BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
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USD 210 In stock
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Cited by 53 Publications

11 Customer Reviews

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

  • Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

  • Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
PI3Kα [1]
(Cell-free assay)
Met [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM 2.407 μM 4.754 μM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUn0[YpFUUN3ME2wMlAxPzd4IN88US=> MVPTRW5ITVJ?
ACN NF3kdXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPJWnpKSzVyPUCuNFA5PDNizszN NYf6bpJTW0GQR1XS
TE-8 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXrJR|UxRTBwMEC5OFEh|ryP M4T0PHNCVkeHUh?=
LC-2-ad NEPONlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmXwTWM2OD1yLkCxNFk{KM7:TR?= NFjXe2ZUSU6JRWK=
ALL-PO NXzON2hDT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1:wWWlEPTB;MD6wNVMh|ryP NIL2RVZUSU6JRWK=
EW-16 M1;5XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlvpTWM2OD1yLkCxN|M3KM7:TR?= MUjTRW5ITVJ?
KM12 MlTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnjjTWM2OD1yLkCxN|Q5KM7:TR?= NXzicVV7W0GQR1XS
GI-1 NV3B[3VUT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4PifmlEPTB;MD6wNVM5OyEQvF2= NF3YTodUSU6JRWK=
LS-411N M3HV[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVvDfFZJUUN3ME2wMlAyPDB5IN88US=> Ml3wV2FPT0WU
ES8 MnzUS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLafpE{UUN3ME2wMlAyPDl2IN88US=> MnfVV2FPT0WU
SNU-C2B NWPLWYltT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{HXWWlEPTB;MD6wNVUzPiEQvF2= MXHTRW5ITVJ?
CESS MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37Gd2lEPTB;MD6wNVYxOiEQvF2= MkXTV2FPT0WU
697 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUf4fIxuUUN3ME2wMlAyPjZ6IN88US=> NWTyVYlSW0GQR1XS
NCI-H1963 MnK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXoUopuUUN3ME2wMlAyPjd|IN88US=> NVnHXYI5W0GQR1XS
IA-LM NXTEeWUzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3fVR2lEPTB;MD6wNVY5QCEQvF2= MXjTRW5ITVJ?
SW954 M{jhNWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWrndXRpUUN3ME2wMlAyPzB3IN88US=> NFnoU4tUSU6JRWK=
RL95-2 MYPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMEG3N|gh|ryP NGDkNYZUSU6JRWK=
LXF-289 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVq0d4ZzUUN3ME2wMlAyPzdizszN MlnHV2FPT0WU
OCUB-M MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnHQTWM2OD1yLkCxPFI3KM7:TR?= M2rzfnNCVkeHUh?=
RKO MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIr5dJVKSzVyPUCuNFE6QDdizszN MnHaV2FPT0WU
LOUCY NFXKUWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlLlTWM2OD1yLkCyNFUh|ryP NVLN[mJ4W0GQR1XS
NOS-1 NYLIfFI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXTJR|UxRTBwMEKwPVMh|ryP NVrheVNCW0GQR1XS
A4-Fuk NUK3fYRqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEKyNVgh|ryP MY\TRW5ITVJ?
A388 M4HMZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7B[XRKSzVyPUCuNFIzOjdizszN NEWwOG5USU6JRWK=
TE-9 MmfBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRTBwMEKyOlEh|ryP MoLOV2FPT0WU
KURAMOCHI MkLDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jrUGlEPTB;MD6wNlI5PSEQvF2= M2GxT3NCVkeHUh?=
KALS-1 NXTaT2ZMT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDhZoZKSzVyPUCuNFI{OzhizszN MoXIV2FPT0WU
HOP-62 NHjB[4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnzZTWM2OD1yLkCyOFIh|ryP NEn5Z4RUSU6JRWK=
RPMI-8402 NUHsW3NvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Ml[yTWM2OD1yLkCyOVA5KM7:TR?= MoPRV2FPT0WU
TE-1 NWjheW1rT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXUPJAzUUN3ME2wMlAzPTF{IN88US=> NFLWeYZUSU6JRWK=
CCRF-CEM NIn2TWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFm0SolKSzVyPUCuNFI2PDNizszN MkCwV2FPT0WU
HUTU-80 MmHMS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{\0TmlEPTB;MD6wNlYzPCEQvF2= NVHUVpp3W0GQR1XS
NCI-H1648 M{nhU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYnJR|UxRTBwMEK2OFch|ryP NYLjfVROW0GQR1XS
HCE-4 M4\0XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTBwMEK2PFIh|ryP NYXVSlVzW0GQR1XS
ETK-1 NYnuWGdVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVvn[JlTUUN3ME2wMlAzPzN4IN88US=> NEjWcoNUSU6JRWK=
TE-15 NXzNSJZQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDjNZZKSzVyPUCuNFI4OzhizszN M33qd3NCVkeHUh?=
BE-13 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVPsW2tqUUN3ME2wMlAzPzRizszN MlHkV2FPT0WU
KE-37 MX\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHTFT5pKSzVyPUCuNFI4PDFizszN Mn;uV2FPT0WU
NCI-H1355 M{\PSmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMEK3PFMh|ryP NUTyTWcxW0GQR1XS
TE-11 Mnv6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUTDZnlKUUN3ME2wMlAzQDB7IN88US=> NYDNdI5EW0GQR1XS
BL-70 NGLpfJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2j1dmlEPTB;MD6wNlg2PyEQvF2= MlfFV2FPT0WU
ES6 NFXkUmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MorqTWM2OD1yLkCyPFgyKM7:TR?= NX;TPW02W0GQR1XS
GT3TKB NEO3WZVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPDSFlWUUN3ME2wMlAzQTV|IN88US=> NEnNUVBUSU6JRWK=
LB647-SCLC M1HEVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXxeIlKSzVyPUCuNFMyQTVizszN NVPQWXVVW0GQR1XS
NB13 NH7MXHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmnxTWM2OD1yLkCzN|E3KM7:TR?= Ml24V2FPT0WU
ST486 NGnpZW1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NImydnBKSzVyPUCuNFM{OzdizszN MUnTRW5ITVJ?
NCI-H82 MnjBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWrJ[YppUUN3ME2wMlA{OzR|IN88US=> Mmq3V2FPT0WU
NTERA-S-cl-D1 NWrPfoJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXzJR|UxRTBwMEOzPVkh|ryP MmHDV2FPT0WU
ES4 M2PqbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkPHTWM2OD1yLkCzOFY{KM7:TR?= M1P1N3NCVkeHUh?=
SK-NEP-1 NYPLeZZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHHDXFlKSzVyPUCuNFM1QTlizszN M4fwT3NCVkeHUh?=
Becker M{DaPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFHtcJBKSzVyPUCuNFM2PTVizszN NIjqd3hUSU6JRWK=
A101D NIftPWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYPJR|UxRTBwMEO3OFgh|ryP NImwXYFUSU6JRWK=
SK-UT-1 MlvRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2nFNGlEPTB;MD6wN|c4PCEQvF2= M1vCSnNCVkeHUh?=
SW982 NFrUWIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXHES2xxUUN3ME2wMlA{PzlizszN M3KwR3NCVkeHUh?=
TE-10 MkjGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWjGdWsxUUN3ME2wMlA1ODR4IN88US=> NUi2Xm81W0GQR1XS
OVCAR-4 M17VUmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX;JR|UxRTBwMESwOVkh|ryP M3\zc3NCVkeHUh?=
KP-N-YS NHLyR4lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XCN2lEPTB;MD6wOFA5PSEQvF2= MmW1V2FPT0WU
BL-41 MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYXJR|UxRTBwMESxNlUh|ryP MX;TRW5ITVJ?
MZ1-PC MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjVd|hbUUN3ME2wMlA1OTJ5IN88US=> MYDTRW5ITVJ?
PF-382 MkTPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XPb2lEPTB;MD6wOFE6QCEQvF2= NYDHUnd[W0GQR1XS
MOLT-13 MkXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGW2[2RKSzVyPUCuNFQzOzhizszN MX;TRW5ITVJ?
HCC1599 MlXiS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MV;JR|UxRTBwMESyOVgh|ryP M2DVTXNCVkeHUh?=
IST-MEL1 M4rEfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXnJR|UxRTBwMES0OFIh|ryP NE\n[GhUSU6JRWK=
LU-139 NVriOYFTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoXqTWM2OD1yLkC0OFQzKM7:TR?= MojaV2FPT0WU
MS-1 NULUd5lmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1i0fGlEPTB;MD6wOFcxOSEQvF2= NYrVfYIzW0GQR1XS
MFH-ino M1jY[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF;W[IFKSzVyPUCuNFUxODNizszN MXvTRW5ITVJ?
IMR-5 MmHJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHewSFhKSzVyPUCuNFUxOjFizszN MlzXV2FPT0WU
TE-5 M{HIeGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUTJR|UxRTBwMEWwOlMh|ryP NU[xOXEzW0GQR1XS
DJM-1 MoHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnHUGFKSzVyPUCuNFUyPDJizszN NGXzfoZUSU6JRWK=
NB17 M3L5cWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Tnb2lEPTB;MD6wOVIxPyEQvF2= NVj2VVhJW0GQR1XS
KARPAS-45 NUHTRVQ4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFPyZnBKSzVyPUCuNFU{PThizszN NYTWcIZzW0GQR1XS
TGBC1TKB NUjaS2NnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVPJR|UxRTBwMEW0NFUh|ryP NFHEToFUSU6JRWK=
ML-2 NEPFcnJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUHKZmxEUUN3ME2wMlA2PDF2IN88US=> MUnTRW5ITVJ?
no-10 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlfQTWM2OD1yLkC1OFc1KM7:TR?= NFPXR2hUSU6JRWK=
CTV-1 MnWzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nkWGlEPTB;MD6wOVUxOiEQvF2= NVfNSYpGW0GQR1XS
SJSA-1 NXPiOGtZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn7sTWM2OD1yLkC1OVIh|ryP M1S4V3NCVkeHUh?=
HC-1 MoO5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFPhS4xKSzVyPUCuNFU2QTdizszN M{PmcnNCVkeHUh?=
TE-12 Mm[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NGHvR|FKSzVyPUCuNFU3OTNizszN MnLUV2FPT0WU
KY821 M1XiSWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MW\JR|UxRTBwMEW2N|Ih|ryP MV\TRW5ITVJ?
TALL-1 NXHkNmZjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVnJR|UxRTBwMEW3NFgh|ryP M4ewdXNCVkeHUh?=
DEL NH7tUHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4L2e2lEPTB;MD6wOVcxQSEQvF2= Ml;VV2FPT0WU
TE-6 NFi4XHNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4LuWGlEPTB;MD6wOVczOiEQvF2= MV\TRW5ITVJ?
SK-LMS-1 M3TaXWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3HLc2lEPTB;MD6wOVgxPSEQvF2= NIDTTpRUSU6JRWK=
EW-1 NF3HbXJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1XpO2lEPTB;MD6wOVg{PyEQvF2= MonuV2FPT0WU
8-MG-BA MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYHJR|UxRTBwMEW4OVEh|ryP NYfwZ3J[W0GQR1XS
NALM-6 NUP1UFZtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYPJR|UxRTBwMEW5O|Mh|ryP M1PHVnNCVkeHUh?=
LB771-HNC M17Ge2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnvoTWM2OD1yLkC1PVc6KM7:TR?= M2\uOHNCVkeHUh?=
HT-144 NV3EcIJKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHfxVnZKSzVyPUCuNFYyOyEQvF2= NIHUN4dUSU6JRWK=
KM-H2 M4S4VGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkLKTWM2OD1yLkC2NlIyKM7:TR?= NVW3[Vd1W0GQR1XS
SF268 NEHNW4xIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWHJR|UxRTBwME[yPFYh|ryP MXfTRW5ITVJ?
RS4-11 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NVn3UHBsUUN3ME2wMlA3OzB2IN88US=> MWjTRW5ITVJ?
MHH-PREB-1 NFmwd4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2DTV2lEPTB;MD6wOlMyQSEQvF2= M4XveHNCVkeHUh?=
ATN-1 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnTtTWM2OD1yLkC2N|Q2KM7:TR?= NVPPNVhwW0GQR1XS
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DMS-114 MUjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYfJR|UxRTBwMEe1Nlgh|ryP MVTTRW5ITVJ?
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HEL NHv5VWZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXjkUGJDUUN3ME2wMlA5PjZ6IN88US=> NGDuO2xUSU6JRWK=
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NCI-H1694 M1myb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NELHdlFKSzVyPUCuNFg4PDRizszN NEDYbmhUSU6JRWK=
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A253 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFTuWpZKSzVyPUCuNFg5OjJizszN MnK0V2FPT0WU
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NCI-SNU-5 NYT6OYdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NY\iNGpCUUN3ME2wMlA6OjV6IN88US=> Mn33V2FPT0WU
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NCI-H446 Mke2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX;mT2Y5UUN3ME2wMlA6PDZ{IN88US=> NXrkWolFW0GQR1XS
COR-L279 NFnOPWdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3TDSWlEPTB;MD6wPVU2PiEQvF2= MVjTRW5ITVJ?
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NCI-H2126 NVr4R|IyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWKwdINlUUN3ME2wMlA6PzlzIN88US=> MXjTRW5ITVJ?
NCI-H1882 NH\wXIFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWrmNWZ4UUN3ME2wMlA6QDB7IN88US=> NFrYVXFUSU6JRWK=
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K-562 NHuzVmNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXH0eIJuUUN3ME2wMlExQDV6IN88US=> NUf2PFU5W0GQR1XS
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NCI-H524 MlPLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWfpN3p4UUN3ME2wMlEyOjd2IN88US=> NX\5TGhwW0GQR1XS
EoL-1-cell NHr2d5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NEfzSXpKSzVyPUCuNVE3PzJizszN MYfTRW5ITVJ?
K052 Ml:5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTG[mNjUUN3ME2wMlEyPzF{IN88US=> NYTXS|RtW0GQR1XS
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RPMI-8226 M2LyZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEDTflZKSzVyPUCuNVIxPTJizszN M4C3VHNCVkeHUh?=
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RPMI-6666 NGKy[I5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkDUTWM2OD1yLkGyO|Q{KM7:TR?= MoS4V2FPT0WU
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NCI-H747 MoXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFWyN45KSzVyPUCuNVM4KM7:TR?= NUmzR2V{W0GQR1XS
NCCIT NEfPRY9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn3vTWM2OD1yLkGzPVM6KM7:TR?= M1r4UHNCVkeHUh?=
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GB-1 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnSNZJ[UUN3ME2wMlE1PTJ4IN88US=> MXPTRW5ITVJ?
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SCLC-21H MmLmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkfqTWM2OD1yLkG1O|AzKM7:TR?= M1\mS3NCVkeHUh?=
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KINGS-1 MnnSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4HT[mlEPTB;MD6xOVkyKM7:TR?= NYexR|hSW0GQR1XS
LS-123 NFfpT|RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX62cnR{UUN3ME2wMlE2QTF5IN88US=> M2nGcnNCVkeHUh?=
MC116 NV\XU403T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlmxTWM2OD1yLkG2NVU5KM7:TR?= MXXTRW5ITVJ?
SU-DHL-1 Mm\NS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX\JR|UxRTBwMU[yNFYh|ryP MkHSV2FPT0WU
NCI-H64 NFz5WVdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnnWTWM2OD1yLkG2N|Q4KM7:TR?= MkPXV2FPT0WU
HCE-T M2jKdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NU\LR|BYUUN3ME2wMlE3PTB2IN88US=> M2fHSnNCVkeHUh?=
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ARH-77 NFmwO45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\aSIpvUUN3ME2wMlE4Ozd7IN88US=> NVnGbZhwW0GQR1XS
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L-428 MVPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\DTWM2OD1yLkG4PFE{KM7:TR?= NF;XZ|dUSU6JRWK=
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NCI-H2141 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX3VTmRSUUN3ME2wMlE6ODFzIN88US=> MkO4V2FPT0WU
KARPAS-299 MXrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIKy[IlKSzVyPUCuNVkzPDFizszN MV7TRW5ITVJ?
LC4-1 NHW2OpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1rQfWlEPTB;MD6xPVUxOiEQvF2= NIXIR4FUSU6JRWK=
UACC-257 NX7OVYlzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWPqZ4ZsUUN3ME2wMlE6QTR5IN88US=> MWfTRW5ITVJ?
EVSA-T NU\Cboh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mor5TWM2OD1yLkKwN|EzKM7:TR?= NY\RfXdyW0GQR1XS
JiyoyeP-2003 M1THeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NILSRWhKSzVyPUCuNlA1PzdizszN MnHKV2FPT0WU
NCI-H720 NXTFWlczT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2DmcGlEPTB;MD6yNFUzPSEQvF2= NHPxV5lUSU6JRWK=
GAK NUC5WlhPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWjJR|UxRTBwMkGxPFkh|ryP NXribYpqW0GQR1XS
HH NI\R[WZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{ixbGlEPTB;MD6yNVQxPSEQvF2= NYK2boRTW0GQR1XS
NCI-H1436 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTBwMkG0OlQh|ryP NVnjdFJIW0GQR1XS
GR-ST NHPWN2lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4Gxd2lEPTB;MD6yNVQ5QCEQvF2= NVjGWHBpW0GQR1XS
BC-1 NILldohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYTJR|UxRTBwMkK2NVYh|ryP MUnTRW5ITVJ?
SIG-M5 M2n4b2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkXoTWM2OD1yLkKyO|I4KM7:TR?= NXex[JR4W0GQR1XS
NCI-H345 NF3RO3FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX7JR|UxRTBwMkO4NFUh|ryP NVn6XIs1W0GQR1XS
OPM-2 Mn36S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4jscmlEPTB;MD6yN|g5OiEQvF2= NEXKbVZUSU6JRWK=
LB1047-RCC NXu0SlZoT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwMkS0NUDPxE1? MYfTRW5ITVJ?
CTB-1 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnkeW1KSzVyPUCuNlQ1QTNizszN NUDSbHdEW0GQR1XS
A3-KAW M1fm[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYTJR|UxRTBwMkWzOFEh|ryP MULTRW5ITVJ?
SF126 NXnueWpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzZT45KSzVyPUCuNlU{QDNizszN NXTwU5BiW0GQR1XS
KARPAS-422 MoHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVPGem51UUN3ME2wMlI2PDN3IN88US=> MYXTRW5ITVJ?
MEG-01 NFzidm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUjJR|UxRTBwMkW2O|Mh|ryP MXPTRW5ITVJ?
NCI-H209 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHW4OZhKSzVyPUCuNlY{PzRizszN MnnBV2FPT0WU
SBC-1 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYGz[pNUUUN3ME2wMlI3PSEQvF2= NFeyWGxUSU6JRWK=
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QIMR-WIL NFq5dIVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWfJR|UxRTBwMkexOVUh|ryP NFvCO4dUSU6JRWK=
NMC-G1 Mk\WS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYjJR|UxRTBwMkiyNVch|ryP MYPTRW5ITVJ?
IST-MES1 NFK2XHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUjmVHdzUUN3ME2wMlI6OjN6IN88US=> NUD3[|NtW0GQR1XS
SW684 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NW\SRZZ5UUN3ME2wMlMxODR5IN88US=> MWXTRW5ITVJ?
MV-4-11 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlTUTWM2OD1yLkOwO|g5KM7:TR?= NXvadVk5W0GQR1XS
LAN-6 M1jEUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4LZc2lEPTB;MD6zNVU4OiEQvF2= MYHTRW5ITVJ?
RH-1 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmi5TWM2OD1yLkOxPFcyKM7:TR?= Mm[2V2FPT0WU
CP66-MEL M3ToWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3fXR2lEPTB;MD6zNVg4QCEQvF2= NGXyfJRUSU6JRWK=
EC-GI-10 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYnoRYwyUUN3ME2wMlMzQTh5IN88US=> MXnTRW5ITVJ?
GDM-1 NUL0NJhLT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4ry[2lEPTB;MD6zN|A2QSEQvF2= NHqxTIZUSU6JRWK=
IST-SL1 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NGnjN2lKSzVyPUCuN|Q6OTRizszN NEDWOoJUSU6JRWK=
KMOE-2 NGDCfnVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPXVoljUUN3ME2wMlM2OTd3IN88US=> Moj2V2FPT0WU
OS-RC-2 NGTNN|lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIXTOZJKSzVyPUCuN|U2PDRizszN M{DENHNCVkeHUh?=
HDLM-2 NYLQUVI6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFH1OpVKSzVyPUCuN|c5OTRizszN MonJV2FPT0WU
DSH1 NGrLXXZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{njWGlEPTB;MD6zPFY{OSEQvF2= MV3TRW5ITVJ?
LS-1034 M1zqOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MV3JR|UxRTBwM{i5OVQh|ryP MV7TRW5ITVJ?
LB373-MEL-D NX;J[Fh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mn;JTWM2OD1yLkO5NVk4KM7:TR?= MkTXV2FPT0WU
GOTO MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVfJR|UxRTBwNEKxNVgh|ryP NWHEelEyW0GQR1XS
MRK-nu-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MkPmTWM2OD1yLkSyNlA2KM7:TR?= NF[0fHdUSU6JRWK=
SK-MM-2 NWP3[JhyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnPDTWM2OD1yLkSzOFQzKM7:TR?= Mnn4V2FPT0WU
BOKU MkexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHPqcGRKSzVyPUCuOFM4QTJizszN NH;UN5VUSU6JRWK=
NOMO-1 MkXWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHTc4txUUN3ME2wMlQ{QDZizszN NVL2cGpWW0GQR1XS
J-RT3-T3-5 M333Wmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV61O3Z3UUN3ME2wMlQ1QDd6IN88US=> NHXyUnhUSU6JRWK=
COLO-668 NWXne5p5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYrwepZFUUN3ME2wMlQ2PjZ6IN88US=> NWfM[XJCW0GQR1XS
SF539 MmfqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlS4TWM2OD1yLkS4Olg1KM7:TR?= NXm1[5BGW0GQR1XS
LB2518-MEL MoHZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXV[Io{UUN3ME2wMlQ6PzB|IN88US=> NYqxVJlSW0GQR1XS
TE-441-T MnP3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVPJR|UxRTBwNUCxNkDPxE1? NVHN[YFVW0GQR1XS
MDA-MB-134-VI MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTBwNUC5NlEh|ryP MYrTRW5ITVJ?
SCC-3 NGTQ[oxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mlf5TWM2OD1yLkWxPFc{KM7:TR?= MYnTRW5ITVJ?
KLE M3XtZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX7JR|UxRTBwNUKxO|Eh|ryP Ml20V2FPT0WU
LB2241-RCC MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVTJR|UxRTBwNUK1NlUh|ryP NHTGe|JUSU6JRWK=
NCI-H1417 M1zRcGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWfJR|UxRTBwNUO0N|Uh|ryP M4Hs[3NCVkeHUh?=
NCI-H2081 NFjYU|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWr5NXZKUUN3ME2wMlU5PjFzIN88US=> NFGwTlRUSU6JRWK=
NCI-H1522 M2XxbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{Xqc2lEPTB;MD61PVM5OyEQvF2= MlXjV2FPT0WU
NCI-H889 NU\VRYtuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYrJR|UxRTBwNUm4OFQh|ryP MUXTRW5ITVJ?
CGTH-W-1 MV;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX3JR|UxRTBwNkC3OVUh|ryP M3jHWXNCVkeHUh?=
EB-3 MkfsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXTyfZh2UUN3ME2wMlYyOTV|IN88US=> MVnTRW5ITVJ?
D-336MG Mlv3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVvJR|UxRTBwNkG3PVEh|ryP MlXhV2FPT0WU
LC-1F MlntS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwNkK1PVIh|ryP MYrTRW5ITVJ?
MHH-NB-11 M3;VdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3rNPGlEPTB;MD62N|gxOSEQvF2= NEG0T5pUSU6JRWK=
SK-N-FI NWKxdXlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV3JR|UxRTBwNkO5NUDPxE1? M37HTXNCVkeHUh?=
NCI-H69 NG\rZo5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{GxTmlEPTB;MD62OFg4QSEQvF2= NVrFeZdrW0GQR1XS
SCH M{fhOGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTBwNk[wNlMh|ryP M3TGeHNCVkeHUh?=
LS-513 M17xZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPQRmdKSzVyPUCuOlczPTlizszN MXPTRW5ITVJ?
CP67-MEL NGqzS5VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3P6XmlEPTB;MD62O|U6PiEQvF2= NUnZOVBiW0GQR1XS
GCIY Ml\6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXqNHN3UUN3ME2wMlcxOzZ|IN88US=> MXrTRW5ITVJ?
SHP-77 MoPVS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3XnO2lEPTB;MD63NFc{PCEQvF2= NH;qOItUSU6JRWK=
EHEB MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFzSXHFKSzVyPUCuO|E5PTRizszN NGjWVoxUSU6JRWK=
D-247MG MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmTkTWM2OD1yLkezNlMzKM7:TR?= Mlr2V2FPT0WU
Raji NVXQSXlyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MV7JR|UxRTBwN{S5PFkh|ryP NV3idmVmW0GQR1XS
MPP-89 M{ThTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnqSINKSzVyPUCuO|U6PzhizszN NFnBVm5USU6JRWK=
EKVX M1rQN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXLJR|UxRTBwN{mwO|Mh|ryP M3zUNHNCVkeHUh?=
HCC2218 M4Hmdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M17kR2lEPTB;MD63PVE{OSEQvF2= NUC2VFV5W0GQR1XS
KNS-81-FD M1zKU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4jufWlEPTB;MD64NVAyOSEQvF2= NUi3fJNoW0GQR1XS
HCC2157 MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3\qSGlEPTB;MD64OFk2OSEQvF2= MVzTRW5ITVJ?
BT-474 MYfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PDSmlEPTB;MD64PFg2PCEQvF2= NUWwOWhkW0GQR1XS
NCI-H748 M3TCVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\2[mlEPTB;MD65NVIh|ryP NYH1SoM1W0GQR1XS
EW-24 MmPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXXScIJnUUN3ME2wMlkzODB{IN88US=> MnGwV2FPT0WU
D-263MG NXPIUG82T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXnJR|UxRTBwOUS1NVIh|ryP NH62d5ZUSU6JRWK=
OMC-1 M4nzfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwOU[zO|Mh|ryP MmnCV2FPT0WU
NCI-H2196 MmK0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{jZN2lEPTB;MD65O|c4PyEQvF2= M3fsRnNCVkeHUh?=
HAL-01 NVz0U4d6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXr2RlVSUUN3ME2wMlk6QDd{IN88US=> NFnTWYJUSU6JRWK=
NCI-H2107 M{[4OWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVf5PIJjUUN3ME2xMlAyQDV2IN88US=> MmDCV2FPT0WU
LB996-RCC MmD3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MljaTWM2OD1zLkC4NFUyKM7:TR?= Mo\SV2FPT0WU
NCI-H1395 NGX6dHhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTFwMUC2O{DPxE1? NFHtTXNUSU6JRWK=
CHP-126 M4G3O2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mmr0TWM2OD1zLkG2NVk6KM7:TR?= M{fmdnNCVkeHUh?=
NB69 NHfHemxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4C0fWlEPTB;MT6yOlE1QCEQvF2= NIXZbolUSU6JRWK=
CAS-1 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTFwM{SyN|Eh|ryP M2GyWHNCVkeHUh?=
JVM-3 NGrhOHBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1njNmlEPTB;MT60O|g2PSEQvF2= Mke4V2FPT0WU
DMS-153 MUfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFrWdoNKSzVyPUGuOVc3PzRizszN NVHUPGpQW0GQR1XS
SK-MEL-2 NFPFRnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{PEN2lEPTB;MT63NVc5QSEQvF2= NIrnWolUSU6JRWK=
NCI-H1155 M2Dlfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{TGN2lEPTB;MT63N|Y4PiEQvF2= NWHKNVFmW0GQR1XS
NCI-H1092 NVGzXWRmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7pTlRKSzVyPUGuO|YyQDJizszN MX3TRW5ITVJ?
LU-165 NITZcnpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkm4TWM2OD1zLki2OFc3KM7:TR?= Ml3DV2FPT0WU
HL-60 NYHpZpFxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmnMTWM2OD1zLkm5PVA5KM7:TR?= NGTQSWxUSU6JRWK=
REH MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MW\JR|UxRTJwMEC1PFIh|ryP NV7yU4NUW0GQR1XS
JVM-2 MWHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTJwME[xN|Uh|ryP Mnn0V2FPT0WU
MN-60 NVmydIYyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL5dmZKSzVyPUKuNVc{ODhizszN M3G4XHNCVkeHUh?=
SCC-15 MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV3k[FJrUUN3ME2yMlIxOjdizszN NWG0VJRGW0GQR1XS
SNU-C1 MoDwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkHETWM2OD1{LkKxN|Q{KM7:TR?= NUG3OXc5W0GQR1XS
SK-MEL-1 NIjGdm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXi1[3FEUUN3ME2yMlMzODR5IN88US=> M3Hub3NCVkeHUh?=
TGW MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnzETWM2OD1{LkO1NFI4KM7:TR?= MkfQV2FPT0WU
CA46 NXXlVXplT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVvJR|UxRTJwN{W5Olch|ryP M33TXXNCVkeHUh?=
NCI-H23 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLWTWM2OD1{LkiwO|kyKM7:TR?= M37Ee3NCVkeHUh?=
MMAC-SF MV3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWjCPWRQUUN3ME2yMlg3PjJ6IN88US=> NVjTZ3l3W0GQR1XS
NCI-H2171 M2mzV2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkTXTWM2OD1|LkCzOFQ5KM7:TR?= MnS1V2FPT0WU
A704 NInYTppIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M4nHUmlEPTB;Mz6xOFE6PCEQvF2= NWPJO4FpW0GQR1XS
DB MmjXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mnm3TWM2OD1|LkK1OVc3KM7:TR?= MmD3V2FPT0WU
NCI-H719 NH3ZNnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\hZ2w5UUN3ME2zMlMxOzh2IN88US=> M2O4eXNCVkeHUh?=
MC-CAR Ml;2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnfNTWM2OD1|LkW0PFE4KM7:TR?= M3rtPXNCVkeHUh?=
SIMA MnexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3[yS2lEPTB;Mz61PFQyPiEQvF2= Ml3WV2FPT0WU
SW872 MmrWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;mUXZKSzVyPUOuO|gyODFizszN M4D4ZnNCVkeHUh?=
HCC1187 NFvrcoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2XPR2lEPTB;Mz63PFMyPSEQvF2= MkezV2FPT0WU
EW-13 NEnjdFFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPE[pBKSzVyPUOuPFM1OTdizszN MVjTRW5ITVJ?
NCI-SNU-1 MnnJS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUe5TGVkUUN3ME20MlIyQTl7IN88US=> M3HzVnNCVkeHUh?=
NCI-H226 NXnTVJBrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mm\ETWM2OD12LkOzOlA3KM7:TR?= MVLTRW5ITVJ?
RPMI-8866 M2jLPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnP0TWM2OD12LkO2NFI6KM7:TR?= NHjkfVZUSU6JRWK=
OCI-AML2 MX3Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUXJR|UxRTRwNUWyN{DPxE1? M{\4fHNCVkeHUh?=
LU-65 NVvNXIpnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2n1U2lEPTB;ND65N|A{OyEQvF2= NYTMSGdGW0GQR1XS
SK-N-DZ NGrIWYNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mo\TTWM2OD13Lk[zOFY2KM7:TR?= NVTTVWNNW0GQR1XS
NB14 NFzTS29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFH1PFFKSzVyPUWuPVcyOzVizszN MlTJV2FPT0WU
COLO-829 MlXXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnXXTWM2OD14LkOzN|U6KM7:TR?= M3\KZ3NCVkeHUh?=
MHH-CALL-2 NWL2dI9xT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHLjTGpKSzVyPU[uOVE2ODhizszN MUXTRW5ITVJ?
NCI-H1770 NVjJOGNiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTZwNk[5NFQh|ryP NF;QWmtUSU6JRWK=
ECC4 NH\hU49Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MknwTWM2OD14LkiyNVc6KM7:TR?= NXXLd5h4W0GQR1XS
A498 NWDMVm5bT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1XifWlEPTB;Nj64O|E6OiEQvF2= M2PIdHNCVkeHUh?=
DMS-79 M{nNeWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoLYTWM2OD15LkC0OVEzKM7:TR?= M3XSb3NCVkeHUh?=
P30-OHK MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUHJR|UxRTdwMkG5NFYh|ryP M4jqOXNCVkeHUh?=
D-502MG M3HSR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1ryWmlEPTB;Nz65PFM3KM7:TR?= M1OyeHNCVkeHUh?=
RCC10RGB MnHoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWDJR|UxRThwME[yPEDPxE1? MmrXV2FPT0WU
U-698-M NIHvVWVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYfJR|UxRThwMkmyNlYh|ryP NHfDOpdUSU6JRWK=
BB49-HNC NVvlNWdtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1;VTWlEPTB;OT60NlI3PSEQvF2= MoTGV2FPT0WU
ES1 M4\wTmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LFcmlEPTB;OT62PFk2PiEQvF2= M3X0THNCVkeHUh?=
MFM-223 NIPabHVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn;6TWM2OD1zMD65PVI4KM7:TR?= NVHBcpZRW0GQR1XS
C2BBe1 Mmf0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2LlS2lEPTB;MUGuN|UzOyEQvF2= M1nUdnNCVkeHUh?=
EB2 NHTWdJNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXrJR|UxRTF{Lk[4PFEh|ryP M{TE[XNCVkeHUh?=
C8166 M1exR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M13UW2lEPTB;MUOuPFMxOyEQvF2= M1LVfXNCVkeHUh?=
ES3 MnnnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV7WTWpvUUN3ME2xN{46QTd5IN88US=> NHjMcZFUSU6JRWK=
NCI-H1650 M2\Sfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV7BNo1qUUN3ME2xOk4{PzZ3IN88US=> NGTjRoZUSU6JRWK=
Mo-T Ml7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH7odlNKSzVyPUG3MlQxOjlizszN M1n5XXNCVkeHUh?=
NB7 MlLhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYXJR|UxRTF5Lke0Olch|ryP M2jl[XNCVkeHUh?=
ES7 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVnJR|UxRTF7LkW1NFch|ryP MVzTRW5ITVJ?
ES5 MYXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzrVW9KSzVyPUKxMlc3PzFizszN MWLTRW5ITVJ?
MSTO-211H M{fnb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEjP[ZJKSzVyPUKxMlg5PThizszN MXHTRW5ITVJ?
U-87-MG M1u0R2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYjJR|UxRTJ3LkG5OlYh|ryP M1WxUnNCVkeHUh?=
THP-1 Mo\aS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{LCdWlEPTB;MkmuO|IxOSEQvF2= NHLqWpNUSU6JRWK=
NB10 NEDOUJdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmDWTWM2OD1|MD6yOlk1KM7:TR?= M3n6NnNCVkeHUh?=
NH-12 MmjwS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHtXo0yUUN3ME2zN{4zODF5IN88US=> M1LMWnNCVkeHUh?=
COLO-824 M3LnS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYLJR|UxRTN2LkGwNFYh|ryP MnW1V2FPT0WU
SKM-1 MUTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mm\oTWM2OD1|Nz64OFIzKM7:TR?= M1fPZ3NCVkeHUh?=
NCI-H1838 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli2TWM2OD1|OD6zO|k4KM7:TR?= MkW3V2FPT0WU
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COLO-800 MlztS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{DmcGlEPTB;NECuNFc4OyEQvF2= MUHTRW5ITVJ?
KG-1 MoLFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX3JR|UxRTRyLki5OVUh|ryP MmDnV2FPT0WU
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LNCaP-Clone-FGC NIrDUpdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;Le5oxUUN3ME20NU46ODF5IN88US=> NXPlXWlSW0GQR1XS
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C4-2 NHHNUVlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1X6b2lEPTB;ODDuUS=> M3rBOFI2PTB3MUe0
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SIL-ALL NF;1dlFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHvaRlUzPCCq Mm\CTWM2OD1zOUmuO|chdk1? MYmyOFUyQTl7NR?=
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NALM-16 M1rZfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVyyOEBp MXPJR|UxRTl4LkK4JI5O MXyyOFUyQTl7NR?=
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NALM-6 MnfXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF;XfZk1QCCq NVjjV3BDUUN3ME2yN{4zPiCwTR?= M{DHOVI1PTF7OUm1
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SIL-ALL MmjFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFXMe3Y1QCCq NFj1XHdKSzVyPUe0MlYzKG6P NHzpV4QzPDVzOUm5OS=>
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NALM-16 Mn7tS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWO0PEBp MkPETWM2OD14Mz6yOEBvVQ>? M1;4U|I1PTF7OUm1
JURKAT NFK2bolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1[0fVczKGh? M{TibWlEPTB;Mz62OUBvVQ>? MYWyOFUyQTl7NR?=
MOLT-4 MlLGS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYHIN3ZYPzJiaB?= NV35eJF1UUN3ME23MlM6KG6P NH7yRmczPDVzOUm5OS=>
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NALM-6 MlziS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYrsOZFDPzJiaB?= NI\GWlBKSzVyPUGuO|ghdk1? NXnxVVJIOjR3MUm5PVU>
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SIL-ALL MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWK3NkBp M3LEWGlEPTB;Nz6yJI5O NFjveHIzPDVzOUm5OS=>
CEM Mn:0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVLzO2xQPzJiaB?= MXPJR|UxRTVwNEKgcm0> NUmyU5FbOjR3MUm5PVU>
P12 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mli3O|IhcA>? MnnhTWM2OD14LkO3JI5O Moi3NlQ2OTl7OUW=
NALM-16 NX7Jc5B3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M13JdVczKGh? M1u4[2lEPTB;N{euO|Mhdk1? MXOyOFUyQTl7NR?=
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WER-Rb-1 Ml:zRZBweHSxc3nzJGF{e2G7 Mn6wNU02OCCwTR?= M2PPWFEzNzJ2IHi= NYrFPYZCTE2VTx?= MWLpcoR2[2WmIHHwc5B1d3OrczD3bIlkcCClYX6gZoUh\W6qYX7j[YQh[nliSGS= MYiyOFM3PjZ4NR?=
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G166 MlfOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXPJR|UxRTdwMDDuUS=> MUGyOFIxPDd|Mx?=
CB660 M2X3dGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlLmTWM2OD14LkSgcm0> M4HwNFI1OjB2N{Oz
CB1117 NFLZV5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF3MUVVKSzVyPUG1MlYhdk1? M1LXNlI1OjB2N{Oz
KB-3-1 NU\kSYZ5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mk[yTWM2OD1zLkS4JOKyKDBwNUOgcm0> MmLlNlM6PjJ2NEW=
KB-8-5-11 MnfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXuyZmF2UUN3ME21MlAyKMLzIEKuNFEhdk1? NUT1XFVTOjN7NkK0OFU>
KB-C-1 M3HJbmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MknXTWM2OD1zNj63OkDDuSB2LkWxJI5O NI\JTIEzOzl4MkS0OS=>
KB-V-1 NXTPelY4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjaW2o3UUN3ME2yPFEvOjRiwsGgN|EvPTdibl2= NXWyTIl{OjN7NkK0OFU>
OVCAR-8 M1WwfWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUPJR|UxRTdwMUmgxtEhOy54MDDuUS=> NHrjU44zOzl4MkS0OS=>
NCI-ADR-RES NIrrNGlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX;hOHhZUUN3ME2xNlc{NjNyINMxJFE6OS5{MDDuUS=> MX6yN|k3OjR2NR?=
MCF7 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3LH[mlEPTB;NT6xNUDDuSBzLkS3JI5O NVriSIlUOjN7NkK0OFU>
MCF7-FLV1000 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYfKToNJUUN3ME2zPVMvOThiwsGgO|QvQDNibl2= MmTBNlM6PjJ2NEW=
S1 NX3wNFhCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHjRbo9KSzVyPUK0MlMxKMLzIESuO|Uhdk1? M2nKU|I{QTZ{NES1
S1-M1-80 MkDYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1e0fmlEPTB;Mk[xMlA3KMLzIES4MlI2KG6P M17QOVI{QTZ{NES1
CORL-23/P MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHz3dZBKSzVyPUSuN|ghyrFiMT6yOUBvVQ>? MmH3NlM6PjJ2NEW=
CORL-23/R NYT6OXZqT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPQTWM2OD13LkG2JOKyKDFwOEOgcm0> M2LBSlI{QTZ{NES1
NIH3T3 MmHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIPKZ|JKSzVyPUSwMlYxKMLzIESuPVchdk1? MVKyN|k3OjR2NR?=
NIH3T3-G185 NWHYRlB{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnryTWM2OD1{NEGzMlQxKMLzIESyN{43PiCwTR?= M2DNRlI{QTZ{NES1
pcDNA-HEK293 NE\ZTnNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP5TWM2OD1{Lke1JOKyKDBwNkegcm0> M1u0N|I{QTZ{NES1
MDR19-HEK293 NInCTVJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHPBUm1KSzVyPUi1MlUxKMLzIEGzMlY4KG6P MonSNlM6PjJ2NEW=
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SF188 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1fZblExNTFyMDDuUS=> MWWyOE06PiCq MWHEUXNQ MkHabY5pcWKrdIOgZ4VtdCCpcn;3eIghcW5iYn;0bEB1cW2nLTDhcoQh[2:wY3XueJJifGmxbj2g[IVx\WSnboSgcYFvdmW{ NIS0XVMzOzh6N{[0OS=>
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DU145 MULHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWnEUXNQ NFjpUHlKSzVy4pk8OlAhdk1? MYKyN|g5PDR{OB?=
LNCaP  NGfaZolIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3EUXNQ M4jCR2lEPTEkiMy3OUBvVQ>? M1vnb|I{QDh2NEK4
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5637 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M17JfWlEPTB;NEWuOFchdk1? NYTsTGtmOjN5OUK2N|k>
T24 MkPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17mcmlEPTB;N{muNVIhdk1? NIjpOGMzOzd7Mk[zPS=>
MCF7  M{LmWmZ2dmO2aX;uJGF{e2G7 NYnrdGZFOTByIH7N MWGxJIg> MWDEUXNQ Mn;4doVlfWOnczD0bIUhcW6mdXP0bY9vKG:owrDHdoVjOS{EoGPnb|EtyqCSc{KsxsBU\XKyaX7hN{wh[W6mwrDXbZNxOg>? NVjFSHFKOjN5N{CyOFQ>
KB-V1  MmHSS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlT2TWM2OD1|LkmyJO69VQ>? NH3RboIzOzV7M{G5Oi=>
Hec50co Ml75S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUXJR|UxRTVibl2= M{HER|I{OTR4Nki3
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Caki-1 MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoLqOU05OCCwTR?= MVy5OkBp NH\ISGtJS2x? M13FS5N2eHC{ZYPz[ZMhfGinIIDyc4xq\mW{YYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZIhf2m2aDDJR|UxyqC4YXz1[ZMhd2ZiMjD0c{AzOCCwTR?= MVqyNVY1OjN5NB?=
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HMC-1.1 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;mXmhZOS1zMECwJI5O NXe5PIhKPzJiaB?= M2jMN4lvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\Q>? MYSyNVI1OjF6OR?=
HMC-1.2 NV\xZWJmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGDmdIoyNTFyMECgcm0> NWTaWYhnPzJiaB?= NIjsbIdqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIEh\G:|ZT3k[ZBmdmSnboSgcYFvdmV? M4LMcVIyOjR{MUi5
C2 Mk[zS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHLhW5EyNTFyMECgcm0> NFvhS|k4OiCq MVzpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> NInpW5UzOTJ2MkG4PS=>
CHP-212 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHG0NncyNTF{NTDuUS=> NWjQSVJuOjRvMUKwJIg> M3PJWolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MnG3NlEyPjl{NEK=
IMR-32 Mn2wS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWXJe5lsOS1zMkWgcm0> MViyOE0yOjBiaB?= MmPMbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NUPENpJ1OjFzNkmyOFI>
Kelly M3TSZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn\tNU0yOjVibl2= MUGyOE0yOjBiaB?= MYrpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n MXOyNVE3QTJ2Mh?=
SH-EP MnXsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MYWxMVEzPSCwTR?= NFftXGczPC1zMkCgbC=> MlL0bY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NFu3cVYzOTF4OUK0Ni=>
SH-SY5Y M2DMbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnK2NU0yOjVibl2= NEfnU4YzPC1zMkCgbC=> MV\pcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHLveIghfGmvZT2gZY5lKGSxc3Wt[IVx\W6mZX70JI1idm6n NEXERWUzOTF4OUK0Ni=>
SK-N-AS M3HIVmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3XB[|EuOTJ3IH7N NGLYTlEzPC1zMkCgbC=> NV3rcVlPcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> MkDVNlEyPjl{NEK=
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KG1 M1TrUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3j2blEwOTBxMUCwJI5O M1r0TFczKGh? NUP1U4dJTE2VTx?= NInzNYJqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l NEfMO2wyQTR3OEO1PC=>
U937 MlSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NG\ze2gyNzFyL{GwNEBvVQ>? NFvwO3k4OiCq MWTEUXNQ M1\FZYlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MoTxNVk1PTh|NUi=
CAL62 M2PGc2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1TZb|AvOS1zMECgcm0> MoP0O|IhcA>? MV;EUXNQ NWPuV5R1TUN3ME2xMlQhdk1? NVjUTZBtOTl{MkO1OVM>
OCUT-1 M17CT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M37aVFAvOS1zMECgcm0> M{\ZflczKGh? M371WWROW09? MXHFR|UxRTJwMzDuUS=> Ml3rNVkzOjN3NUO=
8505C NEfVNYlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkP0NE4yNTFyMDDuUS=> MlTSO|IhcA>? NUTWOWFkTE2VTx?= MV3FR|UxRTNwMjDuUS=> NUi1N5o4OTl{MkO1OVM>
ACT-1 NILw[WJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnLlNE4yNTFyMDDuUS=> NIXTWGo4OiCq NFLvdINFVVOR M4DsUWVEPTB;NT60JI5O M4OxRlE6OjJ|NUWz
SW1736 NEPkbllIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{TvWFAvOS1zMECgcm0> MXG3NkBp MkeySG1UVw>? NEnKO5NGSzVyPUWuOkBvVQ>? NEfDOmEyQTJ{M{W1Ny=>

... Click to View More Cell Line Experimental Data

In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
+ Expand
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
In vivo Add solvents individually and in order:
30% PEG 400+0.5% Tween 80+5% Propylene glycol
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
in solvent
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID