BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 670 In stock
USD 997 In stock
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Cited by 54 Publications

12 Customer Reviews

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

  • Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like cells after treatment with BI 2536 for 24 and 48 hours, respectively.

    Oncotarget, 2017, 8(23):37633-37645. BI 2536 purchased from Selleck.

    Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

  • J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

    Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 Mo\JS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVTCUFlCUUN3ME2wMlAxPzd4IN88US=> NVziTmZQW0GQR1XS
ACN Mk\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;abYJKSzVyPUCuNFA5PDNizszN NET5V|ZUSU6JRWK=
TE-8 NYXORoRDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXmTWM2OD1yLkCwPVQyKM7:TR?= M{TjeXNCVkeHUh?=
LC-2-ad NYTISnJFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEGwPVMh|ryP NYDTXo9JW0GQR1XS
ALL-PO NIH3bnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFq2T3JKSzVyPUCuNFE{KM7:TR?= MVXTRW5ITVJ?
EW-16 M2LmOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mnn0TWM2OD1yLkCxN|M3KM7:TR?= M2O5OnNCVkeHUh?=
KM12 MoHDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYnJR|UxRTBwMEGzOFgh|ryP M33mfnNCVkeHUh?=
GI-1 MojCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrLO4hNUUN3ME2wMlAyOzh|IN88US=> MXPTRW5ITVJ?
LS-411N NV70d411T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX3JR|UxRTBwMEG0NFch|ryP NIi3S49USU6JRWK=
ES8 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnK4TWM2OD1yLkCxOFk1KM7:TR?= MlrTV2FPT0WU
SNU-C2B NVrWSYJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX;JR|UxRTBwMEG1NlYh|ryP MmjTV2FPT0WU
CESS NYry[GdOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3[4ZWlEPTB;MD6wNVYxOiEQvF2= NW[0VGVXW0GQR1XS
697 NFmxcmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUPq[5B[UUN3ME2wMlAyPjZ6IN88US=> NEXa[W1USU6JRWK=
NCI-H1963 MmHXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmeyTWM2OD1yLkCxOlc{KM7:TR?= NImxS3hUSU6JRWK=
IA-LM MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXLVphKSzVyPUCuNFE3QDhizszN NF3tVY9USU6JRWK=
SW954 NEjrSVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUDJR|UxRTBwMEG3NFUh|ryP MYDTRW5ITVJ?
RL95-2 NVv0fYlqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2rp[mlEPTB;MD6wNVc{QCEQvF2= M33Oe3NCVkeHUh?=
LXF-289 NEixflFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwMEG3O{DPxE1? MYnTRW5ITVJ?
OCUB-M MmrES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYDseZNJUUN3ME2wMlAyQDJ4IN88US=> M3XqT3NCVkeHUh?=
RKO NY\jb|JiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXHJR|UxRTBwMEG5PFch|ryP NIfaVodUSU6JRWK=
LOUCY NYHIV4lQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVrJR|UxRTBwMEKwOUDPxE1? M33jN3NCVkeHUh?=
NOS-1 MkPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWHGboNKUUN3ME2wMlAzODl|IN88US=> NF:zfWtUSU6JRWK=
A4-Fuk MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzTV5BKSzVyPUCuNFIzOThizszN NX7DdHU2W0GQR1XS
A388 MlvSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWnJR|UxRTBwMEKyNlch|ryP MVvTRW5ITVJ?
TE-9 NIn6VIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTBwMEKyOlEh|ryP M122WnNCVkeHUh?=
KURAMOCHI MWLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGPDe29KSzVyPUCuNFIzQDVizszN M33lfXNCVkeHUh?=
KALS-1 NFvHUHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmfHTWM2OD1yLkCyN|M5KM7:TR?= NYfS[GxqW0GQR1XS
HOP-62 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mkm0TWM2OD1yLkCyOFIh|ryP NWLRNm9ZW0GQR1XS
RPMI-8402 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXfKbolPUUN3ME2wMlAzPTB6IN88US=> NUDFNHpZW0GQR1XS
TE-1 M2PidGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3izZWlEPTB;MD6wNlUyOiEQvF2= M4i1NXNCVkeHUh?=
CCRF-CEM MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGLyW2xKSzVyPUCuNFI2PDNizszN NGjH[4hUSU6JRWK=
HUTU-80 M3y3Z2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjLR4pKSzVyPUCuNFI3OjRizszN M{nTWnNCVkeHUh?=
NCI-H1648 MlXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mlj0TWM2OD1yLkCyOlQ4KM7:TR?= NIHlfGJUSU6JRWK=
HCE-4 M2PZTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHS1OpRKSzVyPUCuNFI3QDJizszN NGnJPHFUSU6JRWK=
ETK-1 Mnm2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTBZnNJUUN3ME2wMlAzPzN4IN88US=> NWLnNlA5W0GQR1XS
TE-15 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NY\VWHFkUUN3ME2wMlAzPzN6IN88US=> M3qyPXNCVkeHUh?=
BE-13 MmPMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIDmd41KSzVyPUCuNFI4PCEQvF2= MXvTRW5ITVJ?
KE-37 NFXHbmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2HzeWlEPTB;MD6wNlc1OSEQvF2= NGiwU3dUSU6JRWK=
NCI-H1355 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMEK3PFMh|ryP NGXKVpBUSU6JRWK=
TE-11 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fHcWlEPTB;MD6wNlgxQSEQvF2= M2LDd3NCVkeHUh?=
BL-70 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkHVTWM2OD1yLkCyPFU4KM7:TR?= NEjhTm9USU6JRWK=
ES6 NVTDVFI{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3v1NGlEPTB;MD6wNlg5OSEQvF2= M2ixfnNCVkeHUh?=
GT3TKB M1jaRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\Qe3dSUUN3ME2wMlAzQTV|IN88US=> NEjRNmhUSU6JRWK=
LB647-SCLC Mm[1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF3jO4RKSzVyPUCuNFMyQTVizszN MYDTRW5ITVJ?
NB13 M2jLOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{L3c2lEPTB;MD6wN|MyPiEQvF2= MmnZV2FPT0WU
ST486 NFnMbZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTBwMEOzN|ch|ryP M4LDfXNCVkeHUh?=
NCI-H82 M1W5Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF60[YVKSzVyPUCuNFM{PDNizszN M3zHcHNCVkeHUh?=
NTERA-S-cl-D1 MoLQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1n4[GlEPTB;MD6wN|M6QSEQvF2= M{LWSHNCVkeHUh?=
ES4 NV3FT5NDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXjTWM2OD1yLkCzOFY{KM7:TR?= NWPmVVlxW0GQR1XS
SK-NEP-1 M{S2Nmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH7z[5BKSzVyPUCuNFM1QTlizszN MULTRW5ITVJ?
Becker NYG5dnZ6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHXTWM2OD1yLkCzOVU2KM7:TR?= MoftV2FPT0WU
A101D MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mo\CTWM2OD1yLkCzO|Q5KM7:TR?= MXXTRW5ITVJ?
SK-UT-1 NHLPbIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4C5XWlEPTB;MD6wN|c4PCEQvF2= MV7TRW5ITVJ?
SW982 NHzDPGNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4rRW2lEPTB;MD6wN|c6KM7:TR?= NX[2V29{W0GQR1XS
TE-10 M{\ZRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH:wbXNKSzVyPUCuNFQxPDZizszN MWfTRW5ITVJ?
OVCAR-4 NUXOboVZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XaS2lEPTB;MD6wOFA2QSEQvF2= M2HJfnNCVkeHUh?=
KP-N-YS NXHaeYVtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHG3VXNKSzVyPUCuNFQxQDVizszN MkG3V2FPT0WU
BL-41 MlHRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfqTWM2OD1yLkC0NVI2KM7:TR?= MWPTRW5ITVJ?
MZ1-PC NGfrVWlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX:2UYVEUUN3ME2wMlA1OTJ5IN88US=> M1TsfnNCVkeHUh?=
PF-382 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjze|RKSzVyPUCuNFQyQThizszN M3n3WXNCVkeHUh?=
MOLT-13 M2PET2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\EVmlEPTB;MD6wOFI{QCEQvF2= NUf1UHFqW0GQR1XS
HCC1599 M4n4ZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMESyOVgh|ryP NX3BZXlkW0GQR1XS
IST-MEL1 M{PqVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4TVTWlEPTB;MD6wOFQ1OiEQvF2= M163OHNCVkeHUh?=
LU-139 NFHM[2ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYC2SmwyUUN3ME2wMlA1PDR{IN88US=> NIiwV4VUSU6JRWK=
MS-1 MoTSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4nPWWlEPTB;MD6wOFcxOSEQvF2= M1TiO3NCVkeHUh?=
MFH-ino NU\nVlVUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnTaTWM2OD1yLkC1NFA{KM7:TR?= M{iw[XNCVkeHUh?=
IMR-5 M4i4RWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XuVmlEPTB;MD6wOVAzOSEQvF2= MXLTRW5ITVJ?
TE-5 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{HEeGlEPTB;MD6wOVA3OyEQvF2= NVyyRlBUW0GQR1XS
DJM-1 NFrBcGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIHud21KSzVyPUCuNFUyPDJizszN NHjXfVhUSU6JRWK=
NB17 NI\4V49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX\JR|UxRTBwMEWyNFch|ryP NUjuXVlmW0GQR1XS
KARPAS-45 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV3JR|UxRTBwMEWzOVgh|ryP MVLTRW5ITVJ?
TGBC1TKB NG\1bItIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M37WcmlEPTB;MD6wOVQxPSEQvF2= MWHTRW5ITVJ?
ML-2 Mo\kS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MmrBTWM2OD1yLkC1OFE1KM7:TR?= NEnx[GNUSU6JRWK=
no-10 MmO1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoC1TWM2OD1yLkC1OFc1KM7:TR?= M1HSfnNCVkeHUh?=
CTV-1 MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfLRnNmUUN3ME2wMlA2PTB{IN88US=> NUPnRYh5W0GQR1XS
SJSA-1 NH:xfHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2mwWmlEPTB;MD6wOVUzKM7:TR?= NH70[nhUSU6JRWK=
HC-1 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWrQeINKUUN3ME2wMlA2PTl5IN88US=> NEfXfnlUSU6JRWK=
TE-12 M4PpTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXTJR|UxRTBwMEW2NVMh|ryP M4jvOnNCVkeHUh?=
KY821 NXz5VGVuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4P1WWlEPTB;MD6wOVY{OiEQvF2= NXPaPZpQW0GQR1XS
TALL-1 NGXFeYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVXJR|UxRTBwMEW3NFgh|ryP MV;TRW5ITVJ?
DEL MoHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnq5TWM2OD1yLkC1O|A6KM7:TR?= NVO3NHMzW0GQR1XS
TE-6 NVj1bFgyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjwXmVKSzVyPUCuNFU4OjJizszN M2LJVXNCVkeHUh?=
SK-LMS-1 NWjNfG17T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fSbmlEPTB;MD6wOVgxPSEQvF2= Mof3V2FPT0WU
EW-1 NFn4[nBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7Mb2tKSzVyPUCuNFU5OzdizszN MWXTRW5ITVJ?
8-MG-BA NID1PHJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF6w[nlKSzVyPUCuNFU5PTFizszN NVTaZ2R[W0GQR1XS
NALM-6 M3z4NWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV\GPZN[UUN3ME2wMlA2QTd|IN88US=> Ml3VV2FPT0WU
LB771-HNC MoO0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGXuZWhKSzVyPUCuNFU6PzlizszN NWTKOI5jW0GQR1XS
HT-144 MkTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NY\MVWN3UUN3ME2wMlA3OTNizszN NVGweXdPW0GQR1XS
KM-H2 M2Dl[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDmTWM2OD1yLkC2NlIyKM7:TR?= MXjTRW5ITVJ?
SF268 M3zEN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTBwME[yPFYh|ryP NV7vU|dpW0GQR1XS
RS4-11 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTj[XJKSzVyPUCuNFY{ODRizszN NY\EbmwxW0GQR1XS
MHH-PREB-1 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MluyTWM2OD1yLkC2N|E6KM7:TR?= M1u3UXNCVkeHUh?=
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MV-4-11 M{j2UWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;a[mlEPTB;MD6zNFc5QCEQvF2= MlLKV2FPT0WU
LAN-6 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVOze4F6UUN3ME2wMlMyPTd{IN88US=> NYrRU3dXW0GQR1XS
RH-1 MkPoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUXGXYRpUUN3ME2wMlMyQDdzIN88US=> M{DkVnNCVkeHUh?=
CP66-MEL M1zYZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP4TWM2OD1yLkOxPFc5KM7:TR?= M3jTfHNCVkeHUh?=
EC-GI-10 NEDub|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NE\EeppKSzVyPUCuN|I6QDdizszN MXjTRW5ITVJ?
GDM-1 MkD1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWjJR|UxRTBwM{OwOVkh|ryP NFPhPIlUSU6JRWK=
IST-SL1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXHEd|lHUUN3ME2wMlM1QTF2IN88US=> M3nG[3NCVkeHUh?=
KMOE-2 Mly0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHiXYxKSzVyPUCuN|UyPzVizszN NIn5N4hUSU6JRWK=
OS-RC-2 NV7kU3hHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml7jTWM2OD1yLkO1OVQ1KM7:TR?= NFHUbXBUSU6JRWK=
HDLM-2 NW\SeGdIT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml3oTWM2OD1yLkO3PFE1KM7:TR?= M3;MTnNCVkeHUh?=
DSH1 NH;zfFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIC5TYxKSzVyPUCuN|g3OzFizszN MkG5V2FPT0WU
LS-1034 NFrydpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NITCcYxKSzVyPUCuN|g6PTRizszN M4HDd3NCVkeHUh?=
LB373-MEL-D M3fub2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NE[1cZhKSzVyPUCuN|kyQTdizszN NV7KPZRwW0GQR1XS
GOTO M1LnXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NHv6dY1KSzVyPUCuOFIyOThizszN NEP5U3lUSU6JRWK=
MRK-nu-1 NU\hWGNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwNEKyNFUh|ryP M2HDUHNCVkeHUh?=
SK-MM-2 M3HFbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3S5fGlEPTB;MD60N|Q1OiEQvF2= NEWwfGVUSU6JRWK=
BOKU NHmyNoRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1np[mlEPTB;MD60N|c6OiEQvF2= M2rwUXNCVkeHUh?=
NOMO-1 NVHnbmJiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3jmOmlEPTB;MD60N|g3KM7:TR?= M1j4PXNCVkeHUh?=
J-RT3-T3-5 NEPuToNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlr5TWM2OD1yLkS0PFc5KM7:TR?= Mn\1V2FPT0WU
COLO-668 NUG1ZlhFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIPWTmZKSzVyPUCuOFU3PjhizszN MWfTRW5ITVJ?
SF539 MmLRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnnJTWM2OD1yLkS4Olg1KM7:TR?= MVzTRW5ITVJ?
LB2518-MEL M4Tx[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mm[wTWM2OD1yLkS5O|A{KM7:TR?= NEXKeVhUSU6JRWK=
TE-441-T M1zXfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH[0U2RKSzVyPUCuOVAyOiEQvF2= MlnaV2FPT0WU
MDA-MB-134-VI MlW3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfETWM2OD1yLkWwPVIyKM7:TR?= MX3TRW5ITVJ?
SCC-3 M3HO[mdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{SxRmlEPTB;MD61NVg4OyEQvF2= M3HFdnNCVkeHUh?=
KLE M{DtXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTBwNUKxO|Eh|ryP NI\CSZNUSU6JRWK=
LB2241-RCC MX7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnKxTWM2OD1yLkWyOVI2KM7:TR?= M4HXdXNCVkeHUh?=
NCI-H1417 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH60WWlKSzVyPUCuOVM1OzVizszN Mof2V2FPT0WU
NCI-H2081 NED2[WxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYLJR|UxRTBwNUi2NVEh|ryP M1yzfHNCVkeHUh?=
NCI-H1522 MnriS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mn3VTWM2OD1yLkW5N|g{KM7:TR?= Mmm3V2FPT0WU
NCI-H889 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1;adGlEPTB;MD61PVg1PCEQvF2= NFzLNZFUSU6JRWK=
CGTH-W-1 NHHaVGxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3Li[2lEPTB;MD62NFc2PSEQvF2= NFLz[2FUSU6JRWK=
EB-3 MkHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjER3hYUUN3ME2wMlYyOTV|IN88US=> MVrTRW5ITVJ?
D-336MG M1\LOWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV3O[3BMUUN3ME2wMlYyPzlzIN88US=> NUTtR3NOW0GQR1XS
LC-1F NILzW21Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWTqeXpYUUN3ME2wMlYzPTl{IN88US=> NYPPdmpSW0GQR1XS
MHH-NB-11 M2LjRWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUDUepRPUUN3ME2wMlY{QDBzIN88US=> MkDtV2FPT0WU
SK-N-FI NFOySo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHjafXhKSzVyPUCuOlM6OSEQvF2= MULTRW5ITVJ?
NCI-H69 NVy5fmNjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmizTWM2OD1yLk[0PFc6KM7:TR?= MYLTRW5ITVJ?
SCH MUnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;K[GdwUUN3ME2wMlY3ODJ|IN88US=> MUPTRW5ITVJ?
LS-513 Mme1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XjVGlEPTB;MD62O|I2QSEQvF2= M{O2N3NCVkeHUh?=
CP67-MEL MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{XZXmlEPTB;MD62O|U6PiEQvF2= MWnTRW5ITVJ?
GCIY NYXGVFRHT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEPKboJKSzVyPUCuO|A{PjNizszN NVPKSZJ7W0GQR1XS
SHP-77 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVLJR|UxRTBwN{C3N|Qh|ryP M2DjVnNCVkeHUh?=
EHEB M17Jemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHVWG1qUUN3ME2wMlcyQDV2IN88US=> NHTWdo5USU6JRWK=
D-247MG MmHjS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1LncmlEPTB;MD63N|I{OiEQvF2= NVO0dXJFW0GQR1XS
Raji NVToW2ZlT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWHJR|UxRTBwN{S5PFkh|ryP NWLjOW9GW0GQR1XS
MPP-89 M{e3T2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEL3cIdKSzVyPUCuO|U6PzhizszN MlTuV2FPT0WU
EKVX NIPxeGtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFjBT2JKSzVyPUCuO|kxPzNizszN NIjTRndUSU6JRWK=
HCC2218 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M13PUmlEPTB;MD63PVE{OSEQvF2= MknXV2FPT0WU
KNS-81-FD MkHFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MW\JR|UxRTBwOEGwNVEh|ryP NGPIZZJUSU6JRWK=
HCC2157 Ml;FS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWHJR|UxRTBwOES5OVEh|ryP NU[0ZZlVW0GQR1XS
BT-474 MmPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:0TWM2OD1yLki4PFU1KM7:TR?= MkDlV2FPT0WU
NCI-H748 MljvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3HveWlEPTB;MD65NVIh|ryP Mm\qV2FPT0WU
EW-24 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjRc3JsUUN3ME2wMlkzODB{IN88US=> Mnf3V2FPT0WU
D-263MG NYPROJdvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{fBdGlEPTB;MD65OFUyOiEQvF2= M2j5UnNCVkeHUh?=
OMC-1 M4f2Vmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFjoeopKSzVyPUCuPVY{PzNizszN MoPxV2FPT0WU
NCI-H2196 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFnpWVlKSzVyPUCuPVc4PzdizszN NIXTTo5USU6JRWK=
HAL-01 NVPCTZNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIjl[5VKSzVyPUCuPVk5PzJizszN NIHhe29USU6JRWK=
NCI-H2107 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUTJR|UxRTFwMEG4OVQh|ryP MmDSV2FPT0WU
LB996-RCC MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFu1NXFKSzVyPUGuNFgxPTFizszN M4\O[XNCVkeHUh?=
NCI-H1395 NGXMW4ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MU\JR|UxRTFwMUC2O{DPxE1? Mn2xV2FPT0WU
CHP-126 MkHBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MU\JR|UxRTFwMU[xPVkh|ryP NIi2[IlUSU6JRWK=
NB69 MnnsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGDlZ3lKSzVyPUGuNlYyPDhizszN NF;oOlRUSU6JRWK=
CAS-1 NFjCZmJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF7wO3RKSzVyPUGuN|QzOzFizszN MoPvV2FPT0WU
JVM-3 NEexbphIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkHuTWM2OD1zLkS3PFU2KM7:TR?= M2TnSnNCVkeHUh?=
DMS-153 M4fndWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkDVTWM2OD1zLkW3Olc1KM7:TR?= M4jtZnNCVkeHUh?=
SK-MEL-2 M2XC[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUHJR|UxRTFwN{G3PFkh|ryP M4P6OHNCVkeHUh?=
NCI-H1155 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGfWZXdKSzVyPUGuO|M3PzZizszN NYizS5Y4W0GQR1XS
NCI-H1092 NVT1bWFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH7JfGpKSzVyPUGuO|YyQDJizszN MXXTRW5ITVJ?
LU-165 M4TlWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mny2TWM2OD1zLki2OFc3KM7:TR?= NXz1eotyW0GQR1XS
HL-60 M1SxS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjFcYJkUUN3ME2xMlk6QTB6IN88US=> MmLzV2FPT0WU
REH NETPNGFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4XudmlEPTB;Mj6wNFU5OiEQvF2= MYTTRW5ITVJ?
JVM-2 M4n2WWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWX6OnVKUUN3ME2yMlA3OTN3IN88US=> NHfiOXpUSU6JRWK=
MN-60 M{P4dWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\M[mlEPTB;Mj6xO|MxQCEQvF2= MnP4V2FPT0WU
SCC-15 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3GzOGlEPTB;Mj6yNFI4KM7:TR?= NVmwbnNJW0GQR1XS
SNU-C1 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoTvTWM2OD1{LkKxN|Q{KM7:TR?= M4nKbXNCVkeHUh?=
SK-MEL-1 NHzPZVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTJwM{KwOFch|ryP MnftV2FPT0WU
TGW NEDHZZlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MY\JR|UxRTJwM{WwNlch|ryP NWfhOWFXW0GQR1XS
CA46 M2KzNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3nLUmlEPTB;Mj63OVk3PyEQvF2= M1TJXHNCVkeHUh?=
NCI-H23 NWXLNlhtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjkOWtyUUN3ME2yMlgxPzlzIN88US=> MUPTRW5ITVJ?
MMAC-SF MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYr1NY9NUUN3ME2yMlg3PjJ6IN88US=> M1HDW3NCVkeHUh?=
NCI-H2171 NWHaeHB5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PQW2lEPTB;Mz6wN|Q1QCEQvF2= NYHk[lZkW0GQR1XS
A704 MXjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYPJR|UxRTNwMUSxPVQh|ryP NX2xN3JUW0GQR1XS
DB M1:5Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlHTTWM2OD1|LkK1OVc3KM7:TR?= NHzvOZpUSU6JRWK=
NCI-H719 NWfTOFdGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlHFTWM2OD1|LkOwN|g1KM7:TR?= NFjGXHZUSU6JRWK=
MC-CAR NHjPfo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmmyTWM2OD1|LkW0PFE4KM7:TR?= NXTDdWV3W0GQR1XS
SIMA NEnnXJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvFZnpKSzVyPUOuOVg1OTZizszN NVT4RZRTW0GQR1XS
SW872 NHeyVldIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXf6SIFbUUN3ME2zMlc5OTBzIN88US=> NYHGZ5luW0GQR1XS
HCC1187 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1\pN2lEPTB;Mz63PFMyPSEQvF2= NWr6cVZtW0GQR1XS
EW-13 NGDuc3VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M373SmlEPTB;Mz64N|QyPyEQvF2= NX7NRmVnW0GQR1XS
NCI-SNU-1 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTBTYhNUUN3ME20MlIyQTl7IN88US=> M3zyNHNCVkeHUh?=
NCI-H226 MomxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTRwM{O2NFYh|ryP NYrOfJF7W0GQR1XS
RPMI-8866 MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;pS4xKSzVyPUSuN|YxOjlizszN M3jnN3NCVkeHUh?=
OCI-AML2 NILZbY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHxRWNyUUN3ME20MlU2OjNizszN NFjIcFJUSU6JRWK=
LU-65 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvRTWM2OD12LkmzNFM{KM7:TR?= MX\TRW5ITVJ?
SK-N-DZ MoPRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3PCdWlEPTB;NT62N|Q3PSEQvF2= MYHTRW5ITVJ?
NB14 NIPjUXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3BTFN[UUN3ME21Mlk4OTN3IN88US=> NVr4fIY4W0GQR1XS
COLO-829 MnyyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVrIRnVJUUN3ME22MlM{OzV7IN88US=> M4Oyc3NCVkeHUh?=
MHH-CALL-2 NEX2botIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1fMUmlEPTB;Nj61NVUxQCEQvF2= NHnxbZpUSU6JRWK=
NCI-H1770 MmmxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1vpXWlEPTB;Nj62OlkxPCEQvF2= NVLHdWliW0GQR1XS
ECC4 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mn\wTWM2OD14LkiyNVc6KM7:TR?= NUfkcXNFW0GQR1XS
A498 NXznfotnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVfJR|UxRTZwOEexPVIh|ryP MYHTRW5ITVJ?
DMS-79 MkSxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlG4TWM2OD15LkC0OVEzKM7:TR?= NF;1SYlUSU6JRWK=
P30-OHK NWrvN4VGT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrWcIVMUUN3ME23MlIyQTB4IN88US=> NFzH[Y5USU6JRWK=
D-502MG MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWPJR|UxRTdwOUizOkDPxE1? NYC3TG9mW0GQR1XS
RCC10RGB MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGjaNolKSzVyPUiuNFYzQCEQvF2= M362PXNCVkeHUh?=
U-698-M NXnITYFFT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MULJR|UxRThwMkmyNlYh|ryP MVHTRW5ITVJ?
BB49-HNC MoDOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYfJR|UxRTlwNEKyOlUh|ryP Mn7JV2FPT0WU
ES1 M3PoR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NYfNUI9RUUN3ME25MlY5QTV4IN88US=> NFnPdXlUSU6JRWK=
MFM-223 NWjaO|JbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmT1TWM2OD1zMD65PVI4KM7:TR?= M3vHNXNCVkeHUh?=
C2BBe1 MmTlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTFzLkO1NlMh|ryP M17zWHNCVkeHUh?=
EB2 NIPi[|ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEn5R45KSzVyPUGyMlY5QDFizszN NF63ZpZUSU6JRWK=
C8166 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoexTWM2OD1zMz64N|A{KM7:TR?= M4PKT3NCVkeHUh?=
ES3 Ml3rS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIHXVYhKSzVyPUGzMlk6PzdizszN MX;TRW5ITVJ?
NCI-H1650 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTF4LkO3OlUh|ryP NWmxe5U5W0GQR1XS
Mo-T NH\FNZFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVTucYZ1UUN3ME2xO{41ODJ7IN88US=> M{[2dXNCVkeHUh?=
NB7 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTF5Lke0Olch|ryP NFHsb|FUSU6JRWK=
ES7 MmTLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NULHTYF3UUN3ME2xPU42PTB5IN88US=> NXrOfVh[W0GQR1XS
ES5 Mn;US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MoL1TWM2OD1{MT63OlcyKM7:TR?= MmTkV2FPT0WU
MSTO-211H MnHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkS4TWM2OD1{MT64PFU5KM7:TR?= M2\JR3NCVkeHUh?=
U-87-MG NHPSUHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XyXWlEPTB;MkWuNVk3PiEQvF2= MXXTRW5ITVJ?
THP-1 NF7WUnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTJ7LkeyNFEh|ryP M1fHdHNCVkeHUh?=
NB10 NF\kfm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1r3XmlEPTB;M{CuNlY6PCEQvF2= MoLUV2FPT0WU
NH-12 M3fHNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWn0N5ZLUUN3ME2zN{4zODF5IN88US=> NE\ENnRUSU6JRWK=
COLO-824 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITreXNKSzVyPUO0MlExODZizszN MYHTRW5ITVJ?
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8505C MmKwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIH5NXMxNjFvMUCwJI5O NELFT5E4OiCq MmnjSG1UVw>? NV7ydWEzTUN3ME2zMlIhdk1? NW[ybm82OTl{MkO1OVM>
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SW1736 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUiwMlEuOTByIH7N MWK3NkBp NVr4bFVTTE2VTx?= MorLSWM2OD13Lk[gcm0> M2X4[lE6OjJ|NUWz

... Click to View More Cell Line Experimental Data

In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
+ Expand
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
30% PEG 400+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID