Research Area
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HMN-214 Chemical Structure
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Biological Activity
HMN-214 (IVX-214, HMN214) is a potent PLK1 inhibitor an average IC50 of 0.12 μM. HMN-176 is an active metabolite of HMN-214 (IVX-214, HMN214). HMN-214 (IVX-214, HMN214) is an oral stilbene derivative. HMN-176 interferes with PLK1, but does not appear to directly inhibit PLK1. Instead, it alters its spatial distribution, resulting in cell cycle arrest at the G2–M phase, with destruction of the spindle polar bodies followed by DNA fragmentation. In human tumor xenografts, there was a broad spectrum of antitumor activity. The antitumor activity of HMN-214 (IVX-214, HMN214) was equal or superior to that of clinically available agents, including cisplatin, doxorubicin, vincristine, and tegafur-uracil. [1][2][3]
References on HMN-214
- [1] The Oncologist 2009;14:559–570
- [2] Clin Cancer Res 2006;12:5182-5189
- [3] Cancer Res 2003;63:6942-6947
Chemical Information
| Molecular Weight (WM): | 424.47 |
|---|---|
| Formula: | C22H20N2O5S |
| CAS No.: | 173529-46-9 |
| Synonyms: |
N/A
|
| Dissolve in (25°C): | DMSO ≥24mg/mL |
| Water <1mg/mL | |
| Ethanol <1mg/mL | |
| Storage: | 2 years-20°CPowder |
| 1 week-4°Cin DMSO | |
| 1 month-80°in DMSO |
Quality Control & MSDS
Research Area
Notes:
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