BI 2536

Catalog No.S1109

BI 2536 Chemical Structure

Molecular Weight(MW): 521.66

BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.

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In DMSO USD 240 In stock
USD 120 In stock
USD 210 In stock
USD 670 In stock
USD 997 In stock
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Cited by 54 Publications

12 Customer Reviews

  • Comparison between Genetic Ablation of Cdc20 and Current Mitotic Drugs (C) Transformed Cdc20(lox/lox); RERT(+/Cre) MEFs were subcutaneously injected into the two flanks of SCID mice, and tumors were scored every 2-3 days.These mice were injected i.p. (three injections per week) with 4-OHT or mitotic drugs (taxol, vincristine, and BI2536) when tumors reached about 200 mm3 of volume (day 11; arrow) (n = 8 mice per group). (D) Representative images of these fibrosarcomas 3 days after injection with 4-OHT (to generate Cdc20(D/D) cells), BI2536, or taxol. These mice were injected with 10 μM BrdU to score DNA replication. CA3, immunodetection of active caspase 3. Scale bars, 50 or 10 μM (insets).

    Cancer Cell 2010 18, 641–654. BI 2536 purchased from Selleck.

    (a,b) RPE1 cells transfected with control or either of two B56-PP2A siRNA pools (1, 2) were incubated in MG132 (10µM, 15 min), followed by the addition of BI2536 (40 nM) or DMSO for 45 min. (a) The frequency of mitotic cells with few or absent cold-stable K-bres . (b) Maximum-intensity projection of tubulin (green) and an overlay with kinetochores (CREST, red) in B56-PP2A-siRNA (pool 2) cells treated with DMSO or BI2536 (40 nM). Insets are 3 enlargement of the optical sections spanning the outlined centromeres.

    Nat Cell Biol 2011 13, 1265-71. BI 2536 purchased from Selleck.

  • (a) HeLa Tet-On cells were treated with the indicated siRNAs, arrested in mitosis using 500 nM nocodazole (Noc) and 10 μM MG132, and then treated with or without BI 2536. The endogenous Cdc20 was immunoprecipitated from these cells and blotted with the indicated antibodies. The mitotic index of each sample is indicated below each lane. The bottom graph shows the quantification of the Cdc20-pS92 signal normalized to the total Cdc20 signal (mean±range; n=2 independent experiments).

    Nat Commun, 2016, 7:10818. BI 2536 purchased from Selleck.

    Treatment with BI 2536 induces cell-cycle arrest in NB TICs and aberrant accumulation of cyclin B1 and p21. C, expression of cyclin B1 and p21 was assessed in NB88R2 following 16 and 24-hour treatment with different doses of BI 2536 (10, 30, and 100 nmol/L). ERK1 (extracellular signal regulated kinase 1) was used as the loading control. D, inhibition of PLK1 was assessed by in vitro kinase assay following treatment of NB88R2 for 3 hours with BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • Treatment with BI 2536 induces cell death via apoptosis. A,treatment with BI 2536 (10, 30, and 100 nmol/L) reduces viable cell numbers as assessed by trypan blue exclusion. B, representative Western blot demonstrating accumulation of cleaved PARP following treatment with 10 nmol/L BI 2536.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    BI 2536 inhibits NB tumor growth in vivo. A and B, NOD/SCID mice bearing 50- to100-mm3 tumors were injected intravenously with either vehicle (0.1N HCl per saline) or 12.5 to 25 mg/kg BI 2536 for 2 consecutive days a week, for a total of 3 cycles.Two independent experiments were performed in each case with 5 animals per group. Representative tumor growth data are shown.

     

     

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

  • animals with 50- to 100-mm3 tumors were randomized into 4 groups: group 1 injected intravenously with vehicle (0.1N HCl per saline), group 2 injected intravenously with 12.5 mg/kg of BI 2536 (2 consecutive days, 3 cycles), group 3 injected i.p. with 10 mg/kg of irinotecan (3 doses total, 3 days apart), and group 4 injected with BI 2536 and irinotecan. Both representative tumor growth data and a Kaplan-Meyer survival plot are shown.

    Cancer Res 2011 71, 1385-1395. BI 2536 purchased from Selleck.

    Plk-1 knockdown and inhibition by BI 2536 and viability of human melanoma cell lines M14 and WM-115 as demonstrated by MTT assay. Experiments were performed in triplicate. One representative experiment is shown. *P<0.001, ANOVA test with Tukey’s post-test. ANOVA, analysis of variance; MTT, 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; Plk-1, polo-like kinase 1; siRNA, small-interfering RNA; WB, western blot.

    J Invest Dermatol 2011 131, 1886–1895. BI 2536 purchased from Selleck.

  • Western blot analysis of the expression and phosphorylation of Plk1, and phosphorylation of Myt1 in the CSC-like cells after treatment with BI 2536 for 24 and 48 hours, respectively.

    Oncotarget, 2017, 8(23):37633-37645. BI 2536 purchased from Selleck.

    Cells with decreased GRK5 expression are more sensitive to PLK1 inhibition.A , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h of treatment with 0-120 nM BI 2536 as determined by trypan blue exclusion (n = 6).B , shown is cell death in control or GRK5-shRNA stably transfected cells after 72 h treatment with 0 –120 nM GSK461364, as determined by trypan blue exclusion ( n = 4).

    J Biol Chem 2012 287(21), 17088-99. BI 2536 purchased from Selleck.

  • J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

    Example dose response curves of the PLK-1 inhibitor BI-2536. During the large dose response study for each reference compounds 8 dilutions were tested. Curves for IC50 determination for two independent experiments for the PLK1 inhibitor BI-2536 are displayed. This inhibitor is also used to achieve the LC values. IC50 has been determined with 7.48 +/- 0.09 log [M] and 6.75 +/- 0.21 log [M]. Correlating assay performance data are displayed in Suppl. Fig. 5. 

    J Biomol Screen 2013 18(1), 54-66. BI 2536 purchased from Selleck.

Purity & Quality Control

Choose Selective PLK Inhibitors

Biological Activity

Description BI2536 is a potent Plk1 inhibitor with IC50 of 0.83 nM in a cell-free assay. It shows 4- and 11-fold greater selectivity against Plk2 and Plk3. Phase 2.
Features The first potent and selective Plk1 inhibitor that induces all hallmarks of Plk1 inhibition.
Targets
PLK1 [1]
(Cell-free assay)
PLK2 [1]
(Cell-free assay)
PLK3 [1]
(Cell-free assay)
0.83 nM 3.5 nM 9.0 nM
In vitro

BI 2536 blocks the activities of Plk2 and Plk3 to a slightly lesser extent with IC50 of 3.5 nM and 9.0 nM, respectively. In HeLa cells, BI 2536 treatment ranging from 10-100 nM leads to the blocking of the recruitment of γ-tubulin and phosphorylation of Apc6 at mitotic centrosomes, inhibition of cohesin release from chromosome arms, induction of monopolar spindles, as well as a range of other mitotic processes that are known to depend on Plk1. BI 2536 treatment leads to the HeLa cells arrested in G2/M, subsequently a sub-G1 DNA peak indicative of DNA breakdown and apoptosis, and accumulated cleaved PARP p85 fragments in a concentration-dependent manner. BI 2536 inhibits the growth of a panel of 32 human cancer cell lines with EC50 of 2-25 nM, while blocking the proliferation of exponentially growing hTERT-RPE1, human umbilical vein endothelial cells (HUVECs), and normal rat kidney (NRK) cells with EC50 of 12-31 nM. [1] Plk1 inhibition by BI 2536 reduces the growth and viability of anaplastic thyroid carcinoma (ATC) cells such as CAL62, OCUT-1, SW1736, 8505C, and ACT-1 with EC50 values of 1.4-5.6 nM. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
PSN1 MmTqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1niW2lEPTB;MD6wNFc4PiEQvF2= MWXTRW5ITVJ?
ACN NHTn[GVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYXJR|UxRTBwMEC4OFMh|ryP MmG4V2FPT0WU
TE-8 NITCbI9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUTJR|UxRTBwMEC5OFEh|ryP MUnTRW5ITVJ?
LC-2-ad NID5[3BIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mkn2TWM2OD1yLkCxNFk{KM7:TR?= NEHHWGZUSU6JRWK=
ALL-PO M1nOTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGj3elZKSzVyPUCuNFE{KM7:TR?= MlyxV2FPT0WU
EW-16 Moj3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Ml:1TWM2OD1yLkCxN|M3KM7:TR?= NVfVXXNQW0GQR1XS
KM12 NUHNXJlmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzXTWM2OD1yLkCxN|Q5KM7:TR?= NE\mcVFUSU6JRWK=
GI-1 Mn7ZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4DaWWlEPTB;MD6wNVM5OyEQvF2= MnPaV2FPT0WU
LS-411N NXfROIFJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DJ[2lEPTB;MD6wNVQxPyEQvF2= MkjkV2FPT0WU
ES8 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33RW2lEPTB;MD6wNVQ6PCEQvF2= NFLERXBUSU6JRWK=
SNU-C2B MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYD2cHdWUUN3ME2wMlAyPTJ4IN88US=> MlmwV2FPT0WU
CESS MWXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX6zdGo1UUN3ME2wMlAyPjB{IN88US=> MUHTRW5ITVJ?
697 MWfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTBwMEG2Olgh|ryP NUW2VJFSW0GQR1XS
NCI-H1963 NHTxO3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlXQTWM2OD1yLkCxOlc{KM7:TR?= MlyxV2FPT0WU
IA-LM NVPCOmUxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlvMTWM2OD1yLkCxOlg5KM7:TR?= NHWxb2JUSU6JRWK=
SW954 MkD2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUjJR|UxRTBwMEG3NFUh|ryP MVXTRW5ITVJ?
RL95-2 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT0TWM2OD1yLkCxO|M5KM7:TR?= NWLwbJg5W0GQR1XS
LXF-289 Mom5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2D5TWlEPTB;MD6wNVc4KM7:TR?= NXrLcGljW0GQR1XS
OCUB-M M2LNVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{OxcWlEPTB;MD6wNVgzPiEQvF2= NFjnOJpUSU6JRWK=
RKO MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTBwMEG5PFch|ryP M3vBVnNCVkeHUh?=
LOUCY NIL1WZdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoHBTWM2OD1yLkCyNFUh|ryP Ml;BV2FPT0WU
NOS-1 Mlj6S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2Lqe2lEPTB;MD6wNlA6OyEQvF2= NWLiTo94W0GQR1XS
A4-Fuk NEj4RmtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGDCdoFKSzVyPUCuNFIzOThizszN M3nIWnNCVkeHUh?=
A388 MnP1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkH5TWM2OD1yLkCyNlI4KM7:TR?= NFzUWmFUSU6JRWK=
TE-9 NH\QSlJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PBfGlEPTB;MD6wNlI3OSEQvF2= MnHOV2FPT0WU
KURAMOCHI M2XiOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWXLXVhGUUN3ME2wMlAzOjh3IN88US=> Mm\PV2FPT0WU
KALS-1 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjpWHdKSzVyPUCuNFI{OzhizszN M3zwcXNCVkeHUh?=
HOP-62 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml7nTWM2OD1yLkCyOFIh|ryP MkTTV2FPT0WU
RPMI-8402 NFe1T4RIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkC3TWM2OD1yLkCyOVA5KM7:TR?= Mk\CV2FPT0WU
TE-1 NYnMe4pTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWDJR|UxRTBwMEK1NVIh|ryP MVjTRW5ITVJ?
CCRF-CEM NUPUNll[T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnvJTWM2OD1yLkCyOVQ{KM7:TR?= NUHqOWhuW0GQR1XS
HUTU-80 M3P1NGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHZOm5JUUN3ME2wMlAzPjJ2IN88US=> M2rBU3NCVkeHUh?=
NCI-H1648 NW\VXXc2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NH:zdJNKSzVyPUCuNFI3PDdizszN M17PN3NCVkeHUh?=
HCE-4 NX61UVloT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWjaTVI2UUN3ME2wMlAzPjh{IN88US=> MWDTRW5ITVJ?
ETK-1 MmnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXnJR|UxRTBwMEK3N|Yh|ryP MXTTRW5ITVJ?
TE-15 NWq2O4ZpT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2Tl[GlEPTB;MD6wNlc{QCEQvF2= NIXXU2RUSU6JRWK=
BE-13 MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknQTWM2OD1yLkCyO|Qh|ryP NYGzXVlIW0GQR1XS
KE-37 MVrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFf3U3dKSzVyPUCuNFI4PDFizszN M{fCZnNCVkeHUh?=
NCI-H1355 M4jnVWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3YTWM2OD1yLkCyO|g{KM7:TR?= NGH1UWFUSU6JRWK=
TE-11 NUW5eZZRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTGZ3h6UUN3ME2wMlAzQDB7IN88US=> M4OwNHNCVkeHUh?=
BL-70 NGXoNIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2H1W2lEPTB;MD6wNlg2PyEQvF2= MUfTRW5ITVJ?
ES6 NXTmXpJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFn5OpZKSzVyPUCuNFI5QDFizszN M3zxN3NCVkeHUh?=
GT3TKB NX\BdJNVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NWXLdoN7UUN3ME2wMlAzQTV|IN88US=> NHLIT4JUSU6JRWK=
LB647-SCLC MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXv4UnFPUUN3ME2wMlA{OTl3IN88US=> MkTUV2FPT0WU
NB13 NVXGOogxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV[wVWJGUUN3ME2wMlA{OzF4IN88US=> NUO0WXNJW0GQR1XS
ST486 M1\UT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF\yO41KSzVyPUCuNFM{OzdizszN NWHPc4hGW0GQR1XS
NCI-H82 MojQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYnVeIVVUUN3ME2wMlA{OzR|IN88US=> MWHTRW5ITVJ?
NTERA-S-cl-D1 M3;DPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4DVVGlEPTB;MD6wN|M6QSEQvF2= NXf5d2ZMW0GQR1XS
ES4 MWPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{\x[2lEPTB;MD6wN|Q3OyEQvF2= M3;yS3NCVkeHUh?=
SK-NEP-1 NVrkfIpxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX33TVk2UUN3ME2wMlA{PDl7IN88US=> NIf3W25USU6JRWK=
Becker MmLXS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NV\DSGVoUUN3ME2wMlA{PTV3IN88US=> NEnKbGhUSU6JRWK=
A101D MYTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3fvVWlEPTB;MD6wN|c1QCEQvF2= MmnQV2FPT0WU
SK-UT-1 M2TRdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 Mn3NTWM2OD1yLkCzO|c1KM7:TR?= MmL5V2FPT0WU
SW982 MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1S4fGlEPTB;MD6wN|c6KM7:TR?= Mn:yV2FPT0WU
TE-10 M3rBfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVTsXnRKUUN3ME2wMlA1ODR4IN88US=> NWHyeFVCW0GQR1XS
OVCAR-4 MkSzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MlnITWM2OD1yLkC0NFU6KM7:TR?= MWfTRW5ITVJ?
KP-N-YS M4m0e2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEi1fJpKSzVyPUCuNFQxQDVizszN MljpV2FPT0WU
BL-41 M{exTWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV34U4RQUUN3ME2wMlA1OTJ3IN88US=> MkPhV2FPT0WU
MZ1-PC NIXB[HhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NI\LeZhKSzVyPUCuNFQyOjdizszN NYPldlZmW0GQR1XS
PF-382 MkDpS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1XVSmlEPTB;MD6wOFE6QCEQvF2= M2CwW3NCVkeHUh?=
MOLT-13 MXfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MknOTWM2OD1yLkC0NlM5KM7:TR?= NGnTTpNUSU6JRWK=
HCC1599 NYTRcVVmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPaTWM2OD1yLkC0NlU5KM7:TR?= NGnPe3lUSU6JRWK=
IST-MEL1 NGi4d3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrTXWZKSzVyPUCuNFQ1PDJizszN NHXvSoNUSU6JRWK=
LU-139 MVTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFjSNmRKSzVyPUCuNFQ1PDJizszN M4XQXHNCVkeHUh?=
MS-1 NYnSNW1DT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlPUTWM2OD1yLkC0O|AyKM7:TR?= MX;TRW5ITVJ?
MFH-ino MmTuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnPETWM2OD1yLkC1NFA{KM7:TR?= M4TPVHNCVkeHUh?=
IMR-5 NX;T[ohnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmXkTWM2OD1yLkC1NFIyKM7:TR?= MVvTRW5ITVJ?
TE-5 MlHhS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUnicZRQUUN3ME2wMlA2ODZ|IN88US=> MlzrV2FPT0WU
DJM-1 M2D0Zmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1HqTGlEPTB;MD6wOVE1OiEQvF2= NV25S3VzW0GQR1XS
NB17 Ml7US5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4qydmlEPTB;MD6wOVIxPyEQvF2= MYnTRW5ITVJ?
KARPAS-45 NEG4UodIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MkT5TWM2OD1yLkC1N|U5KM7:TR?= NH3lZndUSU6JRWK=
TGBC1TKB NUTrTYN2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MmrCTWM2OD1yLkC1OFA2KM7:TR?= NWKxOZR{W0GQR1XS
ML-2 NXfT[VJ2T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV3LXW1iUUN3ME2wMlA2PDF2IN88US=> M1fjdnNCVkeHUh?=
no-10 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV;NPG51UUN3ME2wMlA2PDd2IN88US=> M3TLNnNCVkeHUh?=
CTV-1 NFL0fpJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGPIS2ZKSzVyPUCuNFU2ODJizszN NVHtelJVW0GQR1XS
SJSA-1 NHH5dJZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MlGzTWM2OD1yLkC1OVIh|ryP NEf6Z29USU6JRWK=
HC-1 NVzo[mVYT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MX\JR|UxRTBwMEW1PVch|ryP M3fRb3NCVkeHUh?=
TE-12 MoPsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTBwMEW2NVMh|ryP M4rseXNCVkeHUh?=
KY821 M{PhZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NIrsS2VKSzVyPUCuNFU3OzJizszN NFTwWJNUSU6JRWK=
TALL-1 NXfoSG5iT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MYXJR|UxRTBwMEW3NFgh|ryP MUfTRW5ITVJ?
DEL MnLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mmm1TWM2OD1yLkC1O|A6KM7:TR?= M2rKSXNCVkeHUh?=
TE-6 MkPnS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? Mln6TWM2OD1yLkC1O|IzKM7:TR?= M2PCVnNCVkeHUh?=
SK-LMS-1 MoroS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkjMTWM2OD1yLkC1PFA2KM7:TR?= MnzKV2FPT0WU
EW-1 NVf0b4pTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUC4R2hKUUN3ME2wMlA2QDN5IN88US=> NXnYXFRKW0GQR1XS
8-MG-BA MoP2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEnsNGVKSzVyPUCuNFU5PTFizszN M3PFXnNCVkeHUh?=
NALM-6 MonYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M17N[WlEPTB;MD6wOVk4OyEQvF2= MlT6V2FPT0WU
LB771-HNC Ml;oS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXvJR|UxRTBwMEW5O|kh|ryP M3TSTXNCVkeHUh?=
HT-144 M37KTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLNZlFvUUN3ME2wMlA3OTNizszN M4n5[3NCVkeHUh?=
KM-H2 MY\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnrxTWM2OD1yLkC2NlIyKM7:TR?= M4HWdXNCVkeHUh?=
SF268 MnT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYSwbYFHUUN3ME2wMlA3Ojh4IN88US=> MYXTRW5ITVJ?
RS4-11 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlPOTWM2OD1yLkC2N|A1KM7:TR?= NFHXenZUSU6JRWK=
MHH-PREB-1 NUPQ[5ZyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlnXTWM2OD1yLkC2N|E6KM7:TR?= MUjTRW5ITVJ?
ATN-1 M1nnZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXLidoR{UUN3ME2wMlA3OzR3IN88US=> MXfTRW5ITVJ?
BB30-HNC M4TadGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUPHd4lsUUN3ME2wMlA3PDN4IN88US=> NHniO3pUSU6JRWK=
CPC-N NHXQ[lFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGKyWVVKSzVyPUCuNFY2OjRizszN MnvwV2FPT0WU
NB1 M1\LUGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXPJR|UxRTBwME[2NVMh|ryP NFzFUGFUSU6JRWK=
KS-1 NWLEfVNJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYnjV482UUN3ME2wMlA3PzR6IN88US=> NGPCZVBUSU6JRWK=
RXF393 NU\pS2VQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUPJR|UxRTBwME[3OlQh|ryP MYTTRW5ITVJ?
IST-SL2 MmS1S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYjnTo96UUN3ME2wMlA4ODB2IN88US=> MWLTRW5ITVJ?
GI-ME-N MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWDJR|UxRTBwMEeyPFYh|ryP MXvTRW5ITVJ?
VA-ES-BJ MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYP3e5NjUUN3ME2wMlA4PDd3IN88US=> MmDIV2FPT0WU
NCI-H1581 NFXRZ45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYXkPFUzUUN3ME2wMlA4PDd6IN88US=> MojQV2FPT0WU
U-266 NG[yNo9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUXJR|UxRTBwMEe0PVch|ryP M37tZnNCVkeHUh?=
DMS-114 M4Pw[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFyzUWFKSzVyPUCuNFc2OjhizszN MmrNV2FPT0WU
NCI-H187 NF7wUm9Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fhOGlEPTB;MD6wO|czPiEQvF2= MXPTRW5ITVJ?
SW962 M1nY[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NH\ZOZhKSzVyPUCuNFc5OzlizszN NUK2c5R4W0GQR1XS
MONO-MAC-6 NHTrO45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYDNZZZwUUN3ME2wMlA4QTh4IN88US=> MYnTRW5ITVJ?
MOLT-16 NILYcpNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXrZSo53UUN3ME2wMlA5OTJzIN88US=> NWDwZXZKW0GQR1XS
KNS-42 MmXYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFvrVJdKSzVyPUCuNFgyPjFizszN NYnZUVh4W0GQR1XS
CMK Mm[4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfqfIJFUUN3ME2wMlA5OjJ3IN88US=> MmXtV2FPT0WU
Ramos-2G6-4C10 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NITQVHVKSzVyPUCuNFgzOjVizszN NV\DTmRoW0GQR1XS
Daudi NV7HNoI5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEnjZmhKSzVyPUCuNFgzPTZizszN M2fNOHNCVkeHUh?=
NCI-H510A NHK3eJRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NYnRboJFUUN3ME2wMlA5OzN4IN88US=> NUDrT5NtW0GQR1XS
LB831-BLC MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH;ifFFKSzVyPUCuNFg2PjFizszN MkLZV2FPT0WU
HEL NW\k[2hsT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DaUGlEPTB;MD6wPFY3QCEQvF2= NYDUemNxW0GQR1XS
LU-134-A NVvUR|JmT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MVzJR|UxRTBwMEi3NFgh|ryP NEj0eGNUSU6JRWK=
NCI-H1694 M1HTWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFXMb5lKSzVyPUCuNFg4PDRizszN M{PXcXNCVkeHUh?=
KGN MoPIS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVfnWpRpUUN3ME2wMlA5PzV7IN88US=> NUfhWYR1W0GQR1XS
A253 MXzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3e4cWlEPTB;MD6wPFgzOiEQvF2= M3z0TnNCVkeHUh?=
DG-75 MnfFS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1nvTmlEPTB;MD6wPFkzOiEQvF2= MWjTRW5ITVJ?
MOLT-4 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{m0XWlEPTB;MD6wPFk5OyEQvF2= M3;1XnNCVkeHUh?=
NCI-SNU-5 NY\ZNWNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4HRPWlEPTB;MD6wPVI2QCEQvF2= M4rYZnNCVkeHUh?=
ONS-76 MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlHjTWM2OD1yLkC5Nlc3KM7:TR?= M33FVnNCVkeHUh?=
NCI-H446 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1XJbGlEPTB;MD6wPVQ3OiEQvF2= MUnTRW5ITVJ?
COR-L279 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NIXqfYtKSzVyPUCuNFk2PTZizszN M1nVNHNCVkeHUh?=
Calu-6 MVjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NH\3emVKSzVyPUCuNFk2QThizszN MVTTRW5ITVJ?
BC-3 NEfnbHZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXPwU3pUUUN3ME2wMlA6PjZ{IN88US=> MnnZV2FPT0WU
NCI-H2126 M1jmNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVz6THNyUUN3ME2wMlA6PzlzIN88US=> MkfGV2FPT0WU
NCI-H1882 MmfCS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYLObG9sUUN3ME2wMlA6QDB7IN88US=> MWfTRW5ITVJ?
BB65-RCC NUnsd2RzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGHHXo1KSzVyPUCuNVAzQTRizszN M4DhW3NCVkeHUh?=
DU-4475 Ml;IS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NUiyPY1OUUN3ME2wMlExPDB5IN88US=> MVnTRW5ITVJ?
NCI-H526 NUD0cmpST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVTZflBMUUN3ME2wMlExPDRizszN MW\TRW5ITVJ?
NEC8 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXjF[5ZJUUN3ME2wMlExPTJ3IN88US=> MmrMV2FPT0WU
NCI-H1304 MmPmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXSyZpFlUUN3ME2wMlExPTl2IN88US=> MUPTRW5ITVJ?
L-540 Mn\BS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVvESXVDUUN3ME2wMlExPzB6IN88US=> NWXobG1qW0GQR1XS
NCI-SNU-16 NXTtc|ZJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoTETWM2OD1yLkGwO|QzKM7:TR?= MX3TRW5ITVJ?
HD-MY-Z NWHp[ZFiT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NW\FXm1WUUN3ME2wMlExQDV4IN88US=> M3zSZ3NCVkeHUh?=
K-562 M364OGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M1j4U2lEPTB;MD6xNFg2QCEQvF2= NYn5bY9bW0GQR1XS
JAR M2TJNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MX\JR|UxRTBwMUC5NlUh|ryP MoPhV2FPT0WU
MZ2-MEL NH;wZoJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX;JR|UxRTBwMUGwOUDPxE1? NXfXWmRxW0GQR1XS
L-363 NUPBZWdyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2n6cGlEPTB;MD6xNVA4QSEQvF2= MmPGV2FPT0WU
BV-173 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTBwMUGyOFMh|ryP MnXFV2FPT0WU
NCI-H524 MoDNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M4ezfWlEPTB;MD6xNVI4PCEQvF2= M3;RdXNCVkeHUh?=
EoL-1-cell M1XsU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnHrTWM2OD1yLkGxOlczKM7:TR?= MYTTRW5ITVJ?
K052 NXLTNml4T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NFzkd3lKSzVyPUCuNVE4OTJizszN M3KxVXNCVkeHUh?=
TK10 NYf2PYhbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4TVN2lEPTB;MD6xNVczQCEQvF2= MlT2V2FPT0WU
KU812 NYD2SXNyT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYfXRXo1UUN3ME2wMlEzODR2IN88US=> NV3heoJlW0GQR1XS
RPMI-8226 M3XMZ2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXHSV2M4UUN3ME2wMlEzODV{IN88US=> M4jVR3NCVkeHUh?=
MZ7-mel MmPPS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHHLSYdKSzVyPUCuNVIzOzdizszN NULacVE4W0GQR1XS
SK-PN-DW NX\5[2JNT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIDIRXVKSzVyPUCuNVIzQDdizszN MUPTRW5ITVJ?
SR MX;Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M33QNmlEPTB;MD6xNlQ1OSEQvF2= M3;KdXNCVkeHUh?=
RPMI-6666 NEL5SYRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3j0UmlEPTB;MD6xNlc1OyEQvF2= M1zSUXNCVkeHUh?=
no-11 MVfHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M4HnbGlEPTB;MD6xNlg3QSEQvF2= M3rlOHNCVkeHUh?=
EW-3 M1SwPGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NY\KVFd3UUN3ME2wMlEzQDl|IN88US=> NHjFe2pUSU6JRWK=
LAMA-84 NGjNNYxIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXXJR|UxRTBwMUOxPFch|ryP MVzTRW5ITVJ?
HT NVHj[2JkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHrmdHdKSzVyPUCuNVM2PzRizszN M{fk[3NCVkeHUh?=
KP-N-RT-BM-1 Mn;KS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYP2OI04UUN3ME2wMlE{PjF{IN88US=> MWjTRW5ITVJ?
NCI-H747 M4DRbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4nLbmlEPTB;MD6xN|ch|ryP NH75ZYxUSU6JRWK=
NCCIT MlLtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX\0eZVbUUN3ME2wMlE{QTN7IN88US=> MXXTRW5ITVJ?
MLMA NHLSe2JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXfRSnROUUN3ME2wMlE1OTZ5IN88US=> NYTxVllCW0GQR1XS
LP-1 NVHGO5BvT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEOzWGhKSzVyPUCuNVQzPCEQvF2= M1XFWHNCVkeHUh?=
CAL-148 M3fDZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NWTmbm4xUUN3ME2wMlE1PDh|IN88US=> M2XU[HNCVkeHUh?=
GB-1 NEG3NHdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mn[zTWM2OD1yLkG0OVI3KM7:TR?= NUjROWs3W0GQR1XS
COR-L88 NFXtSlBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnjCTWM2OD1yLkG0PFAzKM7:TR?= M{SyN3NCVkeHUh?=
NKM-1 NGToSJhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmLPTWM2OD1yLkG0PVA3KM7:TR?= NV[xeJhnW0GQR1XS
NB5 NH[1fGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUj2SJVRUUN3ME2wMlE2PDZ{IN88US=> MVjTRW5ITVJ?
SH-4 NEn3SINIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nBNGlEPTB;MD6xOVQ3PiEQvF2= Mk\UV2FPT0WU
EM-2 M3[1XWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTBwMUW0Olch|ryP NWDGO29qW0GQR1XS
TGBC24TKB NEPWWnBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHrsXmFKSzVyPUCuNVU3PTlizszN NULVdFN[W0GQR1XS
SCLC-21H NWnYUpJCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXe3V4ZZUUN3ME2wMlE2PzB{IN88US=> MVHTRW5ITVJ?
COLO-684 Ml7OS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NYK4PWRmUUN3ME2wMlE2PzJzIN88US=> MV;TRW5ITVJ?
KINGS-1 MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYrJR|UxRTBwMUW5NUDPxE1? MWfTRW5ITVJ?
LS-123 M3vURWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV;nNnBUUUN3ME2wMlE2QTF5IN88US=> NFLHOIlUSU6JRWK=
MC116 NWDKNZVVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MY\JR|UxRTBwMU[xOVgh|ryP NH7DTXBUSU6JRWK=
SU-DHL-1 NUfsTYs{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnHzTWM2OD1yLkG2NlA3KM7:TR?= MWDTRW5ITVJ?
NCI-H64 M2n6VWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NX7QS4ZLUUN3ME2wMlE3OzR5IN88US=> M4jlRnNCVkeHUh?=
HCE-T MkHTS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2GzVWlEPTB;MD6xOlUxPCEQvF2= M1nyWHNCVkeHUh?=
LOXIMVI MnnNS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLlTGRKSzVyPUCuNVY6PDlizszN NX\CXHdUW0GQR1XS
ARH-77 NH\wb|VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWDxXJRCUUN3ME2wMlE4Ozd7IN88US=> MlXTV2FPT0WU
DOHH-2 MmXzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1m1PWlEPTB;MD6xO|Y4OiEQvF2= MYnTRW5ITVJ?
COLO-320-HSR MlvoS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MY\JR|UxRTBwMUixOVQh|ryP MorqV2FPT0WU
NB6 MoTOS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH\3T5JKSzVyPUCuNVg2PjZizszN NHzqdplUSU6JRWK=
L-428 M1n4Rmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnLZTWM2OD1yLkG4PFE{KM7:TR?= M{m5NnNCVkeHUh?=
SNB75 NH;wUm5Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NX3PUplXUUN3ME2wMlE5QDJ2IN88US=> NV;aPGd[W0GQR1XS
NCI-H2141 MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUfJR|UxRTBwMUmwNVEh|ryP MVnTRW5ITVJ?
KARPAS-299 M1W4Smdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVHJR|UxRTBwMUmyOFEh|ryP MoD4V2FPT0WU
LC4-1 NXzWXY56T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkLaTWM2OD1yLkG5OVAzKM7:TR?= NIfjfHZUSU6JRWK=
UACC-257 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVXJR|UxRTBwMUm5OFch|ryP MoXYV2FPT0WU
EVSA-T MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mk\rTWM2OD1yLkKwN|EzKM7:TR?= NUn0SmZxW0GQR1XS
JiyoyeP-2003 MnT3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{TGTGlEPTB;MD6yNFQ4PyEQvF2= Mn;4V2FPT0WU
NCI-H720 M2HX[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\XOGlEPTB;MD6yNFUzPSEQvF2= NXXWZWZVW0GQR1XS
GAK MYDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NYL0WpNsUUN3ME2wMlIyOTh7IN88US=> MnfmV2FPT0WU
HH MWnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NWPOVIRFUUN3ME2wMlIyPDB3IN88US=> MoTDV2FPT0WU
NCI-H1436 NXvwXGxZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MoL0TWM2OD1yLkKxOFY1KM7:TR?= Mn7hV2FPT0WU
GR-ST MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M37EdmlEPTB;MD6yNVQ5QCEQvF2= MV3TRW5ITVJ?
BC-1 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1G4ZWlEPTB;MD6yNlYyPiEQvF2= MnyzV2FPT0WU
SIG-M5 MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NX;CfnJnUUN3ME2wMlIzPzJ5IN88US=> NYHEOJFxW0GQR1XS
NCI-H345 MkT5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M{XrfWlEPTB;MD6yN|gxPSEQvF2= MXrTRW5ITVJ?
OPM-2 M{XIe2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{\xdWlEPTB;MD6yN|g5OiEQvF2= M2j5WHNCVkeHUh?=
LB1047-RCC NX7WOWFST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHq3TXpKSzVyPUCuNlQ1OSEQvF2= MV3TRW5ITVJ?
CTB-1 NGDob|hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{fXc2lEPTB;MD6yOFQ6OyEQvF2= MVPTRW5ITVJ?
A3-KAW MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Ml;rTWM2OD1yLkK1N|QyKM7:TR?= NXv5cIJMW0GQR1XS
SF126 Ml:yS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEX4V5JKSzVyPUCuNlU{QDNizszN MVjTRW5ITVJ?
KARPAS-422 MXXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoDmTWM2OD1yLkK1OFM2KM7:TR?= M{fob3NCVkeHUh?=
MEG-01 NWfzOFVTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1nHWGlEPTB;MD6yOVY4OyEQvF2= NYD0fY06W0GQR1XS
NCI-H209 NHHJZnlIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmeyTWM2OD1yLkK2N|c1KM7:TR?= MkW0V2FPT0WU
SBC-1 NGqzR4hIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Mor0TWM2OD1yLkK2OUDPxE1? MYLTRW5ITVJ?
K5 NGTnT5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1PWNWlEPTB;MD6yOlk5PCEQvF2= NW[zSJk3W0GQR1XS
QIMR-WIL MlS2S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUDJR|UxRTBwMkexOVUh|ryP MVHTRW5ITVJ?
NMC-G1 NYKxZ4RrT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlrzTWM2OD1yLkK4NlE4KM7:TR?= NIPTUJhUSU6JRWK=
IST-MES1 MoHlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHT3eI9KSzVyPUCuNlkzOzhizszN MYrTRW5ITVJ?
SW684 MoDZS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M2rRXmlEPTB;MD6zNFA1PyEQvF2= NYPUUnB1W0GQR1XS
MV-4-11 NX:1WIkxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYn2cpg2UUN3ME2wMlMxPzh6IN88US=> NWm1UIxvW0GQR1XS
LAN-6 NUXqSoh3T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUTJR|UxRTBwM{G1O|Ih|ryP MkDMV2FPT0WU
RH-1 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NHzRNFVKSzVyPUCuN|E5PzFizszN MXHTRW5ITVJ?
CP66-MEL M{[1XGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NVLycnZ4UUN3ME2wMlMyQDd6IN88US=> M4jSNHNCVkeHUh?=
EC-GI-10 M3HBfGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4fUUGlEPTB;MD6zNlk5PyEQvF2= NFjsVGNUSU6JRWK=
GDM-1 MXPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3r1fWlEPTB;MD6zN|A2QSEQvF2= NXPvUJBWW0GQR1XS
IST-SL1 M3Pjdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NFPpfoFKSzVyPUCuN|Q6OTRizszN Ml[xV2FPT0WU
KMOE-2 NYq3PY9tT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3y2SmlEPTB;MD6zOVE4PSEQvF2= M{XlPXNCVkeHUh?=
OS-RC-2 MlzRS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1fzSWlEPTB;MD6zOVU1PCEQvF2= M{W3VXNCVkeHUh?=
HDLM-2 NXfvUpJZT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NX7wVWx{UUN3ME2wMlM4QDF2IN88US=> MYnTRW5ITVJ?
DSH1 NF;lO5JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnPlTWM2OD1yLkO4OlMyKM7:TR?= MlT3V2FPT0WU
LS-1034 NF\EcVVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\IOZBKSzVyPUCuN|g6PTRizszN Ml7oV2FPT0WU
LB373-MEL-D NHPpTGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M12zVmlEPTB;MD6zPVE6PyEQvF2= M4n2enNCVkeHUh?=
GOTO MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYjJR|UxRTBwNEKxNVgh|ryP MYHTRW5ITVJ?
MRK-nu-1 MnnLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXnRbpR[UUN3ME2wMlQzOjB3IN88US=> NF3LSJRUSU6JRWK=
SK-MM-2 NInpPVBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1vzPWlEPTB;MD60N|Q1OiEQvF2= M4HvenNCVkeHUh?=
BOKU MV\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXrT2dMUUN3ME2wMlQ{Pzl{IN88US=> MkjFV2FPT0WU
NOMO-1 NVq1dVlbT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwNEO4OkDPxE1? NEG3coFUSU6JRWK=
J-RT3-T3-5 NV:zcYxJT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVPHb5lwUUN3ME2wMlQ1QDd6IN88US=> M3HTUXNCVkeHUh?=
COLO-668 MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mmj5TWM2OD1yLkS1OlY5KM7:TR?= MkDRV2FPT0WU
SF539 M3;sWWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnrwTWM2OD1yLkS4Olg1KM7:TR?= MWjTRW5ITVJ?
LB2518-MEL MoDsS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHvEfYNKSzVyPUCuOFk4ODNizszN NHG3[|FUSU6JRWK=
TE-441-T NGL4XFBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTBwNUCxNkDPxE1? M17BdnNCVkeHUh?=
MDA-MB-134-VI NGfhWY1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MnO4TWM2OD1yLkWwPVIyKM7:TR?= NVHTTIdsW0GQR1XS
SCC-3 NHvRWo1Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3vtRmlEPTB;MD61NVg4OyEQvF2= MUfTRW5ITVJ?
KLE NHvI[pRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NWSyT202UUN3ME2wMlUzOTdzIN88US=> NXvTXVdJW0GQR1XS
LB2241-RCC M4rxNGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MUnJR|UxRTBwNUK1NlUh|ryP MYPTRW5ITVJ?
NCI-H1417 NGi4[XBIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MmOwTWM2OD1yLkWzOFM2KM7:TR?= MkfXV2FPT0WU
NCI-H2081 MXHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVzJR|UxRTBwNUi2NVEh|ryP MkSzV2FPT0WU
NCI-H1522 MmrxS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEfiWYtKSzVyPUCuOVk{QDNizszN NUnaNYhjW0GQR1XS
NCI-H889 NHfiS|FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF\5bm9KSzVyPUCuOVk5PDRizszN NHjGRmpUSU6JRWK=
CGTH-W-1 NWLicXNOT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NUfPeFBiUUN3ME2wMlYxPzV3IN88US=> MVHTRW5ITVJ?
EB-3 MonKS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NHjNTGlKSzVyPUCuOlEyPTNizszN NGj2ZplUSU6JRWK=
D-336MG NUjRVJBRT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUHJR|UxRTBwNkG3PVEh|ryP NHPYUmFUSU6JRWK=
LC-1F MlO4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWPWZ496UUN3ME2wMlYzPTl{IN88US=> NF;KT2tUSU6JRWK=
MHH-NB-11 NXS3NVduT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NHL1fIpKSzVyPUCuOlM5ODFizszN M4TBbnNCVkeHUh?=
SK-N-FI MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M174bmlEPTB;MD62N|kyKM7:TR?= M1[2VXNCVkeHUh?=
NCI-H69 NXfQWFlxT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NXW3[mdlUUN3ME2wMlY1QDd7IN88US=> NHm0fmdUSU6JRWK=
SCH NVvFXndjT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NGXH[mFKSzVyPUCuOlYxOjNizszN NFTNN3FUSU6JRWK=
LS-513 M{O3emdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NF7nd3FKSzVyPUCuOlczPTlizszN NWXyPJV{W0GQR1XS
CP67-MEL NICxbmVIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NIr5e3dKSzVyPUCuOlc2QTZizszN NYXXSXR[W0GQR1XS
GCIY MlrmS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NIrFZlFKSzVyPUCuO|A{PjNizszN NUDVT4ZQW0GQR1XS
SHP-77 NGnvV3lIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NID6[WJKSzVyPUCuO|A4OzRizszN NVi1TG9NW0GQR1XS
EHEB MkjDS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NX3yfHg6UUN3ME2wMlcyQDV2IN88US=> MlzIV2FPT0WU
D-247MG M3GzW2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVfJR|UxRTBwN{OyN|Ih|ryP M2LjfnNCVkeHUh?=
Raji NIfOcGdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M2nsNGlEPTB;MD63OFk5QSEQvF2= NV\iWnpEW0GQR1XS
MPP-89 NX7QS41lT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3j0WGlEPTB;MD63OVk4QCEQvF2= NX7ZbpNZW0GQR1XS
EKVX NF;BTGJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3z3N2lEPTB;MD63PVA4OyEQvF2= NX;lNI9JW0GQR1XS
HCC2218 NGqwPIZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NXi2dnF6UUN3ME2wMlc6OTNzIN88US=> MXHTRW5ITVJ?
KNS-81-FD MXvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX;JR|UxRTBwOEGwNVEh|ryP MVTTRW5ITVJ?
HCC2157 M{nxU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGXZOFBKSzVyPUCuPFQ6PTFizszN MYXTRW5ITVJ?
BT-474 M1TsOmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkmyTWM2OD1yLki4PFU1KM7:TR?= NEPDXlVUSU6JRWK=
NCI-H748 Mn3vS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFfP[oRKSzVyPUCuPVEzKM7:TR?= NV;yR5BDW0GQR1XS
EW-24 M1LifGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVrJR|UxRTBwOUKwNFIh|ryP MUDTRW5ITVJ?
D-263MG MoC0S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MXjJR|UxRTBwOUS1NVIh|ryP M1XLRXNCVkeHUh?=
OMC-1 M3LEXGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4\oVmlEPTB;MD65OlM4OyEQvF2= MYrTRW5ITVJ?
NCI-H2196 M37j[Wdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4HrWWlEPTB;MD65O|c4PyEQvF2= M2jUUnNCVkeHUh?=
HAL-01 MmrqS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MkTRTWM2OD1yLkm5PFczKM7:TR?= MmPNV2FPT0WU
NCI-H2107 M{nqemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnmN4lKSzVyPUGuNFE5PTRizszN M1;JN3NCVkeHUh?=
LB996-RCC MmHzS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NWTuVYdTUUN3ME2xMlA5ODVzIN88US=> M1fuXnNCVkeHUh?=
NCI-H1395 M3SwS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MVXJR|UxRTFwMUC2O{DPxE1? Ml3vV2FPT0WU
CHP-126 NIP6e|NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MoTSTWM2OD1zLkG2NVk6KM7:TR?= NH7jSIZUSU6JRWK=
NB69 NIi4coNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NHSzW2dKSzVyPUGuNlYyPDhizszN MonKV2FPT0WU
CAS-1 NFrH[lNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{m5Z2lEPTB;MT6zOFI{OSEQvF2= M{Oy[HNCVkeHUh?=
JVM-3 MlnrS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVjRXGR[UUN3ME2xMlQ4QDV3IN88US=> NVHKWY13W0GQR1XS
DMS-153 MVvHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFLHfGhKSzVyPUGuOVc3PzRizszN NVm0cWVWW0GQR1XS
SK-MEL-2 MoLuS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH;2bY5KSzVyPUGuO|E4QDlizszN NGrJeHFUSU6JRWK=
NCI-H1155 M33YbWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2nMXWlEPTB;MT63N|Y4PiEQvF2= NFK1TWdUSU6JRWK=
NCI-H1092 MnexS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3nHbmlEPTB;MT63OlE5OiEQvF2= MmGwV2FPT0WU
LU-165 NG\Nd3ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUP3bYZYUUN3ME2xMlg3PDd4IN88US=> MnXzV2FPT0WU
HL-60 NVzNPWRST3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3nZOWlEPTB;MT65PVkxQCEQvF2= MXfTRW5ITVJ?
REH NUXmRXJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NIT0XGhKSzVyPUKuNFA2QDJizszN M3LvXXNCVkeHUh?=
JVM-2 NWHEVmtCT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M2PhVGlEPTB;Mj6wOlE{PSEQvF2= MWrTRW5ITVJ?
MN-60 MYrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1jITmlEPTB;Mj6xO|MxQCEQvF2= MWDTRW5ITVJ?
SCC-15 NGXwNWtIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NV3ON412UUN3ME2yMlIxOjdizszN MXvTRW5ITVJ?
SNU-C1 MmXaS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MonYTWM2OD1{LkKxN|Q{KM7:TR?= MXTTRW5ITVJ?
SK-MEL-1 NIfw[2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVPmc5NLUUN3ME2yMlMzODR5IN88US=> NGXoZVBUSU6JRWK=
TGW NUjBU5pWT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzyTWM2OD1{LkO1NFI4KM7:TR?= NFu4bohUSU6JRWK=
CA46 M3fsUWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWDJR|UxRTJwN{W5Olch|ryP M{GweXNCVkeHUh?=
NCI-H23 MUHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXXZdFBUUUN3ME2yMlgxPzlzIN88US=> M3LJ[XNCVkeHUh?=
MMAC-SF MVzHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFHicmdKSzVyPUKuPFY3OjhizszN M1XGeXNCVkeHUh?=
NCI-H2171 M{\WN2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXjVWIV5UUN3ME2zMlA{PDR6IN88US=> MmX1V2FPT0WU
A704 NISw[3NIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NFTTR|hKSzVyPUOuNVQyQTRizszN M1KyNXNCVkeHUh?=
DB MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MmjUTWM2OD1|LkK1OVc3KM7:TR?= M3GyZnNCVkeHUh?=
NCI-H719 NVnKb3pzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NYLoSJV5UUN3ME2zMlMxOzh2IN88US=> MkPXV2FPT0WU
MC-CAR MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MXnJR|UxRTNwNUS4NVch|ryP MVvTRW5ITVJ?
SIMA M3zqRmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MoG3TWM2OD1|LkW4OFE3KM7:TR?= NVvnUGRUW0GQR1XS
SW872 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MV7JR|UxRTNwN{ixNFEh|ryP NGH4NGRUSU6JRWK=
HCC1187 NUPST2hTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MUDJR|UxRTNwN{izNVUh|ryP NGK3W5ZUSU6JRWK=
EW-13 MnHYS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NEG0bpBKSzVyPUOuPFM1OTdizszN Mn;nV2FPT0WU
NCI-SNU-1 M3;mWGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3zSXGlEPTB;ND6yNVk6QSEQvF2= NVfvU2JRW0GQR1XS
NCI-H226 MYjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M3jBNGlEPTB;ND6zN|YxPiEQvF2= NFz4VGFUSU6JRWK=
RPMI-8866 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MX\JR|UxRTRwM{[wNlkh|ryP NEP1S4xUSU6JRWK=
OCI-AML2 MWrHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVjJR|UxRTRwNUWyN{DPxE1? NV3TdJNJW0GQR1XS
LU-65 M{DvNmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXzDWIVpUUN3ME20Mlk{ODN|IN88US=> MlXzV2FPT0WU
SK-N-DZ NH\GVWhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVfzR5cyUUN3ME21MlY{PDZ3IN88US=> M2XXbHNCVkeHUh?=
NB14 M3jvS2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2LqfGlEPTB;NT65O|E{PSEQvF2= M1TMR3NCVkeHUh?=
COLO-829 MYHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M1PlbWlEPTB;Nj6zN|M2QSEQvF2= M1q4eHNCVkeHUh?=
MHH-CALL-2 M2XLWmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MkHsTWM2OD14LkWxOVA5KM7:TR?= Mn;SV2FPT0WU
NCI-H1770 NVP2R|F{T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M1H0T2lEPTB;Nj62OlkxPCEQvF2= NV7jbGk6W0GQR1XS
ECC4 M{PuZmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M4XCU2lEPTB;Nj64NlE4QSEQvF2= MXPTRW5ITVJ?
A498 Mlq5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUHJR|UxRTZwOEexPVIh|ryP MV;TRW5ITVJ?
DMS-79 MVXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYnJR|UxRTdwMES1NVIh|ryP NH;E[XlUSU6JRWK=
P30-OHK NFvIVIRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MV3JR|UxRTdwMkG5NFYh|ryP MXrTRW5ITVJ?
D-502MG MknWS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NF\5XJBKSzVyPUeuPVg{PiEQvF2= MVrTRW5ITVJ?
RCC10RGB MUXHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MU\JR|UxRThwME[yPEDPxE1? MXfTRW5ITVJ?
U-698-M MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NV7rWWpmUUN3ME24MlI6OjJ4IN88US=> MmXhV2FPT0WU
BB49-HNC M{Xacmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NGnYVnNKSzVyPUmuOFIzPjVizszN NFTYZW1USU6JRWK=
ES1 MWDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NXnoWoJHUUN3ME25MlY5QTV4IN88US=> MlPoV2FPT0WU
MFM-223 M{LtZWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MYrJR|UxRTFyLkm5Nlch|ryP M1fhW3NCVkeHUh?=
C2BBe1 M3S3[2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{HIV2lEPTB;MUGuN|UzOyEQvF2= MX3TRW5ITVJ?
EB2 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M{fTR2lEPTB;MUKuOlg5OSEQvF2= M1mxenNCVkeHUh?=
C8166 MYLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? Mlz5TWM2OD1zMz64N|A{KM7:TR?= MkeyV2FPT0WU
ES3 NF7sU2FIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWTJR|UxRTF|Lkm5O|ch|ryP MUHTRW5ITVJ?
NCI-H1650 NV;0OpdKT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M3zKTGlEPTB;MU[uN|c3PSEQvF2= MYnTRW5ITVJ?
Mo-T MkniS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M1TiWWlEPTB;MUeuOFAzQSEQvF2= Mof6V2FPT0WU
NB7 NUG4ZpZuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mmi2TWM2OD1zNz63OFY4KM7:TR?= MVTTRW5ITVJ?
ES7 MUPHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2X1UmlEPTB;MUmuOVUxPyEQvF2= MVTTRW5ITVJ?
ES5 MVnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MlLyTWM2OD1{MT63OlcyKM7:TR?= MUXTRW5ITVJ?
MSTO-211H M3fjTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUTMc5NGUUN3ME2yNU45QDV6IN88US=> M3XlW3NCVkeHUh?=
U-87-MG M4DjbGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWXJR|UxRTJ3LkG5OlYh|ryP NIrIWnBUSU6JRWK=
THP-1 MmXES5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUTJR|UxRTJ7LkeyNFEh|ryP M2XsXXNCVkeHUh?=
NB10 NHjxRndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MX3JR|UxRTNyLkK2PVQh|ryP Mn3PV2FPT0WU
NH-12 NFr6ZWpIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M{j3T2lEPTB;M{OuNlAyPyEQvF2= NFnXTZBUSU6JRWK=
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C4-2 M3zaTGdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MWnJR|UxRThibl2= MUGyOVUxPTF5NB?=
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NALM-6 MXTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MUeyOEBp M3LJbmlEPTB;M{SzN|Ahdk1? M{TDR|I1PTF7OUm1
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SIL-ALL NWrxVXJwT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MWKyOEBp M3;5UWlEPTB;MUm5Mlc4KG6P NWe2W3pnOjR3MUm5PVU>
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NALM-16 NHToS4dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NW\TToJ6OjRiaB?= MoPDTWM2OD17Nj6yPEBvVQ>? MmWzNlQ2OTl7OUW=
JURKAT MYnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NF7GfoY1QCCq MorITWM2OD1zND64OEBvVQ>? NEG5XWYzPDVzOUm5OS=>
MOLT-4 NETRd|dIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= Ml60OFghcA>? NHXTVVhKSzVyPUK2MlYhdk1? MXuyOFUyQTl7NR?=
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NALM-6 M3;Q[Gdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2rqdlQ5KGh? MYnJR|UxRTJ|LkK2JI5O M1r2W|I1PTF7OUm1
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SIL-ALL NFO2TpRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NGXKdFk1QCCq MV7JR|UxRTd2Lk[yJI5O MXiyOFUyQTl7NR?=
CEM MV7Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? M2PN[|Q5KGh? NHqxUlRKSzVyPUK0MlU2KG6P NXLQfJl4OjR3MUm5PVU>
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JURKAT MlTyS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MX[3NkBp NUCzSHFQUUN3ME2zMlY2KG6P M{\sXFI1PTF7OUm1
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RS 4;11 NGfvO45Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MYC3NkBp MWrJR|UxRTRwM{igcm0> NFW3c3YzPDVzOUm5OS=>
697 NHLS[XFIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1zjPVczKGh? NIraWWpKSzVyPUe0MlI5KG6P NEPNc|QzPDVzOUm5OS=>
SIL-ALL MlvlS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MUW3NkBp M2fPNGlEPTB;Nz6yJI5O MlrRNlQ2OTl7OUW=
CEM NWqxe2k6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NF7uPHo4OiCq NUCwfVI1UUN3ME21MlQzKG6P MUeyOFUyQTl7NR?=
P12 MVLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MY[3NkBp Mli0TWM2OD14LkO3JI5O MVmyOFUyQTl7NR?=
NALM-16 M2\ofmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofiO|IhcA>? Mo[xTWM2OD15Nz63N{BvVQ>? MYCyOFUyQTl7NR?=
Y79 NGLTVYFCeG:ydH;zbZMhSXO|YYm= MlTHNU02OCCwTR?= NH75bYUyOi9{NDDo MknpSG1UVw>? M3P2WIlv\HWlZXSgZZBweHSxc3nzJJdpcWOqIHPhckBj\SCnbnjhcoNm\CCkeTDIWC=> M1zzdFI1OzZ4Nk[1
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G7 Mly4S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NXLFbYlKUUN3ME2zMlMhdk1? NYToSnBsOjR{MES3N|M>
G166 MWjHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NFvF[m1KSzVyPUeuNEBvVQ>? M1jaXlI1OjB2N{Oz
CB660 M4i1dmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXf0bos1UUN3ME22MlQhdk1? NXXKc3M4OjR{MES3N|M>
CB1117 MoDLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVLJR|UxRTF3Lk[gcm0> M324V|I1OjB2N{Oz
KB-3-1 NHvJS5ZIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M3PofWlEPTB;MT60PEDDuSByLkWzJI5O MoHTNlM6PjJ2NEW=
KB-8-5-11 NXPDUWFzT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NEDSTVVKSzVyPUWuNFEhyrFiMj6wNUBvVQ>? MnHpNlM6PjJ2NEW=
KB-C-1 NXi2[nNTT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MXfJR|UxRTF4Lke2JOKyKDRwNUGgcm0> M3;lNFI{QTZ{NES1
KB-V-1 MnvLS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NH3tT3FKSzVyPUK4NU4zPCEEsTCzNU42PyCwTR?= M1ey[FI{QTZ{NES1
OVCAR-8 M{Gyemdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3vqO2lEPTB;Nz6xPUDDuSB|Lk[wJI5O MUWyN|k3OjR2NR?=
NCI-ADR-RES M1nJdmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MlrZTWM2OD1zMkezMlMxKMLzIEG5NU4zOCCwTR?= Ml62NlM6PjJ2NEW=
MCF7 NWPPWJhVT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MkC3TWM2OD13LkGxJOKyKDFwNEegcm0> MknoNlM6PjJ2NEW=
MCF7-FLV1000 NIT3ZotIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1ruW2lEPTB;M{mzMlE5KMLzIEe0Mlg{KG6P NI[2VHgzOzl4MkS0OS=>
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CORL-23/P NWLHTYR5T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NV\LWJozUUN3ME20MlM5KMLzIEGuNlUhdk1? NGPMUYszOzl4MkS0OS=>
CORL-23/R M{PHR2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NV24Toc3UUN3ME21MlE3KMLzIEGuPFMhdk1? MVSyN|k3OjR2NR?=
NIH3T3 NX\VNVJuT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M4LlV2lEPTB;NECuOlAhyrFiND65O{BvVQ>? NHnw[2gzOzl4MkS0OS=>
NIH3T3-G185 NEn2SmhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MVHJR|UxRTJ2MUOuOFAhyrFiNEKzMlY3KG6P MnK5NlM6PjJ2NEW=
pcDNA-HEK293 MWTHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MVHJR|UxRTJwN{WgxtEhOC54NzDuUS=> Mm[0NlM6PjJ2NEW=
MDR19-HEK293 Mle3S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? M3LWcWlEPTB;OEWuOVAhyrFiMUOuOlchdk1? MmnHNlM6PjJ2NEW=
R482-HEK293 MojBS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MojCTWM2OD1{NT65O{DDuSB2Lkm1JI5O NFSxd2QzOzl4MkS0OS=>
MRP1-HEK293 NYTXUGJtT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MlzETWM2OD1{Lkm5JOKyKDFwNEmgcm0> MV:yN|k3OjR2NR?=
SF188 MoW5S5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NVzOOmtGOTBvMUCwJI5O NVP6O4NIOjRvOU[gbC=> MYHEUXNQ MVfpcohq[mm2czDj[YxtKGe{b4f0bEBqdiCkb4ToJJRqdWVvIHHu[EBkd26lZX70doF1cW:wLTDk[ZBm\GWwdDDtZY5v\XJ? NXXMSVYxOjN6OEe2OFU>
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DU145 M2ryPWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M2DMemROW09? NVvqVmhbUUN3MPMIwFYxKG6P MoTiNlM5QDR2Mki=
LNCaP  MW\Hdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? NUTUdW1xTE2VTx?= NVPpdFB7UUN3MPMIwFc2KG6P M4\YSVI{QDh2NEK4
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RT4 NUjx[YlPT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= Mo\FTWM2OD1{Nz6yNUBvVQ>? MUWyN|c6OjZ|OR?=
5637 MkTQS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MWrJR|UxRTR3LkS3JI5O M{TmT|I{Pzl{NkO5
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MCF7  MlnHSpVv[3Srb36gRZN{[Xl? MnXRNVAxKG6P NGrsOosyKGh? MWXEUXNQ Mo[5doVlfWOnczD0bIUhcW6mdXP0bY9vKG:owrDHdoVjOS{EoGPnb|EtyqCSc{KsxsBU\XKyaX7hN{wh[W6mwrDXbZNxOg>? M4nrN|I{PzdyMkS0
KB-V1  MXnHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MnvxTWM2OD1|LkmyJO69VQ>? Mlu0NlM2QTNzOU[=
Hec50co M3Xpb2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MXfJR|UxRTVibl2= MV6yN|E1PjZ6Nx?=
MDA-MB-468 Ml;lRZBweHSxc3nzJGF{e2G7 Mnq1NU82NzFyIH7N MVuyOE81QC95MjDo M4PxeWROW09? MV\pcoR2[2W|IHHwc5B1d3OrczDpckBiKGSxc3Wt[IVx\W6mZX70JI1idm6nch?= NUjT[VZSOjNzNESyPVQ>
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HeLa  NIHKfFJIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUK3OolpOTBvMUCwJI5O NWnSNGdYPDhiaB?= MX7EUXNQ NEDDS25KSzVyPUWyMlkhdk1? Mn7tNlIxQDB{M{W=
HeLa  NI\FcmdIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M17rSFExNTFyMDDuUS=> NWXzfHg1PzJiaB?= NF24XZFFVVOR MU\JR|UxRTVyLkWgcm0> NHXudGszOjB6MEKzOS=>
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GB-CL-1 M1TEfmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M{ex[lczKGh? NIewV2tKSzVyPUWuNlIhdk1? MnXpNlE6PjV5M{m=
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HMC-1.1 NX3rR5g6T3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{DqdlEuOTByMDDuUS=> MkjhO|IhcA>? M3LybolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZUBld3OnLXTldIVv\GWwdDDtZY5v\Q>? NEnQR3YzOTJ2MkG4PS=>
HMC-1.2 NGXZUohIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MXSxMVExODBibl2= MWK3NkBp Ml;FbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDhJIRwe2VvZHXw[Y5l\W62IH3hco5m M1XHTlIyOjR{MUi5
C2 NFr2UndIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MWKxMVExODBibl2= NIHXdFk4OiCq MUPpcohq[mm2czD0bIUh[2WubDDwdo9tcW[ncnH0bY9vKGmwIHGg[I9{\S2mZYDlcoRmdnRibXHucoU> NFv6Vm4zOTJ2MkG4PS=>
CHP-212 Mo\RS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MVixMVEzPSCwTR?= M4\ITlI1NTF{MDDo MojqbY5pcWKrdIOgeIhmKGOnbHygdJJwdGmoZYLheIlwdiCrbjDic5RpKHSrbXWtJIFv\CCmb4PlMYRmeGWwZHXueEBu[W6wZR?= NGnhc2YzOTF4OUK0Ni=>
IMR-32 M1PIU2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 M3;2NlEuOTJ3IH7N M13zbFI1NTF{MDDo NHrpOHZqdmirYnn0d{B1cGViY3XscEBxem:uaX\ldoF1cW:wIHnuJIJwfGhidHnt[U0h[W6mIHTvd4Uu\GWyZX7k[Y51KG2jbn7l MnzZNlEyPjl{NEK=
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SH-SY5Y NVjWSXJkT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= M{PaU|EuOTJ3IH7N MnnaNlQuOTJyIHi= NWXXUHRlcW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> NH7wVpgzOTF4OUK0Ni=>
SK-N-AS M{PwXmdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NUHCU4VnOS1zMkWgcm0> MVuyOE0yOjBiaB?= M4rsNIlvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= M3jvUlIyOTZ7MkSy
SK-N-BE MnTtS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? MnLaNU0yOjVibl2= MUeyOE0yOjBiaB?= M3HFeolvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= MofzNlEyPjl{NEK=
KG1 M{X4N2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MnzxNU8yOC9zMECgcm0> MW[3NkBp NFXnT3lFVVOR M3nKS4lvcGmkaYTzJJRp\SClZXzsJJBzd2yrZnXyZZRqd25iaX6gZo91cCC2aX3lMUBidmRiZH;z[U1l\XCnbnTlcpQhdWGwbnW= NV\WNmVFOTl2NUizOVg>
U937 NFrUeVhIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NUDDWYhPOS9zMD:xNFAhdk1? M4L6NlczKGh? NVz0TnB6TE2VTx?= NV74TJR7cW6qaXLpeJMhfGinIHPlcIwheHKxbHnm[ZJifGmxbjDpckBjd3SqIITpcYUuKGGwZDDkc5NmNWSncHXu[IVvfCCvYX7u[S=> NXHoOJl5OTl2NUizOVg>
CAL62 NFf4d4JIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NVy2fmNOOC5zLUGwNEBvVQ>? MWG3NkBp MYrEUXNQ NHTGd4tGSzVyPUGuOEBvVQ>? NI\SdpYyQTJ{M{W1Ny=>
OCUT-1 M{T3Omdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NXnEVYQ2OC5zLUGwNEBvVQ>? MV:3NkBp M3vsZ2ROW09? M2HE[2VEPTB;Mj6zJI5O MV:xPVIzOzV3Mx?=
8505C MUDHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MoT6NE4yNTFyMDDuUS=> M3PGcVczKGh? NXSx[WdJTE2VTx?= M3zlOWVEPTB;Mz6yJI5O NETWb5MyQTJ{M{W1Ny=>
ACT-1 NV7CdYFnT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MnXoNE4yNTFyMDDuUS=> MmTRO|IhcA>? NV3JNmhRTE2VTx?= M4TCdGVEPTB;NT60JI5O NXvnOoFlOTl{MkO1OVM>
SW1736 M4jBT2dzd3e2aDDJcohq[mm2aX;uJGF{e2G7 NEPu[|AxNjFvMUCwJI5O M2\JfFczKGh? NXfZPHQ6TE2VTx?= NF7ISGFGSzVyPUWuOkBvVQ>? NYnJbG9qOTl{MkO1OVM>

... Click to View More Cell Line Experimental Data

In vivo BI 2536 given i.v. once or twice per week is highly efficacious in diverse xenograft models with acceptable tolerability by inhibiting cell proliferation through a mitotic arrest, and subsequently induction of tumor-cell death. Administration of BI 2536 at 50 mg/kg once or twice per week significantly inhibits growth of HCT 116 xenografts with T/C of 15% and 0.3%, respectively. BI 2536 treatment twice-weekly also leads to excellent tumor-growth in BxPC-3 and A549 models with T/C of 5% and 14%, respectively. [1]

Protocol

Kinase Assay:[1]
+ Expand

Plk1 in vitro kinase assay:

Recombinant human Plk1 (residues 1-603) is expressed as N-terminal, GST-tagged fusion protein with a baculoviral expression system and purified by affinity chromatography with Glutathione-agarose. Enzyme activity assays for Plk1 are performed in the presence of serially diluted BI 2536 with 20 ng of recombinant kinase and 10 μg casein from bovine milk as the substrate. Kinase reactions are performed in a final volume of 60 μL for 45 minutes at 30 °C (15 mM MgCl2, 25 mM MOPS [pH 7.0], 1 mM DTT, 1% DMSO, 7.5 mM ATP, 0.3 μCi γ-33P-ATP). Reactions are terminated by the addition of 125 μL of ice-cold 5% TCA. After transfer of the precipitates to Multi-Screen mixed ester cellulose filter plates, plates are washed with 1% TCA and quantified radiometrically. Dose-response curve is used for calculating IC50 value.
Cell Research:[1]
+ Expand
  • Cell lines: HeLa, A43, SKOV-3, HT-29, K562, A549, Saos-2, MCF7, HCT116, COLO 205, Hep G2, Raji and PC-3 cells, etc.
  • Concentrations: Dissolved in DMSO, final concentrations ~1 μM
  • Incubation Time: 24 and 72 hours
  • Method: Cells are exposed to various concentrations of BI 2536 for 24, and 72 hours. Cell growth is assessed by the measurement of Alamar Blue dye conversion in a fluorescence spectrophotometer. For determining the DNA content of the cultures, cell suspensions are fixed in 80% ethanol, treated for 5 minutes with 0.25% Triton X-100 in PBS, and incubated with 0.1% RNase and 10 μg/mL propidium iodide (PI) in PBS for 20 minutes at RT. Cell-cycle profiles are determined by flow cytometric analysis.
    (Only for Reference)
Animal Research:[1]
+ Expand
  • Animal Models: Female BomTac:NMRI-Foxn1nu mice injected subcutaneously with HCT 116, NCI-H460, or A549 cells
  • Formulation: Formulated in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl
  • Dosages: ~50 mg/kg
  • Administration: Injection i.v. once or twice per week
    (Only for Reference)

Solubility (25°C)

In vitro Ethanol 100 mg/mL (191.69 mM)
DMSO 21 mg/mL (40.25 mM)
Water Insoluble
In vivo Add solvents to the product individually and in order:
30% PEG 400+0.5% Tween 80+5% Propylene glycol
For best results, use promptly after mixing.
15mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 521.66
Formula

C28H39N7O3

CAS No. 755038-02-9
Storage powder
Synonyms N/A

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT00526149 Completed Breast Cancer|Endometrial Cancer|Head and Neck Cancer|Melanoma (Skin)|Ovarian Cancer|Sarcoma European Organisation for Research and Treatment of Cancer - EORTC July 2007 Phase 2
NCT02215044 Terminated Pancreatic Neoplasms Boehringer Ingelheim June 2007 Phase 1
NCT00412880 Completed Carcinoma, Small Cell Boehringer Ingelheim January 2007 Phase 2
NCT02211833 Completed Carcinoma, Non-Small-Cell Lung Boehringer Ingelheim October 2006 Phase 1
NCT00701766 Completed Leukemia, Myeloid, Acute Boehringer Ingelheim October 2006 Phase 2
NCT00706498 Completed Prostatic Neoplasms Boehringer Ingelheim September 2006 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

Frequently Asked Questions

  • Question 1:

    We need to use BI 2536 in preclinical studies using mice, how to formulate the inhibitor for this in vivo study?

  • Answer:

    For in vivo study, DMSO should not be more than 5% because the toxicity. You can formulated BI2536 in hydrochloric acid (0.1 N), and diluted with 0.9% NaCl for animal study according to the reference :( Supplemental Data) http://linkinghub.elsevier.com/retrieve/pii/S0960-9822(06)02671-6

PLK Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID