NGW0[VFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVvJR|UxRTBwMUSxOlch|ryP MV7TRW5ITVJ?
LP-1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2fEfGlEPTB;MD6xOFI1KM7:TR?= MmLIV2FPT0WU
CAL-148 NGj0TZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml3hTWM2OD1yLkG0OFg{KM7:TR?= MnLUV2FPT0WU
GB-1 M17SSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2qxZ2lEPTB;MD6xOFUzPiEQvF2= NXHHc5N[W0GQR1XS
COR-L88 M4O1OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYS3eJNRUUN3ME2wMlE1QDB{IN88US=> NWDsfmFYW0GQR1XS
NKM-1 Ml3XS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGjtdXBKSzVyPUCuNVQ6ODZizszN NIe1SGxUSU6JRWK=
NB5 M2ewUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwMUW0OlIh|ryP NIfzcI5USU6JRWK=
SH-4 M2T0c2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEn2T2NKSzVyPUCuNVU1PjZizszN Ml\FV2FPT0WU
EM-2 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2jrWWlEPTB;MD6xOVQ3PyEQvF2= MoD3V2FPT0WU
TGBC24TKB Mkj2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{m5d2lEPTB;MD6xOVY2QSEQvF2= M3G4V3NCVkeHUh?=
SCLC-21H M4LGZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLpTWM2OD1yLkG1O|AzKM7:TR?= NUnxdIhoW0GQR1XS
COLO-684 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M32wS2lEPTB;MD6xOVczOSEQvF2= NIHRToxUSU6JRWK=
KINGS-1 M{OweWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMUW5NUDPxE1? NYnXTHpCW0GQR1XS
LS-123 NVnIVZVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwMUW5NVch|ryP NIrITVVUSU6JRWK=
MC116 NX23VZdRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2TVR2lEPTB;MD6xOlE2QCEQvF2= Ml64V2FPT0WU
SU-DHL-1 NXjQO2NsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGTuO5FKSzVyPUCuNVYzODZizszN Mkj0V2FPT0WU
NCI-H64 NH[1T45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vUfmlEPTB;MD6xOlM1PyEQvF2= NInPeWxUSU6JRWK=
HCE-T MonUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV3LelFkUUN3ME2wMlE3PTB2IN88US=> M4nVPXNCVkeHUh?=
LOXIMVI NV\s[II3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYHCd3ZQUUN3ME2wMlE3QTR7IN88US=> M{K4RnNCVkeHUh?=
ARH-77 NVXwWGhuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIC0b5lKSzVyPUCuNVc{PzlizszN MoHhV2FPT0WU
DOHH-2 M3;YN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rWPWlEPTB;MD6xO|Y4OiEQvF2= Moi3V2FPT0WU
COLO-320-HSR MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzhZoZKSzVyPUCuNVgyPTRizszN M{T0RXNCVkeHUh?=
NB6 M2[xWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwMUi1OlYh|ryP M1HBfHNCVkeHUh?=
L-428 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlT4TWM2OD1yLkG4PFE{KM7:TR?= MljZV2FPT0WU
SNB75 NIPie2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYHJR|UxRTBwMUi4NlQh|ryP M2\4dnNCVkeHUh?=
NCI-H2141 M4HE[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NI[yXHFKSzVyPUCuNVkxOTFizszN MUjTRW5ITVJ?
KARPAS-299 M3PrVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIfrTnJKSzVyPUCuNVkzPDFizszN MlnnV2FPT0WU
LC4-1 NE\PVmRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXUTWM2OD1yLkG5OVAzKM7:TR?= M3Hpb3NCVkeHUh?=
UACC-257 M1PB[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVnJR|UxRTBwMUm5OFch|ryP NXHl[3B[W0GQR1XS
EVSA-T M{fBSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGrncJRKSzVyPUCuNlA{OTJizszN M{TGVXNCVkeHUh?=
JiyoyeP-2003 NXXyV2w5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHTKbHBKSzVyPUCuNlA1PzdizszN NV25U4RoW0GQR1XS
NCI-H720 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGTVN5NKSzVyPUCuNlA2OjVizszN NFjOTWlUSU6JRWK=
GAK NIj0N5RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoL0TWM2OD1yLkKxNVg6KM7:TR?= NHLHcZpUSU6JRWK=
HH M1Ha[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV;JR|UxRTBwMkG0NFUh|ryP NXTUUJBJW0GQR1XS
NCI-H1436 M1\kNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwMkG0OlQh|ryP M4\3RXNCVkeHUh?=
GR-ST MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoPuTWM2OD1yLkKxOFg5KM7:TR?= NVi0NItlW0GQR1XS
BC-1 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfOTWM2OD1yLkKyOlE3KM7:TR?= MljBV2FPT0WU
SIG-M5 NXi4UGtjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF;Pb3BKSzVyPUCuNlI4OjdizszN NF6yWZlUSU6JRWK=
NCI-H345 MnP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mof5TWM2OD1yLkKzPFA2KM7:TR?= NV\NcJR2W0GQR1XS
OPM-2 NUDNOGxDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTBTWM2OD1yLkKzPFgzKM7:TR?= NXvFfJpZW0GQR1XS
LB1047-RCC M2jYUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFfPRXFKSzVyPUCuNlQ1OSEQvF2= MnzkV2FPT0WU
CTB-1 MkHtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWW4SIpmUUN3ME2wMlI1PDl|IN88US=> NEL3e45USU6JRWK=
A3-KAW MoeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVzJR|UxRTBwMkWzOFEh|ryP Ml;QV2FPT0WU
SF126 MknaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13id2lEPTB;MD6yOVM5OyEQvF2= M{j4THNCVkeHUh?=
KARPAS-422 NXm1eYQ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX7JR|UxRTBwMkW0N|Uh|ryP MW\TRW5ITVJ?
MEG-01 MmO3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYrJR|UxRTBwMkW2O|Mh|ryP M2TpOXNCVkeHUh?=
NCI-H209 NYXsfmp[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWXJR|UxRTBwMk[zO|Qh|ryP NGnFO3FUSU6JRWK=
SBC-1 MnjLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV7JR|UxRTBwMk[1JO69VQ>? MXnTRW5ITVJ?
K5 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTBwMk[5PFQh|ryP M2XYN3NCVkeHUh?=
QIMR-WIL MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUjHXmg4UUN3ME2wMlI4OTV3IN88US=> NGLaWHFUSU6JRWK=
NMC-G1 NFzScItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3j0UGlEPTB;MD6yPFIyPyEQvF2= MUjTRW5ITVJ?
IST-MES1 MlrFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXWwSlVjUUN3ME2wMlI6OjN6IN88US=> M2OwNnNCVkeHUh?=
SW684 NHTJd3pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVrJR|UxRTBwM{CwOFch|ryP MmrVV2FPT0WU
MV-4-11 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF2ycINKSzVyPUCuN|A4QDhizszN NGficYJUSU6JRWK=
LAN-6 NXPkO4QzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwM{G1O|Ih|ryP MnHZV2FPT0WU
RH-1 MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NES3NFRKSzVyPUCuN|E5PzFizszN MXnTRW5ITVJ?
CP66-MEL M{XmfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUjlS3NYUUN3ME2wMlMyQDd6IN88US=> MoKyV2FPT0WU
EC-GI-10 NVzHfmVPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHryWINKSzVyPUCuN|I6QDdizszN MmfLV2FPT0WU
GDM-1 M4\1Umdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fYPWlEPTB;MD6zN|A2QSEQvF2= M3rXRnNCVkeHUh?=
IST-SL1 NYK5SmtMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1LLNWlEPTB;MD6zOFkyPCEQvF2= NUe2bXE2W0GQR1XS
KMOE-2 NV7XV2N3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWDMTFNvUUN3ME2wMlM2OTd3IN88US=> MkXJV2FPT0WU
OS-RC-2 MlvES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX7JR|UxRTBwM{W1OFQh|ryP NYHJXGJ5W0GQR1XS
HDLM-2 NUTJOIwxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH[3ZmZKSzVyPUCuN|c5OTRizszN MnXyV2FPT0WU
DSH1 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1HUemlEPTB;MD6zPFY{OSEQvF2= MnrSV2FPT0WU
LS-1034 MoLJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnK2TWM2OD1yLkO4PVU1KM7:TR?= MkLSV2FPT0WU
LB373-MEL-D MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmfxTWM2OD1yLkO5NVk4KM7:TR?= M3nJO3NCVkeHUh?=
GOTO Mm\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mm[4TWM2OD1yLkSyNVE5KM7:TR?= MVrTRW5ITVJ?
MRK-nu-1 NYLjU|cxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{LBTmlEPTB;MD60NlIxPSEQvF2= NYLrTWR[W0GQR1XS
SK-MM-2 MknUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2fY[mlEPTB;MD60N|Q1OiEQvF2= MnX6V2FPT0WU
BOKU MnjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHG0VIlKSzVyPUCuOFM4QTJizszN NIDJdphUSU6JRWK=
NOMO-1 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwNEO4OkDPxE1? MmTTV2FPT0WU
J-RT3-T3-5 NHn4eIlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M13aNmlEPTB;MD60OFg4QCEQvF2= Ml;rV2FPT0WU
COLO-668 M{WyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjNcYtKSzVyPUCuOFU3PjhizszN NIfUellUSU6JRWK=
SF539 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWLJR|UxRTBwNEi2PFQh|ryP MmW2V2FPT0WU
LB2518-MEL MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUjJR|UxRTBwNEm3NFMh|ryP MVrTRW5ITVJ?
TE-441-T MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHucmdEUUN3ME2wMlUxOTJizszN NIT0dlJUSU6JRWK=
MDA-MB-134-VI NFjRVW5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHETWM2OD1yLkWwPVIyKM7:TR?= M374dHNCVkeHUh?=
SCC-3 MkeyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWLUdo9LUUN3ME2wMlUyQDd|IN88US=> MWfTRW5ITVJ?
KLE NInGOlVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\SWZhKSzVyPUCuOVIyPzFizszN MYjTRW5ITVJ?
LB2241-RCC MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NI[2TGFKSzVyPUCuOVI2OjVizszN NGHsPYdUSU6JRWK=
NCI-H1417 NVfCe4EzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M37CdmlEPTB;MD61N|Q{PSEQvF2= MYXTRW5ITVJ?
NCI-H2081 NHHvSo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{i4S2lEPTB;MD61PFYyOSEQvF2= NWjvNZpuW0GQR1XS
NCI-H1522 NV7pVY5vT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnL1TWM2OD1yLkW5N|g{KM7:TR?= M4jaWXNCVkeHUh?=
NCI-H889 NUjUbnNuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVnl[HFyUUN3ME2wMlU6QDR2IN88US=> NFK4PIdUSU6JRWK=
CGTH-W-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwNkC3OVUh|ryP NXTZfIgyW0GQR1XS
EB-3 NUTaU5g{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH\t[W1KSzVyPUCuOlEyPTNizszN M3;KbHNCVkeHUh?=
D-336MG NUTtUG5PT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlLLTWM2OD1yLk[xO|kyKM7:TR?= M{\hWHNCVkeHUh?=
LC-1F Mlu1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYm2[2Y1UUN3ME2wMlYzPTl{IN88US=> MVvTRW5ITVJ?
MHH-NB-11 NV[2WGRVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\CTWM2OD1yLk[zPFAyKM7:TR?= NUTrRnpQW0GQR1XS
SK-N-FI MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGKwb25KSzVyPUCuOlM6OSEQvF2= MkOzV2FPT0WU
NCI-H69 Mn:4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVv4N2hEUUN3ME2wMlY1QDd7IN88US=> Mln0V2FPT0WU
SCH NX31dmloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXnpO5hCUUN3ME2wMlY3ODJ|IN88US=> MnfaV2FPT0WU
LS-513 NEn5Z4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwNkeyOVkh|ryP NG[0b|VUSU6JRWK=
CP67-MEL M4DMSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlmzTWM2OD1yLk[3OVk3KM7:TR?= MVfTRW5ITVJ?
GCIY NGDXdWFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDKZlZKSzVyPUCuO|A{PjNizszN NX\uSXc1W0GQR1XS
SHP-77 MlzmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTxTWM2OD1yLkewO|M1KM7:TR?= MknxV2FPT0WU
EHEB NUnsWGVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PxeGlEPTB;MD63NVg2PCEQvF2= MkPBV2FPT0WU
D-247MG NXzrd|JYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3hTWM2OD1yLkezNlMzKM7:TR?= MXjTRW5ITVJ?
Raji MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm[1TWM2OD1yLke0PVg6KM7:TR?= MmHRV2FPT0WU
MPP-89 NVPvcYFQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXPjZ4R4UUN3ME2wMlc2QTd6IN88US=> Ml3mV2FPT0WU
EKVX MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLTTWM2OD1yLke5NFc{KM7:TR?= NGXJWlhUSU6JRWK=
HCC2218 NW[yd|QyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVHJR|UxRTBwN{mxN|Eh|ryP M1XJbHNCVkeHUh?=
KNS-81-FD M4O5Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwOEGwNVEh|ryP MUTTRW5ITVJ?
HCC2157 MmHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M13s[GlEPTB;MD64OFk2OSEQvF2= MWPTRW5ITVJ?
BT-474 MlXNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{PnW2lEPTB;MD64PFg2PCEQvF2= NYrBWnl4W0GQR1XS
NCI-H748 M32yUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWjJR|UxRTBwOUGyJO69VQ>? MVfTRW5ITVJ?
EW-24 NVezfnlQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwOUKwNFIh|ryP NFrrRXdUSU6JRWK=
D-263MG M1Kz[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1rwXGlEPTB;MD65OFUyOiEQvF2= NUHWbHhPW0GQR1XS
OMC-1 NUnmT4JYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4G4dWlEPTB;MD65OlM4OyEQvF2= MmixV2FPT0WU
NCI-H2196 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mnn5TWM2OD1yLkm3O|c4KM7:TR?= MnXoV2FPT0WU
HAL-01 MkPGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoLuTWM2OD1yLkm5PFczKM7:TR?= NUXLcndiW0GQR1XS
NCI-H2107 NW\vcGNnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3HW[2lEPTB;MT6wNVg2PCEQvF2= MlX4V2FPT0WU
LB996-RCC NXPuOJlMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnVTWM2OD1zLkC4NFUyKM7:TR?= NHTUPY1USU6JRWK=
NCI-H1395 NH\J[plIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3\jdWlEPTB;MT6xNFY4KM7:TR?= M1nRRXNCVkeHUh?=
CHP-126 MnPSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlTQTWM2OD1zLkG2NVk6KM7:TR?= NVP5fHQ2W0GQR1XS
NB69 M4i4eWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MmnZTWM2OD1zLkK2NVQ5KM7:TR?= MoTUV2FPT0WU
CAS-1 M4TwWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRTFwM{SyN|Eh|ryP M{HoSXNCVkeHUh?=
JVM-3 Mo\rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVP1Zm9RUUN3ME2xMlQ4QDV3IN88US=> NYjrVHpyW0GQR1XS
DMS-153 M4n4SWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1PKPWlEPTB;MT61O|Y4PCEQvF2= MX3TRW5ITVJ?
SK-MEL-2 M{HHVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTFwN{G3PFkh|ryP M1v5NnNCVkeHUh?=
NCI-H1155 NGDwUG1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUnMRVNjUUN3ME2xMlc{Pjd4IN88US=> M1\ke3NCVkeHUh?=
NCI-H1092 NFHoZpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnK1TWM2OD1zLke2NVgzKM7:TR?= NULUWY9lW0GQR1XS
LU-165 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVLWNYNsUUN3ME2xMlg3PDd4IN88US=> Mle2V2FPT0WU
HL-60 NF\XflNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHnVVmFKSzVyPUGuPVk6ODhizszN MlnJV2FPT0WU
REH M4XCTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rUTmlEPTB;Mj6wNFU5OiEQvF2= M{HTeXNCVkeHUh?=
JVM-2 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmPVTWM2OD1{LkC2NVM2KM7:TR?= M1jrSHNCVkeHUh?=
MN-60 NVTuXWhxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWfJR|UxRTJwMUezNFgh|ryP NHfXZYdUSU6JRWK=
SCC-15 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NE\WNlhKSzVyPUKuNlAzPyEQvF2= NFLTNWdUSU6JRWK=
SNU-C1 NIX2XXlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mk[1TWM2OD1{LkKxN|Q{KM7:TR?= MYjTRW5ITVJ?
SK-MEL-1 NGPXXlZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nNc2lEPTB;Mj6zNlA1PyEQvF2= NF;vbolUSU6JRWK=
TGW M2DEdGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXGwd492UUN3ME2yMlM2ODJ5IN88US=> MmLWV2FPT0WU
CA46 M{LuSGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2q3XmlEPTB;Mj63OVk3PyEQvF2= M4HNR3NCVkeHUh?=
NCI-H23 NUX5d2twT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPielNKSzVyPUKuPFA4QTFizszN M3riS3NCVkeHUh?=
MMAC-SF Mk\5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnkN4FHUUN3ME2yMlg3PjJ6IN88US=> MUTTRW5ITVJ?
NCI-H2171 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1j6XmlEPTB;Mz6wN|Q1QCEQvF2= NGDPVmNUSU6JRWK=
A704 MnLKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTNwMUSxPVQh|ryP MUnTRW5ITVJ?
DB MmT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIj2OG9KSzVyPUOuNlU2PzZizszN M3;EWHNCVkeHUh?=
NCI-H719 NVnyTGFVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXsTWM2OD1|LkOwN|g1KM7:TR?= MoLFV2FPT0WU
MC-CAR NVXYNYk6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NInkOY5KSzVyPUOuOVQ5OTdizszN Mn22V2FPT0WU
SIMA MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33XRmlEPTB;Mz61PFQyPiEQvF2= MX3TRW5ITVJ?
SW872 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlOxTWM2OD1|Lke4NVAyKM7:TR?= MX;TRW5ITVJ?
HCC1187 NF;1Um1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnrCTWM2OD1|Lke4N|E2KM7:TR?= M{XGWHNCVkeHUh?=
EW-13 MkXuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fTcWlEPTB;Mz64N|QyPyEQvF2= NELnWHNUSU6JRWK=
NCI-SNU-1 NIG1WGpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NH3KTGhKSzVyPUSuNlE6QTlizszN MUjTRW5ITVJ?
NCI-H226 NYLIRml4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NED6WW9KSzVyPUSuN|M3ODZizszN NV;SR3NrW0GQR1XS
RPMI-8866 M3PkZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTueWFWUUN3ME20MlM3ODJ7IN88US=> NHHwXo5USU6JRWK=
OCI-AML2 M1XKO2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXTLbVR7UUN3ME20MlU2OjNizszN NUfSdYc{W0GQR1XS
LU-65 MkCxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUPLfFU4UUN3ME20Mlk{ODN|IN88US=> NFHLVllUSU6JRWK=
SK-N-DZ MoTjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\NWodKSzVyPUWuOlM1PjVizszN NYf0OoRrW0GQR1XS
NB14 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWXJR|UxRTVwOUexN|Uh|ryP MoKxV2FPT0WU
COLO-829 M1PCZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVvJR|UxRTZwM{OzOVkh|ryP NXnUNG81W0GQR1XS
MHH-CALL-2 NFyxeHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWXNTopRUUN3ME22MlUyPTB6IN88US=> NY[5RmJjW0GQR1XS
NCI-H1770 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYrpcHVJUUN3ME22MlY3QTB2IN88US=> MXjTRW5ITVJ?
ECC4 NHjTVXVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXOye4lJUUN3ME22MlgzOTd7IN88US=> MnrOV2FPT0WU
A498 NE\ZSIhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHv5OYtKSzVyPU[uPFcyQTJizszN MlX5V2FPT0WU
DMS-79 M{LPemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTdwMES1NVIh|ryP MUDTRW5ITVJ?
P30-OHK MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjXWllSUUN3ME23MlIyQTB4IN88US=> NX\xOpFQW0GQR1XS
D-502MG MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTdwOUizOkDPxE1? MUTTRW5ITVJ?
RCC10RGB MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlK1TWM2OD16LkC2Nlgh|ryP NXjrb4pxW0GQR1XS
U-698-M NU\RRWRET3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1rQR2lEPTB;OD6yPVIzPiEQvF2= MW\TRW5ITVJ?
BB49-HNC MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfNWYVKSzVyPUmuOFIzPjVizszN MYrTRW5ITVJ?
ES1 NYrSOplXT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGSwUXBKSzVyPUmuOlg6PTZizszN MlS3V2FPT0WU
MFM-223 NF3J[2pIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTFyLkm5Nlch|ryP NXvBcVV6W0GQR1XS
C2BBe1 M{D4bmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXzJR|UxRTFzLkO1NlMh|ryP NEDt[3hUSU6JRWK=
EB2 Mm\KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYPtbohQUUN3ME2xNk43QDhzIN88US=> NWXJUopkW0GQR1XS
C8166 NV;xU5I5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LjW2lEPTB;MUOuPFMxOyEQvF2= MkW2V2FPT0WU
ES3 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVzmUmVGUUN3ME2xN{46QTd5IN88US=> MUXTRW5ITVJ?
NCI-H1650 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH30fmxKSzVyPUG2MlM4PjVizszN MWHTRW5ITVJ?
Mo-T MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTF5LkSwNlkh|ryP MmHUV2FPT0WU
NB7 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4SyemlEPTB;MUeuO|Q3PyEQvF2= MXXTRW5ITVJ?
ES7 MlTYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnuRXo{UUN3ME2xPU42PTB5IN88US=> NH64U29USU6JRWK=
ES5 M2L0cmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTKTWM2OD1{MT63OlcyKM7:TR?= M1TUdHNCVkeHUh?=
MSTO-211H NVfpUmNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml65TWM2OD1{MT64PFU5KM7:TR?= MX\TRW5ITVJ?
U-87-MG MnSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NILMSopKSzVyPUK1MlE6PjZizszN NVv2fotqW0GQR1XS
THP-1 NWDo[YNkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1[xWGlEPTB;MkmuO|IxOSEQvF2= M2T1bnNCVkeHUh?=
NB10 NXPnTWd1T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn:1TWM2OD1|MD6yOlk1KM7:TR?= M1:yU3NCVkeHUh?=
NH-12 MoLxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGLlbFFKSzVyPUOzMlIxOTdizszN MWPTRW5ITVJ?
COLO-824 M2XIW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MULJR|UxRTN2LkGwNFYh|ryP MlXhV2FPT0WU
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ACHN NW\EOYpvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{GzRlUuQDBibl2= NWXoNHgxQTZiaB?= NY\wfmtGUEOu NVGye2RZe3WycILld5NmeyC2aHWgdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5meiC5aYToJGlEPTEEoI\hcJVmeyCxZjCyJJRwKDJyIH7N NUPzcIlzOjF4NEKzO|Q>
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HMC-1.1 NFPXWllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXvb5AyNTFyMECgcm0> MVW3NkBp NVK4SJA3cW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6n MUCyNVI1OjF6OR?=
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C2 M1;oWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWLjeWJUOS1zMECwJI5O NEC2cIQ4OiCq MVrpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> NU\C[41FOjF{NEKxPFk>
CHP-212 NVm3R|FwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF\UN5UyNTF{NTDuUS=> M4P2cVI1NTF{MDDo MVrpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n MWGyNVE3QTJ2Mh?=
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Kelly M{XXVGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnSwNU0yOjVibl2= MX6yOE0yOjBiaB?= M3\tW4lvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= NIHF[nAzOTF4OUK0Ni=>
SH-EP MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWCxMVEzPSCwTR?= MnvRNlQuOTJyIHi= NXTEbIxOcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> M2SwPVIyOTZ7MkSy
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KG1 M4L2V2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUX4So5QOS9zMD:xNFAhdk1? NEP3SJE4OiCq NW[yeVJHTE2VTx?= NFK0cZpqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MkLCNVk1PTh|NUi=
U937 M3TSVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{jGSlEwOTBxMUCwJI5O NYfRd2lFPzJiaB?= MYPEUXNQ MWjpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n NXnQeVlzOTl2NUizOVg>
CAL62 NILCR4NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUOwMlEuOTByIH7N NIj4fXY4OiCq NG\rRoFFVVOR MV7FR|UxRTFwNDDuUS=> MWSxPVIzOzV3Mx?=
OCUT-1 NXXifJRlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MojGNE4yNTFyMDDuUS=> MljmO|IhcA>? MYDEUXNQ MYTFR|UxRTJwMzDuUS=> NETROnoyQTJ{M{W1Ny=>
8505C M1TGcmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHvNE4yNTFyMDDuUS=> MoiyO|IhcA>? NH\G[HBFVVOR MkfYSWM2OD1|LkKgcm0> NVrHOIdUOTl{MkO1OVM>
ACT-1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFfpZlgxNjFvMUCwJI5O M1LEZ|czKGh? M1rlR2ROW09? M120XGVEPTB;NT60JI5O MkS3NVkzOjN3NUO=
SW1736 NXjWOpFbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWTvWFdqOC5zLUGwNEBvVQ>? MkX0O|IhcA>? M4LtT2ROW09? MX7FR|UxRTVwNjDuUS=> NX\BNWVSOTl{MkO1OVM>

... Click to View More Cell Line Experimental Data

In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
+ Expand
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
30% PEG 400+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID